{"id":3527,"date":"2026-09-29T08:33:26","date_gmt":"2026-09-29T01:33:26","guid":{"rendered":"https:\/\/cpc1.vn\/colestyramin\/"},"modified":"2026-09-29T08:33:26","modified_gmt":"2026-09-29T01:33:26","slug":"colestyramin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/colestyramin\/","title":{"rendered":"Nh\u1ef1a colestyramin \u2013 t\u00e1 d\u01b0\u1ee3c trao \u0111\u1ed5i ion: t\u1ea1o ph\u1ee9c, che v\u1ecb, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Nh\u1ef1a colestyramin \u2013 t\u00e1 d\u01b0\u1ee3c trao \u0111\u1ed5i ion: t\u1ea1o ph\u1ee9c, che v\u1ecb, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h1>\n<p><strong>Nh\u1ef1a colestyramin<\/strong> (cholestyramine resin) l\u00e0 nh\u1ef1a trao \u0111\u1ed5i anion base m\u1ea1nh \u1edf d\u1ea1ng clorid, g\u1ed3m khung \u0111\u1ed3ng tr\u00f9ng h\u1ee3p styren \u2013 divinylbenzen mang nh\u00f3m amoni b\u1eadc b\u1ed1n. Ngo\u00e0i vai tr\u00f2 ho\u1ea1t ch\u1ea5t quen thu\u1ed9c, colestyramin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m <strong>t\u00e1 d\u01b0\u1ee3c t\u1ea1o ph\u1ee9c (&#8220;resinat&#8221;)<\/strong> v\u1edbi d\u01b0\u1ee3c ch\u1ea5t mang \u0111i\u1ec7n \u00e2m \u0111\u1ec3 <strong>che v\u1ecb<\/strong>, <strong>\u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/strong> v\u00e0 <strong>c\u1ea3i thi\u1ec7n \u0111\u1ed9 tan<\/strong>.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Cholestyramin, colestyramin, colestyraminum; t\u00ean th\u01b0\u01a1ng m\u1ea1i t\u00e1 d\u01b0\u1ee3c: DUOLITE AP143, Purolite A430MR<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>11041-12-6<\/td>\n<\/tr>\n<tr>\n<td>C\u1ea5u t\u1ea1o<\/td>\n<td>Nh\u1ef1a trao \u0111\u1ed5i anion base m\u1ea1nh d\u1ea1ng clorid, khung styren \u2013 divinylbenzen li\u00ean k\u1ebft ch\u00e9o, nh\u00f3m ch\u1ee9c amoni b\u1eadc b\u1ed1n; m\u1ea1ng kh\u00f4ng gian ba chi\u1ec1u n\u00ean kh\u00f4ng x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c KLPT trung b\u00ecnh<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t t\u1ea1o ph\u1ee9c, t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, ch\u1ea5t t\u0103ng \u0111\u1ed9 tan, ch\u1ea5t che v\u1ecb<\/td>\n<\/tr>\n<tr>\n<td>D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>Ph.Eur. (Colestyramine), USP-NF (Cholestyramine Resin)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li><strong>T\u1ea1o resinat:<\/strong> ion clorid c\u1ee7a nh\u1ef1a \u0111\u01b0\u1ee3c trao \u0111\u1ed5i v\u1edbi d\u01b0\u1ee3c ch\u1ea5t d\u1ea1ng anion; trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, d\u01b0\u1ee3c ch\u1ea5t \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng d\u1ea7n khi c\u00e1c anion c\u1ee7a d\u1ecbch ti\u00eau h\u00f3a trao \u0111\u1ed5i tr\u1edf l\u1ea1i. Nh\u1edd \u0111\u00f3 c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng, che v\u1ecb \u0111\u1eafng v\u00e0 t\u0103ng \u0111\u1ed9 tan.<\/li>\n<li>C\u00f2n \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 ch\u1ed1ng l\u1ea1m d\u1ee5ng thu\u1ed1c, t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh d\u01b0\u1ee3c ch\u1ea5t v\u00e0 lo\u1ea1i b\u1ecf hi\u1ec7n t\u01b0\u1ee3ng \u0111a h\u00ecnh.