{"id":2613,"date":"2026-09-27T16:49:28","date_gmt":"2026-09-27T09:49:28","guid":{"rendered":"https:\/\/cpc1.vn\/natri-hyaluronat\/"},"modified":"2026-09-28T21:20:15","modified_gmt":"2026-09-28T14:20:15","slug":"natri-hyaluronat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-hyaluronat\/","title":{"rendered":"Natri hyaluronat (hyaluronan) \u2013 ch\u1ea5t gi\u1eef \u1ea9m, b\u00f4i tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i"},"content":{"rendered":"

Natri hyaluronat (hyaluronan) \u2013 ch\u1ea5t gi\u1eef \u1ea9m, b\u00f4i tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h1>\n

Natri hyaluronat<\/strong> (hyaluronan) l\u00e0 mu\u1ed1i natri c\u1ee7a acid hyaluronic \u2013 glycosaminoglycan g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb disaccharid acid D-glucuronic v\u00e0 N-acetyl-D-glucosamin; l\u00e0 d\u1ea1ng ch\u1ee7 y\u1ebfu c\u1ee7a acid hyaluronic \u1edf pH sinh l\u00fd. Trong b\u00e0o ch\u1ebf d\u00f9ng l\u00e0m ch\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t b\u00f4i tr\u01a1n<\/strong> v\u00e0 c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nHyaluronan, hyaluronate sodium; RITA HA C-1-C<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9067-32-7<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c<\/td>\n(C14<\/sub>H20<\/sub>NO11<\/sub>Na)n<\/sub> \u2013 (401,3)n<\/sub><\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t b\u00f4i tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Trong t\u00e0i li\u1ec7u, “acid hyaluronic” v\u00e0 “natri hyaluronat” th\u01b0\u1eddng d\u00f9ng thay nhau; “hyaluronan” d\u00f9ng khi n\u00f3i chung v\u1ec1 polysaccharid n\u00e0y.<\/p>\n

