{"id":3541,"date":"2026-09-29T08:37:04","date_gmt":"2026-09-29T01:37:04","guid":{"rendered":"https:\/\/cpc1.vn\/diethyl-sebacat\/"},"modified":"2026-09-29T08:37:04","modified_gmt":"2026-09-29T01:37:04","slug":"diethyl-sebacat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/diethyl-sebacat\/","title":{"rendered":"Diethyl sebacat \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m qua da"},"content":{"rendered":"

Diethyl sebacat \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m qua da<\/h1>\n

Diethyl sebacat<\/strong> (DES) l\u00e0 diester ethyl c\u1ee7a acid sebacic (acid decanedioic), ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u ho\u1eb7c h\u01a1i v\u00e0ng, m\u00f9i tr\u00e1i c\u00e2y \u0111\u1eb7c tr\u01b0ng. Trong b\u00e0o ch\u1ebf, diethyl sebacat l\u00e0 ch\u1ea5t l\u00e0m m\u1ec1m<\/strong> v\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/strong> cho ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nEthyl sebacat, diethyl decanedioat, ester diethyl c\u1ee7a acid sebacic, DES<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n110-40-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC14<\/sub>H26<\/sub>O4<\/sub> \u2013 258,35<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t l\u00e0m m\u1ec1m, ch\u1ea5t t\u0103ng th\u1ea5m<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong JPE<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t l\u00e0m m\u1ec1m trong kem, nh\u0169 t\u01b0\u01a1ng v\u00e0 dung d\u1ecbch b\u00f4i ngo\u00e0i.<\/li>\n
  • T\u0103ng th\u1ea5m qua da cho nhi\u1ec1u nh\u00f3m ho\u1ea1t ch\u1ea5t (kh\u00e1ng vi\u00eam, kh\u00e1ng n\u1ea5m, g\u00e2y t\u00ea t\u1ea1i ch\u1ed7) \u1edf n\u1ed3ng \u0111\u1ed9 t\u1edbi 24%.<\/li>\n
  • \u0110\u00e3 d\u00f9ng trong micell copolymer kh\u1ed1i PEG\u2013poly(amin-co-ester) l\u00e0m h\u1ec7 d\u1eabn thu\u1ed1c (nghi\u00ean c\u1ee9u).<\/li>\n
  • Ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng trong th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u ho\u1eb7c h\u01a1i v\u00e0ng, m\u00f9i tr\u00e1i c\u00e2y.<\/li>\n
    • USP-NF: t\u1ef7 tr\u1ecdng 0,958\u20130,968; chi\u1ebft su\u1ea5t 1,435\u20131,437; h\u00e0m l\u01b0\u1ee3ng 98,0\u2013100,5%.<\/li>\n
    • \u0110i\u1ec3m s\u00f4i 307\u2013312 \u00b0C (c\u00f3 ph\u00e2n h\u1ee7y m\u1ed9t ph\u1ea7n); \u0111i\u1ec3m ch\u1ea3y 1\u20133 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 113 \u00b0C (c\u1ed1c h\u1edf).<\/li>\n
    • \u0110\u1ed9 nh\u1edbt 6,1 mPa\u00b7s (20 \u00b0C); s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 33,2 mN\/m; log P (octanol\/n\u01b0\u1edbc) kho\u1ea3ng 3,8\u20134,3 (t\u00ednh to\u00e1n).<\/li>\n
    • \u0110\u1ed9 tan: tr\u1ed9n l\u1eabn v\u1edbi ethanol, ether, hydrocarbon, d\u1ea7u b\u00e9o v\u00e0 m\u1ee1; tan 1 trong 700 ph\u1ea7n n\u01b0\u1edbc l\u1ea1nh, 1 trong 50 ph\u1ea7n n\u01b0\u1edbc s\u00f4i.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n v\u1edbi th\u1ee7y ph\u00e2n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng, kh\u00f4ng c\u00f3 xu h\u01b0\u1edbng \u00f4i. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i m\u00e1t, th\u00f4ng tho\u00e1ng, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t v\u00e0 ngu\u1ed3n l\u1eeda.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a v\u00e0 ki\u1ec1m.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a acid sebacic v\u1edbi ethanol, x\u00fac t\u00e1c acid sulfuric.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u1ed9c nh\u1eb9 khi nu\u1ed1t; k\u00edch \u1ee9ng da, c\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft v\u00e0 ni\u00eam m\u1ea1c; \u0111\u00e3 ghi nh\u1eadn vi\u00eam da ti\u1ebfp x\u00fac do diethyl sebacat trong kem b\u00f4i.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t lang, u\u1ed1ng): 7,28 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 14,47 g\/kg.<\/li>\n
      • Khi \u0111un sinh kh\u00f3i cay, k\u00edch \u1ee9ng. M\u1eb7c \u0111\u1ed3 b\u1ea3o h\u1ed9, tr\u00e1nh ti\u1ebfp x\u00fac da v\u00e0 m\u1eaft.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; c\u00f3 trong danh m\u1ee5c ph\u1ee5 gia th\u1ef1c ph\u1ea9m EAFUS c\u1ee7a FDA.<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (nh\u0169 t\u01b0\u01a1ng, kem, dung d\u1ecbch b\u00f4i).<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex v\u00e0 JPE.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Dibutyl sebacat.<\/p>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 203-764-5; PubChem CID 8049.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Diethyl Sebacate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Diethyl sebacat \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m qua da Diethyl sebacat (DES) l\u00e0 diester ethyl c\u1ee7a acid sebacic (acid decanedioic), ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u ho\u1eb7c h\u01a1i v\u00e0ng, m\u00f9i tr\u00e1i c\u00e2y \u0111\u1eb7c tr\u01b0ng. Trong b\u00e0o ch\u1ebf, diethyl sebacat l\u00e0 ch\u1ea5t l\u00e0m m\u1ec1m v\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m qua da cho ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i. Th\u00f4ng tin […]<\/p>\n","protected":false},"author":1,"featured_media":3540,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/diethyl-sebacat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Diethyl sebacat \u2013 ch\u1ea5t l\u00e0m m\u1ec1m, t\u0103ng th\u1ea5m qua da Diethyl sebacat (DES) l\u00e0 diester ethyl c\u1ee7a acid sebacic (acid decanedioic), ch\u1ea5t l\u1ecfng kh\u00f4ng m\u00e0u ho\u1eb7c h\u01a1i v\u00e0ng, m\u00f9i tr\u00e1i c\u00e2y \u0111\u1eb7c tr\u01b0ng. Trong b\u00e0o ch\u1ebf, diethyl sebacat l\u00e0 ch\u1ea5t l\u00e0m m\u1ec1m v\u00e0 ch\u1ea5t t\u0103ng th\u1ea5m qua da cho ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i. Th\u00f4ng tin…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3541"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3541\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3540"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}