{"id":2609,"date":"2026-09-27T16:48:20","date_gmt":"2026-09-27T09:48:20","guid":{"rendered":"https:\/\/cpc1.vn\/natri-citrat\/"},"modified":"2026-09-27T16:48:20","modified_gmt":"2026-09-27T09:48:20","slug":"natri-citrat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-citrat\/","title":{"rendered":"Natri citrat dihydrat (E331) \u2013 ch\u1ea5t \u0111\u1ec7m, ki\u1ec1m h\u00f3a, c\u00f4 l\u1eadp ion kim lo\u1ea1i"},"content":{"rendered":"

Natri citrat dihydrat (E331) \u2013 ch\u1ea5t \u0111\u1ec7m, ki\u1ec1m h\u00f3a, c\u00f4 l\u1eadp ion kim lo\u1ea1i<\/h1>\n

Natri citrat<\/strong> (trinatri citrat, E331) \u2013 d\u1ea1ng dihydrat ho\u1eb7c khan \u2013 d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m l\u00e0m ch\u1ea5t \u0111\u1ec7m, ki\u1ec1m h\u00f3a<\/strong> v\u00e0 c\u00f4 l\u1eadp ion kim lo\u1ea1i<\/strong>; d\u1ea1ng khan d\u00f9ng trong vi\u00ean s\u1ee7i; natri citrat c\u00f2n l\u00e0 ch\u1ea5t ch\u1ed1ng \u0111\u00f4ng m\u00e1u (ri\u00eang ho\u1eb7c ph\u1ed1i citrat kh\u00e1c).<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nTrisodium citrate, citric acid trisodium salt, sodium citrate tertiary, E331<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n6132-04-3 (dihydrat); 68-04-2 (khan)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC6<\/sub>H5<\/sub>Na3<\/sub>O7<\/sub>\u00b72H2<\/sub>O \u2013 294,10; khan 258,07<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ki\u1ec1m h\u00f3a, ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t c\u00f4 l\u1eadp ion kim lo\u1ea1i<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n\n\n\n\n\n\n\n\n
C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Ch\u1ea5t \u0111\u1ec7m<\/td>\n0,3\u20132,0<\/td>\n<\/tr>\n
Thu\u1ed1c ti\u00eam<\/td>\n0,02\u20134,0<\/td>\n<\/tr>\n
Dung d\u1ecbch nh\u1ecf m\u1eaft<\/td>\n0,1\u20132,0<\/td>\n<\/tr>\n
Ch\u1ea5t c\u00f4 l\u1eadp ion kim lo\u1ea1i<\/td>\n0,3\u20132,0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • Th\u1ef1c ph\u1ea9m: ch\u1ee7 y\u1ebfu \u0111i\u1ec1u ch\u1ec9nh pH, c\u00f4 l\u1eadp ion.<\/li>\n
  • D\u1ea1ng khan trong vi\u00ean s\u1ee7i.<\/li>\n
  • C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Tinh th\u1ec3 \u0111\u01a1n t\u00e0 kh\u00f4ng m\u00e0u ho\u1eb7c b\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng m\u00f9i, v\u1ecb m\u00e1t m\u1eb7n. H\u01a1i ch\u1ea3y r\u1eefa trong kh\u00f4ng kh\u00ed \u1ea9m, l\u00ean hoa trong kh\u00f4ng kh\u00ed kh\u00f4 \u1ea5m. USP ch\u1ea5p nh\u1eadn c\u1ea3 d\u1ea1ng dihydrat v\u00e0 khan; h\u1ea7u h\u1ebft d\u01b0\u1ee3c \u0111i\u1ec3n kh\u00e1c quy \u0111\u1ecbnh d\u1ea1ng dihydrat.<\/li>\n
    • pH dung d\u1ecbch 5%: 7,0\u20139,0; chuy\u1ec3n th\u00e0nh d\u1ea1ng khan \u1edf 150 \u00b0C; t\u1ef7 tr\u1ecdng th\u1ef1c 1,19 g\/cm\u00b3.<\/li>\n
    • Dung d\u1ecbch 3,02% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh.<\/li>\n
    • Tan 1\/1,5 trong n\u01b0\u1edbc (1\/0,6 trong n\u01b0\u1edbc s\u00f4i); h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol 95%.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n. Dung d\u1ecbch n\u01b0\u1edbc ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c b\u1eb1ng h\u1ea5p; khi b\u1ea3o qu\u1ea3n c\u00f3 th\u1ec3 l\u00e0m bong ti\u1ec3u ph\u00e2n r\u1eafn nh\u1ecf t\u1eeb bao b\u00ec th\u1ee7y tinh. