{"id":2664,"date":"2026-09-27T17:07:09","date_gmt":"2026-09-27T10:07:09","guid":{"rendered":"https:\/\/cpc1.vn\/sulfobutylether-beta-cyclodextrin\/"},"modified":"2026-09-29T12:14:42","modified_gmt":"2026-09-29T05:14:42","slug":"sulfobutylether-beta-cyclodextrin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/sulfobutylether-beta-cyclodextrin\/","title":{"rendered":"Sulfobutylether \u03b2-cyclodextrin (SBECD, Captisol) \u2013 ch\u1ea5t tr\u1ee3 tan cho thu\u1ed1c ti\u00eam"},"content":{"rendered":"

Sulfobutylether \u03b2-cyclodextrin (SBECD, Captisol) \u2013 ch\u1ea5t tr\u1ee3 tan cho thu\u1ed1c ti\u00eam<\/h1>\n

Sulfobutylether \u03b2-cyclodextrin natri<\/strong> (SBECD, Captisol) l\u00e0 d\u1eabn ch\u1ea5t anion v\u00f4 \u0111\u1ecbnh h\u00ecnh c\u1ee7a \u03b2-cyclodextrin, c\u00f3 nh\u00f3m natri sulfonat c\u00e1ch khoang k\u1ef5 n\u01b0\u1edbc b\u1eb1ng m\u1ea1ch butyl. SBECD t\u1ea1o ph\u1ee9c kh\u00f4ng c\u1ed9ng h\u00f3a tr\u1ecb<\/strong> v\u1edbi ph\u00e2n t\u1eed nh\u1ecf, peptid, protein \u2013 t\u0103ng \u0111\u1ed9 tan v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh trong n\u01b0\u1edbc<\/strong>; \u1ee9ng d\u1ee5ng \u0111\u1ea7u ti\u00ean v\u00e0 quan tr\u1ecdng nh\u1ea5t l\u00e0 thu\u1ed1c ti\u00eam.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n\u03b2-Cyclodextrin sulfobutylether sodium salt, SBE7-\u03b2-CD, (SBE)7m-\u03b2-CD, SBECD; Captisol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n182410-00-0<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC42<\/sub>H70\u2212n<\/sub>O35<\/sub>(C4<\/sub>H8<\/sub>SO3<\/sub>Na)n<\/sub> \u2013 kho\u1ea3ng 2163 (n \u2248 6,5); \u0111\u1ed9 th\u1ebf trung b\u00ecnh 6,0\u20137,1<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t tr\u1ee3 tan, h\u1ec7 cung c\u1ea5p thu\u1ed1c, t\u00e1c nh\u00e2n th\u1ea9m th\u1ea5u, ch\u1ea5t tr\u1ee3 tan, ch\u1ea5t \u1ed5n \u0111\u1ecbnh, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, ch\u1ea5t l\u00e0m t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Nh\u00f3m th\u1ebf g\u1eafn ng\u1eabu nhi\u00ean \u1edf v\u1ecb tr\u00ed 2, 3, 6 c\u1ee7a c\u00e1c \u0111\u01a1n v\u1ecb glucopyranose \u2013 s\u1ea3n ph\u1ea9m l\u00e0 h\u1ed7n h\u1ee3p kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t; d\u1ea1ng th\u1ebf 7 (SBE7-\u03b2-CD) c\u00f3 \u0111\u1eb7c t\u00ednh ch\u1ea5t mang t\u1ed1t nh\u1ea5t.<\/p>\n

Applications<\/h2>\n
    \n
  • Thu\u1ed1c ti\u00eam (\u1ee9ng d\u1ee5ng \u0111\u1ea7u ti\u00ean); thu\u1ed1c u\u1ed1ng d\u1ea1ng r\u1eafn v\u00e0 l\u1ecfng; nh\u00e3n khoa, h\u00edt, nh\u1ecf m\u0169i.<\/li>\n
  • T\u00e1c nh\u00e2n th\u1ea9m th\u1ea5u v\u00e0\/ho\u1eb7c ch\u1ea5t tr\u1ee3 tan cho h\u1ec7 gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t; c\u00f3 t\u00ednh b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n khi \u0111\u1ee7 n\u1ed3ng \u0111\u1ed9.<\/li>\n
  • L\u01b0\u1ee3ng d\u00f9ng:<\/strong> t\u1ed1i thi\u1ec3u \u0111\u1ec3 h\u00f2a tan th\u01b0\u1eddng \u1edf t\u1ef7 l\u1ec7 mol cyclodextrin\/d\u01b0\u1ee3c ch\u1ea5t kho\u1ea3ng 1\u20135 (x\u00e1c \u0111\u1ecbnh th\u1ef1c nghi\u1ec7m). Gi\u1edbi h\u1ea1n tr\u00ean do \u0111\u1ed9 nh\u1edbt (thu\u1ed1c ti\u00eam c\u00f3 th\u1ec3 \u0111\u1ebfn kho\u1ea3ng 50%), tr\u01b0\u01a1ng l\u1ef1c, kh\u1ed1i l\u01b0\u1ee3ng vi\u00ean (d\u01b0\u1edbi 1 g\/vi\u00ean) ho\u1eb7c c\u00e2n nh\u1eafc PK\/PD.<\/li>\n
