{"id":2682,"date":"2026-09-27T20:59:29","date_gmt":"2026-09-27T13:59:29","guid":{"rendered":"https:\/\/cpc1.vn\/thymol\/"},"modified":"2026-09-27T20:59:29","modified_gmt":"2026-09-27T13:59:29","slug":"thymol","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/thymol\/","title":{"rendered":"Thymol \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, kh\u1eed m\u00f9i, t\u0103ng th\u1ea5m qua da"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Thymol \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, kh\u1eed m\u00f9i, t\u0103ng th\u1ea5m qua da<\/h1>\n<p><strong>Thymol<\/strong> (2-isopropyl-5-methylphenol, isopropyl-m-cresol) l\u00e0 m\u1ed9t phenol monoterpen, c\u00f4ng th\u1ee9c C<sub>10<\/sub>H<sub>14<\/sub>O, l\u00e0 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a tinh d\u1ea7u h\u00fang t\u00e2y (<em>Thymus vulgaris<\/em>). Trong b\u00e0o ch\u1ebf, thymol d\u00f9ng l\u00e0m <strong>ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, kh\u1eed m\u00f9i<\/strong> trong s\u1ea3n ph\u1ea9m r\u0103ng mi\u1ec7ng, <strong>ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong> v\u00e0 g\u1ea7n \u0111\u00e2y l\u00e0 <strong>ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/strong>.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Isopropyl-m-cresol, isopropyl metacresol, 3-p-cymenol, p-cymen-3-ol, 3-hydroxy-p-cymene, thyme camphor, m-thymol, timol<\/td>\n<\/tr>\n<tr>\n<td>T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<td>BP: Thymol; Ph.Eur.: Thymolum; USP-NF: Thymol<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>89-83-8<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed<\/td>\n<td>C<sub>10<\/sub>H<sub>14<\/sub>O \u2013 150,24<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a, ch\u1ea5t s\u00e1t khu\u1ea9n, ch\u1ea5t t\u1ea1o m\u00e1t, ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li><strong>Kh\u1eed m\u00f9i, t\u1ea1o h\u01b0\u01a1ng<\/strong> trong n\u01b0\u1edbc s\u00fac mi\u1ec7ng, thu\u1ed1c s\u00fac h\u1ecdng, kem \u0111\u00e1nh r\u0103ng \u2013 \u1edf n\u1ed3ng \u0111\u1ed9 n\u00e0y thymol ch\u1ee7 y\u1ebfu g\u00f3p ph\u1ea7n m\u00f9i v\u1ecb, kh\u00f4ng mang t\u00e1c d\u1ee5ng s\u00e1t khu\u1ea9n.<\/li>\n<li><strong>Antioxidant protection<\/strong> th\u1ef1c th\u1ee5: 0,01% \u0111\u1ec3 \u1ed5n \u0111\u1ecbnh halothan, tricloroethylen, tetracloroethylen.<\/li>\n<li><strong>T\u0103ng th\u1ea5m qua da:<\/strong> nghi\u00ean c\u1ee9u in vitro cho th\u1ea5y thymol t\u0103ng h\u1ea5p thu qua da c\u1ee7a 5-fluorouracil, piroxicam, propranolol, naproxen, tamoxifen. Tr\u1ed9n v\u1edbi lidocain l\u00e0m h\u1ea1 r\u00f5 nhi\u1ec7t \u0111\u1ed9 n\u00f3ng ch\u1ea3y c\u1ee7a lidocain (t\u1ea1o h\u1ed7n h\u1ee3p eutecti).<\/li>\n<li>L\u00e0 phenol c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n, kh\u00e1ng n\u1ea5m (m\u1ea1nh h\u01a1n phenol, h\u1ec7 s\u1ed1 phenol kho\u1ea3ng 50; hi\u1ec7p \u0111\u1ed3ng v\u1edbi eugenol, carvacrol) nh\u01b0ng <strong>kh\u00f4ng ph\u00f9 h\u1ee3p l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n<\/strong> do r\u1ea5t \u00edt tan trong n\u01b0\u1edbc, k\u00edch \u1ee9ng m\u00f4 v\u00e0 b\u1ecb protein l\u00e0m m\u1ea5t ho\u1ea1t t\u00ednh.