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Dung d\u1ecbch h\u01a1i ki\u1ec1m, ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t acid. C\u00f3 th\u1ec3 l\u00e0m t\u1ee7a mu\u1ed1i alcaloid kh\u1ecfi dung d\u1ecbch n\u01b0\u1edbc ho\u1eb7c n\u01b0\u1edbc\u2013c\u1ed3n. Mu\u1ed1i calci, stronti g\u00e2y t\u1ee7a citrat t\u01b0\u01a1ng \u1ee9ng. T\u01b0\u01a1ng k\u1ef5 v\u1edbi base, ch\u1ea5t kh\u1eed, ch\u1ea5t oxy h\u00f3a.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Th\u00eam natri carbonat v\u00e0o dung d\u1ecbch acid citric \u0111\u1ebfn khi h\u1ebft s\u1ee7i, l\u1ecdc v\u00e0 c\u00f4 kh\u00f4.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      Sau khi u\u1ed1ng \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0 chuy\u1ec3n h\u00f3a th\u00e0nh bicarbonat; n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng, d\u00f9 d\u00f9ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 g\u00e2y kh\u00f3 ch\u1ecbu ti\u00eau h\u00f3a, ti\u00eau ch\u1ea3y. Citrat v\u00e0 acid citric l\u00e0m t\u0103ng h\u1ea5p thu nh\u00f4m \u1edf ru\u1ed9t \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn \u2013 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nh\u00f4m huy\u1ebft thanh c\u00f3 h\u1ea1i; khuy\u1ebfn ngh\u1ecb b\u1ec7nh nh\u00e2n suy th\u1eadn \u0111ang d\u00f9ng h\u1ee3p ch\u1ea5t nh\u00f4m kh\u00f4ng d\u00f9ng s\u1ea3n ph\u1ea9m ch\u1ee9a citrat. LD50<\/sub> natri citrat khan (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 0,17 g\/kg. B\u1ee5i c\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, h\u00f4 h\u1ea5p \u2013 \u0111eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay; l\u00e0m vi\u1ec7c n\u01a1i th\u00f4ng gi\u00f3 ho\u1eb7c \u0111eo kh\u1ea9u trang.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E331).<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (h\u00edt, ti\u00eam, nh\u00e3n khoa, dung d\u1ecbch, h\u1ed7n d\u1ecbch, siro, vi\u00ean n\u00e9n u\u1ed1ng, nh\u1ecf m\u0169i, nh\u1ecf tai, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, qua da, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> natri citrat khan, acid citric monohydrat, kali citrat.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Citrate Dihydrate<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Natri citrat dihydrat (E331) \u2013 ch\u1ea5t \u0111\u1ec7m, ki\u1ec1m h\u00f3a, c\u00f4 l\u1eadp ion kim lo\u1ea1i Natri citrat (trinatri citrat, E331) \u2013 d\u1ea1ng dihydrat ho\u1eb7c khan \u2013 d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m l\u00e0m ch\u1ea5t \u0111\u1ec7m, ki\u1ec1m h\u00f3a v\u00e0 c\u00f4 l\u1eadp ion kim lo\u1ea1i; d\u1ea1ng khan d\u00f9ng trong vi\u00ean s\u1ee7i; natri citrat c\u00f2n l\u00e0 ch\u1ea5t ch\u1ed1ng \u0111\u00f4ng […]<\/p>","protected":false},"author":1,"featured_media":2608,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2609","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-citrat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri citrat dihydrat (E331) \u2013 ch\u1ea5t \u0111\u1ec7m, ki\u1ec1m h\u00f3a, c\u00f4 l\u1eadp ion kim lo\u1ea1i Natri citrat (trinatri citrat, E331) \u2013 d\u1ea1ng dihydrat ho\u1eb7c khan \u2013 d\u00f9ng r\u1ed9ng r\u00e3i trong d\u01b0\u1ee3c ph\u1ea9m l\u00e0m ch\u1ea5t \u0111\u1ec7m, ki\u1ec1m h\u00f3a v\u00e0 c\u00f4 l\u1eadp ion kim lo\u1ea1i; d\u1ea1ng khan d\u00f9ng trong vi\u00ean s\u1ee7i; natri citrat c\u00f2n l\u00e0 ch\u1ea5t ch\u1ed1ng \u0111\u00f4ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2609"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2609\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2608"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}