{"id":2692,"date":"2026-09-27T21:04:58","date_gmt":"2026-09-27T14:04:58","guid":{"rendered":"https:\/\/cpc1.vn\/tributyl-citrat-tbc\/"},"modified":"2026-09-29T12:15:55","modified_gmt":"2026-09-29T05:15:55","slug":"tributyl-citrat-tbc","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/tributyl-citrat-tbc\/","title":{"rendered":"Tributyl citrat (TBC) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo s\u01a1 n\u01b0\u1edbc cho m\u00e0ng bao"},"content":{"rendered":"

Tributyl citrat (TBC) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo s\u01a1 n\u01b0\u1edbc cho m\u00e0ng bao<\/h1>\n

Tributyl citrat<\/strong> (TBC, tri-n-butyl citrat) l\u00e0 triester c\u1ee7a acid citric v\u1edbi n-butanol, c\u00f4ng th\u1ee9c C18<\/sub>H32<\/sub>O7<\/sub>. \u0110\u00e2y l\u00e0 ch\u1ea5t h\u00f3a d\u1ebbo<\/strong> cho polymer trong m\u00e0ng bao d\u01b0\u1ee3c ph\u1ea9m, thu\u1ed9c nh\u00f3m ester citrat th\u01b0\u1eddng \u0111\u01b0\u1ee3c xem l\u00e0 l\u1ef1a ch\u1ecdn thay th\u1ebf c\u00e1c phthalat.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nTBC, tri-n-butyl citrate, citric acid tributyl ester, tributyl 2-hydroxy-1,2,3-propanetricarboxylate; t\u00ean th\u01b0\u01a1ng m\u1ea1i: Citroflex 4<\/td>\n<\/tr>\n
T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nUSP-NF: Tributyl citrate<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n77-94-1<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/td>\nC18<\/sub>H32<\/sub>O7<\/sub> \u2013 360,5<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t h\u00f3a d\u1ebbo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n

H\u00f3a d\u1ebbo polymer trong m\u00e0ng bao vi\u00ean n\u00e9n, nang, pellet v\u00e0 c\u1ed1m cho c\u00e1c m\u1ee5c \u0111\u00edch: che v\u1ecb, gi\u1ea3i ph\u00f3ng ngay, gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i v\u00e0 bao tan trong ru\u1ed9t \u2013 \u0111i\u1ec3n h\u00ecnh v\u1edbi c\u00e1c polymer acrylic (polymethacrylat) h\u1ec7 n\u01b0\u1edbc v\u00e0 h\u1ec7 dung m\u00f4i. Do g\u1ea7n nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc, TBC l\u00e0 ch\u1ea5t h\u00f3a d\u1ebbo s\u01a1 n\u01b0\u1edbc<\/strong>: \u00edt b\u1ecb r\u1eeda tr\u00f4i kh\u1ecfi m\u00e0ng trong m\u00f4i tr\u01b0\u1eddng ti\u00eau h\u00f3a h\u01a1n c\u00e1c ch\u1ea5t h\u00f3a d\u1ebbo th\u00e2n n\u01b0\u1edbc nh\u01b0 triethyl citrat hay triacetin, nh\u01b0ng khi d\u00f9ng trong h\u1ec7 ph\u00e2n t\u00e1n n\u01b0\u1edbc c\u1ea7n nh\u0169 h\u00f3a\/khu\u1ea5y \u0111\u1ee7 l\u00e2u \u0111\u1ec3 polymer h\u1ea5p thu.<\/p>\n

M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
    \n
  • Ch\u1ea5t l\u1ecfng d\u1ea1ng d\u1ea7u, trong, kh\u00f4ng m\u00f9i, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00e0u.<\/li>\n
  • \u0110\u1ed9 nh\u1edbt 32 mPa\u00b7s (25 \u00b0C); \u0111i\u1ec3m \u0111\u00f4ng ch\u1ea3y \u221262 \u00b0C; s\u00f4i 322 \u00b0C (k\u00e8m ph\u00e2n h\u1ee7y); \u0111i\u1ec3m ch\u1edbp ch\u00e1y 185 \u00b0C; ch\u1ec9 s\u1ed1 acid 0,02.<\/li>\n
  • Tr\u1ed9n l\u1eabn v\u1edbi aceton, ethanol v\u00e0 d\u1ea7u th\u1ef1c v\u1eadt; th\u1ef1c t\u1ebf kh\u00f4ng tan trong n\u01b0\u1edbc.<\/li>\n
  • USP-NF: \u0111\u1ecbnh l\u01b0\u1ee3ng \u2265 99,0% (khan); t\u1ef7 tr\u1ecdng 1,037\u20131,045; chi\u1ebft su\u1ea5t 1,443\u20131,445; n\u01b0\u1edbc \u2264 0,2%; kim lo\u1ea1i n\u1eb7ng \u2264 0,001%.<\/li>\n<\/ul>\n

