{"id":2648,"date":"2026-09-27T17:02:29","date_gmt":"2026-09-27T10:02:29","guid":{"rendered":"https:\/\/cpc1.vn\/acid-stearic\/"},"modified":"2026-09-28T21:03:05","modified_gmt":"2026-09-28T14:03:05","slug":"acid-stearic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-stearic\/","title":{"rendered":"Acid stearic \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n, ch\u1ea5t nh\u0169 h\u00f3a kem"},"content":{"rendered":"

Acid stearic \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n, ch\u1ea5t nh\u0169 h\u00f3a kem<\/h1>\n

Acid stearic<\/strong> (acid octadecanoic, E570) th\u01b0\u01a1ng m\u1ea1i l\u00e0 h\u1ed7n h\u1ee3p acid stearic v\u00e0 acid palmitic. Trong thu\u1ed1c u\u1ed1ng, acid stearic ch\u1ee7 y\u1ebfu l\u00e0 t\u00e1 d\u01b0\u1ee3c tr\u01a1n<\/strong> vi\u00ean n\u00e9n v\u00e0 nang (1\u20133%); trong thu\u1ed1c d\u00f9ng ngo\u00e0i l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t h\u00f2a tan<\/strong> \u2013 khi trung h\u00f2a m\u1ed9t ph\u1ea7n b\u1eb1ng ki\u1ec1m ho\u1eb7c triethanolamin t\u1ea1o n\u1ec1n kem.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nOctadecanoic acid, cetylacetic acid, stereophanic acid, E570; Crodacid, Edenor, Emersol, Hystrene, Industrene, Kortacid 1895, Pearl Steric, Pristerene, Tegostearic<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n57-11-4<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC18<\/sub>H36<\/sub>O2<\/sub> \u2013 284,47 (ch\u1ea5t tinh khi\u1ebft)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t h\u00f2a tan, t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

C\u00e1c lo\u1ea1i:<\/strong> USP-NF \u2013 acid stearic \u2265 40,0%, t\u1ed5ng stearic + palmitic \u2265 90,0% (c\u00f3 chuy\u00ean lu\u1eadn ri\u00eang cho acid stearic tinh ch\u1ebf). Ph.Eur. \u2013 acid stearic 50 (40\u201360% C18, \u0111\u00f4ng \u0111\u1eb7c 53\u201359 \u00b0C), 70 (60\u201380%, 57\u201364 \u00b0C), 95 (\u2265 90%, 64\u201369 \u00b0C).<\/p>\n

