{"id":2694,"date":"2026-09-27T21:05:06","date_gmt":"2026-09-27T14:05:06","guid":{"rendered":"https:\/\/cpc1.vn\/triethanolamin-tea\/"},"modified":"2026-09-29T12:16:11","modified_gmt":"2026-09-29T05:16:11","slug":"triethanolamin-tea","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/triethanolamin-tea\/","title":{"rendered":"Triethanolamin (TEA, trolamin) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o x\u00e0 ph\u00f2ng nh\u0169 h\u00f3a"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Triethanolamin (TEA, trolamin) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o x\u00e0 ph\u00f2ng nh\u0169 h\u00f3a<\/h1>\n<p><strong>Triethanolamin<\/strong> (TEA, trolamin, 2,2\u2032,2\u2033-nitrilotriethanol) l\u00e0 amin b\u1eadc ba mang ba nh\u00f3m hydroxyl, c\u00f4ng th\u1ee9c C<sub>6<\/sub>H<sub>15<\/sub>NO<sub>3<\/sub>. \u0110\u00e2y l\u00e0 <strong>ch\u1ea5t ki\u1ec1m h\u00f3a<\/strong> v\u00e0, khi ph\u1ea3n \u1ee9ng v\u1edbi acid b\u00e9o, t\u1ea1o <strong>x\u00e0 ph\u00f2ng nh\u0169 h\u00f3a<\/strong> anion \u2013 d\u00f9ng r\u1ed9ng r\u00e3i trong kem, lotion v\u00e0 gel d\u00f9ng ngo\u00e0i.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>TEA, trolamine, triethylolamine, trihydroxytriethylamine, tris(hydroxyethyl)amine, Tealan<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>BP: Triethanolamine; Ph.Eur.: Trolaminum; USP-NF: Trolamine<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>102-71-6<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/td>\n<td>C<sub>6<\/sub>H<sub>15<\/sub>NO<sub>3<\/sub> \u2013 149,19<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t ki\u1ec1m h\u00f3a, ch\u1ea5t nh\u0169 h\u00f3a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li><strong>Nh\u0169 h\u00f3a b\u1eb1ng x\u00e0 ph\u00f2ng TEA:<\/strong> tr\u1ed9n \u0111\u1eb3ng mol v\u1edbi acid b\u00e9o (acid stearic, acid oleic) t\u1ea1o x\u00e0 ph\u00f2ng anion pH kho\u1ea3ng 8, cho nh\u0169 t\u01b0\u01a1ng d\u1ea7u trong n\u01b0\u1edbc h\u1ea1t m\u1ecbn, b\u1ec1n. Th\u01b0\u1eddng d\u00f9ng TEA 2\u20134% (tt\/tt) v\u00e0 acid b\u00e9o g\u1ea5p 2\u20135 l\u1ea7n l\u01b0\u1ee3ng \u0111\u00f3; v\u1edbi d\u1ea7u kho\u00e1ng c\u1ea7n kho\u1ea3ng 5% TEA v\u00e0 t\u0103ng acid b\u00e9o t\u01b0\u01a1ng \u1ee9ng.<\/li>\n<li>Ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111i\u1ec1u ch\u1ec9nh pH; t\u1ea1o mu\u1ed1i ho\u1ea1t ch\u1ea5t trong dung d\u1ecbch ti\u00eam v\u00e0 ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i; ch\u1ebf ph\u1ea9m ch\u1ed1ng n\u1eafng. (Ngo\u00e0i s\u00e1ch) R\u1ea5t ph\u1ed5 bi\u1ebfn \u0111\u1ec3 trung h\u00f2a carbomer t\u1ea1o gel.<\/li>\n<li>D\u00f9ng chung l\u00e0m \u0111\u1ec7m, dung m\u00f4i, ch\u1ea5t h\u00f3a d\u1ebbo polymer, ch\u1ea5t gi\u1eef \u1ea9m; trung gian s\u1ea3n xu\u1ea5t ch\u1ea5t di\u1ec7n ho\u1ea1t, s\u00e1p, ch\u1ea5t \u0111\u00e1nh b\u00f3ng, m\u1ef9 ph\u1ea9m, ph\u1ee5 gia xi m\u0103ng, d\u1ea7u c\u1eaft g\u1ecdt.<\/li>\n<\/ul>\n<p>L\u01b0u \u00fd: ch\u1ebf ph\u1ea9m ch\u1ee9a x\u00e0 ph\u00f2ng TEA d\u1ec5 <strong>s\u1eabm m\u00e0u khi b\u1ea3o qu\u1ea3n<\/strong> \u2013 h\u1ea1n ch\u1ebf b\u1eb1ng c\u00e1ch tr\u00e1nh \u00e1nh s\u00e1ng v\u00e0 tr\u00e1nh ti\u1ebfp x\u00fac kim lo\u1ea1i, ion kim lo\u1ea1i.