{"id":3497,"date":"2026-09-29T08:17:45","date_gmt":"2026-09-29T01:17:45","guid":{"rendered":"https:\/\/cpc1.vn\/asparagin\/"},"modified":"2026-09-29T08:17:45","modified_gmt":"2026-09-29T01:17:45","slug":"asparagin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/asparagin\/","title":{"rendered":"Asparagin \u2013 ch\u1ea5t \u0111\u1ec7m, t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, ch\u1ea5t mang b\u1ed9t h\u00edt"},"content":{"rendered":"

Asparagin \u2013 ch\u1ea5t \u0111\u1ec7m, t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, ch\u1ea5t mang b\u1ed9t h\u00edt<\/h1>\n

Asparagin<\/strong> (L-asparagin) l\u00e0 acid amin kh\u00f4ng thi\u1ebft y\u1ebfu, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, th\u01b0\u1eddng d\u00f9ng \u1edf d\u1ea1ng monohydrat. Ngo\u00e0i vai tr\u00f2 trong th\u1ef1c ph\u1ea9m b\u1ed5 sung v\u00e0 m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y, asparagin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m<\/strong>, t\u00e1 d\u01b0\u1ee3c h\u1ed7 tr\u1ee3 \u0111\u00f4ng kh\u00f4<\/strong> \u0111\u1ec3 \u1ed5n \u0111\u1ecbnh peptid, protein, v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m t\u00e1 d\u01b0\u1ee3c t\u1ea1o c\u1ed1t, t\u0103ng r\u00e3<\/strong> cho vi\u00ean \u0111\u00f4ng kh\u00f4 v\u00e0 b\u1ed9t h\u00edt.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nL-Asparagin, Asn, acid L-aspartic 4-amid, acid L-\u03b1-aminosuccinamic, asparamid<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n70-47-3 (khan); 5794-13-8 (monohydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC4<\/sub>H8<\/sub>N2<\/sub>O3<\/sub> \u2013 132,12 (khan); C4<\/sub>H8<\/sub>N2<\/sub>O3<\/sub>\u00b7H2<\/sub>O \u2013 150,13 (monohydrat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t \u0111\u1ec7m, ch\u1ea5t mang b\u1ed9t h\u00edt kh\u00f4, t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, t\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean n\u00e9n\/vi\u00ean nang<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, Ph.Eur. (Asparagine Monohydrate), USP-NF (Asparagine)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • C\u00f3 trong th\u1ef1c ph\u1ea9m b\u1ed5 sung, vaccin v\u00e0 ch\u1ebf ph\u1ea9m ti\u00eam trong b\u00e0ng quang; l\u00e0 th\u00e0nh ph\u1ea7n m\u00f4i tr\u01b0\u1eddng nu\u00f4i ch\u1ee7ng \u0111\u1ec3 s\u1ea3n xu\u1ea5t ch\u1ebf ph\u1ea9m BCG \u0111\u00f4ng kh\u00f4.<\/li>\n
  • Th\u1eed nghi\u1ec7m l\u00e0m t\u00e1 d\u01b0\u1ee3c h\u1ed7 tr\u1ee3 \u0111\u00f4ng kh\u00f4 ho\u1eb7c ch\u1ea5t \u0111\u1ec7m \u0111\u1ec3 \u1ed5n \u0111\u1ecbnh peptid, protein v\u00e0 m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t ch\u1ed1ng ung th\u01b0.<\/li>\n
  • Vi\u00ean \u0111\u00f4ng kh\u00f4 r\u00e3 nhanh: nghi\u00ean c\u1ee9u d\u00f9ng asparagin l\u00e0m ch\u1ea5t t\u1ea1o c\u1ed1t v\u00e0 t\u0103ng r\u00e3 \u1edf n\u1ed3ng \u0111\u1ed9 10\u201370%.<\/li>\n
  • B\u1ed9t h\u00edt kh\u00f4: \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed trong c\u00f4ng th\u1ee9c natri cromoglicat phun s\u1ea5y \u1edf n\u1ed3ng \u0111\u1ed9 kho\u1ea3ng 5,1%.<\/li>\n
  • Trong m\u1ef9 ph\u1ea9m: th\u00e0nh ph\u1ea7n d\u01b0\u1ee1ng t\u00f3c v\u00e0 d\u01b0\u1ee1ng da.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, ho\u1eb7c tinh th\u1ec3 kh\u00f4ng m\u00e0u, kh\u00f4ng v\u1ecb (d\u1ea1ng D c\u00f3 v\u1ecb ng\u1ecdt).<\/li>\n
    • pKa1<\/sub> 2,02; pKa2<\/sub> 8,80. \u0110i\u1ec3m ch\u1ea3y 234\u2013235 \u00b0C; t\u1ef7 tr\u1ecdng ri\u00eang 1,543; log Kow<\/sub> \u22123,82.<\/li>\n
    • \u0110\u1ed9 tan: tan trong n\u01b0\u1edbc (kho\u1ea3ng 29 g\/L \u1edf 25 \u00b0C), tan trong acid v\u00e0 ki\u1ec1m; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong methanol, benzen; kh\u00f4ng tan trong ethanol, ether.<\/li>\n
    • D\u1ea1ng monohydrat ch\u1ee9a kho\u1ea3ng 11,5\u201312,5% n\u01b0\u1edbc (m\u1ea5t kh\u1ed1i l\u01b0\u1ee3ng khi l\u00e0m kh\u00f4); dung d\u1ecbch c\u00f3 pH 4,0\u20136,0 theo Ph.Eur.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Nhi\u1ec7t \u0111\u1ed9 tr\u00ean 30 \u00b0C c\u00f3 th\u1ec3 g\u00e2y ph\u00e2n h\u1ee7y. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, ch\u1ed1ng \u00e1nh s\u00e1ng, \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng; tr\u00e1nh \u1ea9m, \u00e1nh n\u1eafng tr\u1ef1c ti\u1ebfp v\u00e0 ti\u1ebfp x\u00fac v\u1edbi acid, base, ch\u1ea5t oxy h\u00f3a. Asparagin d\u1ec5 b\u1ecb kh\u1eed amid th\u00e0nh acid aspartic.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Asparagin c\u00f3 s\u1eb5n trong t\u1ef1 nhi\u00ean \u1edf c\u1ea3 th\u1ef1c v\u1eadt v\u00e0 \u0111\u1ed9ng v\u1eadt. Trong c\u00f4ng nghi\u1ec7p c\u00f3 th\u1ec3 t\u00e1ch t\u1eeb ph\u1ee5 ph\u1ea9m s\u1ea3n xu\u1ea5t tinh b\u1ed9t khoai t\u00e2y, t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc t\u1eeb acid aspartic, ho\u1eb7c l\u00ean men vi sinh tr\u1ef1c ti\u1ebfp t\u1eeb carbohydrat.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c ph\u00e9p b\u1ed5 sung tr\u1ef1c ti\u1ebfp v\u00e0o th\u1ef1c ph\u1ea9m d\u00f9ng cho ng\u01b0\u1eddi.<\/li>\n
      • Li\u1ec1u kh\u00f4ng quan s\u00e1t th\u1ea5y t\u00e1c d\u1ee5ng c\u00f3 h\u1ea1i (NOAEL, chu\u1ed9t c\u1ed1ng, u\u1ed1ng 90 ng\u00e0y): 1,65 g\/kg\/ng\u00e0y (\u0111\u1ef1c) v\u00e0 1,73 g\/kg\/ng\u00e0y (c\u00e1i).<\/li>\n
      • Thao t\u00e1c theo l\u01b0u \u00fd th\u00f4ng th\u01b0\u1eddng. Khi \u0111un t\u1edbi ph\u00e2n h\u1ee7y, asparagin sinh kh\u00f3i \u0111\u1ed9c ch\u1ee9a oxyd nit\u01a1.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • C\u00f3 trong ch\u1ebf ph\u1ea9m ti\u00eam (h\u1ed7n d\u1ecbch nh\u1ecf v\u00e0o b\u00e0ng quang) l\u01b0u h\u00e0nh t\u1ea1i Anh, v\u00e0 trong ch\u1ebf ph\u1ea9m ti\u00eam l\u01b0u h\u00e0nh t\u1ea1i M\u1ef9, Ph\u1ea7n Lan.<\/li>\n
        • C\u00f3 trong danh m\u1ee5c EAFUS c\u1ee7a FDA; c\u1ea3 asparagin v\u00e0 asparagin monohydrat c\u00f3 trong Canadian Natural Health Products Ingredients Database.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n
            \n
          • D-Asparagin<\/strong> (C4<\/sub>H8<\/sub>N2<\/sub>O3<\/sub>, KLPT 132,12; CAS 2058-58-4): \u0111\u1ed3ng ph\u00e2n quang h\u1ecdc, c\u00f3 v\u1ecb ng\u1ecdt, \u0111i\u1ec3m ch\u1ea3y kho\u1ea3ng 280 \u00b0C.<\/li>\n
          • Acid DL-aspartic<\/strong> (C4<\/sub>H7<\/sub>NO4<\/sub>, KLPT 133,10; CAS 617-45-8): s\u1ea3n ph\u1ea9m kh\u1eed amid c\u1ee7a asparagin.<\/li>\n<\/ul>\n

