{"id":2698,"date":"2026-09-27T21:10:44","date_gmt":"2026-09-27T14:10:44","guid":{"rendered":"https:\/\/cpc1.vn\/dau-thuc-vat-hydro-hoa\/"},"modified":"2026-09-29T11:58:44","modified_gmt":"2026-09-29T04:58:44","slug":"dau-thuc-vat-hydro-hoa","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/dau-thuc-vat-hydro-hoa\/","title":{"rendered":"D\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i"},"content":{"rendered":"

D\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h1>\n

D\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a<\/strong> l\u00e0 h\u1ed7n h\u1ee3p triglycerid c\u1ee7a acid b\u00e9o (ch\u1ee7 y\u1ebfu m\u1ea1ch C16 v\u00e0 C18) thu \u0111\u01b0\u1ee3c khi hydro h\u00f3a d\u1ea7u th\u1ef1c v\u1eadt tinh ch\u1ebf nh\u01b0 d\u1ea7u b\u00f4ng, d\u1ea7u c\u1ecd, d\u1ea7u \u0111\u1eadu n\u00e0nh. Lo\u1ea1i I (hydro h\u00f3a ho\u00e0n to\u00e0n, r\u1eafn) \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c tr\u01a1n<\/strong> cho vi\u00ean n\u00e9n, vi\u00ean nang, t\u00e1 d\u01b0\u1ee3c d\u00ednh ph\u1ee5<\/strong> v\u00e0 c\u1ed1t th\u00e2n d\u1ea7u<\/strong> trong d\u1ea1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nD\u1ea7u b\u00f4ng hydro h\u00f3a (Akofine, Lubritab, Sterotex); d\u1ea7u c\u1ecd hydro h\u00f3a (Softisan 154); d\u1ea7u \u0111\u1eadu n\u00e0nh hydro h\u00f3a (Lipovol HS-K, Sterotex HM)<\/td>\n<\/tr>\n
T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nBP, USP-NF: Hydrogenated vegetable oil; JP: Hydrogenated oil<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n68334-00-9 (d\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a); 8016-70-4 (d\u1ea7u \u0111\u1eadu n\u00e0nh hydro h\u00f3a)<\/td>\n<\/tr>\n
C\u1ea5u t\u1ea1o<\/td>\nTriglycerid R\u00b9COOCH2<\/sub>\u2013CH(OOCR\u00b2)\u2013CH2<\/sub>OOCR\u00b3, v\u1edbi R ch\u1ee7 y\u1ebfu l\u00e0 m\u1ea1ch C15 v\u00e0 C17 (g\u1ed1c acid palmitic, stearic)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Lo\u1ea1i I v\u00e0 lo\u1ea1i II<\/h2>\n

USP-NF chia l\u00e0m hai lo\u1ea1i theo t\u00ednh ch\u1ea5t v\u1eadt l\u00fd:<\/p>\n\n\n\n\n\n\n\n\n
Ch\u1ec9 ti\u00eau<\/th>\nLo\u1ea1i I<\/th>\nLo\u1ea1i II<\/th>\n<\/tr>\n<\/thead>\n
M\u1ee9c hydro h\u00f3a<\/td>\nHo\u00e0n to\u00e0n<\/td>\nM\u1ed9t ph\u1ea7n<\/td>\n<\/tr>\n
Kho\u1ea3ng n\u00f3ng ch\u1ea3y<\/td>\n57\u201385 \u00b0C<\/td>\n20\u201350 \u00b0C<\/td>\n<\/tr>\n
Ch\u1ec9 s\u1ed1 iod<\/td>\n0\u20135<\/td>\n55\u201380<\/td>\n<\/tr>\n
\u1ee8ng d\u1ee5ng ch\u00ednh<\/td>\nT\u00e1 d\u01b0\u1ee3c tr\u01a1n, d\u00ednh, c\u1ed1t<\/td>\nM\u1ef9 ph\u1ea9m, n\u1ec1n thu\u1ed1c \u0111\u1ea1n; th\u01b0\u1eddng s\u1ea3n xu\u1ea5t theo y\u00eau c\u1ea7u kh\u00e1ch h\u00e0ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • T\u00e1 d\u01b0\u1ee3c tr\u01a1n<\/strong> cho vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang: 1\u20136% kl\/kl, th\u01b0\u1eddng ph\u1ed1i h\u1ee3p talc. C\u00f3 th\u1ec3 d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh ph\u1ee5.<\/li>\n
