{"id":2706,"date":"2026-09-27T21:11:17","date_gmt":"2026-09-27T14:11:17","guid":{"rendered":"https:\/\/cpc1.vn\/sap-nhu-hoa-anion\/"},"modified":"2026-09-28T21:24:58","modified_gmt":"2026-09-28T14:24:58","slug":"sap-nhu-hoa-anion","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/sap-nhu-hoa-anion\/","title":{"rendered":"S\u00e1p nh\u0169 h\u00f3a anion (emulsifying wax BP) \u2013 ch\u1ea5t nh\u0169 h\u00f3a cho kem D\/N"},"content":{"rendered":"

S\u00e1p nh\u0169 h\u00f3a anion (emulsifying wax BP) \u2013 ch\u1ea5t nh\u0169 h\u00f3a cho kem D\/N<\/h1>\n

S\u00e1p nh\u0169 h\u00f3a anion<\/strong> (emulsifying wax BP) l\u00e0 h\u1ed7n h\u1ee3p alcol cetostearylic v\u1edbi natri lauryl sulfat (ho\u1eb7c mu\u1ed1i natri c\u1ee7a alcol b\u00e9o b\u1eadc m\u1ed9t sulfat h\u00f3a t\u01b0\u01a1ng t\u1ef1) v\u00e0 m\u1ed9t \u00edt n\u01b0\u1edbc tinh khi\u1ebft. \u0110\u00e2y l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a v\u00e0 l\u00e0m c\u1ee9ng<\/strong> gi\u00fap t\u1ea1o kem d\u1ea7u trong n\u01b0\u1edbc kh\u00f4ng nh\u1eddn v\u00e0 thu\u1ed1c m\u1ee1 nh\u0169 h\u00f3a, d\u00f9ng nhi\u1ec1u trong m\u1ef9 ph\u1ea9m v\u00e0 ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nEmulsifying wax BP, anionic emulsifying wax; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Collone HV, Crodex A, Cyclonette Wax, Lanette wax SX BP<\/td>\n<\/tr>\n
T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP: Emulsifying wax (kh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur., JP, USP-NF)<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n8014-38-8<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n (BP)<\/td>\nAlcol cetostearylic 90 g, natri lauryl sulfat 10 g, n\u01b0\u1edbc tinh khi\u1ebft 4 mL<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t l\u00e0m c\u1ee9ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Tr\u00e1nh nh\u1ea7m t\u00ean:<\/strong> \u201cEmulsifying wax BP\u201d l\u00e0 s\u00e1p anion<\/em>, c\u00f2n \u201cEmulsifying wax\u201d c\u1ee7a USP-NF l\u00e0 s\u00e1p kh\u00f4ng ion<\/em> (t\u01b0\u01a1ng \u1ee9ng cetomacrogol emulsifying wax c\u1ee7a Anh). Hai lo\u1ea1i c\u00f3 t\u00ednh ch\u1ea5t v\u1eadt l\u00fd gi\u1ed1ng nhau nh\u01b0ng kh\u00e1c ch\u1ea5t di\u1ec7n ho\u1ea1t n\u00ean ph\u1ea1m vi t\u01b0\u01a1ng h\u1ee3p kh\u00e1c \u2013 kh\u00f4ng thay th\u1ebf cho nhau<\/strong> trong c\u00f4ng th\u1ee9c. Ngo\u00e0i ra c\u00f2n c\u00f3 s\u00e1p nh\u0169 h\u00f3a cation (cetrimid emulsifying wax).<\/p>\n

Applications<\/h2>\n
    \n
  • Th\u00eam v\u00e0o n\u1ec1n b\u00e9o ho\u1eb7c parafin \u0111\u1ec3 t\u1ea1o nh\u0169 t\u01b0\u01a1ng d\u1ea7u trong n\u01b0\u1edbc kh\u00f4ng nh\u1eddn. Kho\u1ea3ng 2%: nh\u0169 t\u01b0\u01a1ng r\u00f3t \u0111\u01b0\u1ee3c; kem \u0111\u1eb7c h\u01a1n (v\u00ed d\u1ee5 aqueous cream BP) ch\u1ee9a \u0111\u1ebfn 10%.<\/li>\n
  • Th\u00eam m\u1ed9t \u00edt ki\u1ec1m v\u00e0o pha n\u01b0\u1edbc cho nh\u0169 t\u01b0\u01a1ng ch\u1ea5t l\u01b0\u1ee3ng t\u1ed1t h\u01a1n, nh\u01b0ng tr\u00e1nh d\u01b0.<\/li>\n
