{"id":2607,"date":"2026-09-27T16:47:43","date_gmt":"2026-09-27T09:47:43","guid":{"rendered":"https:\/\/cpc1.vn\/natri-clorid\/"},"modified":"2026-09-27T16:47:43","modified_gmt":"2026-09-27T09:47:43","slug":"natri-clorid","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-clorid\/","title":{"rendered":"Natri clorid \u2013 ch\u1ea5t \u0111\u1eb3ng tr\u01b0\u01a1ng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, ch\u1ea5t th\u1ea9m th\u1ea5u trong vi\u00ean ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng"},"content":{"rendered":"

Natri clorid \u2013 ch\u1ea5t \u0111\u1eb3ng tr\u01b0\u01a1ng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, ch\u1ea5t th\u1ea9m th\u1ea5u trong vi\u00ean ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng<\/h1>\n

Natri clorid<\/strong> (NaCl) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam; vai tr\u00f2 ch\u00ednh l\u00e0 t\u1ea1o dung d\u1ecbch \u0111\u1eb3ng tr\u01b0\u01a1ng<\/strong> (0,9% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh). Ngo\u00e0i ra NaCl l\u00e0 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n<\/strong>, t\u00e1 d\u01b0\u1ee3c tr\u01a1n tan trong n\u01b0\u1edbc, ch\u1ea5t t\u1ea1o k\u00eanh v\u00e0 t\u00e1c nh\u00e2n th\u1ea9m th\u1ea5u<\/strong> trong vi\u00ean gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nCommon salt, rock salt, sea salt, table salt, halite, saline; Alberger<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n7647-14-5<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nNaCl \u2013 58,44<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nT\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n v\u00e0 nang, ch\u1ea5t \u0111\u1eb3ng tr\u01b0\u01a1ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n\n\n\n\n\n\n\n\n\n
C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
T\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n nang<\/td>\n10\u201380<\/td>\n<\/tr>\n
Keo t\u1ee5 c\u00f3 ki\u1ec3m so\u00e1t h\u1ed7n d\u1ecbch<\/td>\n\u2264 1<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean d\u1eadp th\u1eb3ng<\/td>\n10\u201380<\/td>\n<\/tr>\n
T\u1ea1o dung d\u1ecbch \u0111\u1eb3ng tr\u01b0\u01a1ng (ti\u00eam t\u0129nh m\u1ea1ch, nh\u1ecf m\u1eaft)<\/td>\n\u2264 0,9<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c tr\u01a1n tan trong n\u01b0\u1edbc<\/td>\n5\u201320<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • Tr\u01b0\u1edbc \u0111\u00e2y d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c tr\u01a1n v\u00e0 \u0111\u1ed9n trong nang, vi\u00ean d\u1eadp th\u1eb3ng (nay \u00edt d\u00f9ng).<\/li>\n
  • Ch\u1ea5t t\u1ea1o k\u00eanh v\u00e0 t\u00e1c nh\u00e2n th\u1ea9m th\u1ea5u trong nh\u00e2n vi\u00ean gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t (b\u01a1m th\u1ea9m th\u1ea5u); \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ed9 x\u1ed1p m\u00e0ng bao; ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng t\u1eeb vi nang, gel, nh\u0169 t\u01b0\u01a1ng.<\/li>\n
  • Th\u00eam v\u00e0o d\u1ecbch phun bao ch\u1ee9a HPC ho\u1eb7c HPMC \u0111\u1ec3 h\u1ea1n ch\u1ebf k\u1ebft t\u1ee5 ti\u1ec3u ph\u00e2n; \u0111i\u1ec1u ch\u1ec9nh k\u00edch th\u01b0\u1edbc micelle v\u00e0 \u0111\u1ed9 nh\u1edbt c\u1ee7a ph\u00e2n t\u00e1n polymer qua l\u1ef1c ion.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c tinh th\u1ec3 kh\u00f4ng m\u00e0u, v\u1ecb m\u1eb7n; m\u1ea1ng l\u1eadp ph\u01b0\u01a1ng t\u00e2m m\u1eb7t; kh\u00f4ng c\u00f3 n\u01b0\u1edbc k\u1ebft tinh (d\u01b0\u1edbi 0 \u00b0C c\u00f3 th\u1ec3 k\u1ebft tinh d\u1ea1ng dihydrat).<\/li>\n
    • pH dung d\u1ecbch b\u00e3o h\u00f2a 6,7\u20137,3; n\u00f3ng ch\u1ea3y 804 \u00b0C; s\u00f4i 1413 \u00b0C; t\u1ef7 tr\u1ecdng 2,17 g\/cm\u00b3; t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,93, g\u00f5 1,09 g\/cm\u00b3; g\u00f3c ngh\u1ec9 38\u00b0 (tinh th\u1ec3 l\u1eadp ph\u01b0\u01a1ng); \u0111\u1ed9 c\u1ee9ng Mohs 2\u20132,5.<\/li>\n
    • Kh\u1ea3 n\u0103ng ch\u1ecbu n\u00e9n: b\u1ed9t d\u01b0\u1edbi 30 \u00b5m t\u1ea1o vi\u00ean do bi\u1ebfn d\u1ea1ng d\u1ebbo; l\u1edbn h\u01a1n th\u00ec c\u1ea3 bi\u1ebfn d\u1ea1ng d\u1ebbo v\u00e0 v\u1ee1.<\/li>\n
    • H\u00fat \u1ea9m tr\u00ean 75% \u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i (dung d\u1ecbch b\u00e3o h\u00f2a c\u00e2n b\u1eb1ng v\u1edbi 75,3% RH).<\/li>\n
    • Dung d\u1ecbch 0,9% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh; \u0111\u1ed9 nh\u1edbt dung d\u1ecbch 10%: 1,19 mPa\u00b7s.<\/li>\n