<\/li>\n<li>D\u00f9ng trong th\u1ef1c ph\u1ea9m, n\u01b0\u1edbc hoa, m\u1ef9 ph\u1ea9m; trong nha khoa ph\u1ed1i h\u1ee3p phenol, long n\u00e3o ho\u1eb7c k\u1ebdm oxid. C\u00e1c c\u00f4ng d\u1ee5ng l\u00e0m thu\u1ed1c (h\u00edt, r\u1eafc b\u1ed9t, l\u0129nh v\u1ef1c k\u00fd sinh tr\u00f9ng) n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Tinh th\u1ec3 kh\u00f4ng m\u00e0u, th\u01b0\u1eddng to v\u00e0 trong m\u1edd, ho\u1eb7c b\u1ed9t k\u1ebft tinh tr\u1eafng; m\u00f9i th\u01a1m th\u1ea3o m\u1ed9c gi\u1ed1ng h\u00fang t\u00e2y; v\u1ecb cay n\u00f3ng, g\u1eaft.<\/li>\n<li>N\u00f3ng ch\u1ea3y 48\u201351 \u00b0C, nh\u01b0ng sau khi ch\u1ea3y l\u1ecfng c\u00f3 th\u1ec3 c\u00f2n l\u1ecfng \u1edf nhi\u1ec7t \u0111\u1ed9 th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 (ch\u1eadm \u0111\u00f4ng); s\u00f4i kho\u1ea3ng 233 \u00b0C. Khi ch\u1ea3y l\u1ecfng nh\u1eb9 h\u01a1n n\u01b0\u1edbc.<\/li>\n<li>pKa = 10,6 (20 \u00b0C); log P (octanol\/n\u01b0\u1edbc) = 3,3; chi\u1ebft su\u1ea5t kho\u1ea3ng 1,52.<\/li>\n<li>Dung d\u1ecbch 4% trong ethanol 50% trung t\u00ednh v\u1edbi qu\u1ef3.<\/li>\n<li>R\u1ea5t \u00edt tan trong n\u01b0\u1edbc (1 trong 1000); d\u1ec5 tan trong cloroform (1 trong 0,7\u20131), ethanol 95% (1 trong 1), ether (1 trong 1,5), acid acetic b\u0103ng, d\u1ea7u \u00f4 liu (1 trong 1,7\u20132); tan t\u1ef1 do trong tinh d\u1ea7u, d\u1ea7u b\u00e9o, ch\u1ea5t b\u00e9o; h\u01a1i tan trong glycerin. Tan trong dung d\u1ecbch ki\u1ec1m hydroxid lo\u00e3ng t\u1ea1o mu\u1ed1i d\u1ec5 tan h\u01a1n nh\u01b0ng dung d\u1ecbch s\u1eabm m\u00e0u khi \u0111\u1ec3 l\u00e2u.<\/li>\n<li>Bay h\u01a1i \u0111\u00e1ng k\u1ec3 \u1edf 100 \u00b0C, bay theo h\u01a1i n\u01b0\u1edbc; \u00e1p su\u1ea5t h\u01a1i 0,04 mmHg (20 \u00b0C).<\/li>\n<li>D\u01b0\u1ee3c \u0111i\u1ec3n: kho\u1ea3ng n\u00f3ng ch\u1ea3y 48\u201352 \u00b0C (Ph.Eur.) \/ 48\u201351 \u00b0C (USP-NF); c\u1eb7n sau bay h\u01a1i \u2264 0,05%; \u0111\u1ecbnh l\u01b0\u1ee3ng 99,0\u2013101,0% (USP-NF).<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>B\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi \u00e1nh s\u00e1ng. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, ch\u1ed1ng \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<ul>\n<li>T\u01b0\u01a1ng k\u1ef5 v\u1edbi iod, ki\u1ec1m v\u00e0 ch\u1ea5t oxy h\u00f3a.<\/li>\n<li>H\u00f3a l\u1ecfng ho\u1eb7c th\u00e0nh kh\u1ed1i m\u1ec1m (h\u1ed7n h\u1ee3p eutecti) khi nghi\u1ec1n chung v\u1edbi acetanilid, antipyrin, long n\u00e3o, long n\u00e3o brom h\u00f3a, cloral hydrat, menthol, phenol, quinin sulfat \u2013 c\u1ea7n l\u01b0u \u00fd khi b\u00e0o ch\u1ebf b\u1ed9t, vi\u00ean c\u00f3 c\u00e1c ch\u1ea5t n\u00e0y.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Thu t\u1eeb tinh d\u1ea7u h\u00fang t\u00e2y (<em>Thymus vulgaris<\/em> L., h\u1ecd Hoa m\u00f4i) b\u1eb1ng ch\u01b0ng c\u1ea5t ph\u00e2n \u0111o\u1ea1n, sau \u0111\u00f3 chi\u1ebft v\u00e0 k\u1ebft tinh l\u1ea1i; tinh d\u1ea7u h\u00fang t\u00e2y ch\u1ee9a kho\u1ea3ng 20\u201330% thymol. C\u0169ng t\u1ed5ng h\u1ee3p \u0111\u01b0\u1ee3c t\u1eeb p-cymen, menthon ho\u1eb7c piperiton, ho\u1eb7c cho m-cresol ph\u1ea3n \u1ee9ng v\u1edbi isopropyl clorid.