<\/p>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Ch\u1ea5t l\u1ecfng s\u00e1nh, trong, kh\u00f4ng m\u00e0u \u0111\u1ebfn v\u00e0ng nh\u1ea1t, m\u00f9i amoniac nh\u1eb9. L\u00e0 h\u1ed7n h\u1ee3p base: ch\u1ee7 y\u1ebfu triethanolamin, k\u00e8m diethanolamin v\u00e0 l\u01b0\u1ee3ng nh\u1ecf monoethanolamin.<\/li>\n<li>Lo\u1ea1i th\u01b0\u01a1ng m\u1ea1i ti\u00eau chu\u1ea9n ch\u1ee9a kho\u1ea3ng 85% TEA; lo\u1ea1i cao c\u1ea5p 98\u201399%.<\/li>\n<li>pH \u2248 10,5 (dung d\u1ecbch 0,1 N); n\u00f3ng ch\u1ea3y 20\u201321 \u00b0C (\u0111\u00f4ng \u0111\u1eb7c 21,6 \u00b0C); s\u00f4i 335 \u00b0C; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 208 \u00b0C.<\/li>\n<li>R\u1ea5t h\u00fat \u1ea9m; \u0111\u1ed9 nh\u1edbt 590 mPa\u00b7s (30 \u00b0C); s\u1ee9c c\u0103ng b\u1ec1 m\u1eb7t 48,9 mN\/m (25 \u00b0C).<\/li>\n<li>Tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc, methanol, aceton, carbon tetraclorid; tan trong benzen (1 trong 24), ether (1 trong 63).<\/li>\n<li>D\u01b0\u1ee3c \u0111i\u1ec3n: \u0111\u1ecbnh l\u01b0\u1ee3ng 99,0\u2013103,0% (Ph.Eur.) ho\u1eb7c 99,0\u2013107,4% (USP-NF); n\u01b0\u1edbc \u2264 1,0% (Ph.Eur.) \/ \u2264 0,5% (USP-NF); t\u1ef7 tr\u1ecdng 1,120\u20131,128; chi\u1ebft su\u1ea5t 1,481\u20131,486 (USP-NF).<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>C\u00f3 th\u1ec3 h\u00f3a n\u00e2u khi ti\u1ebfp x\u00fac kh\u00f4ng kh\u00ed v\u00e0 \u00e1nh s\u00e1ng.<\/li>\n<li>Lo\u1ea1i 85% d\u1ec5 ph\u00e2n l\u1edbp d\u01b0\u1edbi 15 \u00b0C \u2013 l\u00e0m \u1ea5m v\u00e0 tr\u1ed9n \u0111\u1ec1u tr\u01b0\u1edbc khi d\u00f9ng.<\/li>\n<li>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<ul>\n<li>C\u00f3 ph\u1ea3n \u1ee9ng \u0111\u1eb7c tr\u01b0ng c\u1ee7a amin b\u1eadc ba v\u00e0 alcol: v\u1edbi acid v\u00f4 c\u01a1 t\u1ea1o mu\u1ed1i k\u1ebft tinh v\u00e0 ester; v\u1edbi acid b\u00e9o m\u1ea1ch d\u00e0i t\u1ea1o mu\u1ed1i tan trong n\u01b0\u1edbc c\u00f3 t\u00ednh ch\u1ea5t x\u00e0 ph\u00f2ng.<\/li>\n<li>T\u1ea1o ph\u1ee9c v\u1edbi \u0111\u1ed3ng; mu\u1ed1i kim lo\u1ea1i n\u1eb7ng g\u00e2y \u0111\u1ed5i m\u00e0u v\u00e0 t\u1ee7a.<\/li>\n<li>Ph\u1ea3n \u1ee9ng v\u1edbi t\u00e1c nh\u00e2n nh\u01b0 thionyl clorid thay nh\u00f3m hydroxyl b\u1eb1ng halogen, t\u1ea1o s\u1ea3n ph\u1ea9m r\u1ea5t \u0111\u1ed9c.<\/li>\n<li>(Ngo\u00e0i s\u00e1ch) Nh\u01b0 c\u00e1c amin kh\u00e1c, c\u00f3 th\u1ec3 t\u1ea1o nitrosamin khi c\u00f3 t\u00e1c nh\u00e2n nitroso h\u00f3a \u2013 c\u1ea7n ki\u1ec3m so\u00e1t nitrit trong nguy\u00ean li\u1ec7u v\u00e0 c\u00f4ng th\u1ee9c.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Amoni ph\u00e2n ethylen oxid, thu h\u1ed7n h\u1ee3p monoethanolamin, diethanolamin v\u00e0 triethanolamin, sau \u0111\u00f3 t\u00e1ch ri\u00eang t\u1eebng ch\u1ea5t.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>Ch\u1ee7 y\u1ebfu d\u00f9ng l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a trong ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i. Nh\u00ecn chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c nh\u01b0ng c\u00f3 th\u1ec3 g\u00e2y qu\u00e1 m\u1eabn ho\u1eb7c k\u00edch \u1ee9ng da trong th\u00e0nh ph\u1ea9m. Li\u1ec1u u\u1ed1ng g\u00e2y ch\u1ebft \u1edf ng\u01b0\u1eddi \u01b0\u1edbc t\u00ednh 5\u201315 g\/kg.