{"id":2654,"date":"2026-09-27T17:03:51","date_gmt":"2026-09-27T10:03:51","guid":{"rendered":"https:\/\/cpc1.vn\/sucralose\/"},"modified":"2026-09-28T14:32:16","modified_gmt":"2026-09-28T07:32:16","slug":"sucralose","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/sucralose\/","title":{"rendered":"Sucralose \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao kh\u00f4ng n\u0103ng l\u01b0\u1ee3ng, b\u1ec1n nhi\u1ec7t"},"content":{"rendered":"

Sucralose \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao kh\u00f4ng n\u0103ng l\u01b0\u1ee3ng, b\u1ec1n nhi\u1ec7t<\/h1>\n

Sucralose<\/strong> (1\u2032,4,6\u2032-triclorogalactosucrose, TGS, E955) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao<\/strong> ng\u1ecdt kho\u1ea3ng 300\u20131000 l\u1ea7n saccarose<\/strong>, kh\u00f4ng c\u00f3 h\u1eadu v\u1ecb, kh\u00f4ng c\u00f3 gi\u00e1 tr\u1ecb dinh d\u01b0\u1ee1ng, kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng v\u00e0 kh\u00f4ng g\u00e2y \u0111\u00e1p \u1ee9ng \u0111\u01b0\u1eddng huy\u1ebft. D\u00f9ng trong \u0111\u1ed3 u\u1ed1ng, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nTrichlorogalactosucrose, TGS, E955; Splenda<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n56038-13-2<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC12<\/sub>H19<\/sub>Cl3<\/sub>O8<\/sub> \u2013 397,64<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nSweeteners<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u1ea1o ng\u1ecdt trong thu\u1ed1c u\u1ed1ng, \u0111\u1ed3 u\u1ed1ng, th\u1ef1c ph\u1ea9m (th\u1ef1c ph\u1ea9m th\u01b0\u1eddng d\u00f9ng 0,03\u20130,24%).<\/li>\n
  • Kh\u00f4ng gi\u1ea3m \u0111\u1ed9 ng\u1ecdt khi \u0111un n\u00f3ng<\/strong> \u2013 ch\u1ecbu \u0111\u01b0\u1ee3c thanh tr\u00f9ng, ti\u1ec7t tr\u00f9ng, UHT, n\u01b0\u1edbng b\u00e1nh.<\/li>\n
  • D\u1ea1ng h\u1ea1t th\u01b0\u1eddng ph\u1ed1i maltodextrin ho\u1eb7c dextrose l\u00e0m ch\u1ea5t t\u1ea1o kh\u1ed1i.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u01a1n ch\u1ea3y, tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0.<\/li>\n
    • pH dung d\u1ecbch 10%: 5\u20136; n\u00f3ng ch\u1ea3y 130 \u00b0C (tinh th\u1ec3 khan), 36,5 \u00b0C (pentahydrat); t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,35, g\u00f5 0,62, th\u1ef1c 1,63 g\/cm\u00b3; 90% ti\u1ec3u ph\u00e2n nh\u1ecf h\u01a1n 12 \u00b5m.<\/li>\n
    • log P (octanol\/n\u01b0\u1edbc) \u22120,51; g\u00f3c quay c\u1ef1c ri\u00eang +84,0\u00b0 \u0111\u1ebfn +87,5\u00b0 (dung d\u1ecbch n\u01b0\u1edbc 1%).<\/li>\n
    • D\u1ec5 tan trong n\u01b0\u1edbc, ethanol 95%, methanol; h\u01a1i tan trong ethyl acetat.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      T\u01b0\u01a1ng \u0111\u1ed1i b\u1ec1n. Trong dung d\u1ecbch n\u01b0\u1edbc \u1edf pH r\u1ea5t acid (d\u01b0\u1edbi 3) v\u00e0 nhi\u1ec7t \u0111\u1ed9 cao (t\u1eeb 35 \u00b0C) b\u1ecb th\u1ee7y ph\u00e2n m\u1ed9t ph\u1ea7n th\u00e0nh 4-cloro-4-deoxygalactose v\u00e0 1,6-dicloro-1,6-dideoxyfructose; b\u1ec1n nh\u1ea5t \u1edf pH 5\u20136, v\u1eabn b\u1ec1n trong th\u1ef1c ph\u1ea9m b\u1ea3o qu\u1ea3n l\u00e2u k\u1ec3 c\u1ea3 pH th\u1ea5p. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t, kh\u00f4ng qu\u00e1 21 \u00b0C. \u0110un \u1edf nhi\u1ec7t \u0111\u1ed9 cao c\u00f3 th\u1ec3 ph\u00e2n h\u1ee7y gi\u1ea3i ph\u00f3ng CO2<\/sub>, CO v\u00e0 l\u01b0\u1ee3ng nh\u1ecf HCl.