  • C\u1ed1t th\u00e2n d\u1ea7u<\/strong> trong d\u1ea1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i; ch\u1ea5t h\u1ed7 tr\u1ee3 bao trong d\u1ea1ng ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng.<\/li>\n
  • \u0110i\u1ec1u ch\u1ec9nh \u0111\u1ed9 nh\u1edbt cho ch\u1ebf ph\u1ea9m l\u1ecfng v\u00e0 b\u00e1n r\u1eafn n\u1ec1n d\u1ea7u; trong thu\u1ed1c \u0111\u1ea1n gi\u00fap gi\u1ea3m l\u1eafng c\u00e1c th\u00e0nh ph\u1ea7n ph\u00e2n t\u00e1n v\u00e0 c\u1ea3i thi\u1ec7n qu\u00e1 tr\u00ecnh \u0111\u00f4ng r\u1eafn; l\u00e0m vi\u00ean nang c\u1ee9ng \u0111\u00f3ng ch\u1ea5t l\u1ecfng ho\u1eb7c b\u00e1n r\u1eafn.<\/li>\n
  • Lo\u1ea1i hydro h\u00f3a ho\u00e0n to\u00e0n thay s\u00e1p c\u1ee9ng trong m\u1ef9 ph\u1ea9m v\u00e0 ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Lo\u1ea1i I \u1edf d\u1ea1ng b\u1ed9t m\u1ecbn, v\u1ea3y ho\u1eb7c h\u1ea1t; m\u00e0u tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0, d\u1ea1ng b\u1ed9t tr\u00f4ng tr\u1eafng h\u01a1n d\u1ea1ng th\u00f4; m\u00e0u ph\u1ee5 thu\u1ed9c quy tr\u00ecnh v\u00e0 d\u1ea1ng s\u1ea3n ph\u1ea9m.<\/li>\n
    • V\u00ed d\u1ee5 Lubritab: n\u00f3ng ch\u1ea3y 61\u201366 \u00b0C; t\u1ef7 tr\u1ecdng sau g\u00f5 0,57 g\/cm\u00b3; c\u1ee1 h\u1ea1t trung b\u00ecnh kho\u1ea3ng 104 \u00b5m (85% d\u01b0\u1edbi 177 \u00b5m).<\/li>\n
    • Tan trong cloroform, ether d\u1ea7u h\u1ecfa v\u00e0 propan-2-ol n\u00f3ng; th\u1ef1c t\u1ebf kh\u00f4ng tan trong n\u01b0\u1edbc.<\/li>\n
    • D\u01b0\u1ee3c \u0111i\u1ec3n (BP, USP-NF lo\u1ea1i I): ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a 175\u2013205 (BP) \/ 175\u2013200 (USP-NF); ch\u1ec9 s\u1ed1 acid \u2264 4,0; ch\u1ea5t kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a \u2264 0,8%; m\u1ea5t kh\u1ed1i l\u01b0\u1ee3ng khi l\u00e0m kh\u00f4 \u2264 0,1%; kim lo\u1ea1i n\u1eb7ng \u2264 10 ppm. JP ki\u1ec3m th\u00eam nickel (x\u00fac t\u00e1c hydro h\u00f3a).<\/li>\n
    • S\u1ea3n ph\u1ea9m c\u1ee7a c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t kh\u00e1c nhau c\u00f3 th\u1ec3 kh\u00e1c nhau do ngu\u1ed3n d\u1ea7u v\u00e0 m\u1ee9c hydro h\u00f3a.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Lo\u1ea1i I \u1ed5n \u0111\u1ecbnh, th\u01b0\u1eddng c\u00f3 h\u1ea1n d\u00f9ng 2 n\u0103m. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Hydro h\u00f3a d\u1ea7u th\u1ef1c v\u1eadt tinh ch\u1ebf v\u1edbi x\u00fac t\u00e1c. M\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m l\u00e0m t\u1eeb h\u1ed7n h\u1ee3p d\u1ea7u hydro h\u00f3a, v\u00ed d\u1ee5 d\u1ea7u \u0111\u1eadu n\u00e0nh hydro h\u00f3a ph\u1ed1i d\u1ea7u th\u1ea7u d\u1ea7u hydro h\u00f3a (Sterotex K).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
        \n
      • Lo\u1ea1i I d\u00f9ng trong th\u1ef1c ph\u1ea9m v\u00e0 thu\u1ed1c u\u1ed1ng; nh\u00ecn chung \u0111\u01b0\u1ee3c xem l\u00e0 t\u00e1 d\u01b0\u1ee3c kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng.<\/li>\n
