{"id":3418,"date":"2026-09-28T22:05:17","date_gmt":"2026-09-28T15:05:17","guid":{"rendered":"https:\/\/cpc1.vn\/acid-adipic\/"},"modified":"2026-09-28T22:05:17","modified_gmt":"2026-09-28T15:05:17","slug":"acid-adipic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-adipic\/","title":{"rendered":"Acid adipic (E355) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng thu\u1ed1c"},"content":{"rendered":"

Acid adipic (E355) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng thu\u1ed1c<\/h1>\n

Acid adipic<\/strong> (acid hexanedioic, E355) l\u00e0 acid dicarboxylic m\u1ea1ch th\u1eb3ng 6 carbon, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng h\u00fat \u1ea9m. Trong b\u00e0o ch\u1ebf, acid adipic d\u00f9ng l\u00e0m ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m<\/strong> v\u00e0 ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng ho\u1ea1t ch\u1ea5t<\/strong> trong d\u1ea1ng b\u00e0o ch\u1ebf gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAcidum adipicum, 1,4-butanedicarboxylic acid, 1,6-hexanedioic acid, E355<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n124-04-9<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC6<\/sub>H10<\/sub>O4<\/sub> \u2013 146,14<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, t\u00e1c nh\u00e2n \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng<\/td>\n<\/tr>\n
D\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nPh.Eur., USP-NF<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t acid h\u00f3a v\u00e0 ch\u1ea5t \u0111\u1ec7m trong thu\u1ed1c ti\u00eam b\u1eafp, ti\u00eam t\u0129nh m\u1ea1ch v\u00e0 ch\u1ebf ph\u1ea9m \u0111\u1eb7t \u00e2m \u0111\u1ea1o.<\/li>\n
  • Vi\u00ean c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i:<\/strong> th\u00eam acid adipic v\u00e0o c\u1ed1t gi\u00fap gi\u1eef pH vi m\u00f4i tr\u01b0\u1eddng \u1ed5n \u0111\u1ecbnh, nh\u1edd \u0111\u00f3 t\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng \u00edt ph\u1ee5 thu\u1ed9c pH \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u2013 \u0111\u00e3 \u00e1p d\u1ee5ng cho c\u1ea3 ho\u1ea1t ch\u1ea5t base y\u1ebfu l\u1eabn acid y\u1ebfu.<\/li>\n
  • \u0110\u01b0a v\u00e0o l\u1edbp bao polymer c\u1ee7a h\u1ec7 c\u1ed1t th\u00e2n n\u01b0\u1edbc \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh pH b\u00ean trong gel, cho gi\u1ea3i ph\u00f3ng g\u1ea7n b\u1eadc kh\u00f4ng; d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o l\u1ed7 gi\u00fap l\u1edbp bao shellac r\u00e3 t\u1ed1t h\u01a1n \u1edf pH ru\u1ed9t m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng gi\u1ea3i ph\u00f3ng trong m\u00f4i tr\u01b0\u1eddng acid; d\u00f9ng trong h\u1ec7 gi\u1ea3i ph\u00f3ng mu\u1ed9n d\u1ea1ng “b\u00f9ng ph\u00e1t”.<\/li>\n
  • Trong th\u1ef1c ph\u1ea9m: ch\u1ea5t t\u1ea1o x\u1ed1p, \u0111i\u1ec1u ch\u1ec9nh pH, t\u1ea1o v\u1ecb chua.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f4ng m\u00f9i, kh\u00f4ng h\u00fat \u1ea9m; tinh th\u1ec3 h\u1ec7 \u0111\u01a1n t\u00e0.<\/li>\n
    • \u0110i\u1ec3m ch\u1ea3y kho\u1ea3ng 152 \u00b0C (d\u01b0\u1ee3c \u0111i\u1ec3n: 151\u2013154 \u00b0C); \u0111i\u1ec3m s\u00f4i 337,5 \u00b0C; t\u1ef7 tr\u1ecdng 1,360 g\/cm\u00b3; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 196 \u00b0C (c\u1ed1c k\u00edn).<\/li>\n
    • pKa1<\/sub> 4,42 v\u00e0 pKa2<\/sub> 5,41 (25 \u00b0C); dung d\u1ecbch 0,1% c\u00f3 pH kho\u1ea3ng 3,2, dung d\u1ecbch b\u00e3o h\u00f2a pH kho\u1ea3ng 2,7.<\/li>\n
    • \u0110\u1ed9 tan: 1 ph\u1ea7n tan trong kho\u1ea3ng 71 ph\u1ea7n n\u01b0\u1edbc \u1edf 20 \u00b0C, tan r\u1ea5t nhi\u1ec1u trong n\u01b0\u1edbc s\u00f4i; d\u1ec5 tan trong ethanol 95% v\u00e0 methanol; tan trong aceton, ethyl acetat; h\u01a1i tan trong cyclohexan; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong benzen, ether d\u1ea7u h\u1ecfa.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n trong \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng, ph\u00e2n h\u1ee7y khi \u0111un tr\u00ean \u0111i\u1ec3m s\u00f4i. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh ngu\u1ed3n nhi\u1ec7t, tia l\u1eeda v\u00e0 ng\u1ecdn l\u1eeda tr\u1ea7n.