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>D\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng khi h\u00edt ho\u1eb7c ti\u1ebfp x\u00fac da, m\u1eaft. U\u1ed1ng c\u00f3 th\u1ec3 g\u00e2y \u0111au b\u1ee5ng, n\u00f4n, \u0111\u00f4i khi k\u00edch th\u00edch r\u1ed3i \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng.<\/li>\n<li>\u0110\u00e3 ghi nh\u1eadn ng\u1eebng th\u1edf do sung huy\u1ebft v\u00e0 ph\u00f9 n\u1ec1 m\u0169i c\u1ea5p \u1edf tr\u1ebb 3 tu\u1ea7n tu\u1ed5i b\u1ecb nh\u1ecf nh\u1ea7m v\u00e0o m\u0169i m\u1ed9t ch\u1ebf ph\u1ea9m h\u00edt c\u00f3 thymol; tr\u1ebb h\u1ed3i ph\u1ee5c nh\u01b0ng khuy\u1ebfn c\u00e1o kh\u00f4ng d\u00f9ng thu\u1ed1c h\u00edt th\u00f4ng m\u0169i cho tr\u1ebb d\u01b0\u1edbi 5 tu\u1ed5i.<\/li>\n<li>LD<sub>50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 0,64 g\/kg; (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 0,98 g\/kg; (chu\u1ed9t lang, u\u1ed1ng): 0,88 g\/kg; (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 0,1 g\/kg.<\/li>\n<li>Tr\u00e1nh h\u00edt v\u00e0 ti\u1ebfp x\u00fac da, m\u1eaft; d\u00f9ng k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 g\u0103ng tay. Nhi\u1ec7t ph\u00e2n t\u1ea1o CO<sub>2<\/sub> v\u00e0 CO.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS t\u1ea1i M\u1ef9.<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (ch\u1ea5t l\u1ecfng \u0111\u1ec3 h\u00edt; b\u1ed9t pha dung d\u1ecbch u\u1ed1ng); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> menthol.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Thymol<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Thymol \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, kh\u1eed m\u00f9i, t\u0103ng th\u1ea5m qua da Thymol (2-isopropyl-5-methylphenol, isopropyl-m-cresol) l\u00e0 m\u1ed9t phenol monoterpen, c\u00f4ng th\u1ee9c C10H14O, l\u00e0 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a tinh d\u1ea7u h\u00fang t\u00e2y (Thymus vulgaris). Trong b\u00e0o ch\u1ebf, thymol d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, kh\u1eed m\u00f9i trong s\u1ea3n ph\u1ea9m r\u0103ng mi\u1ec7ng, ch\u1ea5t ch\u1ed1ng oxy h\u00f3a v\u00e0 g\u1ea7n \u0111\u00e2y [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2681,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2682","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thymol-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Thymol \u2013 ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, kh\u1eed m\u00f9i, t\u0103ng th\u1ea5m qua da Thymol (2-isopropyl-5-methylphenol, isopropyl-m-cresol) l\u00e0 m\u1ed9t phenol monoterpen, c\u00f4ng th\u1ee9c C10H14O, l\u00e0 th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a tinh d\u1ea7u h\u00fang t\u00e2y (Thymus vulgaris). Trong b\u00e0o ch\u1ebf, thymol d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, kh\u1eed m\u00f9i trong s\u1ea3n ph\u1ea9m r\u0103ng mi\u1ec7ng, ch\u1ea5t ch\u1ed1ng oxy h\u00f3a v\u00e0 g\u1ea7n \u0111\u00e2y&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2682"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2682\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2681"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}