{"id":2678,"date":"2026-09-27T20:59:13","date_gmt":"2026-09-27T13:59:13","guid":{"rendered":"https:\/\/cpc1.vn\/thaumatin\/"},"modified":"2026-09-29T12:15:06","modified_gmt":"2026-09-29T05:15:06","slug":"thaumatin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/thaumatin\/","title":{"rendered":"Thaumatin \u2013 ch\u1ea5t ng\u1ecdt protein c\u01b0\u1eddng \u0111\u1ed9 cao, ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb"},"content":{"rendered":"

Thaumatin \u2013 ch\u1ea5t ng\u1ecdt protein c\u01b0\u1eddng \u0111\u1ed9 cao, ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb<\/h1>\n

Thaumatin<\/strong> (E957, Talin) l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c protein ng\u1ecdt chi\u1ebft t\u1eeb qu\u1ea3 c\u00e2y Thaumatococcus daniellii<\/em> (T\u00e2y Phi). \u0110\u00e2y l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao<\/strong> t\u1ef1 nhi\u00ean, ng\u1ecdt kho\u1ea3ng 2000\u20133000 l\u1ea7n \u0111\u01b0\u1eddng k\u00ednh, \u0111\u1ed3ng th\u1eddi l\u00e0 ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb<\/strong> d\u00f9ng r\u1ed9ng r\u00e3i trong th\u1ef1c ph\u1ea9m v\u00e0 c\u00f3 ti\u1ec1m n\u0103ng cho ch\u1ebf ph\u1ea9m u\u1ed1ng.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nE957, Talin, thalin, thaumatine, thaumatins protein<\/td>\n<\/tr>\n
T\u00ean d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\nKh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n53850-34-3<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n<\/td>\nH\u1ed7n h\u1ee3p n\u0103m protein thaumatin (I, II, III, a, b), ch\u1ee7 y\u1ebfu thaumatin I v\u00e0 II v\u1edbi tr\u00ecnh t\u1ef1 acid amin g\u1ea7n nh\u01b0 gi\u1ed1ng nhau; kh\u00f4ng c\u00f3 m\u1ea1ch nh\u00e1nh hay li\u00ean k\u1ebft peptid b\u1ea5t th\u01b0\u1eddng. (Ngo\u00e0i s\u00e1ch) M\u1ed7i chu\u1ed7i kho\u1ea3ng 207 acid amin, kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed kho\u1ea3ng 22 kDa<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ng\u1ecdt, ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u1ea1o ng\u1ecdt v\u00e0 t\u0103ng h\u01b0\u01a1ng v\u1ecb trong th\u1ef1c ph\u1ea9m; m\u1ee9c d\u00f9ng \u0111i\u1ec3n h\u00ecnh r\u1ea5t th\u1ea5p, 0,5\u20133 ppm (cao h\u01a1n trong m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m nh\u01b0 k\u1eb9o cao su).<\/li>\n
  • C\u00f3 ti\u1ec1m n\u0103ng trong d\u01b0\u1ee3c ph\u1ea9m u\u1ed1ng, v\u00ed d\u1ee5 h\u1ed7n d\u1ecbch, siro \u2013 nh\u1ea5t l\u00e0 \u0111\u1ec3 che v\u1ecb \u0111\u1eafng.<\/li>\n
  • D\u00f9ng trong s\u1ea3n ph\u1ea9m v\u1ec7 sinh r\u0103ng mi\u1ec7ng nh\u01b0 n\u01b0\u1edbc s\u00fac mi\u1ec7ng, kem \u0111\u00e1nh r\u0103ng.<\/li>\n
  • Hi\u1ec7p \u0111\u1ed3ng v\u1edbi c\u00e1c ch\u1ea5t ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao kh\u00e1c nh\u01b0 acesulfam kali v\u00e0 saccharin \u2013 ph\u1ed1i h\u1ee3p gi\u00fap gi\u1ea3m l\u01b0\u1ee3ng d\u00f9ng v\u00e0 c\u1ea3i thi\u1ec7n h\u1eadu v\u1ecb.<\/li>\n<\/ul>\n

