{"id":2634,"date":"2026-09-27T16:56:51","date_gmt":"2026-09-27T09:56:51","guid":{"rendered":"https:\/\/cpc1.vn\/acid-sorbic\/"},"modified":"2026-09-27T16:56:51","modified_gmt":"2026-09-27T09:56:51","slug":"acid-sorbic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-sorbic\/","title":{"rendered":"Acid sorbic (E200) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Acid sorbic (E200) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i<\/h1>\n<p><strong>Acid sorbic<\/strong> (acid 2,4-hexadienoic, E200) l\u00e0 <strong>ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/strong> \u2013 ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m, c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n \u2013 d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, ch\u1ebf ph\u1ea9m dinh d\u01b0\u1ee1ng qua \u1ed1ng v\u00e0 m\u1ef9 ph\u1ea9m, n\u1ed3ng \u0111\u1ed9 <strong>0,05\u20130,2%<\/strong> trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i, nh\u1ea5t l\u00e0 c\u00f4ng th\u1ee9c ch\u1ee9a ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>2,4-Hexadienoic acid, (E,E)-sorbic acid, hexadienic acid, crotylidene acetic acid, 2-propenylacrylic acid, E200; Sorbistat K<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>110-44-1 (\u0111\u1ed3ng ph\u00e2n E,E)<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>6<\/sub>H<sub>8<\/sub>O<sub>2<\/sub> \u2013 112,13<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ea5t b\u1ea3o qu\u1ea3n 0,05\u20130,2% trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i; d\u00f9ng \u0111\u01b0\u1ee3c c\u00f9ng protein, enzym, gelatin, g\u00f4m th\u1ef1c v\u1eadt. Hi\u1ec7u qu\u1ea3 cho dung d\u1ecbch promethazin hydroclorid \u1edf 1 g\/L.<\/li>\n<li>K\u00e9m b\u1ec1n v\u00e0 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n h\u1ea1n ch\u1ebf \u2013 th\u01b0\u1eddng ph\u1ed1i ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c ho\u1eb7c glycol (hi\u1ec7p \u0111\u1ed3ng).<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t k\u1ebft tinh tr\u1eafng \u0111\u1ebfn tr\u1eafng v\u00e0ng, kh\u00f4ng v\u1ecb, m\u00f9i nh\u1eb9 \u0111\u1eb7c tr\u01b0ng.<\/li>\n<li><strong>Ho\u1ea1t t\u00ednh:<\/strong> t\u1ed1t nh\u1ea5t \u1edf pH 4,5, h\u1ea7u nh\u01b0 kh\u00f4ng t\u00e1c d\u1ee5ng tr\u00ean pH 6. MIC \u1edf pH 6 (\u00b5g\/mL): <em>C. albicans<\/em> 25\u201350; <em>E. coli<\/em>, <em>K. pneumoniae<\/em>, <em>P. cepacia<\/em>, <em>S. aureus<\/em> 50\u2013100; <em>P. aeruginosa<\/em>, <em>P. fluorescens<\/em> 100\u2013300; <em>Penicillium notatum<\/em> 200\u2013300; <em>Clostridium sporogenes<\/em> 100\u2013500; <em>A. niger<\/em>, <em>S. cerevisiae<\/em> 200\u2013500.<\/li>\n<li>N\u00f3ng ch\u1ea3y 134,5 \u00b0C; s\u00f4i 228 \u00b0C (ph\u00e2n h\u1ee7y); pKa 4,76; t\u1ef7 tr\u1ecdng 1,20 g\/cm\u00b3; \u0111i\u1ec3m ch\u1edbp ch\u00e1y 127 \u00b0C.<\/li>\n<li>\u0110\u1ed9 tan (20 \u00b0C): ethanol, methanol 1\/8; ethanol 95% 1\/10; aceton 1\/11; cloroform 1\/15; propylen glycol 1\/19; ether 1\/30; glycerin 1\/320; n\u01b0\u1edbc 1\/400 (30 \u00b0C), 1\/26 (100 \u00b0C). Trong siro, \u0111\u1ed9 tan gi\u1ea3m khi t\u0103ng h\u00e0m l\u01b0\u1ee3ng \u0111\u01b0\u1eddng.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>Nh\u1ea1y oxy h\u00f3a, nh\u1ea5t l\u00e0 d\u01b0\u1edbi \u00e1nh s\u00e1ng; d\u1ec5 oxy h\u00f3a trong dung d\u1ecbch n\u01b0\u1edbc h\u01a1n \u1edf d\u1ea1ng r\u1eafn; \u1ed5n \u0111\u1ecbnh \u0111\u01b0\u1ee3c b\u1eb1ng ch\u1ea5t ch\u1ed1ng oxy h\u00f3a phenol nh\u01b0 0,02% propyl gallat.<\/li>\n<li>Dung d\u1ecbch kh\u00f4ng c\u00f3 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a ph\u00e2n h\u1ee7y nhanh trong bao b\u00ec polypropylen, PVC, polyethylen; trong th\u1ee7y tinh dung d\u1ecbch r\u1ea5t nh\u1ea1y pH \u2013 c\u1ea7n ki\u1ec3m tra \u0111\u1ed9 tinh khi\u1ebft vi sinh sau b\u1ea3o qu\u1ea3n l\u00e2u.