  • V\u1edbi ch\u1ebf ph\u1ea9m kh\u00f4ng b\u1ecb pha lo\u00e3ng khi d\u00f9ng (nh\u01b0 thu\u1ed1c nh\u1ecf m\u1eaft), d\u01b0 cyclodextrin l\u00e0m gi\u1ea3m d\u01b0\u1ee3c ch\u1ea5t t\u1ef1 do \u2013 c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm kh\u1edfi ph\u00e1t, gi\u1ea3m Cmax<\/sub> v\u00e0 sinh kh\u1ea3 d\u1ee5ng.<\/li>\n
  • Ngo\u00e0i d\u01b0\u1ee3c ph\u1ea9m: t\u00e1ch \u0111\u1ed1i quang trong HPLC, \u0111i\u1ec7n di mao qu\u1ea3n.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t v\u00f4 \u0111\u1ecbnh h\u00ecnh tr\u1eafng; dung d\u1ecbch 30% trong, kh\u00f4ng m\u00e0u.<\/li>\n
    • pH dung d\u1ecbch 30%: kho\u1ea3ng 6; g\u00f3c quay c\u1ef1c ri\u00eang +94\u00b0; ph\u00e2n h\u1ee7y \u1edf 275 \u00b0C.<\/li>\n
    • Captisol: g\u00f3c ngh\u1ec9 20,5\u00b0 (\u0111\u00f4ng kh\u00f4), 31,6\u00b0 (s\u1ea5y phun); t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,45\u20130,52 g\/cm\u00b3; c\u1ee1 h\u1ea1t trung b\u00ecnh (s\u1ea5y phun) 70\u2013120 \u00b5m.<\/li>\n
    • H\u00fat \u1ea9m thu\u1eadn ngh\u1ecbch \u0111\u1ebfn 60% RH; t\u1eeb 60% RH tr\u1edf l\u00ean ch\u1ea3y r\u1eefa (n\u01b0\u1edbc kho\u1ea3ng 16%). \u0110\u1ed9 \u1ea9m th\u01b0\u1eddng 2\u20135% (t\u1ed1i \u0111a 10%).<\/li>\n
    • Dung d\u1ecbch 12,7% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh.<\/li>\n
    • Tan d\u01b0\u1edbi 1\/2 trong n\u01b0\u1edbc; 1\/30\u201340 trong methanol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol, hexan, butanol, acetonitril, 2-propanol, ethyl acetat.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt dung d\u1ecbch 8,5%: 1,75 mPa\u00b7s; 60%: 528 mPa\u00b7s (25 \u00b0C).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n \u1edf tr\u1ea1ng th\u00e1i r\u1eafn, tr\u00e1nh \u0111\u1ed9 \u1ea9m cao; m\u1ed9t khi \u0111\u00e3 ch\u1ea3y r\u1eefa, c\u00f3 th\u1ec3 l\u00e0m kh\u00f4 nh\u01b0ng th\u00e0nh s\u1ea3n ph\u1ea9m d\u1ea1ng th\u1ee7y tinh. Dung d\u1ecbch h\u1ea5p ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c; b\u1ec1n \u1edf pH tr\u00ean kho\u1ea3ng 1, trong acid r\u1ea5t m\u1ea1nh (pH d\u01b0\u1edbi 1) v\u00e0 nhi\u1ec7t cao b\u1ecb m\u1edf v\u00f2ng r\u1ed3i th\u1ee7y ph\u00e2n li\u00ean k\u1ebft glucosid. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      L\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh b\u1ea3o qu\u1ea3n c\u1ee7a benzalkonium clorid.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Alkyl h\u00f3a \u03b2-cyclodextrin b\u1eb1ng 1,4-butan sulton trong \u0111i\u1ec1u ki\u1ec7n ki\u1ec1m; m\u1ee9c \u0111\u1ed9 th\u1ebf \u0111\u01b0\u1ee3c \u0111i\u1ec1u khi\u1ec3n qua t\u1ef7 l\u1ec7 \u03b2-cyclodextrin\/sulton.