{"id":3517,"date":"2026-09-29T08:26:14","date_gmt":"2026-09-29T01:26:14","guid":{"rendered":"https:\/\/cpc1.vn\/cellaburat\/"},"modified":"2026-09-29T11:55:17","modified_gmt":"2026-09-29T04:55:17","slug":"cellaburat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/cellaburat\/","title":{"rendered":"Cellaburat (cellulose acetat butyrat) \u2013 m\u00e0ng b\u00e1n th\u1ea5m, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i"},"content":{"rendered":"

Cellaburat (cellulose acetat butyrat) \u2013 m\u00e0ng b\u00e1n th\u1ea5m, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h1>\n

Cellaburat<\/strong> (cellulose acetat butyrat, CAB) l\u00e0 ester h\u1ed7n h\u1ee3p c\u1ee7a cellulose, trong \u0111\u00f3 m\u1ed9t ph\u1ea7n nh\u00f3m hydroxyl \u0111\u01b0\u1ee3c acetyl h\u00f3a v\u00e0 m\u1ed9t ph\u1ea7n \u0111\u01b0\u1ee3c butyryl h\u00f3a. Trong b\u00e0o ch\u1ebf, cellaburat l\u00e0 t\u00e1 d\u01b0\u1ee3c t\u1ea1o m\u00e0ng, t\u1ea1o m\u00e0ng b\u00e1n th\u1ea5m<\/strong> v\u00e0 t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/strong> cho d\u1ea1ng u\u1ed1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCellulose acetat butyrat, cellulose acetat butanoat, acetylbutyrylcellulose, CAB<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9004-36-8<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nD\u1eabn ch\u1ea5t cellulose: 1\u201341% nh\u00f3m hydroxyl \u0111\u01b0\u1ee3c acetyl h\u00f3a, 5\u201356% \u0111\u01b0\u1ee3c butyryl h\u00f3a<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c bao, t\u1ea1o m\u00e0ng, t\u1ea1o m\u00e0ng b\u00e1n th\u1ea5m, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n\/vi\u00ean nang<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (Cellulose Acetate Butyrate), USP-NF (Cellaburate)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • H\u1ec7 cung c\u1ea5p thu\u1ed1c u\u1ed1ng gi\u1ea3i ph\u00f3ng c\u00f3 \u0111i\u1ec1u ch\u1ec9nh.<\/li>\n
  • B\u01a1m th\u1ea9m th\u1ea5u:<\/strong> thay th\u1ebf cellulose acetat l\u00e0m l\u1edbp m\u00e0ng b\u00e1n th\u1ea5m bao quanh nh\u00e2n vi\u00ean.<\/li>\n
  • D\u1ea1ng r\u1eafn gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng hi\u1ec7n t\u01b0\u1ee3ng “gi\u1ea3i ph\u00f3ng \u1ed3 \u1ea1t do r\u01b0\u1ee3u” (alcohol-induced dose dumping).<\/li>\n
  • Ngo\u00e0i d\u01b0\u1ee3c ph\u1ea9m: v\u1eadt li\u1ec7u k\u00ednh \u00e1p tr\u00f2ng k\u1ef5 n\u01b0\u1edbc.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t ho\u1eb7c h\u1ea1t tr\u1eafng t\u1edbi tr\u1eafng ng\u00e0, h\u01a1i h\u00fat \u1ea9m.<\/li>\n
    • Ph.Eur. m\u00f4 t\u1ea3 l\u00e0 cellulose \u0111\u01b0\u1ee3c O-acetyl h\u00f3a v\u00e0 O-butyryl h\u00f3a m\u1ed9t ph\u1ea7n ho\u1eb7c ho\u00e0n to\u00e0n, ch\u1ee9a 2,0\u201330,0% nh\u00f3m acetyl v\u00e0 16,0\u201353,0% nh\u00f3m butyryl (ch\u1ebf ph\u1ea9m kh\u00f4); USP-NF cho ph\u00e9p 1,0\u201341,0% acetyl v\u00e0 5,0\u201356,0% butyryl.<\/li>\n
    • T\u1ef7 tr\u1ecdng 1,26 g\/cm\u00b3; kh\u1ed1i l\u01b0\u1ee3ng ri\u00eang bi\u1ec3u ki\u1ebfn 0,224 g\/cm\u00b3, sau g\u00f5 0,256 g\/cm\u00b3.<\/li>\n
    • Nhi\u1ec7t \u0111\u1ed9 chuy\u1ec3n th\u1ee7y tinh (Tg) 151 \u00b0C; \u0111i\u1ec3m ch\u1ea3y 230\u2013240 \u00b0C; chi\u1ebft su\u1ea5t 1,475.<\/li>\n