    L\u01b0u \u00fd khi x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c: v\u1ecb ng\u1ecdt xu\u1ea5t hi\u1ec7n ch\u1eadm v\u00e0 h\u1eadu v\u1ecb k\u00e9o d\u00e0i (\u0111\u1ebfn kho\u1ea3ng m\u1ed9t gi\u1edd), h\u01a1i gi\u1ed1ng cam th\u1ea3o \u2013 th\u01b0\u1eddng ph\u1ed1i h\u1ee3p ch\u1ea5t ng\u1ecdt kh\u00e1c thay v\u00ec d\u00f9ng m\u1ed9t m\u00ecnh. V\u1ecb ng\u1ecdt ph\u1ee5 thu\u1ed9c v\u00e0o c\u1ea5u tr\u00fac b\u1eadc ba \u0111\u01b0\u1ee3c gi\u1eef b\u1edfi nhi\u1ec1u c\u1ea7u disulfid; ch\u1ec9 c\u1ea7n c\u1eaft m\u1ed9t c\u1ea7u disulfid l\u00e0 m\u1ea5t v\u1ecb ng\u1ecdt.<\/p>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t m\u00e0u n\u00e2u nh\u1ea1t, kh\u00f4ng m\u00f9i, h\u00fat \u1ea9m, v\u1ecb r\u1ea5t ng\u1ecdt.<\/li>\n
    • Tan trong n\u01b0\u1edbc (1 trong 5 \u1edf pH 3), glycerin, propylen glycol; theo s\u00e1ch tan trong ethanol 95%; th\u1ef1c t\u1ebf kh\u00f4ng tan trong aceton.<\/li>\n
    • L\u00e0 protein n\u00ean c\u00f3 n\u0103ng l\u01b0\u1ee3ng, nh\u01b0ng l\u01b0\u1ee3ng d\u00f9ng qu\u00e1 nh\u1ecf n\u00ean n\u0103ng l\u01b0\u1ee3ng \u0111\u00f3ng g\u00f3p kh\u00f4ng \u0111\u00e1ng k\u1ec3.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • \u1ed4n \u0111\u1ecbnh trong dung d\u1ecbch n\u01b0\u1edbc \u1edf pH 2\u20138.<\/li>\n
      • B\u1ec1n nhi\u1ec7t \u1edf pH d\u01b0\u1edbi 5,5 (ch\u1ecbu \u0111\u01b0\u1ee3c n\u01b0\u1edbng, \u0111\u00f3ng h\u1ed9p, ti\u1ec7t tr\u00f9ng Pasteur hay UHT).<\/li>\n
      • Do h\u00fat \u1ea9m, b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        S\u00e1ch kh\u00f4ng ghi nh\u1eadn t\u01b0\u01a1ng k\u1ef5 c\u1ee5 th\u1ec3. L\u00e0 protein, c\u1ea7n l\u01b0u \u00fd c\u00e1c \u0111i\u1ec1u ki\u1ec7n l\u00e0m bi\u1ebfn t\u00ednh (pH ngo\u00e0i kho\u1ea3ng \u1ed5n \u0111\u1ecbnh, \u0111un n\u00f3ng \u1edf pH cao, ch\u1ea5t kh\u1eed c\u1eaft c\u1ea7u disulfid) v\u00ec s\u1ebd l\u00e0m m\u1ea5t v\u1ecb ng\u1ecdt.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Chi\u1ebft t\u1eeb qu\u1ea3 Thaumatococcus daniellii<\/em> (Benth.) b\u1eb1ng n\u01b0\u1edbc \u1edf pH th\u1ea5p, sau \u0111\u00f3 tinh ch\u1ebf b\u1eb1ng c\u00e1c qu\u00e1 tr\u00ecnh v\u1eadt l\u00fd nh\u01b0 th\u1ea9m th\u1ea5u ng\u01b0\u1ee3c.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
          \n
        • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt ho\u1eb7c \u0111i\u1ec1u v\u1ecb th\u1ef1c ph\u1ea9m \u1edf nhi\u1ec1u n\u01a1i, g\u1ed3m ch\u00e2u \u00c2u v\u00e0 \u00dac; d\u00f9ng trong s\u1ea3n ph\u1ea9m v\u1ec7 sinh r\u0103ng mi\u1ec7ng.<\/li>\n
        • Nh\u00ecn chung \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c. Do \u0111\u1ed9c t\u00ednh r\u1ea5t th\u1ea5p, JECFA \u0111\u1eb7t ADI \u1edf m\u1ee9c \u201ckh\u00f4ng x\u00e1c \u0111\u1ecbnh\u201d (not specified).<\/li>\n
        • LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng) > 20 g\/kg; LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng) > 20 g\/kg.<\/li>\n
        • Thao t\u00e1c theo c\u00e1c bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba th\u00f4ng th\u01b0\u1eddng, ph\u00f9 h\u1ee3p v\u1edbi l\u01b0\u1ee3ng nguy\u00ean li\u1ec7u.<\/li>\n<\/ul>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • GRAS t\u1ea1i M\u1ef9; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E957).<\/li>\n
          • C\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh.<\/li>\n
          • Kh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. hay USP-NF.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan:<\/strong> s\u00e1ch kh\u00f4ng n\u00eau; c\u00e1c ch\u1ea5t ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao th\u01b0\u1eddng ph\u1ed1i h\u1ee3p: acesulfam kali, saccharin, sucralose, aspartam.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Thaumatin<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Thaumatin \u2013 ch\u1ea5t ng\u1ecdt protein c\u01b0\u1eddng \u0111\u1ed9 cao, ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb Thaumatin (E957, Talin) l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c protein ng\u1ecdt chi\u1ebft t\u1eeb qu\u1ea3 c\u00e2y Thaumatococcus daniellii (T\u00e2y Phi). \u0110\u00e2y l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao t\u1ef1 nhi\u00ean, ng\u1ecdt kho\u1ea3ng 2000\u20133000 l\u1ea7n \u0111\u01b0\u1eddng k\u00ednh, \u0111\u1ed3ng th\u1eddi l\u00e0 ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb d\u00f9ng r\u1ed9ng r\u00e3i […]<\/p>\n","protected":false},"author":1,"featured_media":2677,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/thaumatin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Thaumatin \u2013 ch\u1ea5t ng\u1ecdt protein c\u01b0\u1eddng \u0111\u1ed9 cao, ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb Thaumatin (E957, Talin) l\u00e0 h\u1ed7n h\u1ee3p c\u00e1c protein ng\u1ecdt chi\u1ebft t\u1eeb qu\u1ea3 c\u00e2y Thaumatococcus daniellii (T\u00e2y Phi). \u0110\u00e2y l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao t\u1ef1 nhi\u00ean, ng\u1ecdt kho\u1ea3ng 2000\u20133000 l\u1ea7n \u0111\u01b0\u1eddng k\u00ednh, \u0111\u1ed3ng th\u1eddi l\u00e0 ch\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb d\u00f9ng r\u1ed9ng r\u00e3i…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2678"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2678\/revisions"}],"predecessor-version":[{"id":3965,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2678\/revisions\/3965"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2677"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}