<\/li>\n<li>Do lo ng\u1ea1i h\u00ecnh th\u00e0nh nitrosamin trong d\u1ea1 d\u00e0y, c\u01a1 quan qu\u1ea3n l\u00fd Th\u1ee5y S\u0129 h\u1ea1n ch\u1ebf TEA ch\u1ec9 trong ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i.<\/li>\n<li>LD<sub>50<\/sub> (u\u1ed1ng): chu\u1ed9t c\u1ed1ng 8 g\/kg, chu\u1ed9t nh\u1eaft 7,4 g\/kg, chu\u1ed9t lang 5,3 g\/kg; (chu\u1ed9t nh\u1eaft, m\u00e0ng b\u1ee5ng) 1,45 g\/kg.<\/li>\n<li>K\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c; h\u00edt h\u01a1i c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i. D\u00f9ng qu\u1ea7n \u00e1o b\u1ea3o h\u1ed9, g\u0103ng, k\u00ednh v\u00e0 m\u1eb7t n\u1ea1; t\u1ed1t nh\u1ea5t thao t\u00e1c trong t\u1ee7 h\u00fat. Khi \u0111un t\u1ea1o kh\u00f3i nit\u01a1 oxid r\u1ea5t \u0111\u1ed9c; ch\u1ea5t d\u1ec5 ch\u00e1y.<\/li>\n<li>TEA \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb l\u00e0m ch\u1ea5t \u1ed5n \u0111\u1ecbnh trong tr\u00f9ng h\u1ee3p latex v\u00ec t\u00e1c d\u1ee5ng g\u00e2y \u0111\u1ed9t bi\u1ebfn y\u1ebfu trong th\u1eed nghi\u1ec7m Ames.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (ch\u1ebf ph\u1ea9m tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> diethanolamin, monoethanolamin.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Triethanolamine<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Triethanolamin (TEA, trolamin) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o x\u00e0 ph\u00f2ng nh\u0169 h\u00f3a Triethanolamin (TEA, trolamin, 2,2\u2032,2\u2033-nitrilotriethanol) l\u00e0 amin b\u1eadc ba mang ba nh\u00f3m hydroxyl, c\u00f4ng th\u1ee9c C6H15NO3. \u0110\u00e2y l\u00e0 ch\u1ea5t ki\u1ec1m h\u00f3a v\u00e0, khi ph\u1ea3n \u1ee9ng v\u1edbi acid b\u00e9o, t\u1ea1o x\u00e0 ph\u00f2ng nh\u0169 h\u00f3a anion \u2013 d\u00f9ng r\u1ed9ng r\u00e3i trong kem, lotion v\u00e0 gel d\u00f9ng [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2693,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2694","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/triethanolamin-tea-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Triethanolamin (TEA, trolamin) \u2013 ch\u1ea5t ki\u1ec1m h\u00f3a, t\u1ea1o x\u00e0 ph\u00f2ng nh\u0169 h\u00f3a Triethanolamin (TEA, trolamin, 2,2\u2032,2\u2033-nitrilotriethanol) l\u00e0 amin b\u1eadc ba mang ba nh\u00f3m hydroxyl, c\u00f4ng th\u1ee9c C6H15NO3. \u0110\u00e2y l\u00e0 ch\u1ea5t ki\u1ec1m h\u00f3a v\u00e0, khi ph\u1ea3n \u1ee9ng v\u1edbi acid b\u00e9o, t\u1ea1o x\u00e0 ph\u00f2ng nh\u0169 h\u00f3a anion \u2013 d\u00f9ng r\u1ed9ng r\u00e3i trong kem, lotion v\u00e0 gel d\u00f9ng&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2694"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2694\/revisions"}],"predecessor-version":[{"id":3977,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2694\/revisions\/3977"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2693"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}