{"id":3523,"date":"2026-09-29T08:26:38","date_gmt":"2026-09-29T01:26:38","guid":{"rendered":"https:\/\/cpc1.vn\/cetrimonium-bromid\/"},"modified":"2026-09-29T08:26:38","modified_gmt":"2026-09-29T01:26:38","slug":"cetrimonium-bromid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/cetrimonium-bromid\/","title":{"rendered":"Cetrimonium bromid (CTAB) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Cetrimonium bromid (CTAB) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation<\/h1>\n<p><strong>Cetrimonium bromid<\/strong> (CTAB, hexadecyltrimethylamoni bromid) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n, <strong>ch\u1ea5t di\u1ec7n ho\u1ea1t cation<\/strong> c\u00f3 <strong>t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n<\/strong>. Trong b\u00e0o ch\u1ebf, CTAB \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m <strong>ch\u1ea5t b\u1ea3o qu\u1ea3n<\/strong> v\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t trong ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i, thu\u1ed1c \u0111\u1ea1n, v\u00e0 trong vi nh\u0169 t\u01b0\u01a1ng, ti\u1ec3u ph\u00e2n nano gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>CTAB, cetyltrimethylamoni bromid, hexadecyltrimethylamoni bromid, HTAB, palmityltrimethylamoni bromid, cetrimid BP 1953<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>57-09-0<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>19<\/sub>H<sub>42<\/sub>BrN \u2013 364,45<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation<\/td>\n<\/tr>\n<tr>\n<td>D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>USP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t cation trong ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i; \u0111\u00e3 d\u00f9ng trong thu\u1ed1c \u0111\u1ea1n.<\/li>\n<li>Th\u00e0nh ph\u1ea7n vi nh\u0169 t\u01b0\u01a1ng v\u00e0 ti\u1ec3u ph\u00e2n nano \u0111\u1ec3 ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng; ch\u1ea5t \u0111\u1ecbnh h\u01b0\u1edbng trong t\u1ed5ng h\u1ee3p ti\u1ec3u ph\u00e2n nano v\u00e0ng (nghi\u00ean c\u1ee9u).<\/li>\n<li>Trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 s\u1ea3n xu\u1ea5t sinh h\u1ecdc: ch\u1ea5t t\u1ea9y r\u1eeda cation trong \u0111\u1ec7m chi\u1ebft DNA; k\u1ebft t\u1ee7a, \u0111\u1ecbnh l\u01b0\u1ee3ng polysaccharid v\u1ecf trong ph\u00e1t tri\u1ec3n vaccin \u0111a gi\u00e1; x\u00e1c \u0111\u1ecbnh kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed protein b\u1eb1ng \u0111i\u1ec7n di; x\u00e1c \u0111\u1ecbnh n\u1ed3ng \u0111\u1ed9 micell t\u1edbi h\u1ea1n.<\/li>\n<li>D\u00f9ng r\u1ed9ng r\u00e3i trong s\u1ea3n ph\u1ea9m ch\u0103m s\u00f3c t\u00f3c v\u00e0 da.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t ho\u1eb7c tinh th\u1ec3 tr\u1eafng, m\u00f9i nh\u1eb9 \u0111\u1eb7c tr\u01b0ng.<\/li>\n<li>Kh\u00e1ng khu\u1ea9n t\u1ed1t \u1edf pH ki\u1ec1m, tr\u00ean c\u1ea3 vi khu\u1ea9n Gram d\u01b0\u01a1ng v\u00e0 Gram \u00e2m; b\u1ecb x\u00e0 ph\u00f2ng v\u00e0 ch\u1ea5t t\u1ea9y anion (nh\u01b0 natri dodecyl sulfat) trung h\u00f2a. MIC \u0111i\u1ec3n h\u00ecnh: <em>Staphylococcus aureus<\/em> 1 \u00b5g\/mL; <em>Escherichia coli<\/em> 8 \u00b5g\/mL.