Applications<\/h2>\n
    \n
  • Gel hyaluronan kh\u00e2u m\u1ea1ch l\u00e0m h\u1ec7 ph\u00e2n ph\u1ed1i thu\u1ed1c.<\/li>\n
  • Nh\u00e3n khoa: l\u00e0 glycosaminoglycan mang \u0111i\u1ec7n \u00e2m ph\u1ed5 bi\u1ebfn nh\u1ea5t trong d\u1ecbch k\u00ednh; t\u01b0\u01a1ng t\u00e1c v\u1edbi ph\u1ee9c DNA d\u1ea1ng polymer v\u00e0 liposom \u2013 gi\u00fap t\u0103ng sinh kh\u1ea3 d\u1ee5ng v\u00e0 th\u1eddi gian l\u01b0u thu\u1ed1c \u1edf m\u1eaft.<\/li>\n
  • Trung t\u00ednh mi\u1ec5n d\u1ecbch \u2013 d\u00f9ng g\u1eafn v\u1eadt li\u1ec7u sinh h\u1ecdc trong k\u1ef9 thu\u1eadt m\u00f4 v\u00e0 ph\u00e2n ph\u1ed1i thu\u1ed1c; \u1ee9ng d\u1ee5ng trong ph\u1eabu thu\u1eadt m\u1ea1ch.<\/li>\n
  • M\u1ef9 ph\u1ea9m (gi\u1eef \u1ea9m). C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c (v\u00ed d\u1ee5 ti\u00eam kh\u1edbp) n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t ho\u1eb7c h\u1ea1t tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0, r\u1ea5t h\u00fat \u1ea9m.<\/li>\n
    • pH dung d\u1ecbch 0,5%: 5,0\u20138,5.<\/li>\n
    • Tan trong n\u01b0\u1edbc \u2013 t\u1ed1c \u0111\u1ed9 tan ph\u1ee5 thu\u1ed9c KLPT (KLPT c\u00e0ng cao tan c\u00e0ng ch\u1eadm, khu\u1ea5y nh\u1eb9 gi\u00fap nhanh h\u01a1n); h\u01a1i tan trong h\u1ed7n h\u1ee3p dung m\u00f4i h\u1eefu c\u01a1\u2013n\u01b0\u1edbc.<\/li>\n
    • Ph.Eur. ki\u1ec3m tra \u0111\u1ed9 nh\u1edbt n\u1ed9i t\u1ea1i, glycosaminoglycan sulfat h\u00f3a, acid nucleic, protein (\u2264 0,3%; < 0,1% cho d\u1ea1ng ti\u00eam), n\u1ed9i \u0111\u1ed9c t\u1ed1 (\u2264 0,5 IU\/mg cho d\u1ea1ng ti\u00eam).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t; b\u1ed9t b\u1ec1n 3 n\u0103m trong bao b\u00ec ch\u01b0a m\u1edf.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      C\u00f3 trong d\u1ecbch k\u00ednh, huy\u1ebft thanh, m\u00e0o g\u00e0, da c\u00e1 m\u1eadp, s\u1ee5n c\u00e1 voi; th\u01b0\u1eddng chi\u1ebft v\u00e0 tinh ch\u1ebf t\u1eeb m\u00e0o g\u00e0. Ho\u1eb7c l\u00ean men ch\u1ee7ng Streptococcus zooepidemicus<\/em> ch\u1ecdn l\u1ecdc: l\u1ecdc t\u00e1ch kh\u1ecfi m\u00f4i tr\u01b0\u1eddng l\u00ean men, tinh ch\u1ebf b\u1eb1ng si\u00eau l\u1ecdc, k\u1ebft t\u1ee7a b\u1eb1ng dung m\u00f4i h\u1eefu c\u01a1 v\u00e0 s\u1ea5y kh\u00f4.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng trong m\u1ef9 ph\u1ea9m, thu\u1ed1c d\u00f9ng ngo\u00e0i, ti\u00eam v\u00e0 nh\u00e3n khoa; n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. \u0110\u01b0\u1ee3c b\u00e1o c\u00e1o g\u00e2y qu\u00e1i thai tr\u00ean th\u1ef1c nghi\u1ec7m. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, ti\u00eam ph\u00fac m\u1ea1c): 1,77 g\/kg. Khi \u0111un \u0111\u1ebfn ph\u00e2n h\u1ee7y t\u1ecfa kh\u00f3i \u0111\u1ed9c Na2<\/sub>O.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (gel d\u00f9ng ngo\u00e0i).<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP v\u00e0 Ph.Eur.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> acid hyaluronic, natri chondroitin sulfat.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Hyaluronate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Natri hyaluronat (hyaluronan) \u2013 ch\u1ea5t gi\u1eef \u1ea9m, b\u00f4i tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Natri hyaluronat (hyaluronan) l\u00e0 mu\u1ed1i natri c\u1ee7a acid hyaluronic \u2013 glycosaminoglycan g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb disaccharid acid D-glucuronic v\u00e0 N-acetyl-D-glucosamin; l\u00e0 d\u1ea1ng ch\u1ee7 y\u1ebfu c\u1ee7a acid hyaluronic \u1edf pH sinh l\u00fd. Trong b\u00e0o ch\u1ebf d\u00f9ng l\u00e0m ch\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t b\u00f4i […]<\/p>","protected":false},"author":1,"featured_media":2612,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2613","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-hyaluronat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri hyaluronat (hyaluronan) \u2013 ch\u1ea5t gi\u1eef \u1ea9m, b\u00f4i tr\u01a1n, c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i Natri hyaluronat (hyaluronan) l\u00e0 mu\u1ed1i natri c\u1ee7a acid hyaluronic \u2013 glycosaminoglycan g\u1ed3m c\u00e1c \u0111\u01a1n v\u1ecb disaccharid acid D-glucuronic v\u00e0 N-acetyl-D-glucosamin; l\u00e0 d\u1ea1ng ch\u1ee7 y\u1ebfu c\u1ee7a acid hyaluronic \u1edf pH sinh l\u00fd. Trong b\u00e0o ch\u1ebf d\u00f9ng l\u00e0m ch\u1ea5t gi\u1eef \u1ea9m, ch\u1ea5t b\u00f4i…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2613"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2613\/revisions"}],"predecessor-version":[{"id":3317,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2613\/revisions\/3317"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2612"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}