{"id":2622,"date":"2026-09-27T16:52:26","date_gmt":"2026-09-27T09:52:26","guid":{"rendered":"https:\/\/cpc1.vn\/natri-metabisulfit\/"},"modified":"2026-09-27T16:52:26","modified_gmt":"2026-09-27T09:52:26","slug":"natri-metabisulfit","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-metabisulfit\/","title":{"rendered":"Natri metabisulfit (E223) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho ch\u1ebf ph\u1ea9m pH acid"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Natri metabisulfit (E223) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho ch\u1ebf ph\u1ea9m pH acid<\/h1>\n<p><strong>Natri metabisulfit<\/strong> (natri pyrosulfit, Na<sub>2<\/sub>S<sub>2<\/sub>O<sub>5<\/sub>, E223) l\u00e0 <strong>ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong> d\u00f9ng trong thu\u1ed1c u\u1ed1ng, ti\u00eam v\u00e0 d\u00f9ng ngo\u00e0i \u1edf n\u1ed3ng \u0111\u1ed9 <strong>0,01\u20131,0%<\/strong>, ch\u1ee7 y\u1ebfu cho <strong>ch\u1ebf ph\u1ea9m c\u00f3 pH acid<\/strong> (v\u1edbi ch\u1ebf ph\u1ea9m ki\u1ec1m th\u01b0\u1eddng d\u00f9ng natri sulfit). Ngo\u00e0i ra c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng khu\u1ea9n (m\u1ea1nh nh\u1ea5t \u1edf pH acid), d\u00f9ng b\u1ea3o qu\u1ea3n siro.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Sodium pyrosulfite, disodium disulfite, disodium pyrosulfite, sodium acid sulfite, natrii disulfis, E223<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>7681-57-4<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>Na<sub>2<\/sub>S<sub>2<\/sub>O<sub>5<\/sub> \u2013 190,11<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ed1ng oxy h\u00f3a 0,01\u20131,0% trong thu\u1ed1c u\u1ed1ng, ti\u00eam, d\u00f9ng ngo\u00e0i \u2013 ch\u1ee7 y\u1ebfu ch\u1ebf ph\u1ea9m acid.<\/li>\n<li>Quy t\u1eafc ch\u1ecdn: <strong>metabisulfit cho pH th\u1ea5p, bisulfit cho pH trung gian, sulfit cho pH cao<\/strong>.<\/li>\n<li>Ch\u1ea5t b\u1ea3o qu\u1ea3n trong siro u\u1ed1ng.<\/li>\n<li>Th\u1ef1c ph\u1ea9m, s\u1ea3n xu\u1ea5t r\u01b0\u1ee3u vang: ch\u1ed1ng oxy h\u00f3a, b\u1ea3o qu\u1ea3n, ch\u1ed1ng h\u00f3a n\u00e2u \u2013 tr\u00ean kho\u1ea3ng 550 ppm g\u00e2y v\u1ecb nh\u1eadn bi\u1ebft \u0111\u01b0\u1ee3c.<\/li>\n<li>Th\u01b0\u1eddng ch\u1ee9a l\u01b0\u1ee3ng nh\u1ecf natri sulfit v\u00e0 natri sulfat.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>Tinh th\u1ec3 l\u0103ng tr\u1ee5 kh\u00f4ng m\u00e0u ho\u1eb7c b\u1ed9t k\u1ebft tinh tr\u1eafng \u0111\u1ebfn tr\u1eafng kem, m\u00f9i SO<sub>2<\/sub>, v\u1ecb chua m\u1eb7n. K\u1ebft tinh t\u1eeb n\u01b0\u1edbc d\u01b0\u1edbi d\u1ea1ng heptahydrat.<\/li>\n<li>pH dung d\u1ecbch 5%: 3,5\u20135,0; n\u00f3ng ch\u1ea3y k\u00e8m ph\u00e2n h\u1ee7y d\u01b0\u1edbi 150 \u00b0C.<\/li>\n<li>Dung d\u1ecbch 1,38% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh.<\/li>\n<li>\u0110\u1ed9 tan: n\u01b0\u1edbc 1\/1,9 (1\/1,2 \u1edf 100 \u00b0C); d\u1ec5 tan trong glycerin; h\u01a1i tan trong ethanol 95%.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>Ti\u1ebfp x\u00fac kh\u00f4ng kh\u00ed, \u1ea9m b\u1ecb oxy h\u00f3a ch\u1eadm th\u00e0nh natri sulfat, tinh th\u1ec3 r\u00e3 v\u1ee5n. Acid m\u1ea1nh gi\u1ea3i ph\u00f3ng SO<sub>2<\/sub>.<\/li>\n<li>Trong n\u01b0\u1edbc chuy\u1ec3n ngay th\u00e0nh ion Na<sup>+<\/sup> v\u00e0 bisulfit (HSO<sub>3<\/sub><sup>\u2212<\/sup>). Dung d\u1ecbch ph\u00e2n h\u1ee7y trong kh\u00f4ng kh\u00ed, nh\u1ea5t l\u00e0 khi \u0111un \u2013 dung d\u1ecbch c\u1ea7n h\u1ea5p ti\u1ec7t khu\u1ea9n n\u00ean \u0111\u00f3ng v\u00e0o bao b\u00ec \u0111\u00e3 thay kh\u00f4ng kh\u00ed b\u1eb1ng kh\u00ed tr\u01a1 (nit\u01a1). Dextrose l\u00e0m gi\u1ea3m \u0111\u1ed9 b\u1ec1n c\u1ee7a metabisulfit.<\/li>\n<li>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<ul>\n<li>Ph\u1ea3n \u1ee9ng v\u1edbi thu\u1ed1c c\u01b0\u1eddng giao c\u1ea3m v\u00e0 d\u1eabn ch\u1ea5t o- ho\u1eb7c p-hydroxybenzyl alcol t\u1ea1o d\u1eabn ch\u1ea5t acid sulfonic m\u1ea5t ho\u1ea1t t\u00ednh \u2013 quan tr\u1ecdng nh\u1ea5t l\u00e0 epinephrin v\u00e0 d\u1eabn ch\u1ea5t.<\/li>\n<li>T\u01b0\u01a1ng k\u1ef5 v\u1edbi cloramphenicol; l\u00e0m m\u1ea5t ho\u1ea1t t\u00ednh cisplatin trong dung d\u1ecbch; t\u01b0\u01a1ng k\u1ef5 v\u1edbi phenylmercuric acetat khi h\u1ea5p thu\u1ed1c nh\u1ecf m\u1eaft.