{"id":3507,"date":"2026-09-29T08:21:27","date_gmt":"2026-09-29T01:21:27","guid":{"rendered":"https:\/\/cpc1.vn\/calci-acetat\/"},"modified":"2026-09-29T11:54:24","modified_gmt":"2026-09-29T04:54:24","slug":"calci-acetat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/calci-acetat\/","title":{"rendered":"Calci acetat (E263) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t t\u1ea1o ph\u1ee9c, \u1ed5n \u0111\u1ecbnh, \u0111\u1ec7m"},"content":{"rendered":"

Calci acetat (E263) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t t\u1ea1o ph\u1ee9c, \u1ed5n \u0111\u1ecbnh, \u0111\u1ec7m<\/h1>\n

Calci acetat<\/strong> (E263) l\u00e0 mu\u1ed1i calci c\u1ee7a acid acetic, d\u1ea1ng b\u1ed9t tr\u1eafng r\u1ea5t h\u00fat \u1ea9m; tr\u00ean th\u1ecb tr\u01b0\u1eddng th\u01b0\u1eddng g\u1eb7p d\u1ea1ng monohydrat. Trong b\u00e0o ch\u1ebf, calci acetat \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n<\/strong> cho ch\u1ebf ph\u1ea9m u\u1ed1ng v\u00e0 b\u00f4i ngo\u00e0i; trong th\u1ef1c ph\u1ea9m l\u00e0 ch\u1ea5t \u1ed5n \u0111\u1ecbnh, ch\u1ea5t \u0111\u1ec7m v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c (c\u00f4 l\u1eadp ion kim lo\u1ea1i)<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCalci diacetat, mu\u1ed1i calci c\u1ee7a acid acetic, acetat v\u00f4i, E263<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n62-54-4 (khan); 5743-26-0 (monohydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC4<\/sub>H6<\/sub>CaO4<\/sub> \u2013 158,18 (khan); C4<\/sub>H6<\/sub>CaO4<\/sub>\u00b7H2<\/sub>O \u2013 176,17 (monohydrat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t t\u1ea1o ph\u1ee9c<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur., USP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n trong ch\u1ebf ph\u1ea9m u\u1ed1ng (h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n) v\u00e0 b\u00f4i ngo\u00e0i (nh\u0169 t\u01b0\u01a1ng, lotion, kem).<\/li>\n
  • Trong c\u00f4ng nghi\u1ec7p th\u1ef1c ph\u1ea9m: ch\u1ea5t \u1ed5n \u0111\u1ecbnh, ch\u1ea5t \u0111\u1ec7m v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i.<\/li>\n
  • Trong c\u00f4ng nghi\u1ec7p h\u00f3a ch\u1ea5t: nguy\u00ean li\u1ec7u s\u1ea3n xu\u1ea5t acid acetic, c\u00e1c acetat, aceton; d\u00f9ng \u0111\u1ec3 k\u1ebft t\u1ee7a oxalat.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng m\u00f9i ho\u1eb7c g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i, h\u00fat \u1ea9m; d\u1ea1ng monohydrat \u1edf d\u1ea1ng h\u00ecnh kim, h\u1ea1t ho\u1eb7c b\u1ed9t.<\/li>\n
    • pH dung d\u1ecbch 5%: 6,3\u20139,6 (Ph.Eur. y\u00eau c\u1ea7u 7,2\u20138,2); dung d\u1ecbch 0,2 M d\u1ea1ng monohydrat c\u00f3 pH kho\u1ea3ng 7,6. T\u1ef7 tr\u1ecdng 1,50 g\/cm\u00b3.<\/li>\n
    • \u0110\u1ed9 tan: tan trong n\u01b0\u1edbc; h\u01a1i tan trong methanol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong aceton, ethanol khan v\u00e0 benzen.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n gi\u1edbi h\u1ea1n n\u01b0\u1edbc \u2264 7,0%, fluorid \u2264 50 ppm, arsen \u2264 3 ppm c\u00f9ng c\u00e1c ion magnesi, kali, natri, stronti, bari, nh\u00f4m; h\u00e0m l\u01b0\u1ee3ng (ch\u1ebf ph\u1ea9m khan) 98,0\u2013102,0% (USP-NF) ho\u1eb7c 99,0\u2013100,5% (Ph.Eur.).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n nh\u01b0ng r\u1ea5t h\u00fat \u1ea9m, v\u00ec v\u1eady d\u1ea1ng monohydrat ph\u1ed5 bi\u1ebfn h\u01a1n. \u0110un tr\u00ean 160 \u00b0C ph\u00e2n h\u1ee7y th\u00e0nh calci carbonat v\u00e0 aceton. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 h\u01a1i \u1ea9m.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho calci carbonat ho\u1eb7c calci hydroxid ph\u1ea3n \u1ee9ng v\u1edbi acid acetic ho\u1eb7c gi\u1ea5m g\u1ed7 (acid pyroligneous).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng trong ch\u1ebf ph\u1ea9m u\u1ed1ng v\u00e0 b\u00f4i ngo\u00e0i. \u1ede d\u1ea1ng tinh khi\u1ebft, calci acetat \u0111\u1ed9c khi ti\u00eam ph\u00fac m\u1ea1c v\u00e0 ti\u00eam t\u0129nh m\u1ea1ch.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft, ph\u00fac m\u1ea1c): 0,075 g\/kg; (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 0,052 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 4,28 g\/kg.<\/li>\n
      • C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft v\u00e0 \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p. Ch\u00e1y \u0111\u01b0\u1ee3c; khi \u0111un t\u1edbi ph\u00e2n h\u1ee7y sinh kh\u00f3i cay. Tr\u00e1nh h\u00edt b\u1ee5i; \u0111eo g\u0103ng, k\u00ednh b\u1ea3o h\u1ed9, kh\u1ea9u trang v\u00e0 \u0111\u1ed3 b\u1ea3o h\u1ed9.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E263).<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (h\u1ed7n d\u1ecbch v\u00e0 vi\u00ean n\u00e9n u\u1ed1ng; nh\u0169 t\u01b0\u01a1ng, lotion, kem); c\u00f3 trong vi\u00ean n\u00e9n u\u1ed1ng l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n