<\/li>\n<li>D\u1ec5 ch\u00e1y khi g\u1eb7p nhi\u1ec7t, l\u1eeda. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, kh\u00f4ng qu\u00e1 40 \u00b0C.<\/li>\n<\/ul>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u01b0\u01a1ng k\u1ef5 v\u1edbi base, ch\u1ea5t oxy h\u00f3a, ch\u1ea5t kh\u1eed. M\u1ea5t m\u1ed9t ph\u1ea7n ho\u1ea1t t\u00ednh khi c\u00f3 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion v\u00e0 nh\u1ef1a. Mu\u1ed1i kim lo\u1ea1i n\u1eb7ng x\u00fac t\u00e1c oxy h\u00f3a. Ph\u1ea3n \u1ee9ng v\u1edbi acid amin ch\u1ee9a l\u01b0u hu\u1ef3nh \u2013 c\u00f3 th\u1ec3 ng\u0103n b\u1eb1ng acid ascorbic, propyl gallat ho\u1eb7c BHT.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Chi\u1ebft d\u1ea1ng lacton (acid parasorbic) t\u1eeb qu\u1ea3 thanh l\u01b0\u01a1ng tr\u00e0 (<em>Sorbus aucuparia<\/em>). T\u1ed5ng h\u1ee3p b\u1eb1ng ng\u01b0ng t\u1ee5 crotonaldehyd v\u1edbi keten (x\u00fac t\u00e1c bor trifluorid) ho\u1eb7c v\u1edbi acid malonic trong pyridin; ho\u1eb7c t\u1eeb 1,1,3,5-tetraalkoxyhexan; ho\u1eb7c l\u00ean men sorbaldehyd\/sorbitol.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>N\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c; \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng k\u00edch \u1ee9ng da v\u00e0 (\u00edt h\u01a1n) qu\u00e1 m\u1eabn d\u1ecb \u1ee9ng da, vi\u00eam da tr\u00f3c v\u1ea3y do thu\u1ed1c m\u1ee1, vi\u00eam k\u1ebft m\u1ea1c d\u1ecb \u1ee9ng do dung d\u1ecbch k\u00ednh \u00e1p tr\u00f2ng, m\u00e0y \u0111ay ti\u1ebfp x\u00fac quanh mi\u1ec7ng. Ch\u01b0a ghi nh\u1eadn ph\u1ea3n \u1ee9ng khi d\u00f9ng to\u00e0n th\u00e2n. WHO \u0111\u1eb7t ADI t\u1ed5ng cho acid sorbic v\u00e0 mu\u1ed1i calci, kali, natri (t\u00ednh theo acid sorbic) \u0111\u1ebfn 25 mg\/kg. Kh\u00f4ng g\u00e2y ung th\u01b0, qu\u00e1i thai khi \u0111\u1ed9ng v\u1eadt \u0103n \u0111\u1ebfn 10% kh\u1ea9u ph\u1ea7n. LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 7,36 g\/kg. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, h\u00f4 h\u1ea5p \u2013 \u0111eo k\u00ednh, g\u0103ng tay, kh\u1ea9u trang.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E200).<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (dung d\u1ecbch nh\u1ecf m\u1eaft; nang, dung d\u1ecbch, siro, vi\u00ean n\u00e9n u\u1ed1ng; d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> kali sorbat, calci sorbat, natri sorbat, acid benzoic.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Sorbic Acid<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Acid sorbic (E200) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i Acid sorbic (acid 2,4-hexadienoic, E200) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n \u2013 ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m, c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n \u2013 d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, ch\u1ebf ph\u1ea9m dinh d\u01b0\u1ee1ng qua \u1ed1ng v\u00e0 m\u1ef9 ph\u1ea9m, n\u1ed3ng \u0111\u1ed9 0,05\u20130,2% trong [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2633,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2634","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-sorbic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid sorbic (E200) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i Acid sorbic (acid 2,4-hexadienoic, E200) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n \u2013 ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m, c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n \u2013 d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, ch\u1ebf ph\u1ea9m dinh d\u01b0\u1ee1ng qua \u1ed1ng v\u00e0 m\u1ef9 ph\u1ea9m, n\u1ed3ng \u0111\u1ed9 0,05\u20130,2% trong&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2634"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2634\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2633"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}