{"id":2688,"date":"2026-09-27T21:04:41","date_gmt":"2026-09-27T14:04:41","guid":{"rendered":"https:\/\/cpc1.vn\/trehalose\/"},"modified":"2026-09-28T21:27:05","modified_gmt":"2026-09-28T14:27:05","slug":"trehalose","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/trehalose\/","title":{"rendered":"Trehalose \u2013 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed b\u1ea3o v\u1ec7 protein khi \u0111\u00f4ng kh\u00f4"},"content":{"rendered":"

Trehalose \u2013 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed b\u1ea3o v\u1ec7 protein khi \u0111\u00f4ng kh\u00f4<\/h1>\n

Trehalose<\/strong> (\u03b1,\u03b1-trehalose, mycose) l\u00e0 disaccharid g\u1ed3m hai ph\u00e2n t\u1eed glucose n\u1ed1i v\u1edbi nhau qua hai nh\u00f3m hydroxyl b\u00e1n acetal (li\u00ean k\u1ebft \u03b1-1,1), c\u00f4ng th\u1ee9c C12<\/sub>H22<\/sub>O11<\/sub>, th\u01b0\u01a1ng m\u1ea1i \u1edf d\u1ea1ng dihydrat. L\u00e0 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed<\/strong>, trehalose n\u1ed5i b\u1eadt v\u1edbi vai tr\u00f2 b\u1ea3o v\u1ec7 protein khi \u0111\u00f4ng kh\u00f4<\/strong>, \u0111\u1eb7c bi\u1ec7t trong thu\u1ed1c ti\u00eam sinh h\u1ecdc.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n\u03b1,\u03b1-Trehalose, mycose, natural trehalose, trehalose dihydrate, \u03b1-D-glucopyranosyl-\u03b1-D-glucopyranoside<\/td>\n<\/tr>\n
T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n \u1edf th\u1eddi \u0111i\u1ec3m s\u00e1ch xu\u1ea5t b\u1ea3n. (Ngo\u00e0i s\u00e1ch) Nay c\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. (trehalose dihydrat) v\u00e0 USP-NF<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n99-20-7 (khan); 6138-23-4 (dihydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/td>\nC12<\/sub>H22<\/sub>O11<\/sub> \u2013 342,31 (khan); C12<\/sub>H22<\/sub>O11<\/sub>\u00b72H2<\/sub>O \u2013 378,33 (dihydrat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4, ch\u1ea5t \u1ed5n \u0111\u1ecbnh, ch\u1ea5t t\u1ea1o ng\u1ecdt, ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb, ch\u1ea5t gi\u1eef \u1ea9m, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n, ch\u1ea5t l\u00e0m \u0111\u1eb7c, ch\u1ea5t h\u1ed7 tr\u1ee3 t\u1ea1o m\u00e0u<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • B\u1ea3o v\u1ec7 khi \u0111\u00f4ng kh\u00f4 (lyoprotectant)<\/strong> cho protein, \u0111\u1eb7c bi\u1ec7t trong thu\u1ed1c ti\u00eam; \u1ed5n \u0111\u1ecbnh kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng. (Ngo\u00e0i s\u00e1ch) Hi\u1ec7n l\u00e0 t\u00e1 d\u01b0\u1ee3c trong nhi\u1ec1u kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng \u0111\u00f4ng kh\u00f4 v\u00e0 d\u1ea1ng dung d\u1ecbch l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng.<\/li>\n
  • \u1ed4n \u0111\u1ecbnh liposome trong qu\u00e1 tr\u00ecnh \u0111\u00f4ng\u2013r\u00e3 \u0111\u00f4ng v\u00e0 \u0111\u00f4ng kh\u00f4; \u1ed5n \u0111\u1ecbnh t\u1ebf b\u00e0o m\u00e1u.<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c cho vi\u00ean th\u1eed x\u00e9t nghi\u1ec7m; m\u1ef9 ph\u1ea9m; ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i (v\u00ed d\u1ee5 vi c\u1ea7u trehalose\u2013hydroxyethylcellulose).<\/li>\n