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh, base m\u1ea1nh v\u00e0 ch\u1ea5t kh\u1eed. Ti\u1ebfp x\u00fac v\u1edbi alcol, glycol, aldehyd, epoxid ho\u1eb7c c\u00e1c h\u1ee3p ch\u1ea5t d\u1ec5 tr\u00f9ng h\u1ee3p c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Oxy h\u00f3a cyclohexanol, cyclohexanon ho\u1eb7c h\u1ed7n h\u1ee3p hai ch\u1ea5t b\u1eb1ng acid nitric. M\u1ed9t h\u01b0\u1edbng “xanh” \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t l\u00e0 oxy h\u00f3a cyclohexen b\u1eb1ng hydro peroxyd 30% kh\u00f4ng d\u00f9ng dung m\u00f4i h\u1eefu c\u01a1 v\u00e0 halogen, cho acid adipic tinh th\u1ec3 kh\u00f4ng m\u00e0u.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • D\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m. \u1ede d\u1ea1ng tinh khi\u1ebft, acid adipic \u0111\u1ed9c khi ti\u00eam ph\u00fac m\u1ea1c v\u00e0 \u0111\u1ed9c v\u1eeba ph\u1ea3i theo c\u00e1c \u0111\u01b0\u1eddng kh\u00e1c; g\u00e2y k\u00edch \u1ee9ng m\u1eaft m\u1ea1nh, c\u00f3 th\u1ec3 g\u00e2y hen ngh\u1ec1 nghi\u1ec7p.<\/li>\n
      • LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 1,9 g\/kg; (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 0,68 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): tr\u00ean 11 g\/kg.<\/li>\n
      • L\u00e0 ch\u1ea5t ch\u00e1y \u0111\u01b0\u1ee3c; b\u1ee5i m\u1ecbn tr\u1ed9n v\u1edbi kh\u00f4ng kh\u00ed c\u00f3 nguy c\u01a1 n\u1ed5 b\u1ee5i; khi \u0111un ph\u00e2n h\u1ee7y sinh kh\u00f3i cay. N\u00ean d\u00f9ng kh\u1ea9u trang l\u1ecdc b\u1ee5i\/m\u1eb7t n\u1ea1, k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 g\u0103ng cao su d\u00e0y khi thao t\u00e1c.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E355).<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Database (ti\u00eam b\u1eafp, ti\u00eam t\u0129nh m\u1ea1ch, ch\u1ebf ph\u1ea9m \u0111\u1eb7t \u00e2m \u0111\u1ea1o); c\u00f3 trong m\u1ed9t ch\u1ebf ph\u1ea9m vi\u00ean ng\u1eadm l\u01b0u h\u00e0nh t\u1ea1i Anh.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF; c\u00f3 ti\u00eau chu\u1ea9n trong Food Chemicals Codex.<\/li>\n<\/ul>\n

          Ghi ch\u00fa:<\/strong> s\u1ed1 EINECS 204-673-3; PubChem CID 196.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Adipic Acid<\/em> trong: Sheskey P.J., Cook W.G., Cable C.G. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 8. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2017. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2017. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Acid adipic (E355) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng thu\u1ed1c Acid adipic (acid hexanedioic, E355) l\u00e0 acid dicarboxylic m\u1ea1ch th\u1eb3ng 6 carbon, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng h\u00fat \u1ea9m. Trong b\u00e0o ch\u1ebf, acid adipic d\u00f9ng l\u00e0m ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m v\u00e0 ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng […]<\/p>\n","protected":false},"author":1,"featured_media":3417,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-3418","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-adipic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid adipic (E355) \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng thu\u1ed1c Acid adipic (acid hexanedioic, E355) l\u00e0 acid dicarboxylic m\u1ea1ch th\u1eb3ng 6 carbon, d\u1ea1ng b\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng h\u00fat \u1ea9m. Trong b\u00e0o ch\u1ebf, acid adipic d\u00f9ng l\u00e0m ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m v\u00e0 ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3i ph\u00f3ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=3418"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/3418\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/3417"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=3418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=3418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=3418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}