    \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

    \u1ed4n \u0111\u1ecbnh khi b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 38 \u00b0C.<\/p>\n

    T\u01b0\u01a1ng k\u1ef5<\/h2>\n

    T\u01b0\u01a1ng k\u1ef5 v\u1edbi ki\u1ec1m m\u1ea1nh (th\u1ee7y ph\u00e2n ester) v\u00e0 ch\u1ea5t oxy h\u00f3a.<\/p>\n

    S\u1ea3n xu\u1ea5t<\/h2>\n

    Ester h\u00f3a acid citric v\u1edbi butanol.<\/p>\n

    An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
      \n
    • D\u00f9ng trong thu\u1ed1c u\u1ed1ng; nh\u00ecn chung \u0111\u01b0\u1ee3c xem l\u00e0 v\u1ec1 c\u01a1 b\u1ea3n kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; tuy nhi\u00ean u\u1ed1ng l\u01b0\u1ee3ng l\u1edbn c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i.<\/li>\n
    • LD50<\/sub> (m\u00e8o, u\u1ed1ng) > 50 mL\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng) > 30 mL\/kg; (chu\u1ed9t nh\u1eaft, m\u00e0ng b\u1ee5ng) 2,9 g\/kg.<\/li>\n
    • C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft; \u1edf nhi\u1ec7t \u0111\u1ed9 cao c\u00f3 th\u1ec3 k\u00edch \u1ee9ng h\u00f4 h\u1ea5p. D\u00f9ng g\u0103ng tay v\u00e0 k\u00ednh b\u1ea3o h\u1ed9 khi thao t\u00e1c th\u00f4ng th\u01b0\u1eddng; d\u00f9ng m\u1eb7t n\u1ea1 ph\u00f2ng \u0111\u1ed9c khi l\u00e0m vi\u1ec7c \u1edf nhi\u1ec7t \u0111\u1ed9 cao.<\/li>\n<\/ul>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c ph\u00e9p t\u1ea1i M\u1ef9 trong m\u00e0ng ti\u1ebfp x\u00fac gi\u00e1n ti\u1ebfp v\u1edbi th\u1ef1c ph\u1ea9m.<\/li>\n
      • C\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> acetyltributyl citrat, acetyltriethyl citrat, triethyl citrat.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Tributyl Citrate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Tributyl citrat (TBC) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo s\u01a1 n\u01b0\u1edbc cho m\u00e0ng bao Tributyl citrat (TBC, tri-n-butyl citrat) l\u00e0 triester c\u1ee7a acid citric v\u1edbi n-butanol, c\u00f4ng th\u1ee9c C18H32O7. \u0110\u00e2y l\u00e0 ch\u1ea5t h\u00f3a d\u1ebbo cho polymer trong m\u00e0ng bao d\u01b0\u1ee3c ph\u1ea9m, thu\u1ed9c nh\u00f3m ester citrat th\u01b0\u1eddng \u0111\u01b0\u1ee3c xem l\u00e0 l\u1ef1a ch\u1ecdn thay th\u1ebf c\u00e1c phthalat. Th\u00f4ng tin […]<\/p>\n","protected":false},"author":1,"featured_media":2691,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/tributyl-citrat-tbc-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Tributyl citrat (TBC) \u2013 ch\u1ea5t h\u00f3a d\u1ebbo s\u01a1 n\u01b0\u1edbc cho m\u00e0ng bao Tributyl citrat (TBC, tri-n-butyl citrat) l\u00e0 triester c\u1ee7a acid citric v\u1edbi n-butanol, c\u00f4ng th\u1ee9c C18H32O7. \u0110\u00e2y l\u00e0 ch\u1ea5t h\u00f3a d\u1ebbo cho polymer trong m\u00e0ng bao d\u01b0\u1ee3c ph\u1ea9m, thu\u1ed9c nh\u00f3m ester citrat th\u01b0\u1eddng \u0111\u01b0\u1ee3c xem l\u00e0 l\u1ef1a ch\u1ecdn thay th\u1ebf c\u00e1c phthalat. Th\u00f4ng tin…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2692","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2692"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2692\/revisions"}],"predecessor-version":[{"id":3974,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2692\/revisions\/3974"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2691"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2692"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2692"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}