{"id":3539,"date":"2026-09-29T08:36:57","date_gmt":"2026-09-29T01:36:57","guid":{"rendered":"https:\/\/cpc1.vn\/dextran\/"},"modified":"2026-09-29T08:36:57","modified_gmt":"2026-09-29T01:36:57","slug":"dextran","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/dextran\/","title":{"rendered":"Dextran \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, b\u1ea3o v\u1ec7 protein, t\u00e1 d\u01b0\u1ee3c d\u00ednh"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Dextran \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, b\u1ea3o v\u1ec7 protein, t\u00e1 d\u01b0\u1ee3c d\u00ednh<\/h1>\n<p><strong>Dextran<\/strong> l\u00e0 polysaccharid ph\u00e2n nh\u00e1nh, ph\u00e2n t\u1eed l\u01b0\u1ee3ng l\u1edbn, t\u1ea1o t\u1eeb c\u00e1c \u0111\u01a1n v\u1ecb \u03b1-D-glucose, thu \u0111\u01b0\u1ee3c khi vi khu\u1ea9n l\u00ean men saccarose. Trong b\u00e0o ch\u1ebf, dextran ch\u1ee7 y\u1ebfu d\u00f9ng l\u00e0m <strong>t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho ch\u1ebf ph\u1ea9m \u0111\u00f4ng kh\u00f4<\/strong> v\u00e0 <strong>ch\u1ea5t b\u1ea3o v\u1ec7 protein khi \u0111\u00f4ng kh\u00f4<\/strong> (lyoprotectant); ngo\u00e0i ra \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh, t\u00e1 d\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t v\u00e0 v\u1eadt li\u1ec7u d\u1eabn thu\u1ed1c.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Polymer glucose, c\u00e1c dextran (dextran 1, 40, 60, 70\u2026)<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>9004-54-0<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c<\/td>\n<td>(C<sub>6<\/sub>H<sub>10<\/sub>O<sub>5<\/sub>)<sub>n<\/sub>; ph\u00e2n \u0111o\u1ea1n t\u1eeb 1000 Da (dextran 1) t\u1edbi 2 000 000 Da (dextran 2000), th\u00f4ng d\u1ee5ng nh\u1ea5t: dextran 1, dextran 40 (40 000 Da), dextran 70 (70 000 Da)<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>T\u00e1 d\u01b0\u1ee3c h\u1ed7 tr\u1ee3 \u0111\u00f4ng kh\u00f4<\/td>\n<\/tr>\n<tr>\n<td>D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>BP, Ph.Eur. (Dextran 1, 60, 70 for Injection), JP (Dextran 40, 70), USP-NF (Dextran 1, 70); c\u00f3 ti\u00eau chu\u1ea9n trong JPE<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>C\u1ea5u t\u1ea1o<\/h2>\n<p>M\u1ea1ch ch\u00ednh n\u1ed1i \u03b1(1\u21926); nh\u00e1nh ch\u1ee7 y\u1ebfu \u1edf C3 (\u03b1(1\u21923)), \u0111\u00f4i khi \u1edf C4 ho\u1eb7c C2. Dextran th\u01b0\u01a1ng m\u1ea1i c\u00f3 kho\u1ea3ng 95% li\u00ean k\u1ebft \u03b1(1\u21926) \u1edf m\u1ea1ch ch\u00ednh v\u00e0 kho\u1ea3ng 5% nh\u00e1nh; kho\u1ea3ng 80% nh\u00e1nh ch\u1ec9 l\u00e0 m\u1ed9t \u0111\u01a1n v\u1ecb glucose. Dextran t\u1ef1 nhi\u00ean c\u00f3 \u0111\u1ed9 \u0111a ph\u00e2n t\u00e1n r\u1ed9ng; qua th\u1ee7y ph\u00e2n acid m\u1ed9t ph\u1ea7n v\u00e0 ph\u00e2n \u0111o\u1ea1n, \u0111\u1ed9 \u0111a ph\u00e2n t\u00e1n gi\u1ea3m. Ph\u00e2n t\u1eed l\u01b0\u1ee3ng trung b\u00ecnh c\u00e0ng cao th\u00ec \u0111\u1ed9 \u0111a ph\u00e2n t\u00e1n th\u01b0\u1eddng c\u00e0ng l\u1edbn.<\/p>\n<h2>Applications<\/h2>\n<ul>\n<li>T\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho b\u00e1nh \u0111\u00f4ng kh\u00f4 v\u00e0 ch\u1ea5t b\u1ea3o v\u1ec7 protein trong ch\u1ebf ph\u1ea9m protein \u0111\u00f4ng kh\u00f4.<\/li>\n<li>\u0110\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh cho vi\u00ean gi\u1ea3i ph\u00f3ng t\u1ee9c th\u00ec v\u00e0 t\u00e1 d\u01b0\u1ee3c vi\u00ean gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t.