{"id":2628,"date":"2026-09-27T16:54:35","date_gmt":"2026-09-27T09:54:35","guid":{"rendered":"https:\/\/cpc1.vn\/natri-propionat\/"},"modified":"2026-09-27T16:54:35","modified_gmt":"2026-09-27T09:54:35","slug":"natri-propionat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-propionat\/","title":{"rendered":"Natri propionat (E281) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m m\u1ed1c"},"content":{"rendered":"

Natri propionat (E281) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m m\u1ed1c<\/h1>\n

Natri propionat<\/strong> (E281) l\u00e0 mu\u1ed1i natri c\u1ee7a acid propionic, d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/strong> trong thu\u1ed1c u\u1ed1ng \u2013 ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m m\u1ed1c<\/strong>; m\u1ea1nh v\u1edbi m\u1ed1c h\u01a1n natri benzoat nh\u01b0ng h\u1ea7u nh\u01b0 kh\u00f4ng t\u00e1c d\u1ee5ng tr\u00ean n\u1ea5m men. Trong l\u00e0m b\u00e1nh, natri propionat l\u00e0 ch\u1ea5t ch\u1ed1ng m\u1ed1c ph\u1ed5 bi\u1ebfn.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nSodium propanoate hydrate, ethylformic acid sodium salt, methylacetic acid sodium salt, E281<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n6700-17-0 (hydrat); 137-40-6 (khan)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC3<\/sub>H5<\/sub>NaO2<\/sub>\u00b7xH2<\/sub>O \u2013 114,06 (monohydrat); 96,06 (khan)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n trong thu\u1ed1c u\u1ed1ng (nang, b\u1ed9t, h\u1ed7n d\u1ecbch, siro).<\/li>\n
  • Th\u1ef1c ph\u1ea9m, nh\u1ea5t l\u00e0 b\u00e1nh m\u00ec: ch\u1ed1ng m\u1ed1c; hi\u1ec7u qu\u1ea3 v\u1edbi Bacillus mesentericus<\/em> g\u00e2y h\u1ecfng b\u00e1nh (“rope”); c\u0169ng d\u00f9ng t\u1ea1o h\u01b0\u01a1ng.<\/li>\n
  • C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c v\u00e0 th\u00fa y n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Tinh th\u1ec3 trong su\u1ed1t kh\u00f4ng m\u00e0u ho\u1eb7c b\u1ed9t k\u1ebft tinh d\u1ea1ng h\u1ea1t tr\u01a1n ch\u1ea3y; kh\u00f4ng m\u00f9i ho\u1eb7c m\u00f9i nh\u1eb9; v\u1ecb h\u01a1i gi\u1ed1ng pho m\u00e1t (ri\u00eang l\u1ebb th\u00ec kh\u00f3 \u0103n). Ch\u1ea3y r\u1eefa trong kh\u00f4ng kh\u00ed \u1ea9m.<\/li>\n
    • Ho\u1ea1t t\u00ednh:<\/strong> ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m m\u1ed1c, h\u1ea7u nh\u01b0 kh\u00f4ng t\u00e1c d\u1ee5ng v\u1edbi n\u1ea5m men; \u00edt t\u00e1c d\u1ee5ng v\u1edbi vi khu\u1ea9n (tr\u1eeb m\u1ed9t s\u1ed1 c\u1ea7u khu\u1ea9n Gram d\u01b0\u01a1ng). Ph\u1ee5 thu\u1ed9c acid t\u1ef1 do \u2013 t\u1ed1t nh\u1ea5t \u1edf pH d\u01b0\u1edbi 5. Hi\u1ec7p \u0111\u1ed3ng v\u1edbi CO2<\/sub> ho\u1eb7c acid sorbic.<\/li>\n
    • \u0110\u1ed9 tan: n\u01b0\u1edbc 1\/1 (1\/0,65 n\u01b0\u1edbc s\u00f4i); ethanol 95% 1\/24; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong cloroform, ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Ch\u1ea3y r\u1eefa \u2013 b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng t\u1ef1 c\u00e1c acid h\u1eefu c\u01a1 y\u1ebfu kh\u00e1c.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho acid propionic ph\u1ea3n \u1ee9ng v\u1edbi natri carbonat ho\u1eb7c natri hydroxid.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      Acid propionic c\u00f3 t\u1ef1 nhi\u00ean \u0111\u1ebfn 1% trong m\u1ed9t s\u1ed1 lo\u1ea1i pho m\u00e1t; propionat \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a nh\u01b0 acid b\u00e9o. Nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c; ng\u01b0\u1eddi d\u00f9ng 6 g\/ng\u00e0y kh\u00f4ng c\u00f3 h\u1ea1i, nh\u01b0ng c\u00f3 th\u1ec3 c\u00f3 ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng. LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 6,33 g\/kg. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, da \u2013 \u0111eo g\u0103ng tay, k\u00ednh, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i; khi ph\u00e2n h\u1ee7y do nhi\u1ec7t t\u1ecfa kh\u00f3i \u0111\u1ed9c Na2<\/sub>O.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E281) \u2013 gi\u1edbi h\u1ea1n 0,3% trong pho m\u00e1t, 0,32% trong b\u1ed9t m\u00ec v\u00e0 b\u00e1nh m\u00ec tr\u1eafng, 0,38% trong s\u1ea3n ph\u1ea9m l\u00faa m\u00ec nguy\u00ean c\u00e1m (theo s\u00e1ch).<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (nang, b\u1ed9t, h\u1ed7n d\u1ecbch, siro u\u1ed1ng); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> acid propionic, calci propionat, kali propionat, k\u1ebdm propionat.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Propionate<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Natri propionat (E281) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m m\u1ed1c Natri propionat (E281) l\u00e0 mu\u1ed1i natri c\u1ee7a acid propionic, d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n trong thu\u1ed1c u\u1ed1ng \u2013 ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m m\u1ed1c; m\u1ea1nh v\u1edbi m\u1ed1c h\u01a1n natri benzoat nh\u01b0ng h\u1ea7u nh\u01b0 kh\u00f4ng t\u00e1c d\u1ee5ng tr\u00ean n\u1ea5m men. Trong l\u00e0m b\u00e1nh, natri propionat […]<\/p>","protected":false},"author":1,"featured_media":2627,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-propionat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri propionat (E281) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m m\u1ed1c Natri propionat (E281) l\u00e0 mu\u1ed1i natri c\u1ee7a acid propionic, d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n trong thu\u1ed1c u\u1ed1ng \u2013 ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m m\u1ed1c; m\u1ea1nh v\u1edbi m\u1ed1c h\u01a1n natri benzoat nh\u01b0ng h\u1ea7u nh\u01b0 kh\u00f4ng t\u00e1c d\u1ee5ng tr\u00ean n\u1ea5m men. Trong l\u00e0m b\u00e1nh, natri propionat…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2628"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2628\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2627"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}