{"id":2652,"date":"2026-09-27T17:03:42","date_gmt":"2026-09-27T10:03:42","guid":{"rendered":"https:\/\/cpc1.vn\/alcol-stearylic\/"},"modified":"2026-09-28T14:32:18","modified_gmt":"2026-09-28T07:32:18","slug":"alcol-stearylic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/alcol-stearylic\/","title":{"rendered":"Alcol stearylic \u2013 ch\u1ea5t l\u00e0m c\u1ee9ng, \u1ed5n \u0111\u1ecbnh kem v\u00e0 thu\u1ed1c m\u1ee1"},"content":{"rendered":"

Alcol stearylic \u2013 ch\u1ea5t l\u00e0m c\u1ee9ng, \u1ed5n \u0111\u1ecbnh kem v\u00e0 thu\u1ed1c m\u1ee1<\/h1>\n

Alcol stearylic<\/strong> (1-octadecanol) l\u00e0 alcol b\u00e9o no C18 d\u1ea1ng r\u1eafn s\u00e1p. Trong m\u1ef9 ph\u1ea9m, kem v\u00e0 thu\u1ed1c m\u1ee1 d\u00f9ng ngo\u00e0i, alcol stearylic l\u00e0 ch\u1ea5t l\u00e0m c\u1ee9ng<\/strong> \u2013 t\u0103ng \u0111\u1ed9 nh\u1edbt, qua \u0111\u00f3 t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a nh\u0169 t\u01b0\u01a1ng; ngo\u00e0i ra c\u00f3 t\u00ednh l\u00e0m m\u1ec1m, nh\u0169 h\u00f3a y\u1ebfu v\u00e0 t\u0103ng kh\u1ea3 n\u0103ng gi\u1eef n\u01b0\u1edbc<\/strong> c\u1ee7a thu\u1ed1c m\u1ee1 (v\u00ed d\u1ee5 vaselin).<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n1-Octadecanol, n-octadecanol, octadecyl alcohol; Cachalot, Crodacol S95, Hyfatol 18-95\/18-98, Lanette 18, Lipocol S, Rita SA, Stearol, Stenol, Tego Alkanol 18<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n112-92-5<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC18<\/sub>H38<\/sub>O \u2013 270,48 (ch\u1ea5t tinh khi\u1ebft)<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n<\/td>\nPh.Eur.: 1-octadecanol \u2265 95%; USP-NF: \u2265 90%, ph\u1ea7n c\u00f2n l\u1ea1i ch\u1ee7 y\u1ebfu l\u00e0 alcol c\u00f9ng d\u00e3y<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t l\u00e0m c\u1ee9ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t l\u00e0m c\u1ee9ng, \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng trong kem, thu\u1ed1c m\u1ee1, m\u1ef9 ph\u1ea9m.<\/li>\n
  • L\u00e0m m\u1ec1m; t\u0103ng kh\u1ea3 n\u0103ng gi\u1eef n\u01b0\u1edbc c\u1ee7a thu\u1ed1c m\u1ee1.<\/li>\n
  • Vi\u00ean n\u00e9n gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t, thu\u1ed1c \u0111\u1eb7t, vi c\u1ea7u.<\/li>\n
  • \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m qua da.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • M\u1ea3nh, v\u1ea3y ho\u1eb7c h\u1ea1t s\u00e1p c\u1ee9ng, tr\u1eafng, m\u00f9i nh\u1eb9 \u0111\u1eb7c tr\u01b0ng, v\u1ecb nh\u1ea1t.<\/li>\n
    • Kho\u1ea3ng n\u00f3ng ch\u1ea3y theo d\u01b0\u1ee3c \u0111i\u1ec3n: JP 56\u201362 \u00b0C; Ph.Eur. 57\u201360 \u00b0C; USP-NF 55\u201360 \u00b0C (ch\u1ea5t tinh khi\u1ebft 59,4\u201359,8 \u00b0C); \u0111i\u1ec3m \u0111\u00f4ng \u0111\u1eb7c 55\u201357 \u00b0C.<\/li>\n
    • S\u00f4i 210,5 \u00b0C \u1edf 2 kPa; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 191 \u00b0C (c\u1ed1c h\u1edf); t\u1ef7 tr\u1ecdng th\u1ef1c 0,884\u20130,906 g\/cm\u00b3; chi\u1ebft su\u1ea5t 1,4388 (60 \u00b0C); \u0111\u1ed9 nh\u1edbt 9,82 mPa\u00b7s (64 \u00b0C).<\/li>\n