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Th\u1ebf ch\u1ecdn l\u1ecdc ba nh\u00f3m hydroxyl c\u1ee7a saccarose b\u1eb1ng clor theo nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p, ho\u1eb7c cho saccarose (hay ester acetat) ph\u1ea3n \u1ee9ng v\u1edbi thionyl clorid.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      N\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; \u0111\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong th\u1ef1c ph\u1ea9m \u1edf nhi\u1ec1u n\u01b0\u1edbc. Khi u\u1ed1ng, sucralose h\u1ea7u nh\u01b0 kh\u00f4ng h\u1ea5p thu, th\u1ea3i qua ph\u00e2n. WHO \u0111\u1eb7t ADI \u0111\u1ebfn 15 mg\/kg th\u1ec3 tr\u1ecdng. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): > 10 g\/kg. Thao t\u00e1c theo bi\u1ec7n ph\u00e1p th\u00f4ng th\u01b0\u1eddng.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • FDA ph\u00ea duy\u1ec7t n\u0103m 1998 l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt \u0111\u1ec3 b\u00e0n v\u00e0 ph\u1ee5 gia trong nhi\u1ec1u th\u1ef1c ph\u1ea9m; Anh cho ph\u00e9p t\u1ea1m th\u1eddi n\u0103m 2002 (ngo\u00e0i s\u00e1ch:<\/em> EU ph\u00ea duy\u1ec7t ch\u00ednh th\u1ee9c v\u1edbi m\u00e3 E955 t\u1eeb 2004); \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn \u1edf nhi\u1ec1u n\u01b0\u1edbc; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> saccarose, aspartam, acesulfam kali, saccharin, neohesperidin dihydrochalcon.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sucralose<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Sucralose \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao kh\u00f4ng n\u0103ng l\u01b0\u1ee3ng, b\u1ec1n nhi\u1ec7t Sucralose (1\u2032,4,6\u2032-triclorogalactosucrose, TGS, E955) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao ng\u1ecdt kho\u1ea3ng 300\u20131000 l\u1ea7n saccarose, kh\u00f4ng c\u00f3 h\u1eadu v\u1ecb, kh\u00f4ng c\u00f3 gi\u00e1 tr\u1ecb dinh d\u01b0\u1ee1ng, kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng v\u00e0 kh\u00f4ng g\u00e2y \u0111\u00e1p \u1ee9ng \u0111\u01b0\u1eddng huy\u1ebft. D\u00f9ng trong \u0111\u1ed3 u\u1ed1ng, th\u1ef1c […]<\/p>","protected":false},"author":1,"featured_media":2653,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2654","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/sucralose-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Sucralose \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao kh\u00f4ng n\u0103ng l\u01b0\u1ee3ng, b\u1ec1n nhi\u1ec7t Sucralose (1\u2032,4,6\u2032-triclorogalactosucrose, TGS, E955) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao ng\u1ecdt kho\u1ea3ng 300\u20131000 l\u1ea7n saccarose, kh\u00f4ng c\u00f3 h\u1eadu v\u1ecb, kh\u00f4ng c\u00f3 gi\u00e1 tr\u1ecb dinh d\u01b0\u1ee1ng, kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng v\u00e0 kh\u00f4ng g\u00e2y \u0111\u00e1p \u1ee9ng \u0111\u01b0\u1eddng huy\u1ebft. D\u00f9ng trong \u0111\u1ed3 u\u1ed1ng, th\u1ef1c…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2654"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2654\/revisions"}],"predecessor-version":[{"id":2754,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2654\/revisions\/2754"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2653"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}