{"id":2712,"date":"2026-09-27T21:11:41","date_gmt":"2026-09-27T14:11:41","guid":{"rendered":"https:\/\/cpc1.vn\/vanilin\/"},"modified":"2026-09-27T21:11:41","modified_gmt":"2026-09-27T14:11:41","slug":"vanilin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/vanilin\/","title":{"rendered":"Vanilin \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng vani, che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Vanilin \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng vani, che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu<\/h1>\n<p><strong>Vanilin<\/strong> (4-hydroxy-3-methoxybenzaldehyd) l\u00e0 h\u1ee3p ch\u1ea5t t\u1ea1o m\u00f9i ch\u00ednh c\u1ee7a qu\u1ea3 vani, c\u00f4ng th\u1ee9c C<sub>8<\/sub>H<sub>8<\/sub>O<sub>3<\/sub>. \u0110\u00e2y l\u00e0 <strong>ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng<\/strong> d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, \u0111\u1ed3 u\u1ed1ng v\u00e0 b\u00e1nh k\u1eb9o, \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 <strong>che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu<\/strong> c\u1ee7a thu\u1ed1c.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Vanillin, vanillic aldehyde, 3-methoxy-4-hydroxybenzaldehyde, 4-hydroxy-m-anisaldehyde, methylprotocatechuic aldehyde; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Rhovanil<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>BP, USP-NF: Vanillin; Ph.Eur.: Vanillinum<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>121-33-5<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/td>\n<td>C<sub>8<\/sub>H<sub>8<\/sub>O<sub>3<\/sub> \u2013 152,15<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>T\u1ea1o h\u01b0\u01a1ng v\u1ecb vani t\u1ef1 nhi\u00ean trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, \u0111\u1ed3 u\u1ed1ng, b\u00e1nh k\u1eb9o; d\u00f9ng trong n\u01b0\u1edbc hoa.<\/li>\n<li>L\u00e0 t\u00e1 d\u01b0\u1ee3c: d\u00f9ng trong vi\u00ean n\u00e9n, dung d\u1ecbch (0,01\u20130,02% kl\/tt), siro v\u00e0 thu\u1ed1c b\u1ed9t \u0111\u1ec3 che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu (v\u00ed d\u1ee5 vi\u00ean cafein, vi\u00ean polythiazid); d\u00f9ng trong m\u00e0ng bao \u0111\u1ec3 che m\u00f9i v\u1ecb vi\u00ean vitamin.<\/li>\n<li>\u0110\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t \u1ed5n \u0111\u1ecbnh quang cho m\u1ed9t s\u1ed1 thu\u1ed1c ti\u00eam (furosemid, haloperidol, thiothixen); \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ef1c ph\u1ea9m v\u00e0 \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 t\u00ednh kh\u00e1ng n\u1ea5m nh\u1ea5t \u0111\u1ecbnh.<\/li>\n<li>Thu\u1ed1c th\u1eed ph\u00e2n t\u00edch; ch\u1ea5t trung gian t\u1ed5ng h\u1ee3p m\u1ed9t s\u1ed1 d\u01b0\u1ee3c ch\u1ea5t (\u0111\u1eb7c bi\u1ec7t methyldopa). C\u00e1c h\u01b0\u1edbng nghi\u00ean c\u1ee9u l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Tinh th\u1ec3 h\u00ecnh kim ho\u1eb7c b\u1ed9t m\u00e0u tr\u1eafng \u0111\u1ebfn kem, m\u00f9i vani \u0111\u1eb7c tr\u01b0ng, v\u1ecb ng\u1ecdt.<\/li>\n<li>N\u00f3ng ch\u1ea3y 81\u201383 \u00b0C; s\u00f4i 284\u2013285 \u00b0C (k\u00e8m ph\u00e2n h\u1ee7y); \u0111i\u1ec3m ch\u1edbp ch\u00e1y 153 \u00b0C (c\u1ed1c k\u00edn); t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,6 g\/cm\u00b3. Dung d\u1ecbch n\u01b0\u1edbc c\u00f3 ph\u1ea3n \u1ee9ng acid v\u1edbi qu\u1ef3.<\/li>\n<li>Kh\u00f3 tan trong n\u01b0\u1edbc (1 trong 100; 1 trong 16 \u1edf 80 \u00b0C); tan trong ethanol 95% (1 trong 2), ethanol 70% (1 trong 3), glycerin (1 trong 20); tan trong aceton, cloroform, ether, methanol, d\u1ea7u v\u00e0 dung d\u1ecbch ki\u1ec1m hydroxid.<\/li>\n<li>D\u01b0\u1ee3c \u0111i\u1ec3n: kho\u1ea3ng n\u00f3ng ch\u1ea3y 81\u201384 \u00b0C (Ph.Eur.) \/ 81\u201383 \u00b0C (USP-NF); m\u1ea5t kh\u1ed1i l\u01b0\u1ee3ng khi l\u00e0m kh\u00f4 \u2264 1,0%; \u0111\u1ecbnh l\u01b0\u1ee3ng 99,0\u2013101,0% (Ph.Eur.) ho\u1eb7c 97,0\u2013103,0% (USP-NF).<\/li>\n<li>M\u1ed9t ph\u1ea7n vanilin t\u1ed5ng h\u1ee3p t\u01b0\u01a1ng \u0111\u01b0\u01a1ng kho\u1ea3ng 400 ph\u1ea7n qu\u1ea3 vani v\u1ec1 c\u01b0\u1eddng \u0111\u1ed9 h\u01b0\u01a1ng.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>B\u1ecb oxy h\u00f3a ch\u1eadm trong kh\u00f4ng kh\u00ed \u1ea9m v\u00e0 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi \u00e1nh s\u00e1ng.