<\/li>\n<li>C\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi n\u00fat cao su l\u1ecd \u0111a li\u1ec1u \u2013 n\u00ean x\u1eed l\u00fd tr\u01b0\u1edbc n\u00fat b\u1eb1ng dung d\u1ecbch natri metabisulfit.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>B\u00e3o h\u00f2a dung d\u1ecbch NaOH (ho\u1eb7c natri carbonat) b\u1eb1ng SO<sub>2<\/sub> r\u1ed3i k\u1ebft tinh (s\u1ee5c hydro \u0111\u1ec3 lo\u1ea1i kh\u00f4ng kh\u00ed); ho\u1eb7c kh\u1eed n\u01b0\u1edbc natri bisulfit b\u1eb1ng nhi\u1ec7t.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>D\u00f9 d\u00f9ng r\u1ed9ng r\u00e3i, natri metabisulfit v\u00e0 sulfit li\u00ean quan m\u1ed9t s\u1ed1 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i n\u1eb7ng \u0111\u1ebfn t\u1eed vong \u2013 ch\u1ee7 y\u1ebfu ki\u1ec3u qu\u00e1 m\u1eabn (co th\u1eaft ph\u1ebf qu\u1ea3n, ph\u1ea3n v\u1ec7). D\u1ecb \u1ee9ng sulfit \u01b0\u1edbc t\u00ednh 5\u201310% ng\u01b0\u1eddi hen, nh\u01b0ng c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf ng\u01b0\u1eddi kh\u00f4ng hen, kh\u00f4ng ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng.<\/li>\n<li>U\u1ed1ng v\u00e0o b\u1ecb oxy h\u00f3a th\u00e0nh sulfat th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u; c\u00f3 th\u1ec3 k\u00edch \u1ee9ng d\u1ea1 d\u00e0y (gi\u1ea3i ph\u00f3ng acid sulfur\u01a1); l\u01b0\u1ee3ng l\u1edbn g\u00e2y \u0111au qu\u1eb7n, ti\u00eau ch\u1ea3y, r\u1ed1i lo\u1ea1n tu\u1ea7n ho\u00e0n, \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng, t\u1eed vong.<\/li>\n<li>ADI nh\u00f3m sulfit (t\u00ednh theo SO<sub>2<\/sub>) theo JECFA: 0\u20130,7 mg\/kg th\u1ec3 tr\u1ecdng.<\/li>\n<li>LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, t\u0129nh m\u1ea1ch): 0,12 g\/kg. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft \u2013 \u0111eo k\u00ednh, g\u0103ng tay. Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh (TWA 8 gi\u1edd): 5 mg\/m\u00b3.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E223).<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (ngo\u00e0i m\u00e0ng c\u1ee9ng; h\u00edt; ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch; dung d\u1ecbch nh\u1ecf m\u1eaft; u\u1ed1ng, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> kali metabisulfit; natri bisulfit (NaHSO<sub>3<\/sub>, 104,07; CAS 7631-90-5; E222 \u2013 h\u00e0ng th\u01b0\u01a1ng m\u1ea1i th\u01b0\u1eddng ch\u1ee9a l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3 metabisulfit v\u00ec b\u1ec1n h\u01a1n); natri sulfit.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Sodium Metabisulfite<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Natri metabisulfit (E223) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho ch\u1ebf ph\u1ea9m pH acid Natri metabisulfit (natri pyrosulfit, Na2S2O5, E223) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a d\u00f9ng trong thu\u1ed1c u\u1ed1ng, ti\u00eam v\u00e0 d\u00f9ng ngo\u00e0i \u1edf n\u1ed3ng \u0111\u1ed9 0,01\u20131,0%, ch\u1ee7 y\u1ebfu cho ch\u1ebf ph\u1ea9m c\u00f3 pH acid (v\u1edbi ch\u1ebf ph\u1ea9m ki\u1ec1m th\u01b0\u1eddng d\u00f9ng natri sulfit). Ngo\u00e0i ra c\u00f3 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2621,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2622","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-metabisulfit-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri metabisulfit (E223) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a cho ch\u1ebf ph\u1ea9m pH acid Natri metabisulfit (natri pyrosulfit, Na2S2O5, E223) l\u00e0 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a d\u00f9ng trong thu\u1ed1c u\u1ed1ng, ti\u00eam v\u00e0 d\u00f9ng ngo\u00e0i \u1edf n\u1ed3ng \u0111\u1ed9 0,01\u20131,0%, ch\u1ee7 y\u1ebfu cho ch\u1ebf ph\u1ea9m c\u00f3 pH acid (v\u1edbi ch\u1ebf ph\u1ea9m ki\u1ec1m th\u01b0\u1eddng d\u00f9ng natri sulfit). Ngo\u00e0i ra c\u00f3&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2622"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2622\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2621"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}