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      \u03b2-Cyclodextrin g\u1ed1c g\u00e2y \u0111\u1ed9c khi ti\u00eam, nh\u01b0ng SBECD \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t \u1edf li\u1ec1u cao khi ti\u00eam t\u0129nh m\u1ea1ch nhanh, u\u1ed1ng v\u00e0 h\u00edt; \u0111\u1ebfn 9 g\/ng\u00e0y \u0111\u01b0\u1ee3c truy\u1ec1n t\u0129nh m\u1ea1ch trong m\u1ed9t ch\u1ebf ph\u1ea9m voriconazol \u0111\u00e3 c\u1ea5p ph\u00e9p. Kh\u00f4ng g\u00e2y \u0111\u1ed9c gen, kh\u00f4ng \u0111\u1ed9t bi\u1ebfn trong lo\u1ea1t th\u1eed nghi\u1ec7m; t\u01b0\u01a1ng h\u1ee3p sinh h\u1ecdc, kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd; th\u1ea3i nhanh nguy\u00ean d\u1ea1ng sau ti\u00eam t\u0129nh m\u1ea1ch. Thao t\u00e1c theo bi\u1ec7n ph\u00e1p th\u00f4ng th\u01b0\u1eddng.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong thu\u1ed1c ti\u00eam t\u0129nh m\u1ea1ch, ti\u00eam b\u1eafp \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t t\u1ea1i M\u1ef9 v\u00e0 ch\u00e2u \u00c2u; c\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch). C\u00e1c \u0111\u01b0\u1eddng d\u00f9ng kh\u00e1c \u0111ang \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e2m s\u00e0ng (theo s\u00e1ch).<\/li>\n
      • Kh\u00f4ng c\u00f3 t\u00ean ch\u00ednh th\u1ee9c trong d\u01b0\u1ee3c \u0111i\u1ec3n t\u1ea1i th\u1eddi \u0111i\u1ec3m s\u00e1ch xu\u1ea5t b\u1ea3n.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> \u03b1-, \u03b2-, \u03b3-cyclodextrin; hydroxypropyl-\u03b2-cyclodextrin; dimethyl-\u03b2-cyclodextrin; trimethyl-\u03b2-cyclodextrin.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sulfobutylether beta-Cyclodextrin<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Sulfobutylether \u03b2-cyclodextrin (SBECD, Captisol) \u2013 ch\u1ea5t tr\u1ee3 tan cho thu\u1ed1c ti\u00eam Sulfobutylether \u03b2-cyclodextrin natri (SBECD, Captisol) l\u00e0 d\u1eabn ch\u1ea5t anion v\u00f4 \u0111\u1ecbnh h\u00ecnh c\u1ee7a \u03b2-cyclodextrin, c\u00f3 nh\u00f3m natri sulfonat c\u00e1ch khoang k\u1ef5 n\u01b0\u1edbc b\u1eb1ng m\u1ea1ch butyl. SBECD t\u1ea1o ph\u1ee9c kh\u00f4ng c\u1ed9ng h\u00f3a tr\u1ecb v\u1edbi ph\u00e2n t\u1eed nh\u1ecf, peptid, protein \u2013 t\u0103ng \u0111\u1ed9 tan v\u00e0 \u0111\u1ed9 […]<\/p>\n","protected":false},"author":1,"featured_media":2663,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2664","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sulfobutylether-beta-cyclodextrin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Sulfobutylether \u03b2-cyclodextrin (SBECD, Captisol) \u2013 ch\u1ea5t tr\u1ee3 tan cho thu\u1ed1c ti\u00eam Sulfobutylether \u03b2-cyclodextrin natri (SBECD, Captisol) l\u00e0 d\u1eabn ch\u1ea5t anion v\u00f4 \u0111\u1ecbnh h\u00ecnh c\u1ee7a \u03b2-cyclodextrin, c\u00f3 nh\u00f3m natri sulfonat c\u00e1ch khoang k\u1ef5 n\u01b0\u1edbc b\u1eb1ng m\u1ea1ch butyl. SBECD t\u1ea1o ph\u1ee9c kh\u00f4ng c\u1ed9ng h\u00f3a tr\u1ecb v\u1edbi ph\u00e2n t\u1eed nh\u1ecf, peptid, protein \u2013 t\u0103ng \u0111\u1ed9 tan v\u00e0 \u0111\u1ed9…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2664"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2664\/revisions"}],"predecessor-version":[{"id":3961,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2664\/revisions\/3961"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2663"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}