    • Tan trong cloroform, ethanol 95%, ether, hexan, propylen glycol, d\u1ea7u th\u1ef1c v\u1eadt; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n v\u1edbi acid v\u00e0 ki\u1ec1m, th\u01b0\u1eddng kh\u00f4ng b\u1ecb \u00f4i. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 acid m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Tr\u01b0\u1edbc \u0111\u00e2y \u0111i\u1ec1u ch\u1ebf t\u1eeb d\u1ea7u c\u00e1 nh\u00e0 t\u00e1ng; nay ch\u1ee7 y\u1ebfu t\u1ed5ng h\u1ee3p b\u1eb1ng kh\u1eed ethyl stearat v\u1edbi lithi nh\u00f4m hydrid (ho\u1eb7c hydro h\u00f3a acid b\u00e9o\/ester t\u1eeb d\u1ea7u th\u1ef1c v\u1eadt).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      N\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 v\u00f4 h\u1ea1i, kh\u00f4ng \u0111\u1ed9c; \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o m\u00e0y \u0111ay ti\u1ebfp x\u00fac v\u00e0 qu\u00e1 m\u1eabn v\u1edbi ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i ch\u1ee9a alcol stearylic, c\u00f3 th\u1ec3 do t\u1ea1p ch\u1ea5t h\u01a1n l\u00e0 b\u1ea3n th\u00e2n alcol stearylic. Li\u1ec1u u\u1ed1ng c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong \u1edf ng\u01b0\u1eddi \u0111\u01b0\u1ee3c \u01b0\u1edbc t\u00ednh tr\u00ean 15 g\/kg. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 20 g\/kg. \u0110eo k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 g\u0103ng tay.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean n\u00e9n u\u1ed1ng, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> alcol cetostearylic, alcol cetylic, acid stearic.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Stearyl Alcohol<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Alcol stearylic \u2013 ch\u1ea5t l\u00e0m c\u1ee9ng, \u1ed5n \u0111\u1ecbnh kem v\u00e0 thu\u1ed1c m\u1ee1 Alcol stearylic (1-octadecanol) l\u00e0 alcol b\u00e9o no C18 d\u1ea1ng r\u1eafn s\u00e1p. Trong m\u1ef9 ph\u1ea9m, kem v\u00e0 thu\u1ed1c m\u1ee1 d\u00f9ng ngo\u00e0i, alcol stearylic l\u00e0 ch\u1ea5t l\u00e0m c\u1ee9ng \u2013 t\u0103ng \u0111\u1ed9 nh\u1edbt, qua \u0111\u00f3 t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a nh\u0169 t\u01b0\u01a1ng; ngo\u00e0i ra c\u00f3 t\u00ednh […]<\/p>","protected":false},"author":1,"featured_media":2651,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/alcol-stearylic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Alcol stearylic \u2013 ch\u1ea5t l\u00e0m c\u1ee9ng, \u1ed5n \u0111\u1ecbnh kem v\u00e0 thu\u1ed1c m\u1ee1 Alcol stearylic (1-octadecanol) l\u00e0 alcol b\u00e9o no C18 d\u1ea1ng r\u1eafn s\u00e1p. Trong m\u1ef9 ph\u1ea9m, kem v\u00e0 thu\u1ed1c m\u1ee1 d\u00f9ng ngo\u00e0i, alcol stearylic l\u00e0 ch\u1ea5t l\u00e0m c\u1ee9ng \u2013 t\u0103ng \u0111\u1ed9 nh\u1edbt, qua \u0111\u00f3 t\u0103ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a nh\u0169 t\u01b0\u01a1ng; ngo\u00e0i ra c\u00f3 t\u00ednh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2652"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2652\/revisions"}],"predecessor-version":[{"id":2755,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2652\/revisions\/2755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2651"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}