<\/li>\n<li>V\u00ed d\u1ee5: ph\u1ee9c kali diclofenac \u2013 colestyramin cho t\u00e1c d\u1ee5ng kh\u1edfi ph\u00e1t nhanh h\u01a1n, k\u00e9o d\u00e0i h\u01a1n v\u00e0 dung n\u1ea1p t\u1ed1t h\u01a1n.<\/li>\n<\/ul>\n<h2>N\u1ea1p d\u01b0\u1ee3c ch\u1ea5t l\u00ean nh\u1ef1a<\/h2>\n<ul>\n<li>L\u01b0\u1ee3ng d\u01b0\u1ee3c ch\u1ea5t n\u1ea1p th\u01b0\u1eddng 5\u201350% t\u1ed5ng dung l\u01b0\u1ee3ng trao \u0111\u1ed5i, ph\u1ee5 thu\u1ed9c \u0111\u1ed9 ch\u1ecdn l\u1ecdc c\u1ee7a nh\u1ef1a v\u1edbi d\u01b0\u1ee3c ch\u1ea5t, n\u1ed3ng \u0111\u1ed9 d\u01b0\u1ee3c ch\u1ea5t v\u00e0 m\u1ee9c c\u1ea1nh tranh c\u1ee7a c\u00e1c anion kh\u00e1c; t\u1ed1c \u0111\u1ed9 n\u1ea1p ph\u1ee5 thu\u1ed9c k\u00edch th\u01b0\u1edbc ph\u00e2n t\u1eed v\u00e0 m\u1ee9c tr\u01b0\u01a1ng n\u1edf c\u1ee7a nh\u1ef1a.<\/li>\n<li>C\u00f3 th\u1ec3 n\u1ea1p theo m\u1ebb ho\u1eb7c c\u1ed9t li\u00ean t\u1ee5c; v\u1edbi b\u1ed9t m\u1ecbn n\u00ean d\u00f9ng c\u00e2n b\u1eb1ng theo m\u1ebb, c\u00f3 khi ph\u1ea3i l\u1eb7p l\u1ea1i 2 l\u1ea7n tr\u1edf l\u00ean \u0111\u1ec3 \u0111\u1ea1t m\u1ee9c n\u1ea1p t\u1ed1i \u0111a.<\/li>\n<li>Thu\u1eadn l\u1ee3i cho n\u1ea1p cao: d\u01b0\u1ee3c ch\u1ea5t c\u00f3 m\u1eadt \u0111\u1ed9 \u0111i\u1ec7n t\u00edch cao, ph\u00e2n t\u1eed l\u01b0\u1ee3ng nh\u1ecf, n\u1ed3ng \u0111\u1ed9 cao v\u00e0 \u00edt anion c\u1ea1nh tranh.<\/li>\n<li>Gi\u1ea3i ph\u00f3ng in vivo \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi t\u1ed1c \u0111\u1ed9 khu\u1ebfch t\u00e1n d\u01b0\u1ee3c ch\u1ea5t ra kh\u1ecfi h\u1ea1t nh\u1ef1a, \u0111\u1ed9 ch\u1ecdn l\u1ecdc c\u1ee7a nh\u1ef1a v\u00e0 n\u1ed3ng \u0111\u1ed9 ch\u1ea5t \u0111i\u1ec7n ly t\u1ea1i n\u01a1i trao \u0111\u1ed5i.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t m\u1ecbn tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, h\u00fat \u1ea9m; kh\u00f4ng m\u00f9i ho\u1eb7c tho\u00e1ng m\u00f9i amin.<\/li>\n<li>D\u01b0\u1ee3c \u0111i\u1ec3n: pH 4,0\u20136,0; h\u00e0m l\u01b0\u1ee3ng clorid 13,0\u201317,0% v\u00e0 dung l\u01b0\u1ee3ng trao \u0111\u1ed5i 1,8\u20132,2 g\/g (ch\u1ebf ph\u1ea9m kh\u00f4).<\/li>\n<li>\u0110\u1ed9 \u1ea9m kho\u1ea3ng 12%; t\u1ef7 tr\u1ecdng t\u01b0\u01a1ng \u0111\u1ed1i 1,15\u20131,20; nhi\u1ec7t \u0111\u1ed9 t\u1ef1 b\u1ed1c ch\u00e1y tr\u00ean 500 \u00b0C.<\/li>\n<li>Kh\u00f4ng tan trong n\u01b0\u1edbc, ethanol, benzen, cloroform, ether.<\/li>\n<li>D\u01b0\u1ee3c \u0111i\u1ec3n kh\u00f4ng quy \u0111\u1ecbnh ph\u00e2n b\u1ed1 k\u00edch th\u01b0\u1edbc h\u1ea1t; nh\u00e0 s\u1ea3n xu\u1ea5t cung c\u1ea5p nhi\u1ec1u c\u1ee1 t\u1eeb m\u1ecbn (ch\u1ec9 10\u201330% c\u00f2n tr\u00ean r\u00e2y 50 \u00b5m) t\u1edbi th\u00f4 (kho\u1ea3ng 40\u201350% c\u00f2n tr\u00ean r\u00e2y 110\u2013125 \u00b5m).<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>B\u1ec1n \u00edt nh\u1ea5t 2 n\u0103m. B\u1ea3o qu\u1ea3n trong bao b\u00ec g\u1ed1c k\u00edn kh\u00ed, \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng, tr\u00e1nh nhi\u1ec7t, \u00e1nh s\u00e1ng v\u00e0 \u1ea9m.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>Ch\u1ea5t oxy h\u00f3a c\u00f3 th\u1ec3 ph\u00e2n h\u1ee7y nh\u1ef1a; ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 acid nitric c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng n\u1ed5.