  • Tr\u1ed9n 3\u201330% v\u1edbi vaselin v\u00e0 parafin l\u1ecfng t\u1ea1o n\u1ec1n thu\u1ed1c m\u1ee1 khan (v\u00ed d\u1ee5 emulsifying ointment BP). Ch\u1ebf ph\u1ea9m 80% s\u00e1p trong vaselin tr\u1eafng t\u1eebng d\u00f9ng l\u00e0m ch\u1ea5t thay x\u00e0 ph\u00f2ng cho da nh\u1ea1y c\u1ea3m (c\u00f4ng d\u1ee5ng n\u00e0y n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft).<\/li>\n
  • Th\u00eam 10% v\u00e0o b\u01a1 ca cao t\u1ea1o n\u1ec1n thu\u1ed1c \u0111\u1ea1n n\u00f3ng ch\u1ea3y kho\u1ea3ng 34 \u00b0C.<\/li>\n
  • Kem c\u1ea7n \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n ch\u1ed1ng vi sinh \u0111\u1ea7y \u0111\u1ee7; th\u01b0\u1eddng ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c b\u1eb1ng h\u1ea5p nhi\u1ec7t \u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t r\u1eafn d\u1ea1ng s\u00e1p ho\u1eb7c v\u1ea3y, g\u1ea7n tr\u1eafng ho\u1eb7c v\u00e0ng nh\u1ea1t, khi l\u00e0m \u1ea5m tr\u1edf n\u00ean d\u1ebbo tr\u01b0\u1edbc khi ch\u1ea3y; m\u00f9i nh\u1eb9 \u0111\u1eb7c tr\u01b0ng, v\u1ecb nh\u1ea1t.<\/li>\n
    • N\u00f3ng ch\u1ea3y kho\u1ea3ng 52 \u00b0C; t\u1ef7 tr\u1ecdng 0,97 g\/cm\u00b3; \u0111i\u1ec3m ch\u1edbp ch\u00e1y > 100 \u00b0C.<\/li>\n
    • Tan trong cloroform, ethanol 95%, ether; tan trong d\u1ea7u b\u00e9o v\u00e0 d\u1ea7u kho\u00e1ng khi l\u00e0m \u1ea5m; th\u1ef1c t\u1ebf kh\u00f4ng tan trong n\u01b0\u1edbc nh\u01b0ng t\u1ea1o nh\u0169 t\u01b0\u01a1ng.<\/li>\n
    • BP: natri alkyl sulfat \u2265 8,7%; ch\u1ea5t kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a \u2265 86,0%; ch\u1ec9 s\u1ed1 iod \u2264 3,0; ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a \u2264 2,0; n\u01b0\u1edbc \u2264 4,0%; tro sulfat 2,5\u20134,0%.<\/li>\n
    • Nhi\u1ec1u s\u00e1p nh\u0169 h\u00f3a th\u01b0\u01a1ng m\u1ea1i d\u00f9ng natri alkyl sulfat kh\u00e1c v\u00e0 c\u00f3 th\u1ec3 kh\u00f4ng \u0111\u1ea1t ti\u00eau chu\u1ea9n d\u01b0\u1ee3c \u0111i\u1ec3n.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      D\u1ea1ng r\u1eafn \u1ed5n \u0111\u1ecbnh h\u00f3a h\u1ecdc. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • V\u1ec1 c\u01a1 b\u1ea3n l\u00e0 t\u01b0\u01a1ng k\u1ef5 c\u1ee7a natri alkyl sulfat: h\u1ee3p ch\u1ea5t cation (amoni b\u1eadc b\u1ed1n, acriflavin, ephedrin hydroclorid, thu\u1ed1c kh\u00e1ng histamin v\u00e0 h\u1ee3p ch\u1ea5t ch\u1ee9a nit\u01a1 kh\u00e1c), mu\u1ed1i kim lo\u1ea1i \u0111a h\u00f3a tr\u1ecb (nh\u00f4m, k\u1ebdm, thi\u1ebfc, ch\u00ec), thioglycolat.<\/li>\n
      • T\u01b0\u01a1ng h\u1ee3p v\u1edbi h\u1ea7u h\u1ebft acid \u1edf pH tr\u00ean 2,5, v\u1edbi ki\u1ec1m v\u00e0 n\u01b0\u1edbc c\u1ee9ng.<\/li>\n
      • Kh\u00f4ng \u0111un s\u00e1p trong n\u1ed3i s\u1eaft; d\u00f9ng n\u1ed3i th\u00e9p kh\u00f4ng g\u1ec9.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        \u0110un ch\u1ea3y alcol cetostearylic t\u1edbi kho\u1ea3ng 95 \u00b0C, th\u00eam natri lauryl sulfat (ho\u1eb7c ch\u1ea5t di\u1ec7n ho\u1ea1t anion ph\u00f9 h\u1ee3p) v\u00e0 n\u01b0\u1edbc tinh khi\u1ebft; n\u00e2ng l\u00ean 115 \u00b0C v\u00e0 gi\u1eef nhi\u1ec7t \u0111\u1ed9, khu\u1ea5y m\u1ea1nh \u0111\u1ebfn khi h\u1ebft s\u1ee7i b\u1ecdt; sau \u0111\u00f3 l\u00e0m l\u1ea1nh nhanh.