{"id":2624,"date":"2026-09-27T16:53:08","date_gmt":"2026-09-27T09:53:08","guid":{"rendered":"https:\/\/cpc1.vn\/dinatri-hydrophosphat\/"},"modified":"2026-09-27T16:53:08","modified_gmt":"2026-09-27T09:53:08","slug":"dinatri-hydrophosphat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/dinatri-hydrophosphat\/","title":{"rendered":"Dinatri hydrophosphat (natri phosphat dibasic, E339) \u2013 ch\u1ea5t \u0111\u1ec7m, c\u00f4 l\u1eadp ion"},"content":{"rendered":"

Dinatri hydrophosphat (natri phosphat dibasic, E339) \u2013 ch\u1ea5t \u0111\u1ec7m, c\u00f4 l\u1eadp ion<\/h1>\n

Dinatri hydrophosphat<\/strong> (natri phosphat dibasic, Na2<\/sub>HPO4<\/sub>\u00b7xH2<\/sub>O v\u1edbi x = 0, 1, 2, 7 ho\u1eb7c 12; E339) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t \u0111\u1ec7m<\/strong> v\u00e0 ch\u1ea5t c\u00f4 l\u1eadp ion kim lo\u1ea1i<\/strong>; th\u01b0\u1eddng ph\u1ed1i v\u1edbi natri dihydrophosphat \u0111\u1ec3 t\u1ea1o h\u1ec7 \u0111\u1ec7m phosphat.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nDisodium hydrogen phosphate, disodium phosphate, secondary sodium phosphate, sodium orthophosphate, E339<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n7558-79-4 (khan); 10028-24-7 (dihydrat); 7782-85-6 (heptahydrat); 10039-32-4 (dodecahydrat); 118830-14-1 (monohydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nNa2<\/sub>HPO4<\/sub> \u2013 141,96 (khan); \u00b72H2<\/sub>O \u2013 177,99; \u00b77H2<\/sub>O \u2013 268,07; \u00b712H2<\/sub>O \u2013 358,14<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t \u0111\u1ec7m, ch\u1ea5t c\u00f4 l\u1eadp ion kim lo\u1ea1i<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t \u0111\u1ec7m, c\u00f4 l\u1eadp ion kim lo\u1ea1i trong thu\u1ed1c ti\u00eam, d\u1ecbch truy\u1ec1n, nh\u1ecf m\u0169i, nh\u1ecf m\u1eaft, u\u1ed1ng, nh\u1ecf tai, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o.<\/li>\n
  • Th\u1ef1c ph\u1ea9m, v\u00ed d\u1ee5 ch\u1ea5t nh\u0169 h\u00f3a trong pho m\u00e1t ch\u1ebf bi\u1ebfn.<\/li>\n
  • C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Khan: b\u1ed9t tr\u1eafng, h\u00fat \u1ea9m. Dihydrat: tinh th\u1ec3 tr\u1eafng, kh\u00f4ng m\u00f9i. Heptahydrat: tinh th\u1ec3 kh\u00f4ng m\u00e0u ho\u1eb7c mu\u1ed1i d\u1ea1ng h\u1ea1t\/\u0111\u00f3ng b\u00e1nh, l\u00ean hoa trong kh\u00f4ng kh\u00ed kh\u00f4 \u1ea5m, b\u1ec1n trong kh\u00f4ng kh\u00ed. Dodecahydrat: tinh th\u1ec3 trong su\u1ed1t, l\u00ean hoa m\u1ea1nh.<\/li>\n
    • pH dung d\u1ecbch 1% d\u1ea1ng khan: 9,1; dung d\u1ecbch b\u00e3o h\u00f2a dodecahydrat kho\u1ea3ng 9,5. pKa c\u1ee7a acid phosphoric: 2,15; 7,20; 12,38.<\/li>\n
    • Dung d\u1ecbch \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh: dihydrat 2,23%; dodecahydrat 4,45%.<\/li>\n
    • R\u1ea5t d\u1ec5 tan trong n\u01b0\u1edbc (khan 1\/8; heptahydrat 1\/4; dodecahydrat 1\/3), tan h\u01a1n trong n\u01b0\u1edbc n\u00f3ng; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol 95%.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      D\u1ea1ng khan h\u00fat \u1ea9m. Dodecahydrat ch\u1ea3y \u1edf 40 \u00b0C, m\u1ea5t n\u01b0\u1edbc k\u1ebft tinh \u1edf 100 \u00b0C, chuy\u1ec3n th\u00e0nh pyrophosphat Na4<\/sub>P2<\/sub>O7<\/sub> \u1edf kho\u1ea3ng 240 \u00b0C. Dung d\u1ecbch n\u01b0\u1edbc b\u1ec1n, h\u1ea5p ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t. L\u01b0u \u00fd ch\u1ecdn \u0111\u00fang d\u1ea1ng hydrat khi t\u00ednh kh\u1ed1i l\u01b0\u1ee3ng.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi alcaloid, antipyrin, cloral hydrat, ch\u00ec acetat, pyrogallol, resorcinol, calci gluconat, ciprofloxacin. Trong h\u1ed7n h\u1ee3p d\u1ecbch ti\u00eam c\u00f3 th\u1ec3 t\u1ea1o t\u1ee7a calci phosphat kh\u00f4ng tan.