Applications<\/h2>\n\n\n\n\n\n\n
C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Thu\u1ed1c m\u1ee1 v\u00e0 kem<\/td>\n1\u201320<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n<\/td>\n1\u20133<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • T\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n, nang; c\u0169ng l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh ho\u1eb7c ph\u1ed1i shellac \u0111\u1ec3 bao vi\u00ean; \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t l\u00e0m ch\u1ea5t mang gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i. L\u00e0 t\u00e1 d\u01b0\u1ee3c tr\u01a1n \u0111\u01b0\u1ee3c \u01b0a d\u00f9ng v\u1edbi tinh b\u1ed9t ti\u1ec1n gelatin h\u00f3a.<\/li>\n
  • D\u00f9ng ngo\u00e0i: acid stearic trung h\u00f2a m\u1ed9t ph\u1ea7n t\u1ea1o n\u1ec1n kem khi tr\u1ed9n v\u1edbi 5\u201315 l\u1ea7n kh\u1ed1i l\u01b0\u1ee3ng pha n\u01b0\u1edbc; h\u00ecnh th\u1ee9c v\u00e0 \u0111\u1ed9 d\u1ebbo kem ph\u1ee5 thu\u1ed9c t\u1ef7 l\u1ec7 ki\u1ec1m.<\/li>\n
  • Ch\u1ea5t l\u00e0m c\u1ee9ng trong thu\u1ed1c \u0111\u1eb7t glycerin.<\/li>\n
  • M\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Ch\u1ea5t r\u1eafn k\u1ebft tinh c\u1ee9ng, tr\u1eafng ho\u1eb7c h\u01a1i v\u00e0ng, h\u01a1i b\u00f3ng, ho\u1eb7c b\u1ed9t tr\u1eafng ng\u00e0 v\u00e0ng; m\u00f9i v\u1ecb nh\u1eb9 g\u1ee3i m\u1ee1 \u0111\u1ed9ng v\u1eadt.<\/li>\n
    • N\u00f3ng ch\u1ea3y t\u1eeb kho\u1ea3ng 55 \u00b0C (t\u00f9y lo\u1ea1i); ch\u1ec9 s\u1ed1 acid 200\u2013212; ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a 200\u2013220; t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,537, g\u00f5 0,571, th\u1ef1c 0,980 g\/cm\u00b3; h\u1ea7u nh\u01b0 kh\u00f4ng ch\u1ee9a n\u01b0\u1edbc.<\/li>\n
    • D\u1ec5 tan trong benzen, carbon tetraclorid, cloroform, ether; tan trong ethanol 95%, hexan, propylen glycol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n; c\u00f3 th\u1ec3 th\u00eam ch\u1ea5t ch\u1ed1ng oxy h\u00f3a (nh\u01b0 0,005% BHT). B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • T\u01b0\u01a1ng k\u1ef5 v\u1edbi h\u1ea7u h\u1ebft hydroxid kim lo\u1ea1i, c\u00f3 th\u1ec3 t\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a.<\/li>\n
      • T\u1ea1o stearat kh\u00f4ng tan v\u1edbi nhi\u1ec1u kim lo\u1ea1i \u2013 n\u1ec1n thu\u1ed1c m\u1ee1 acid stearic c\u00f3 th\u1ec3 kh\u00f4, v\u00f3n khi ph\u1ed1i mu\u1ed1i k\u1ebdm ho\u1eb7c calci.<\/li>\n
      • Nghi\u00ean c\u1ee9u DSC g\u1ee3i \u00fd t\u01b0\u01a1ng k\u1ef5 v\u1edbi m\u1ed9t s\u1ed1 d\u01b0\u1ee3c ch\u1ea5t (v\u00ed d\u1ee5 naproxen) nh\u01b0ng kh\u00f4ng nh\u1ea5t thi\u1ebft \u00e1p d\u1ee5ng cho s\u1ea3n ph\u1ea9m th\u1ef1c t\u1ebf.<\/li>\n
      • C\u00f3 b\u00e1o c\u00e1o g\u00e2y r\u1ed7 b\u1ec1 m\u1eb7t m\u00e0ng bao phim n\u01b0\u1edbc, ph\u1ee5 thu\u1ed9c \u0111i\u1ec3m ch\u1ea3y c\u1ee7a acid stearic.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Th\u1ee7y ph\u00e2n ch\u1ea5t b\u00e9o b\u1eb1ng d\u00f2ng n\u01b0\u1edbc nhi\u1ec7t \u0111\u1ed9 cao ng\u01b0\u1ee3c chi\u1ec1u trong bu\u1ed3ng \u00e1p su\u1ea5t cao, tinh ch\u1ebf b\u1eb1ng c\u1ea5t h\u01a1i n\u01b0\u1edbc ch\u00e2n kh\u00f4ng v\u00e0 t\u00e1ch b\u1eb1ng dung m\u00f4i ch\u1ecdn l\u1ecdc; ho\u1eb7c hydro h\u00f3a d\u1ea7u h\u1ea1t b\u00f4ng v\u00e0 d\u1ea7u th\u1ef1c v\u1eadt; ho\u1eb7c x\u00e0 ph\u00f2ng h\u00f3a m\u1ee1 \u0103n \u0111\u01b0\u1ee3c, t\u00e1ch glycerin, ph\u00e2n h\u1ee7y x\u00e0 ph\u00f2ng b\u1eb1ng acid, \u00e9p l\u1ea1nh lo\u1ea1i acid oleic. Acid stearic d\u00f9ng trong thu\u1ed1c u\u1ed1ng ph\u1ea3i t\u1eeb ngu\u1ed3n m\u1ee1 \u0103n \u0111\u01b0\u1ee3c (lo\u1ea1i ch\u1ec9 d\u00f9ng ngo\u00e0i \u0111\u01b0\u1ee3c mi\u1ec5n).<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        D\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i, m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m; n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng, d\u00f9 d\u00f9ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, t\u0129nh m\u1ea1ch): 21,5 mg\/kg. B\u1ee5i c\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 \u0111eo k\u00ednh, g\u0103ng tay, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i; d\u1ec5 ch\u00e1y.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (acid b\u00e9o, E570).<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean d\u01b0\u1edbi l\u01b0\u1ee1i; nang, dung d\u1ecbch, h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> acid stearic tinh ch\u1ebf (n\u00f3ng ch\u1ea3y 66\u201369 \u00b0C; ch\u1ec9 s\u1ed1 acid 195\u2013200), calci stearat, magnesi stearat, k\u1ebdm stearat, polyoxyethylen stearat, alcol stearylic.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Stearic Acid<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Acid stearic \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n, ch\u1ea5t nh\u0169 h\u00f3a kem Acid stearic (acid octadecanoic, E570) th\u01b0\u01a1ng m\u1ea1i l\u00e0 h\u1ed7n h\u1ee3p acid stearic v\u00e0 acid palmitic. Trong thu\u1ed1c u\u1ed1ng, acid stearic ch\u1ee7 y\u1ebfu l\u00e0 t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 nang (1\u20133%); trong thu\u1ed1c d\u00f9ng ngo\u00e0i l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t h\u00f2a tan \u2013 […]<\/p>","protected":false},"author":1,"featured_media":2647,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2648","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-stearic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid stearic \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n, ch\u1ea5t nh\u0169 h\u00f3a kem Acid stearic (acid octadecanoic, E570) th\u01b0\u01a1ng m\u1ea1i l\u00e0 h\u1ed7n h\u1ee3p acid stearic v\u00e0 acid palmitic. Trong thu\u1ed1c u\u1ed1ng, acid stearic ch\u1ee7 y\u1ebfu l\u00e0 t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 nang (1\u20133%); trong thu\u1ed1c d\u00f9ng ngo\u00e0i l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t h\u00f2a tan \u2013…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2648"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2648\/revisions"}],"predecessor-version":[{"id":3129,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2648\/revisions\/3129"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2647"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}