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • Ch\u1ee7 y\u1ebfu d\u00f9ng ngo\u00e0i; nh\u00ecn chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. Tuy nhi\u00ean natri lauryl sulfat trong th\u00e0nh ph\u1ea7n g\u00e2y k\u00edch \u1ee9ng da \u1edf n\u1ed3ng \u0111\u1ed9 cao; natri cetyl sulfat \u0111\u01b0\u1ee3c cho l\u00e0 \u00edt k\u00edch \u1ee9ng h\u01a1n.<\/li>\n
        • Emulsifying ointment BP (ch\u1ee9a s\u00e1p n\u00e0y) c\u00f3 t\u00e1c d\u1ee5ng ch\u1eafn n\u1eafng \u0111\u00e1ng k\u1ec3 tr\u00ean da b\u00ecnh th\u01b0\u1eddng \u2013 kh\u00f4ng n\u00ean b\u00f4i tr\u01b0\u1edbc c\u00e1c th\u1ee7 thu\u1eadt chi\u1ebfu tia UV.<\/li>\n
        • D\u00f9ng k\u00ednh b\u1ea3o h\u1ed9 khi thao t\u00e1c.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • C\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
          • C\u00f3 chuy\u00ean lu\u1eadn trong BP.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan:<\/strong> alcol cetostearylic, natri lauryl sulfat, s\u00e1p nh\u0169 h\u00f3a kh\u00f4ng ion.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Wax, Anionic Emulsifying<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            S\u00e1p nh\u0169 h\u00f3a anion (emulsifying wax BP) \u2013 ch\u1ea5t nh\u0169 h\u00f3a cho kem D\/N S\u00e1p nh\u0169 h\u00f3a anion (emulsifying wax BP) l\u00e0 h\u1ed7n h\u1ee3p alcol cetostearylic v\u1edbi natri lauryl sulfat (ho\u1eb7c mu\u1ed1i natri c\u1ee7a alcol b\u00e9o b\u1eadc m\u1ed9t sulfat h\u00f3a t\u01b0\u01a1ng t\u1ef1) v\u00e0 m\u1ed9t \u00edt n\u01b0\u1edbc tinh khi\u1ebft. \u0110\u00e2y l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a v\u00e0 l\u00e0m […]<\/p>","protected":false},"author":1,"featured_media":2705,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2706","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sap-nhu-hoa-anion-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"S\u00e1p nh\u0169 h\u00f3a anion (emulsifying wax BP) \u2013 ch\u1ea5t nh\u0169 h\u00f3a cho kem D\/N S\u00e1p nh\u0169 h\u00f3a anion (emulsifying wax BP) l\u00e0 h\u1ed7n h\u1ee3p alcol cetostearylic v\u1edbi natri lauryl sulfat (ho\u1eb7c mu\u1ed1i natri c\u1ee7a alcol b\u00e9o b\u1eadc m\u1ed9t sulfat h\u00f3a t\u01b0\u01a1ng t\u1ef1) v\u00e0 m\u1ed9t \u00edt n\u01b0\u1edbc tinh khi\u1ebft. \u0110\u00e2y l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a v\u00e0 l\u00e0m…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2706","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2706"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2706\/revisions"}],"predecessor-version":[{"id":3369,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2706\/revisions\/3369"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2705"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2706"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2706"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2706"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}