            Ghi ch\u00fa:<\/strong> asparagin c\u00f2n d\u00f9ng trong m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o. C\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft. S\u1ed1 EINECS 200-735-9; PubChem CID 6267 (khan), 170358 (monohydrat).<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Asparagine<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Asparagin \u2013 ch\u1ea5t \u0111\u1ec7m, t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, ch\u1ea5t mang b\u1ed9t h\u00edt Asparagin (L-asparagin) l\u00e0 acid amin kh\u00f4ng thi\u1ebft y\u1ebfu, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, th\u01b0\u1eddng d\u00f9ng \u1edf d\u1ea1ng monohydrat. Ngo\u00e0i vai tr\u00f2 trong th\u1ef1c ph\u1ea9m b\u1ed5 sung v\u00e0 m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y, asparagin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m, t\u00e1 d\u01b0\u1ee3c h\u1ed7 tr\u1ee3 \u0111\u00f4ng kh\u00f4 […]<\/p>\n","protected":false},"author":1,"featured_media":3496,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3497","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/asparagin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Asparagin \u2013 ch\u1ea5t \u0111\u1ec7m, t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, ch\u1ea5t mang b\u1ed9t h\u00edt Asparagin (L-asparagin) l\u00e0 acid amin kh\u00f4ng thi\u1ebft y\u1ebfu, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, th\u01b0\u1eddng d\u00f9ng \u1edf d\u1ea1ng monohydrat. Ngo\u00e0i vai tr\u00f2 trong th\u1ef1c ph\u1ea9m b\u1ed5 sung v\u00e0 m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y, asparagin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m, t\u00e1 d\u01b0\u1ee3c h\u1ed7 tr\u1ee3 \u0111\u00f4ng kh\u00f4…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3497"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3497\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3496"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}