    • \u0110\u1ed9 tan: n\u01b0\u1edbc 1\/2,8 (1\/2,6 \u1edf 100 \u00b0C); glycerin 1\/10; ethanol 95% 1\/250; h\u01a1i tan trong ethanol.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Dung d\u1ecbch n\u01b0\u1edbc b\u1ec1n nh\u01b0ng c\u00f3 th\u1ec3 l\u00e0m bong m\u1ea3nh th\u1ee7y tinh t\u1eeb m\u1ed9t s\u1ed1 lo\u1ea1i bao b\u00ec th\u1ee7y tinh; ti\u1ec7t khu\u1ea9n b\u1eb1ng h\u1ea5p ho\u1eb7c l\u1ecdc. Ch\u1ea5t r\u1eafn b\u1ec1n \u2013 b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t. \u0110\u1ed9 \u1ea9m khi b\u1ea3o qu\u1ea3n NaCl \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng n\u00e9n v\u00e0 c\u01a1 t\u00ednh c\u1ee7a vi\u00ean.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Dung d\u1ecbch \u0103n m\u00f2n s\u1eaft; t\u1ea1o t\u1ee7a v\u1edbi mu\u1ed1i b\u1ea1c, ch\u00ec, th\u1ee7y ng\u00e2n; ch\u1ea5t oxy h\u00f3a m\u1ea1nh gi\u1ea3i ph\u00f3ng clor t\u1eeb dung d\u1ecbch NaCl \u0111\u00e3 acid h\u00f3a. L\u00e0m gi\u1ea3m \u0111\u1ed9 tan c\u1ee7a methylparaben; l\u00e0m gi\u1ea3m \u0111\u1ed9 nh\u1edbt gel carbomer v\u00e0 dung d\u1ecbch hydroxyethyl cellulose, hydroxypropyl cellulose.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      C\u00f3 trong t\u1ef1 nhi\u00ean d\u01b0\u1edbi d\u1ea1ng kho\u00e1ng halit; th\u01b0\u01a1ng m\u1ea1i thu b\u1eb1ng bay h\u01a1i n\u01b0\u1edbc bi\u1ec3n b\u1eb1ng n\u0103ng l\u01b0\u1ee3ng m\u1eb7t tr\u1eddi, khai th\u00e1c m\u1ecf ho\u1eb7c bay h\u01a1i n\u01b0\u1edbc mu\u1ed1i t\u1eeb m\u1ecf mu\u1ed1i ng\u1ea7m.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      L\u00e0 mu\u1ed1i quan tr\u1ecdng nh\u1ea5t duy tr\u00ec \u00e1p l\u1ef1c th\u1ea9m th\u1ea5u c\u1ee7a m\u00e1u v\u00e0 m\u00f4; kh\u1ea9u ph\u1ea7n ng\u01b0\u1eddi l\u1edbn kho\u1ea3ng 5\u201312 g\/ng\u00e0y. L\u00e0m t\u00e1 d\u01b0\u1ee3c v\u1ec1 c\u01a1 b\u1ea3n kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; tuy nhi\u00ean u\u1ed1ng 0,5\u20131,0 g\/kg \u1edf ng\u01b0\u1eddi l\u1edbn c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c \u2013 k\u00edch \u1ee9ng ti\u00eau h\u00f3a, n\u00f4n, t\u0103ng natri m\u00e1u, suy h\u00f4 h\u1ea5p, co gi\u1eadt ho\u1eb7c t\u1eed vong khi l\u01b0\u1ee3ng l\u1edbn. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 3,0 g\/kg. \u0110un \u1edf nhi\u1ec7t \u0111\u1ed9 cao t\u1ecfa h\u01a1i k\u00edch \u1ee9ng m\u1eaft.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • GRAS.<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c ti\u00eam; h\u00edt; nh\u1ecf m\u0169i, nh\u00e3n khoa, u\u1ed1ng, nh\u1ecf tai, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> kali clorid. Mu\u1ed1i \u0103n gia d\u1ee5ng c\u00f3 th\u1ec3 ch\u1ee9a natri iodid v\u00e0 ch\u1ea5t ch\u1ed1ng v\u00f3n \u2013 kh\u00f4ng d\u00f9ng thay c\u1ea5p d\u01b0\u1ee3c d\u1ee5ng.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Chloride<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Natri clorid \u2013 ch\u1ea5t \u0111\u1eb3ng tr\u01b0\u01a1ng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, ch\u1ea5t th\u1ea9m th\u1ea5u trong vi\u00ean ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng Natri clorid (NaCl) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam; vai tr\u00f2 ch\u00ednh l\u00e0 t\u1ea1o dung d\u1ecbch \u0111\u1eb3ng tr\u01b0\u01a1ng (0,9% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh). Ngo\u00e0i ra NaCl l\u00e0 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, t\u00e1 […]<\/p>","protected":false},"author":1,"featured_media":2606,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2607","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-clorid-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri clorid \u2013 ch\u1ea5t \u0111\u1eb3ng tr\u01b0\u01a1ng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, ch\u1ea5t th\u1ea9m th\u1ea5u trong vi\u00ean ki\u1ec3m so\u00e1t gi\u1ea3i ph\u00f3ng Natri clorid (NaCl) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam; vai tr\u00f2 ch\u00ednh l\u00e0 t\u1ea1o dung d\u1ecbch \u0111\u1eb3ng tr\u01b0\u01a1ng (0,9% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh). Ngo\u00e0i ra NaCl l\u00e0 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n, t\u00e1…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2607"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2607\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2606"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}