  • Trong th\u1ef1c ph\u1ea9m: ch\u1ea5t t\u1ea1o ng\u1ecdt nh\u1eb9, gi\u1eef \u1ea9m, \u1ed5n \u0111\u1ecbnh c\u1ea5u tr\u00fac.<\/li>\n<\/ul>\n

    V\u00ec sao trehalose b\u1ea3o v\u1ec7 t\u1ed1t: nhi\u1ec7t \u0111\u1ed9 chuy\u1ec3n th\u1ee7y tinh c\u1ee7a pha v\u00f4 \u0111\u1ecbnh h\u00ecnh khan cao (kho\u1ea3ng 120 \u00b0C) gi\u00fap b\u00e1nh \u0111\u00f4ng kh\u00f4 gi\u1eef tr\u1ea1ng th\u00e1i th\u1ee7y tinh b\u1ec1n; l\u00e0 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed n\u00ean kh\u00f4ng g\u00e2y ph\u1ea3n \u1ee9ng Maillard (h\u00f3a n\u00e2u) v\u1edbi acid amin, protein; b\u1ec1n h\u01a1n c\u00e1c disaccharid kh\u00e1c \u1edf pH th\u1ea5p.<\/p>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Tinh th\u1ec3 tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, h\u1ea7u nh\u01b0 kh\u00f4ng m\u00f9i, v\u1ecb ng\u1ecdt b\u1eb1ng kho\u1ea3ng 45% sucrose.<\/li>\n
    • pH dung d\u1ecbch 30% kl\/tt: 4,5\u20136,5; n\u0103ng su\u1ea5t quay c\u1ef1c ri\u00eang kho\u1ea3ng +179,7\u00b0 (dung d\u1ecbch 5%).<\/li>\n
    • Dihydrat: \u201cn\u00f3ng ch\u1ea3y\u201d kho\u1ea3ng 97 \u00b0C (b\u1ea3n ch\u1ea5t qu\u00e1 tr\u00ecnh n\u00e0y \u2013 g\u1ed3m c\u1ea3 chuy\u1ec3n th\u00e0nh d\u1ea1ng khan \u2013 c\u00f2n tranh lu\u1eadn); \u0111\u1ed9 \u1ea9m kho\u1ea3ng 9,5%. D\u1ea1ng khan k\u1ebft tinh n\u00f3ng ch\u1ea3y kho\u1ea3ng 203 \u00b0C (c\u00f3 t\u00e0i li\u1ec7u ghi 215 \u00b0C).<\/li>\n
    • Tan trong n\u01b0\u1edbc; r\u1ea5t \u00edt tan trong ethanol 95%; th\u1ef1c t\u1ebf kh\u00f4ng tan trong ether.<\/li>\n
    • \u03b1,\u03b1-trehalose l\u00e0 \u0111\u1ed3ng ph\u00e2n t\u1ef1 nhi\u00ean duy nh\u1ea5t; neotrehalose (\u03b1,\u03b2) v\u00e0 isotrehalose (\u03b2,\u03b2) \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p v\u00e0 c\u00f3 b\u00e1n th\u01b0\u01a1ng m\u1ea1i.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • T\u01b0\u01a1ng \u0111\u1ed1i \u1ed5n \u0111\u1ecbnh: \u1edf 60 \u00b0C trong 5 gi\u1edd m\u1ea5t kh\u00f4ng qu\u00e1 1,5% n\u01b0\u1edbc (n\u01b0\u1edbc k\u1ebft tinh c\u1ee7a dihydrat v\u1eabn gi\u1eef l\u1ea1i).<\/li>\n
      • B\u1ed9t \u0111\u1ec3 h\u1edf c\u00f3 th\u1ec3 h\u00f3a l\u1ecfng \u1edf \u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i cao (\u2265 90%).<\/li>\n
      • B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh, nh\u1ea5t l\u00e0 khi c\u00f3 nhi\u1ec7t.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        S\u1ea3n xu\u1ea5t t\u1eeb tinh b\u1ed9t \u0111\u00e3 h\u00f3a l\u1ecfng qua quy tr\u00ecnh enzym nhi\u1ec1u b\u01b0\u1edbc; s\u1ea3n ph\u1ea9m th\u01b0\u01a1ng m\u1ea1i \u1edf d\u1ea1ng dihydrat.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • D\u00f9ng trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m, thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam; nh\u00ecn chung \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c.<\/li>\n
        • Trong ru\u1ed9t, trehalose b\u1ecb enzym trehalase th\u1ee7y ph\u00e2n nhanh th\u00e0nh glucose. M\u1ed9t s\u1ed1 \u00edt ng\u01b0\u1eddi thi\u1ebfu trehalase (b\u1ea9m sinh ho\u1eb7c m\u1eafc ph\u1ea3i) c\u00f3 th\u1ec3 kh\u00f3 ch\u1ecbu \u0111\u01b0\u1eddng ru\u1ed9t khi \u0103n qu\u00e1 nhi\u1ec1u do trehalose ch\u01b0a ti\u00eau h\u00f3a g\u00e2y t\u00e1c d\u1ee5ng th\u1ea9m th\u1ea5u; l\u01b0\u1ee3ng nh\u1ecf v\u1eabn dung n\u1ea1p t\u1ed1t.<\/li>\n
