{"id":3545,"date":"2026-09-29T08:37:18","date_gmt":"2026-09-29T01:37:18","guid":{"rendered":"https:\/\/cpc1.vn\/dimethyl-beta-cyclodextrin\/"},"modified":"2026-09-29T08:37:18","modified_gmt":"2026-09-29T01:37:18","slug":"dimethyl-beta-cyclodextrin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/dimethyl-beta-cyclodextrin\/","title":{"rendered":"Dimethyl-\u03b2-cyclodextrin (DIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan d\u01b0\u1ee3c ch\u1ea5t"},"content":{"rendered":"

Dimethyl-\u03b2-cyclodextrin (DIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan d\u01b0\u1ee3c ch\u1ea5t<\/h1>\n

Dimethyl-\u03b2-cyclodextrin<\/strong> (DIMEB, 2,6-di-O-methyl-\u03b2-cyclodextrin) l\u00e0 d\u1eabn ch\u1ea5t methyl h\u00f3a kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin, trong \u0111\u00f3 to\u00e0n b\u1ed9 nh\u00f3m hydroxyl \u1edf C2 v\u00e0 C6 \u0111\u01b0\u1ee3c methyl h\u00f3a. Nh\u01b0 c\u00e1c cyclodextrin kh\u00e1c, DIMEB t\u1ea1o ph\u1ee9c l\u1ed3ng<\/strong> v\u1edbi d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 h\u00f2a tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh<\/strong>, nh\u01b0ng tan trong n\u01b0\u1edbc t\u1ed1t h\u01a1n nhi\u1ec1u so v\u1edbi \u03b2-cyclodextrin.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nDIMEB, DM-\u03b2-CD, heptakis(2,6-di-O-methyl)-\u03b2-cyclodextrin, tetradeca-O-methyl-\u03b2-cyclodextrin<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n51166-71-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC56<\/sub>H98<\/sub>O35<\/sub> \u2013 1331,36<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ph\u1ee9c, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u1ea1o vi nang, t\u0103ng tan, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1eb3ng tr\u01b0\u01a1ng<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn ch\u00ednh th\u1ee9c; c\u00f3 trong ph\u1ee5 l\u1ee5c thu\u1ed1c th\u1eed c\u1ee7a BP v\u00e0 Ph.Eur.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • T\u1ea1o ph\u1ee9c l\u1ed3ng \u0111\u1ec3 c\u1ea3i thi\u1ec7n h\u00f2a tan, \u0111\u1ed9 tan, sinh kh\u1ea3 d\u1ee5ng v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan trong ch\u1ebf ph\u1ea9m u\u1ed1ng, b\u00f4i, nh\u1ecf m\u1eaft, \u0111\u1eb7t tr\u1ef1c tr\u00e0ng, x\u1ecbt m\u0169i v\u00e0 h\u00edt qua ph\u1ed5i; \u1ee9ng d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 \u03b2-cyclodextrin.<\/li>\n
  • Nghi\u00ean c\u1ee9u trong ti\u1ec3u ph\u00e2n nano, vi c\u1ea7u gi\u1ea3i ph\u00f3ng c\u00f3 \u0111i\u1ec1u ch\u1ec9nh v\u00e0 l\u00e0m ch\u1ea5t mang thu\u1ed1c \u0111\u01b0\u1eddng ti\u00eam.<\/li>\n
  • C\u00e1c \u03b2-cyclodextrin methyl h\u00f3a \u0111\u00e3 c\u00f3 m\u1eb7t trong thu\u1ed1c x\u1ecbt m\u0169i v\u00e0 thu\u1ed1c nh\u1ecf m\u1eaft t\u1ea1i ch\u00e2u \u00c2u.<\/li>\n
  • Ngo\u00e0i d\u01b0\u1ee3c ph\u1ea9m: d\u00f9ng trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y Bordetella pertussis<\/em> \u0111\u1ec3 s\u1ea3n xu\u1ea5t vaccin; c\u00f3 th\u1ec3 d\u00f9ng lo\u1ea1i cholesterol kh\u1ecfi th\u1ef1c ph\u1ea9m ch\u1ebf bi\u1ebfn.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng.<\/li>\n
    • pH 4,6\u20135,7; \u0111\u01b0\u1eddng k\u00ednh khoang kho\u1ea3ng 6 \u00c5; m\u1ee9c th\u1ebf methyl 12\u201316; \u0111i\u1ec3m ch\u1ea3y 295\u2013300 \u00b0C; s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 62 mN\/m (25 \u00b0C).<\/li>\n
    • \u0110\u1ed9 tan: 1 trong 1,75 ph\u1ea7n n\u01b0\u1edbc v\u00e0 1 trong 135 ph\u1ea7n ethanol 95% \u1edf 25 \u00b0C \u2013 cao h\u01a1n nhi\u1ec1u so v\u1edbi \u03b1-, \u03b2-, \u03b3-cyclodextrin t\u1ef1 nhi\u00ean; \u0111\u1ed9 tan trong n\u01b0\u1edbc gi\u1ea3m khi nhi\u1ec7t \u0111\u1ed9 t\u0103ng.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf tr\u1ea1ng th\u00e1i r\u1eafn n\u1ebfu tr\u00e1nh \u0111\u1ed9 \u1ea9m cao. T\u01b0\u01a1ng \u0111\u1ed1i b\u1ec1n trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m, nh\u01b0ng b\u1ecb acid m\u1ea1nh th\u1ee7y ph\u00e2n th\u00e0nh oligosaccharid m\u1ea1ch th\u1eb3ng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, th\u00f4ng tho\u00e1ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Methyl h\u00f3a ch\u1ecdn l\u1ecdc \u03b2-cyclodextrin \u1edf to\u00e0n b\u1ed9 nh\u00f3m hydroxyl b\u1eadc hai C2 v\u00e0 nh\u00f3m hydroxyl b\u1eadc m\u1ed9t C6; nh\u00f3m hydroxyl C3 gi\u1eef nguy\u00ean.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u1ede d\u1ea1ng tinh khi\u1ebft c\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p v\u00e0 c\u00f3 h\u1ea1i khi nu\u1ed1t.<\/li>\n
      • DIMEB t\u00e1ch cholesterol, l\u00e0m bi\u1ebfn \u0111\u1ed5i vi v\u00f9ng lipid (lipid raft) c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o; \u0111\u1ed9c t\u1ebf b\u00e0o cao h\u01a1n c\u00e1c \u03b2-cyclodextrin methyl h\u00f3a kh\u00e1c do kh\u1ea3 n\u0103ng r\u00fat cholesterol m\u1ea1nh h\u01a1n \u2013 c\u1ea7n c\u00e2n nh\u1eafc khi ch\u1ecdn cho \u0111\u01b0\u1eddng d\u00f9ng nh\u1ea1y c\u1ea3m.<\/li>\n
      • OSHA (M\u1ef9): gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m 5 mg\/m\u00b3 b\u1ee5i h\u00f4 h\u1ea5p. LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): tr\u00ean 3,0 g\/kg.<\/li>\n
      • Tr\u00e1nh ti\u1ebfp x\u00fac da, m\u1eaft; tr\u00e1nh h\u00edt; \u0111eo g\u0103ng, k\u00ednh v\u00e0 thao t\u00e1c n\u01a1i th\u00f4ng tho\u00e1ng.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Cyclodextrin (\u03b1, \u03b2, \u03b3), hydroxyethyl-\u03b2-cyclodextrin, hydroxypropyl betadex, sulfobutylether-\u03b2-cyclodextrin, trimethyl-\u03b2-cyclodextrin.<\/p>\n

