{"id":3513,"date":"2026-09-29T08:21:51","date_gmt":"2026-09-29T01:21:51","guid":{"rendered":"https:\/\/cpc1.vn\/calci-polycarbophil\/"},"modified":"2026-09-29T08:21:51","modified_gmt":"2026-09-29T01:21:51","slug":"calci-polycarbophil","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/calci-polycarbophil\/","title":{"rendered":"Calci polycarbophil \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, h\u1ea5p ph\u1ee5, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng"},"content":{"rendered":"

Calci polycarbophil \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, h\u1ea5p ph\u1ee5, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/h1>\n

Calci polycarbophil<\/strong> l\u00e0 mu\u1ed1i calci c\u1ee7a polymer acid polyacrylic li\u00ean k\u1ebft ch\u00e9o b\u1eb1ng divinyl glycol. \u0110\u00e2y l\u00e0 polymer h\u00fat n\u01b0\u1edbc<\/strong>, \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh<\/strong>, ch\u1ea5t h\u1ea5p ph\u1ee5<\/strong> v\u00e0 t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/strong> trong vi\u00ean ng\u1eadm, vi\u00ean n\u00e9n.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nPolycarbophil calci, Noveon CA<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9003-97-8; 126040-58-2<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nMu\u1ed1i calci c\u1ee7a acid polyacrylic li\u00ean k\u1ebft ch\u00e9o v\u1edbi divinyl glycol; KLPT \u01b0\u1edbc t\u00ednh t\u1eeb 700 000 t\u1edbi h\u00e0ng t\u1ef7 (kh\u00f4ng \u0111o \u0111\u01b0\u1ee3c tr\u1ef1c ti\u1ebfp v\u1edbi polymer m\u1ea1ng kh\u00f4ng gian ba chi\u1ec1u)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t h\u1ea5p ph\u1ee5, t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n\/vi\u00ean nang<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • T\u00e1 d\u01b0\u1ee3c cho vi\u00ean ng\u1eadm, vi\u00ean ng\u1eadm c\u1ee9ng (troche) v\u00e0 vi\u00ean n\u00e9n u\u1ed1ng. M\u1ee9c h\u00fat n\u01b0\u1edbc ph\u1ee5 thu\u1ed9c chi\u1ec1u d\u00e0i m\u1ea1ch polymer, m\u1ee9c \u0111\u1ed9 li\u00ean k\u1ebft ch\u00e9o v\u00e0 pH m\u00f4i tr\u01b0\u1eddng.<\/li>\n
  • Trong vi\u00ean ng\u1eadm nicotin: l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh khi t\u1ea1o h\u1ea1t t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n \u2013 ch\u1ea5t \u0111\u1ec7m, \u0111\u1ed3ng th\u1eddi \u0111i\u1ec1u ch\u1ec9nh t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng ch\u1ea5t \u0111\u1ec7m.<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c trong thu\u1ed1c x\u1ecbt mi\u1ec7ng th\u00fa y.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng t\u1edbi tr\u1eafng ng\u00e0, m\u00f9i h\u01a1i gi\u1ed1ng acid acetic.<\/li>\n
    • pH ph\u00e2n t\u00e1n 1% (kl\/tt) trong n\u01b0\u1edbc: 6,0\u20138,0; pKa kho\u1ea3ng 4,75.<\/li>\n
    • Kh\u00f4ng tan trong n\u01b0\u1edbc, acid lo\u00e3ng, ki\u1ec1m lo\u00e3ng v\u00e0 c\u00e1c dung m\u00f4i h\u1eefu c\u01a1 th\u00f4ng d\u1ee5ng.<\/li>\n
    • USP-NF y\u00eau c\u1ea7u kh\u1ea3 n\u0103ng h\u00fat n\u01b0\u1edbc \u2265 35,0 g\/g v\u00e0 h\u00e0m l\u01b0\u1ee3ng calci (ch\u1ebf ph\u1ea9m kh\u00f4) 18,0\u201322,0%.<\/li>\n
    • Kh\u00e1c v\u1edbi polycarbophil, d\u1ea1ng mu\u1ed1i calci nh\u00ecn chung kh\u00f4ng c\u00f3 t\u00ednh b\u00e1m d\u00ednh sinh h\u1ecdc (c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ebf ri\u00eang d\u1ea1ng b\u00e1m d\u00ednh). Trong m\u00f4i tr\u01b0\u1eddng acid nh\u01b0 d\u1ea1 d\u00e0y, calci polycarbophil b\u1ecb kh\u1eed calci th\u00e0nh polycarbophil; \u1edf pH 4 tr\u1edf xu\u1ed1ng qu\u00e1 tr\u00ecnh kh\u1eed calci di\u1ec5n ra ho\u00e0n to\u00e0n.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, h\u00e0n k\u00edn; tr\u00e1nh \u1ea9m v\u00e0 nhi\u1ec7t \u0111\u1ed9 cao.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Ion calci gi\u1ea3i ph\u00f3ng c\u00f3 th\u1ec3 t\u1ea1o ph\u1ee9c chelat v\u1edbi m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t: \u0111\u00e3 ghi nh\u1eadn gi\u1ea3m h\u1ea5p thu ciprofloxacin v\u00e0 mycophenolat khi d\u00f9ng c\u00f9ng calci polycarbophil.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      T\u1ed5ng h\u1ee3p b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft ch\u00e9o mu\u1ed1i calci c\u1ee7a acid polyacrylic v\u1edbi divinyl glycol.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • WHO kh\u00f4ng x\u00e1c \u0111\u1ecbnh ADI cho calci polycarbophil; xem th\u00eam b\u00e0i polycarbophil.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 20 g\/kg.<\/li>\n
      • Thao t\u00e1c theo l\u01b0u \u00fd th\u00f4ng th\u01b0\u1eddng; n\u00ean \u0111eo k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 g\u0103ng tay.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong FDA Inactive Ingredients Database (vi\u00ean ng\u1eadm u\u1ed1ng); c\u00f3 trong ch\u1ebf ph\u1ea9m kh\u00f4ng ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i Anh; c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Polycarbophil; xem th\u00eam carbomer.<\/p>\n