<\/li>\n<li>N\u1ed3ng \u0111\u1ed9 micell t\u1edbi h\u1ea1n (CMC) 0,92\u20131,0 mM trong n\u01b0\u1edbc; log P (octanol\/n\u01b0\u1edbc) 3,18.<\/li>\n<li>pH dung d\u1ecbch 3,64% (kl\/tt): 5,0\u20137,0 (25 \u00b0C); \u0111i\u1ec3m ch\u1ea3y 237\u2013243 \u00b0C (c\u00f3 t\u00e0i li\u1ec7u ghi 248\u2013251 \u00b0C), ph\u00e2n h\u1ee7y kho\u1ea3ng 237 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 244 \u00b0C.<\/li>\n<li>\u0110\u1ed9 tan: d\u1ec5 tan trong ethanol 95%; tan 1 trong 10 ph\u1ea7n n\u01b0\u1edbc; h\u01a1i tan trong aceton; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ether, benzen.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>H\u00fat \u1ea9m nh\u01b0ng b\u1ec1n trong \u0111i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n khuy\u1ebfn ngh\u1ecb; b\u1ec1n trong dung d\u1ecbch acid. \u0110\u1ef1ng trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, th\u00f4ng tho\u00e1ng, tr\u00e1nh nhi\u1ec7t v\u00e0 ngu\u1ed3n l\u1eeda.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh. Nh\u01b0 c\u00e1c ch\u1ea5t di\u1ec7n ho\u1ea1t cation kh\u00e1c, ho\u1ea1t t\u00ednh b\u1ecb m\u1ea5t khi g\u1eb7p x\u00e0 ph\u00f2ng v\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t anion.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Cho cetyl bromid ph\u1ea3n \u1ee9ng v\u1edbi trimethylamin.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>\u0110\u01b0\u1ee3c coi l\u00e0 an to\u00e0n khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c trong ch\u1ebf ph\u1ea9m b\u00f4i; h\u1ed9i \u0111\u1ed3ng CIR k\u1ebft lu\u1eadn an to\u00e0n trong m\u1ef9 ph\u1ea9m.<\/li>\n<li>Ph\u01a1i nhi\u1ec5m c\u1ea5p c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng m\u1eaft nghi\u00eam tr\u1ecdng; c\u00f3 h\u1ea1i khi nu\u1ed1t. Li\u1ec1u to\u00e0n th\u00e2n l\u1edbn g\u00e2y bu\u1ed3n n\u00f4n, n\u00f4n, li\u1ec7t c\u01a1, \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng, t\u1ee5t huy\u1ebft \u00e1p v\u00e0 t\u1ed5n th\u01b0\u01a1ng m\u00f4 t\u1ea1i ch\u1ed7; c\u00f3 th\u1ec3 k\u00edch \u1ee9ng da v\u00e0 \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p. \u0110\u00e3 ghi nh\u1eadn nhi\u1ec5m toan chuy\u1ec3n h\u00f3a khi r\u1eeda \u1ed5 nang b\u1eb1ng dung d\u1ecbch CTAB.<\/li>\n<li>LD<sub>50<\/sub>: chu\u1ed9t lang (d\u01b0\u1edbi da) 0,1 g\/kg; chu\u1ed9t nh\u1eaft (ph\u00fac m\u1ea1c) 0,106 g\/kg, (t\u0129nh m\u1ea1ch) 0,032 g\/kg; th\u1ecf (ph\u00fac m\u1ea1c, d\u01b0\u1edbi da) 0,125 g\/kg; chu\u1ed9t c\u1ed1ng (t\u0129nh m\u1ea1ch) 0,044 g\/kg, (u\u1ed1ng) 0,410 g\/kg.<\/li>\n<li>\u0110un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i r\u1ea5t \u0111\u1ed9c: amoniac, h\u01a1i nit\u01a1, hydro bromid, CO, CO<sub>2<\/sub>. Tr\u00e1nh ti\u1ebfp x\u00fac da, m\u1eaft; tr\u00e1nh h\u00edt; thao t\u00e1c n\u01a1i th\u00f4ng tho\u00e1ng, d\u00f9ng \u0111\u1ed3 b\u1ea3o h\u1ed9.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<li>Ch\u00e2u \u00c2u: thu\u1ed9c danh m\u1ee5c ch\u1ea5t b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c ph\u00e9p trong m\u1ef9 ph\u1ea9m, t\u1ed1i \u0111a 0,1% trong s\u1ea3n ph\u1ea9m d\u00f9ng ngay.