<\/li>\n<li>Li\u00ean h\u1ee3p v\u1edbi protein \u0111\u1ec3 d\u1eabn thu\u1ed1c \u0111\u00edch \u0111\u01b0\u1eddng ti\u00eam v\u00e0 \u1ed5n \u0111\u1ecbnh protein; t\u1ea1o ti\u1ec3u ph\u00e2n nano li\u00ean h\u1ee3p dextran \u2013 acid \u0111\u1ec3 d\u1eabn thu\u1ed1c t\u1edbi t\u1ebf b\u00e0o ung th\u01b0; ch\u1ea5t b\u00e1m d\u00ednh ni\u00eam m\u1ea1c k\u00e9o d\u00e0i th\u1eddi gian l\u01b0u c\u1ee7a b\u1ed9t x\u1ecbt m\u0169i.<\/li>\n<li>D\u1eabn thu\u1ed1c \u0111\u00edch \u0111\u01b0\u1eddng u\u1ed1ng c\u00f2n h\u1ea1n ch\u1ebf do h\u1ea5p thu r\u1ea5t \u00edt. Dextran bi\u1ebfn t\u00ednh cation l\u00e0 m\u1ed9t trong nh\u1eefng h\u1ec7 polymer kh\u00f4ng virus \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u nh\u1ea5t \u0111\u1ec3 d\u1eabn gen.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh tr\u1eafng t\u1edbi tr\u1eafng ng\u00e0, h\u00fat \u1ea9m; trong b\u00e1nh \u0111\u00f4ng kh\u00f4, dextran v\u00f4 \u0111\u1ecbnh h\u00ecnh v\u00e0 h\u00fat \u1ea9m c\u1ea3 tr\u01b0\u1edbc v\u00e0 sau \u0111\u00f4ng kh\u00f4.<\/li>\n<li>\u0110\u1ed9 tan: d\u1ec5 tan trong n\u01b0\u1edbc (tr\u00ean 50% kl\/tt); tan trong dimethyl sulfid, formamid, ethylen glycol, glycerol; kh\u00f4ng tan trong methanol, ethanol, isopropanol, aceton v\u00e0 c\u00e1c ceton kh\u00e1c.<\/li>\n<li>\u0110\u1ed9 nh\u1edbt dung d\u1ecbch t\u0103ng tuy\u1ebfn t\u00ednh theo ph\u00e2n t\u1eed l\u01b0\u1ee3ng polymer.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn \u0111\u1ec3 tr\u00e1nh h\u00fat n\u01b0\u1edbc. USP-NF: dextran 1 b\u1ea3o qu\u1ea3n 4\u201330 \u00b0C; dextran 40 v\u00e0 70 b\u1ea3o qu\u1ea3n 15\u201330 \u00b0C. B\u1ed9t dextran b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c t\u1edbi 5 n\u0103m \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng; dung d\u1ecbch n\u01b0\u1edbc h\u1ea5p ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c v\u00e0 b\u1ec1n trong m\u00f4i tr\u01b0\u1eddng acid ho\u1eb7c ki\u1ec1m nh\u1eb9.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u00e0i li\u1ec7u g\u1ed1c kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 c\u1ee5 th\u1ec3.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>T\u1ed5ng h\u1ee3p enzym b\u1eb1ng vi khu\u1ea9n <em>Leuconostoc mesenteroides<\/em> nu\u00f4i trong m\u00f4i tr\u01b0\u1eddng saccarose (enzym dextransucrase). T\u1ee7a polymer b\u1eb1ng ethanol ho\u1eb7c methanol, r\u1ed3i th\u1ee7y ph\u00e2n b\u1eb1ng acid lo\u00e3ng \u0111\u1ec3 thu ph\u00e2n \u0111o\u1ea1n ph\u00e2n t\u1eed l\u01b0\u1ee3ng mong mu\u1ed1n.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>\u0110\u01b0\u1ee3c coi l\u00e0 an to\u00e0n \u0111\u01b0\u1eddng u\u1ed1ng.<\/li>\n<li>Ti\u00eam dextran 40 v\u00e0 dextran 70 c\u00f3 nguy c\u01a1 ph\u1ea3n v\u1ec7 n\u1eb7ng, k\u1ec3 c\u1ea3 suy h\u00f4 h\u1ea5p v\u00e0 t\u1eed vong; m\u1ee9c \u0111\u1ed9 li\u00ean quan t\u1edbi l\u01b0\u1ee3ng kh\u00e1ng th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi dextran s\u1eb5n c\u00f3. D\u00f9ng tr\u01b0\u1edbc dextran 1 (dung d\u1ecbch 15% trong n\u01b0\u1edbc mu\u1ed1i sinh l\u00fd) l\u00e0m gi\u1ea3m m\u1ea1nh nguy c\u01a1 n\u00e0y.<\/li>\n<li>LD<sub>50<\/sub> (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 12,1 g\/kg; (chu\u1ed9t nh\u1eaft, d\u01b0\u1edbi da): 13,9 g\/kg; (th\u1ecf, t\u0129nh m\u1ea1ch): 17,4 g\/kg.