        • Kh\u1ea3 n\u0103ng g\u00e2y s\u00e2u r\u0103ng th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi sucrose.<\/li>\n
        • LD50<\/sub> (u\u1ed1ng) > 5 g\/kg \u1edf ch\u00f3, chu\u1ed9t nh\u1eaft, chu\u1ed9t c\u1ed1ng; (t\u0129nh m\u1ea1ch) > 1 g\/kg.<\/li>\n
        • Thao t\u00e1c theo bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba th\u00f4ng th\u01b0\u1eddng; d\u00f9ng k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 g\u0103ng tay.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • GRAS t\u1ea1i M\u1ef9; \u0111\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong m\u1ed9t s\u1ed1 \u1ee9ng d\u1ee5ng th\u1ef1c ph\u1ea9m t\u1ea1i Anh.<\/li>\n
          • Theo s\u00e1ch: c\u00f3 trong c\u00f4ng th\u1ee9c thu\u1ed1c nghi\u00ean c\u1ee9u d\u1ea1ng ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam. (Ngo\u00e0i s\u00e1ch) Nay \u0111\u00e3 c\u00f3 trong nhi\u1ec1u thu\u1ed1c sinh h\u1ecdc \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan:<\/strong> isotrehalose (\u03b2,\u03b2-trehalose, CAS 499-23-0), neotrehalose (\u03b1,\u03b2-trehalose, CAS 585-91-1); xem th\u00eam sucrose, maltose, mannitol trong vai tr\u00f2 t\u00e1 d\u01b0\u1ee3c \u0111\u00f4ng kh\u00f4.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Trehalose<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Trehalose \u2013 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed b\u1ea3o v\u1ec7 protein khi \u0111\u00f4ng kh\u00f4 Trehalose (\u03b1,\u03b1-trehalose, mycose) l\u00e0 disaccharid g\u1ed3m hai ph\u00e2n t\u1eed glucose n\u1ed1i v\u1edbi nhau qua hai nh\u00f3m hydroxyl b\u00e1n acetal (li\u00ean k\u1ebft \u03b1-1,1), c\u00f4ng th\u1ee9c C12H22O11, th\u01b0\u01a1ng m\u1ea1i \u1edf d\u1ea1ng dihydrat. L\u00e0 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed, trehalose n\u1ed5i b\u1eadt v\u1edbi vai tr\u00f2 b\u1ea3o v\u1ec7 protein khi […]<\/p>\n","protected":false},"author":1,"featured_media":2687,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/trehalose-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Trehalose \u2013 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed b\u1ea3o v\u1ec7 protein khi \u0111\u00f4ng kh\u00f4 Trehalose (\u03b1,\u03b1-trehalose, mycose) l\u00e0 disaccharid g\u1ed3m hai ph\u00e2n t\u1eed glucose n\u1ed1i v\u1edbi nhau qua hai nh\u00f3m hydroxyl b\u00e1n acetal (li\u00ean k\u1ebft \u03b1-1,1), c\u00f4ng th\u1ee9c C12H22O11, th\u01b0\u01a1ng m\u1ea1i \u1edf d\u1ea1ng dihydrat. L\u00e0 \u0111\u01b0\u1eddng kh\u00f4ng kh\u1eed, trehalose n\u1ed5i b\u1eadt v\u1edbi vai tr\u00f2 b\u1ea3o v\u1ec7 protein khi…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2688"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2688\/revisions"}],"predecessor-version":[{"id":3391,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2688\/revisions\/3391"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2687"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}