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>\u0110\u1ed3ng tr\u00f9ng h\u1ee3p styren \u2013 divinylbenzen \u0111\u01b0\u1ee3c clormethyl h\u00f3a (ph\u1ea3n \u1ee9ng Friedel\u2013Crafts) r\u1ed3i amin h\u00f3a b\u1eb1ng amin b\u1eadc ba nh\u01b0 trimethylamin, t\u1ea1o nh\u1ef1a trao \u0111\u1ed5i anion d\u1ea1ng h\u1ea1t c\u1ea7u; sau \u0111\u00f3 nghi\u1ec1n th\u00e0nh b\u1ed9t.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>Kh\u00f4ng g\u00e2y \u0111\u1ed9t bi\u1ebfn trong th\u1eed nghi\u1ec7m Ames. Nu\u1ed1t, h\u00edt ho\u1eb7c d\u00ednh m\u1eaft, da c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng.<\/li>\n<li>LD<sub>50<\/sub> (\u0111\u01b0\u1eddng u\u1ed1ng): chu\u1ed9t c\u1ed1ng tr\u00ean 2 g\/kg; th\u1ecf tr\u00ean 3 g\/kg; chu\u1ed9t nh\u1eaft tr\u00ean 7,5 g\/kg.<\/li>\n<li>Tr\u00e1nh t\u1ea1o b\u1ee5i, tr\u00e1nh d\u00ednh m\u1eaft; n\u00ean \u0111eo k\u00ednh v\u00e0 g\u0103ng. Kh\u00f4ng \u0111\u1ec3 tr\u00ean 220 \u00b0C; khi ph\u00e2n h\u1ee7y c\u00f3 th\u1ec3 sinh oxyd carbon, oxyd nit\u01a1, styren v\u00e0 amoniac.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>L\u00e0 t\u00e1 d\u01b0\u1ee3c trong ch\u1ebf ph\u1ea9m resinat diclofenac l\u01b0u h\u00e0nh t\u1ea1i Brazil, Chile, Mexico v\u00e0 Venezuela.<\/li>\n<li>C\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF; l\u00e0 ho\u1ea1t ch\u1ea5t trong nhi\u1ec1u thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t t\u1ea1i M\u1ef9, Anh, Canada, Ph\u00e1p.<\/li>\n<\/ul>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<p>Polacrilin kali (nh\u1ef1a trao \u0111\u1ed5i cation); xem th\u00eam nh\u1ef1a polacrilex.<\/p>\n<p><strong>Ghi ch\u00fa:<\/strong> colestyramin l\u00e0 ch\u1ea5t g\u1eafn acid m\u1eadt; c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 234-270-8; UNII 4B33BGI082.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Cholestyramine Resin<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Nh\u1ef1a colestyramin \u2013 t\u00e1 d\u01b0\u1ee3c trao \u0111\u1ed5i ion: t\u1ea1o ph\u1ee9c, che v\u1ecb, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Nh\u1ef1a colestyramin (cholestyramine resin) l\u00e0 nh\u1ef1a trao \u0111\u1ed5i anion base m\u1ea1nh \u1edf d\u1ea1ng clorid, g\u1ed3m khung \u0111\u1ed3ng tr\u00f9ng h\u1ee3p styren \u2013 divinylbenzen mang nh\u00f3m amoni b\u1eadc b\u1ed1n. Ngo\u00e0i vai tr\u00f2 ho\u1ea1t ch\u1ea5t quen thu\u1ed9c, colestyramin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3526,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/colestyramin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Nh\u1ef1a colestyramin \u2013 t\u00e1 d\u01b0\u1ee3c trao \u0111\u1ed5i ion: t\u1ea1o ph\u1ee9c, che v\u1ecb, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Nh\u1ef1a colestyramin (cholestyramine resin) l\u00e0 nh\u1ef1a trao \u0111\u1ed5i anion base m\u1ea1nh \u1edf d\u1ea1ng clorid, g\u1ed3m khung \u0111\u1ed3ng tr\u00f9ng h\u1ee3p styren \u2013 divinylbenzen mang nh\u00f3m amoni b\u1eadc b\u1ed1n. Ngo\u00e0i vai tr\u00f2 ho\u1ea1t ch\u1ea5t quen thu\u1ed9c, colestyramin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3527"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3527\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3526"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}