<\/li>\n<li>Thao t\u00e1c theo l\u01b0u \u00fd th\u00f4ng th\u01b0\u1eddng.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong FDA Inactive Ingredients Database (d\u1ecbch \u0111\u1eadm \u0111\u1eb7c pha ti\u00eam t\u0129nh m\u1ea1ch; b\u1ed9t \u0111\u00f4ng kh\u00f4 pha ti\u00eam t\u0129nh m\u1ea1ch); c\u00f3 trong thu\u1ed1c ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<li>EU: \u0111\u01b0\u1ee3c ph\u00e9p trong b\u00e1nh n\u01b0\u1edbng t\u1edbi 5%, d\u00f9ng h\u1ea1n ch\u1ebf trong dinh d\u01b0\u1ee1ng l\u00e2m s\u00e0ng, l\u00e0m ph\u1ee5 gia kem v\u00e0 k\u1eb9o.<\/li>\n<li>T\u1eebng thu\u1ed9c danh s\u00e1ch GRAS tr\u01b0\u1edbc n\u0103m 1977 nh\u01b0ng b\u1ecb lo\u1ea1i do thi\u1ebfu d\u1eef li\u1ec7u an to\u00e0n \u1edf m\u1ee9c d\u00f9ng cao v\u00e0 kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c d\u00f9ng trong th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<p>Dextrin, pullulan, tinh b\u1ed9t, maltodextrin \u2013 \u0111\u1ec1u l\u00e0 polysaccharid \u0111a ph\u00e2n t\u00e1n c\u1ea5u t\u1ea1o t\u1eeb \u03b1-D-glucose, kh\u00e1c nhau v\u1ec1 \u0111\u1ed9 d\u00e0i m\u1ea1ch trung b\u00ecnh v\u00e0 \u0111\u1ed9 \u0111a ph\u00e2n t\u00e1n (do ngu\u1ed3n th\u1ef1c v\u1eadt, quy tr\u00ecnh th\u1ee7y ph\u00e2n ho\u1eb7c \u0111i\u1ec1u ki\u1ec7n ph\u00e2n \u0111o\u1ea1n sau l\u00ean men). Dextran v\u00e0 pullulan \u0111\u1ec1u thu t\u1eeb l\u00ean men vi sinh.<\/p>\n<p><strong>Ghi ch\u00fa:<\/strong> dextran c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t (n\u01b0\u1edbc m\u1eaft nh\u00e2n t\u1ea1o; d\u1ecbch thay th\u1ebf huy\u1ebft t\u01b0\u01a1ng) \u2013 c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. PubChem CID 4125253.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Dextran<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Dextran \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, b\u1ea3o v\u1ec7 protein, t\u00e1 d\u01b0\u1ee3c d\u00ednh Dextran l\u00e0 polysaccharid ph\u00e2n nh\u00e1nh, ph\u00e2n t\u1eed l\u01b0\u1ee3ng l\u1edbn, t\u1ea1o t\u1eeb c\u00e1c \u0111\u01a1n v\u1ecb \u03b1-D-glucose, thu \u0111\u01b0\u1ee3c khi vi khu\u1ea9n l\u00ean men saccarose. Trong b\u00e0o ch\u1ebf, dextran ch\u1ee7 y\u1ebfu d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho ch\u1ebf ph\u1ea9m \u0111\u00f4ng kh\u00f4 v\u00e0 ch\u1ea5t b\u1ea3o v\u1ec7 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3538,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3539","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dextran-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Dextran \u2013 t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, b\u1ea3o v\u1ec7 protein, t\u00e1 d\u01b0\u1ee3c d\u00ednh Dextran l\u00e0 polysaccharid ph\u00e2n nh\u00e1nh, ph\u00e2n t\u1eed l\u01b0\u1ee3ng l\u1edbn, t\u1ea1o t\u1eeb c\u00e1c \u0111\u01a1n v\u1ecb \u03b1-D-glucose, thu \u0111\u01b0\u1ee3c khi vi khu\u1ea9n l\u00ean men saccarose. Trong b\u00e0o ch\u1ebf, dextran ch\u1ee7 y\u1ebfu d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho ch\u1ebf ph\u1ea9m \u0111\u00f4ng kh\u00f4 v\u00e0 ch\u1ea5t b\u1ea3o v\u1ec7&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3539"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3539\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3538"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}