          Natri acetat.<\/p>\n

          Ghi ch\u00fa:<\/strong> calci acetat c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t (ngu\u1ed3n ion calci; ch\u1ea5t g\u1eafn phosphat \u0111\u01b0\u1eddng u\u1ed1ng) \u2013 c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 200-540-9; PubChem CID 6116.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Calcium Acetate<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Calci acetat (E263) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t t\u1ea1o ph\u1ee9c, \u1ed5n \u0111\u1ecbnh, \u0111\u1ec7m Calci acetat (E263) l\u00e0 mu\u1ed1i calci c\u1ee7a acid acetic, d\u1ea1ng b\u1ed9t tr\u1eafng r\u1ea5t h\u00fat \u1ea9m; tr\u00ean th\u1ecb tr\u01b0\u1eddng th\u01b0\u1eddng g\u1eb7p d\u1ea1ng monohydrat. Trong b\u00e0o ch\u1ebf, calci acetat \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n cho ch\u1ebf ph\u1ea9m u\u1ed1ng v\u00e0 b\u00f4i ngo\u00e0i; trong th\u1ef1c […]<\/p>\n","protected":false},"author":1,"featured_media":3506,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3507","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/calci-acetat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Calci acetat (E263) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n, ch\u1ea5t t\u1ea1o ph\u1ee9c, \u1ed5n \u0111\u1ecbnh, \u0111\u1ec7m Calci acetat (E263) l\u00e0 mu\u1ed1i calci c\u1ee7a acid acetic, d\u1ea1ng b\u1ed9t tr\u1eafng r\u1ea5t h\u00fat \u1ea9m; tr\u00ean th\u1ecb tr\u01b0\u1eddng th\u01b0\u1eddng g\u1eb7p d\u1ea1ng monohydrat. Trong b\u00e0o ch\u1ebf, calci acetat \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n cho ch\u1ebf ph\u1ea9m u\u1ed1ng v\u00e0 b\u00f4i ngo\u00e0i; trong th\u1ef1c…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3507"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3507\/revisions"}],"predecessor-version":[{"id":3746,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3507\/revisions\/3746"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3506"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}