<\/li>\n<li>Kh\u00f4ng c\u00f3 m\u1eb7t trong thu\u1ed1c n\u00e0o \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t t\u1ea1i M\u1ef9. T\u1ea1i Anh, c\u00f3 trong danh s\u00e1ch ch\u1ea5t v\u1ebft c\u00f3 th\u1ec3 d\u00f9ng trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t vaccin c\u00fam.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n<h2>Ch\u1ea5t li\u00ean quan<\/h2>\n<ul>\n<li>Cetrimid, benzalkonium clorid, benzethonium clorid.<\/li>\n<li><strong>Cetrimonium clorid<\/strong> (C<sub>19<\/sub>H<sub>42<\/sub>ClN, KLPT 320,01; CAS 112-02-7): ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 di\u1ec7n ho\u1ea1t cation; c\u00f3 trong FDA Inactive Ingredients Database (lotion b\u00f4i).<\/li>\n<li><strong>Cetrimonium tosylat<\/strong> (C<sub>26<\/sub>H<sub>49<\/sub>NO<sub>3<\/sub>S; CAS 138-32-9): c\u00f9ng c\u00f4ng d\u1ee5ng.<\/li>\n<\/ul>\n<p><strong>Ghi ch\u00fa:<\/strong> t\u00ean cetrimonium bromid tr\u01b0\u1edbc \u0111\u00e2y t\u1eebng d\u00f9ng cho cetrimid. Cetrimid BP 1953 nguy\u00ean th\u1ee7y ch\u1ee7 y\u1ebfu l\u00e0 hexadecyltrimethylamoni bromid, k\u00e8m c\u00e1c alkyltrimethylamoni bromid t\u01b0\u01a1ng t\u1ef1 v\u00e0 kh\u00e1 nhi\u1ec1u mu\u1ed1i v\u00f4 c\u01a1 (ch\u1ee7 y\u1ebfu natri bromid), k\u00e9m tan h\u01a1n s\u1ea3n ph\u1ea9m hi\u1ec7n nay. \u1ede n\u1ed3ng \u0111\u1ed9 cao h\u01a1n, CTAB l\u00e0 ch\u1ea5t s\u00e1t khu\u1ea9n d\u00f9ng ngo\u00e0i \u2013 c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 200-311-3; PubChem CID 5974.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Cetrimonium Bromide<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Cetrimonium bromid (CTAB) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation Cetrimonium bromid (CTAB, hexadecyltrimethylamoni bromid) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n. Trong b\u00e0o ch\u1ebf, CTAB \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t trong ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i, thu\u1ed1c \u0111\u1ea1n, v\u00e0 trong vi nh\u0169 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3522,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cetrimonium-bromid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cetrimonium bromid (CTAB) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, di\u1ec7n ho\u1ea1t cation Cetrimonium bromid (CTAB, hexadecyltrimethylamoni bromid) l\u00e0 h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n, ch\u1ea5t di\u1ec7n ho\u1ea1t cation c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n. Trong b\u00e0o ch\u1ebf, CTAB \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n v\u00e0 ch\u1ea5t di\u1ec7n ho\u1ea1t trong ch\u1ebf ph\u1ea9m b\u00f4i ngo\u00e0i, thu\u1ed1c \u0111\u1ea1n, v\u00e0 trong vi nh\u0169&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3523"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3523\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3522"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}