    • \u0110\u1ed9 tan: h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc v\u00e0 ethanol 95%; tan trong aceton, acid formic v\u00e0 h\u1ed7n h\u1ee3p methanol \u2013 dicloromethan (1:1).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Trong \u0111i\u1ec1u ki\u1ec7n b\u1ea5t l\u1ee3i k\u00e9o d\u00e0i (nhi\u1ec7t \u0111\u1ed9 cao, \u0111\u1ed9 \u1ea9m cao) cellaburat b\u1ecb th\u1ee7y ph\u00e2n ch\u1eadm, l\u00e0m t\u0103ng acid t\u1ef1 do v\u00e0 h\u00e0m l\u01b0\u1ee3ng n\u01b0\u1edbc. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a. Khu\u1ea5y ester cellulose trong hydrocarbon kh\u00f4ng ph\u00e2n c\u1ef1c (toluen, xylen) c\u00f3 th\u1ec3 t\u00edch \u0111i\u1ec7n t\u0129nh, g\u00e2y b\u1eaft l\u1eeda ch\u1edbp nho\u00e1ng ho\u1eb7c n\u1ed5; khi cho ester cellulose v\u00e0o ch\u1ea5t l\u1ecfng d\u1ec5 ch\u00e1y c\u1ea7n duy tr\u00ec kh\u00ed tr\u01a1 trong thi\u1ebft b\u1ecb.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho cellulose ph\u1ea3n \u1ee9ng v\u1edbi anhydrid acetic v\u00e0 anhydrid n-butyric v\u1edbi x\u00fac t\u00e1c base h\u1eefu c\u01a1 b\u1eadc ba ho\u1eb7c acid m\u1ea1nh.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u00e3 d\u00f9ng trong thu\u1ed1c u\u1ed1ng, nh\u00ecn chung \u0111\u01b0\u1ee3c coi l\u00e0 an to\u00e0n. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da nh\u1eb9; kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m da tr\u00ean chu\u1ed9t lang.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t lang, qua da): tr\u00ean 1,0 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 6,4 g\/kg (li\u1ec1u cao nh\u1ea5t \u0111\u00e3 th\u1eed).<\/li>\n
      • Thao t\u00e1c theo l\u01b0u \u00fd th\u00f4ng th\u01b0\u1eddng; c\u00f3 bi\u1ec7n ph\u00e1p tr\u00e1nh n\u1ed3ng \u0111\u1ed9 b\u1ee5i d\u1ec5 ch\u00e1y trong kh\u00f4ng kh\u00ed.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (vi\u00ean n\u00e9n u\u1ed1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i) v\u00e0 Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Cellulose acetat, cellulose acetat phthalat (CAP).<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Cellaburate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Cellaburat (cellulose acetat butyrat) \u2013 m\u00e0ng b\u00e1n th\u1ea5m, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Cellaburat (cellulose acetat butyrat, CAB) l\u00e0 ester h\u1ed7n h\u1ee3p c\u1ee7a cellulose, trong \u0111\u00f3 m\u1ed9t ph\u1ea7n nh\u00f3m hydroxyl \u0111\u01b0\u1ee3c acetyl h\u00f3a v\u00e0 m\u1ed9t ph\u1ea7n \u0111\u01b0\u1ee3c butyryl h\u00f3a. Trong b\u00e0o ch\u1ebf, cellaburat l\u00e0 t\u00e1 d\u01b0\u1ee3c t\u1ea1o m\u00e0ng, t\u1ea1o m\u00e0ng b\u00e1n th\u1ea5m v\u00e0 t\u00e1c nh\u00e2n \u0111i\u1ec1u […]<\/p>\n","protected":false},"author":1,"featured_media":3516,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3517","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/cellaburat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Cellaburat (cellulose acetat butyrat) \u2013 m\u00e0ng b\u00e1n th\u1ea5m, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Cellaburat (cellulose acetat butyrat, CAB) l\u00e0 ester h\u1ed7n h\u1ee3p c\u1ee7a cellulose, trong \u0111\u00f3 m\u1ed9t ph\u1ea7n nh\u00f3m hydroxyl \u0111\u01b0\u1ee3c acetyl h\u00f3a v\u00e0 m\u1ed9t ph\u1ea7n \u0111\u01b0\u1ee3c butyryl h\u00f3a. Trong b\u00e0o ch\u1ebf, cellaburat l\u00e0 t\u00e1 d\u01b0\u1ee3c t\u1ea1o m\u00e0ng, t\u1ea1o m\u00e0ng b\u00e1n th\u1ea5m v\u00e0 t\u00e1c nh\u00e2n \u0111i\u1ec1u…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3517"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3517\/revisions"}],"predecessor-version":[{"id":3755,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3517\/revisions\/3755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3516"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}