      • (Ngo\u00e0i s\u00e1ch) D\u1ea7u hydro h\u00f3a ho\u00e0n to\u00e0n g\u1ea7n nh\u01b0 kh\u00f4ng ch\u1ee9a acid b\u00e9o d\u1ea1ng trans; ng\u01b0\u1ee3c l\u1ea1i d\u1ea7u hydro h\u00f3a m\u1ed9t ph\u1ea7n (lo\u1ea1i II) c\u00f3 th\u1ec3 ch\u1ee9a acid b\u00e9o trans \u2013 \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ecb h\u1ea1n ch\u1ebf trong th\u1ef1c ph\u1ea9m \u1edf nhi\u1ec1u n\u01b0\u1edbc, n\u00ean ki\u1ec3m tra quy \u0111\u1ecbnh khi d\u00f9ng.<\/li>\n
      • V\u1edbi lo\u1ea1i b\u1ed9t m\u1ecbn: d\u00f9ng g\u0103ng tay, k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 kh\u1ea9u trang ch\u1ed1ng b\u1ee5i.<\/li>\n<\/ul>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS t\u1ea1i M\u1ef9.<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Guide (nang, vi\u00ean n\u00e9n u\u1ed1ng; thu\u1ed1c \u0111\u1ea1n tr\u1ef1c tr\u00e0ng, \u00e2m \u0111\u1ea1o; ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> d\u1ea7u th\u1ea7u d\u1ea7u hydro h\u00f3a, d\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a lo\u1ea1i II, triglycerid m\u1ea1ch trung b\u00ecnh, n\u1ec1n thu\u1ed1c \u0111\u1ea1n.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Vegetable Oil, Hydrogenated<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          D\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i D\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a l\u00e0 h\u1ed7n h\u1ee3p triglycerid c\u1ee7a acid b\u00e9o (ch\u1ee7 y\u1ebfu m\u1ea1ch C16 v\u00e0 C18) thu \u0111\u01b0\u1ee3c khi hydro h\u00f3a d\u1ea7u th\u1ef1c v\u1eadt tinh ch\u1ebf nh\u01b0 d\u1ea7u b\u00f4ng, d\u1ea7u c\u1ecd, d\u1ea7u \u0111\u1eadu n\u00e0nh. Lo\u1ea1i I (hydro h\u00f3a ho\u00e0n […]<\/p>\n","protected":false},"author":1,"featured_media":2697,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2698","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dau-thuc-vat-hydro-hoa-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"D\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i D\u1ea7u th\u1ef1c v\u1eadt hydro h\u00f3a l\u00e0 h\u1ed7n h\u1ee3p triglycerid c\u1ee7a acid b\u00e9o (ch\u1ee7 y\u1ebfu m\u1ea1ch C16 v\u00e0 C18) thu \u0111\u01b0\u1ee3c khi hydro h\u00f3a d\u1ea7u th\u1ef1c v\u1eadt tinh ch\u1ebf nh\u01b0 d\u1ea7u b\u00f4ng, d\u1ea7u c\u1ecd, d\u1ea7u \u0111\u1eadu n\u00e0nh. Lo\u1ea1i I (hydro h\u00f3a ho\u00e0n…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2698","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2698"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2698\/revisions"}],"predecessor-version":[{"id":3791,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2698\/revisions\/3791"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2697"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2698"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}