<\/li>\n<li>Dung d\u1ecbch trong ethanol ph\u00e2n h\u1ee7y nhanh d\u01b0\u1edbi \u00e1nh s\u00e1ng th\u00e0nh dung d\u1ecbch m\u00e0u v\u00e0ng, h\u01a1i \u0111\u1eafng (t\u1ea1o dimer divanilin); dung d\u1ecbch ki\u1ec1m c\u0169ng ph\u00e2n h\u1ee7y nhanh th\u00e0nh m\u00e0u n\u00e2u.<\/li>\n<li>Th\u00eam natri metabisulfit 0,2% kl\/tt l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a gi\u00fap dung d\u1ecbch \u1ed5n \u0111\u1ecbnh \u0111\u01b0\u1ee3c v\u00e0i th\u00e1ng.<\/li>\n<li>B\u1ea3o qu\u1ea3n nguy\u00ean li\u1ec7u trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<ul>\n<li>V\u1edbi aceton t\u1ea1o h\u1ee3p ch\u1ea5t c\u00f3 m\u00e0u s\u00e1ng.<\/li>\n<li>V\u1edbi glycerin t\u1ea1o h\u1ee3p ch\u1ea5t th\u1ef1c t\u1ebf kh\u00f4ng tan trong ethanol.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>C\u00f3 t\u1ef1 nhi\u00ean trong nhi\u1ec1u tinh d\u1ea7u, nh\u1ea5t l\u00e0 qu\u1ea3 <em>Vanilla planifolia<\/em> v\u00e0 <em>Vanilla tahitensis<\/em>. C\u00f4ng nghi\u1ec7p s\u1ea3n xu\u1ea5t t\u1eeb lignin trong d\u1ecbch th\u1ea3i sulfit ng\u00e0nh gi\u1ea5y: x\u1eed l\u00fd lignin b\u1eb1ng ki\u1ec1m \u1edf nhi\u1ec7t \u0111\u1ed9, \u00e1p su\u1ea5t cao c\u00f3 x\u00fac t\u00e1c, t\u00e1ch vanilin kh\u1ecfi h\u1ed7n h\u1ee3p s\u1ea3n ph\u1ea9m r\u1ed3i k\u1ebft tinh l\u1ea1i nhi\u1ec1u l\u1ea7n. C\u0169ng t\u1ed5ng h\u1ee3p t\u1eeb guaiacol ng\u01b0ng t\u1ee5 v\u1edbi acid glyoxylic trong ki\u1ec1m y\u1ebfu, oxy h\u00f3a b\u1eb1ng kh\u00f4ng kh\u00ed c\u00f3 x\u00fac t\u00e1c r\u1ed3i acid h\u00f3a \u2013 kh\u1eed carboxyl \u0111\u1ed3ng th\u1eddi, sau \u0111\u00f3 k\u1ebft tinh l\u1ea1i.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>\u00cdt b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i; c\u00f3 gi\u1ea3 thuy\u1ebft m\u1eabn c\u1ea3m ch\u00e9o v\u1edbi ph\u00e2n t\u1eed c\u1ea5u tr\u00fac t\u01b0\u01a1ng t\u1ef1 nh\u01b0 acid benzoic. \u0110\u00e3 ghi nh\u1eadn vi\u00eam da ti\u1ebfp x\u00fac v\u00e0 co th\u1eaft ph\u1ebf qu\u1ea3n do qu\u00e1 m\u1eabn.<\/li>\n<li>WHO\/JECFA \u0111\u1eb7t ADI \u01b0\u1edbc t\u00ednh \u0111\u1ebfn 10 mg\/kg th\u1ec3 tr\u1ecdng.<\/li>\n<li>LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 1,58 g\/kg; (chu\u1ed9t lang, u\u1ed1ng): 1,4 g\/kg; (chu\u1ed9t nh\u1eaft, m\u00e0ng b\u1ee5ng): 0,48 g\/kg.<\/li>\n<li>D\u00f9ng k\u00ednh b\u1ea3o h\u1ed9. B\u1ee5i n\u1ed3ng \u0111\u1ed9 cao trong kh\u00f4ng kh\u00ed c\u00f3 nguy c\u01a1 n\u1ed5.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS t\u1ea1i M\u1ef9.<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (dung d\u1ecbch, h\u1ed7n d\u1ecbch, siro, vi\u00ean n\u00e9n u\u1ed1ng); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> ethyl vanilin.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Vanillin<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Vanilin \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng vani, che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu Vanilin (4-hydroxy-3-methoxybenzaldehyd) l\u00e0 h\u1ee3p ch\u1ea5t t\u1ea1o m\u00f9i ch\u00ednh c\u1ee7a qu\u1ea3 vani, c\u00f4ng th\u1ee9c C8H8O3. \u0110\u00e2y l\u00e0 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, \u0111\u1ed3 u\u1ed1ng v\u00e0 b\u00e1nh k\u1eb9o, \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu c\u1ee7a thu\u1ed1c. Th\u00f4ng tin [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2711,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2712","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/vanilin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Vanilin \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng vani, che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu Vanilin (4-hydroxy-3-methoxybenzaldehyd) l\u00e0 h\u1ee3p ch\u1ea5t t\u1ea1o m\u00f9i ch\u00ednh c\u1ee7a qu\u1ea3 vani, c\u00f4ng th\u1ee9c C8H8O3. \u0110\u00e2y l\u00e0 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, \u0111\u1ed3 u\u1ed1ng v\u00e0 b\u00e1nh k\u1eb9o, \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 che m\u00f9i v\u1ecb kh\u00f3 ch\u1ecbu c\u1ee7a thu\u1ed1c. Th\u00f4ng tin&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2712"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2712\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2711"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}