          Ghi ch\u00fa:<\/strong> PubChem CID 122143.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Dimethyl-beta-cyclodextrin<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Dimethyl-\u03b2-cyclodextrin (DIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan d\u01b0\u1ee3c ch\u1ea5t Dimethyl-\u03b2-cyclodextrin (DIMEB, 2,6-di-O-methyl-\u03b2-cyclodextrin) l\u00e0 d\u1eabn ch\u1ea5t methyl h\u00f3a kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin, trong \u0111\u00f3 to\u00e0n b\u1ed9 nh\u00f3m hydroxyl \u1edf C2 v\u00e0 C6 \u0111\u01b0\u1ee3c methyl h\u00f3a. Nh\u01b0 c\u00e1c cyclodextrin kh\u00e1c, DIMEB t\u1ea1o ph\u1ee9c l\u1ed3ng v\u1edbi d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9 […]<\/p>\n","protected":false},"author":1,"featured_media":3544,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dimethyl-beta-cyclodextrin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Dimethyl-\u03b2-cyclodextrin (DIMEB) \u2013 t\u1ea1o ph\u1ee9c l\u1ed3ng, t\u0103ng \u0111\u1ed9 tan d\u01b0\u1ee3c ch\u1ea5t Dimethyl-\u03b2-cyclodextrin (DIMEB, 2,6-di-O-methyl-\u03b2-cyclodextrin) l\u00e0 d\u1eabn ch\u1ea5t methyl h\u00f3a kh\u00f4ng ion c\u1ee7a \u03b2-cyclodextrin, trong \u0111\u00f3 to\u00e0n b\u1ed9 nh\u00f3m hydroxyl \u1edf C2 v\u00e0 C6 \u0111\u01b0\u1ee3c methyl h\u00f3a. Nh\u01b0 c\u00e1c cyclodextrin kh\u00e1c, DIMEB t\u1ea1o ph\u1ee9c l\u1ed3ng v\u1edbi d\u01b0\u1ee3c ch\u1ea5t k\u00e9m tan \u0111\u1ec3 t\u0103ng \u0111\u1ed9 tan, t\u1ed1c \u0111\u1ed9…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3545"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3545\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3544"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}