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      T\u1eeb tricalci phosphat (tro x\u01b0\u01a1ng ho\u1eb7c kho\u00e1ng phosphorit): nghi\u1ec1n m\u1ecbn, x\u1eed l\u00fd acid sulfuric, chi\u1ebft b\u1eb1ng n\u01b0\u1edbc n\u00f3ng, trung h\u00f2a b\u1eb1ng natri carbonat, k\u1ebft tinh t\u1eeb d\u1ecbch l\u1ecdc.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      Phosphat l\u00e0 anion ch\u00ednh c\u1ee7a d\u1ecbch n\u1ed9i b\u00e0o, tham gia nhi\u1ec1u qu\u00e1 tr\u00ecnh sinh l\u00fd; kho\u1ea3ng 2\/3 phosphat u\u1ed1ng v\u00e0o \u0111\u01b0\u1ee3c h\u1ea5p thu, th\u1ea3i g\u1ea7n h\u1ebft qua n\u01b0\u1edbc ti\u1ec3u. D\u00f9ng qu\u00e1 nhi\u1ec1u (nh\u1ea5t l\u00e0 ti\u00eam t\u0129nh m\u1ea1ch, tr\u1ef1c tr\u00e0ng ho\u1eb7c \u1edf ng\u01b0\u1eddi suy th\u1eadn) c\u00f3 th\u1ec3 g\u00e2y t\u0103ng phosphat m\u00e1u d\u1eabn t\u1edbi h\u1ea1 calci m\u00e1u v\u00e0 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i n\u1eb7ng. \u0110\u01b0\u1eddng u\u1ed1ng \u00edt t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i h\u01a1n, nh\u01b0ng phosphat c\u00f3 t\u00e1c d\u1ee5ng nhu\u1eadn tr\u00e0ng mu\u1ed1i nh\u1eb9 \u2013 c\u00f3 th\u1ec3 g\u00e2y ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, n\u00f4n; \u1edf m\u1ee9c t\u00e1 d\u01b0\u1ee3c th\u01b0\u1eddng kh\u00f4ng g\u00e2y t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 17 g\/kg. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 \u0111eo k\u00ednh, g\u0103ng tay.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E339).<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam; truy\u1ec1n; nh\u1ecf m\u0169i, nh\u00e3n khoa, u\u1ed1ng, nh\u1ecf tai, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP (nhi\u1ec1u d\u1ea1ng hydrat).<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> natri dihydrophosphat (monobasic); trinatri phosphat; dikali hydrophosphat (K2<\/sub>HPO4<\/sub>, 174,15; CAS 7758-11-4; E340 \u2013 dung d\u1ecbch 2,08% \u0111\u1eb3ng th\u1ea9m th\u1ea5u).<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Phosphate, Dibasic<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Dinatri hydrophosphat (natri phosphat dibasic, E339) \u2013 ch\u1ea5t \u0111\u1ec7m, c\u00f4 l\u1eadp ion Dinatri hydrophosphat (natri phosphat dibasic, Na2HPO4\u00b7xH2O v\u1edbi x = 0, 1, 2, 7 ho\u1eb7c 12; E339) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t \u0111\u1ec7m v\u00e0 ch\u1ea5t c\u00f4 l\u1eadp ion kim lo\u1ea1i; th\u01b0\u1eddng ph\u1ed1i v\u1edbi natri dihydrophosphat \u0111\u1ec3 t\u1ea1o h\u1ec7 \u0111\u1ec7m phosphat. Th\u00f4ng tin nhanh […]<\/p>","protected":false},"author":1,"featured_media":2623,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2624","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/dinatri-hydrophosphat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Dinatri hydrophosphat (natri phosphat dibasic, E339) \u2013 ch\u1ea5t \u0111\u1ec7m, c\u00f4 l\u1eadp ion Dinatri hydrophosphat (natri phosphat dibasic, Na2HPO4\u00b7xH2O v\u1edbi x = 0, 1, 2, 7 ho\u1eb7c 12; E339) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t \u0111\u1ec7m v\u00e0 ch\u1ea5t c\u00f4 l\u1eadp ion kim lo\u1ea1i; th\u01b0\u1eddng ph\u1ed1i v\u1edbi natri dihydrophosphat \u0111\u1ec3 t\u1ea1o h\u1ec7 \u0111\u1ec7m phosphat. Th\u00f4ng tin nhanh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2624"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2624\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2623"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}