          Ghi ch\u00fa:<\/strong> calci polycarbophil c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t t\u1ea1o kh\u1ed1i tr\u01b0\u01a1ng n\u1edf trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u2013 c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Calcium Polycarbophil<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Calci polycarbophil \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, h\u1ea5p ph\u1ee5, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng Calci polycarbophil l\u00e0 mu\u1ed1i calci c\u1ee7a polymer acid polyacrylic li\u00ean k\u1ebft ch\u00e9o b\u1eb1ng divinyl glycol. \u0110\u00e2y l\u00e0 polymer h\u00fat n\u01b0\u1edbc, \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh, ch\u1ea5t h\u1ea5p ph\u1ee5 v\u00e0 t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng trong vi\u00ean ng\u1eadm, vi\u00ean n\u00e9n. Th\u00f4ng tin […]<\/p>\n","protected":false},"author":1,"featured_media":3512,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3513","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-polycarbophil-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Calci polycarbophil \u2013 t\u00e1 d\u01b0\u1ee3c d\u00ednh, h\u1ea5p ph\u1ee5, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng Calci polycarbophil l\u00e0 mu\u1ed1i calci c\u1ee7a polymer acid polyacrylic li\u00ean k\u1ebft ch\u00e9o b\u1eb1ng divinyl glycol. \u0110\u00e2y l\u00e0 polymer h\u00fat n\u01b0\u1edbc, \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh, ch\u1ea5t h\u1ea5p ph\u1ee5 v\u00e0 t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng trong vi\u00ean ng\u1eadm, vi\u00ean n\u00e9n. Th\u00f4ng tin…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3513"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3513\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3512"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}