{"id":2603,"date":"2026-09-27T16:46:18","date_gmt":"2026-09-27T09:46:18","guid":{"rendered":"https:\/\/cpc1.vn\/natri-bicarbonat\/"},"modified":"2026-09-27T16:46:18","modified_gmt":"2026-09-27T09:46:18","slug":"natri-bicarbonat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-bicarbonat\/","title":{"rendered":"Natri bicarbonat \u2013 ngu\u1ed3n CO2 cho vi\u00ean s\u1ee7i, ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m"},"content":{"rendered":"

Natri bicarbonat \u2013 ngu\u1ed3n CO2 cho vi\u00ean s\u1ee7i, ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m<\/h1>\n

Natri bicarbonat<\/strong> (NaHCO3<\/sub>, E500, baking soda) \u0111\u01b0\u1ee3c d\u00f9ng trong b\u00e0o ch\u1ebf ch\u1ee7 y\u1ebfu l\u00e0m ngu\u1ed3n CO2<\/sub> cho vi\u00ean s\u1ee7i, c\u1ed1m s\u1ee7i<\/strong> v\u00e0 \u0111\u1ec3 t\u1ea1o ho\u1eb7c duy tr\u00ec pH ki\u1ec1m<\/strong>; ngo\u00e0i ra l\u00e0 ch\u1ea5t \u0111\u1ec7m trong vi\u00ean n\u00e9n v\u00e0 dung d\u1ecbch ti\u00eam.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nSodium hydrogen carbonate, sodium acid carbonate, monosodium carbonate, baking soda, Sal de Vichy, E500; Effer-Soda<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n144-55-8<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nNaHCO3<\/sub> \u2013 84,01<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t ki\u1ec1m h\u00f3a (\u0111\u1ed3ng th\u1eddi l\u00e0 d\u01b0\u1ee3c ch\u1ea5t)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n\n\n\n\n\n\n\n
C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
\u0110\u1ec7m trong vi\u00ean n\u00e9n<\/td>\n10\u201340<\/td>\n<\/tr>\n
Vi\u00ean s\u1ee7i<\/td>\n25\u201350<\/td>\n<\/tr>\n
Dung d\u1ecbch ti\u00eam\/truy\u1ec1n \u0111\u1eb3ng tr\u01b0\u01a1ng<\/td>\n1,39<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • Vi\u00ean s\u1ee7i, c\u1ed1m s\u1ee7i:<\/strong> th\u01b0\u1eddng ph\u1ed1i acid citric v\u00e0\/ho\u1eb7c tartaric \u2013 ph\u1ed1i c\u1ea3 hai th\u01b0\u1eddng \u0111\u01b0\u1ee3c \u01b0a v\u00ec acid citric ri\u00eang t\u1ea1o h\u1ed7n h\u1ee3p d\u00ednh kh\u00f3 x\u00e1t h\u1ea1t, c\u00f2n acid tartaric ri\u00eang l\u00e0m c\u1ed1m k\u00e9m ch\u1eafc. G\u1eb7p n\u01b0\u1edbc, ph\u1ea3n \u1ee9ng gi\u1ea3i ph\u00f3ng CO2<\/sub> l\u00e0m r\u00e3. T\u1ea1o h\u1ea1t n\u00f3ng ch\u1ea3y trong t\u1ea7ng s\u00f4i (acid citric khan + NaHCO3<\/sub>) l\u00e0 ph\u01b0\u01a1ng ph\u00e1p m\u1ed9t b\u01b0\u1edbc.<\/li>\n
  • Vi\u00ean ch\u1ec9 c\u00f3 NaHCO3<\/sub> v\u1eabn s\u1ee7i nh\u1edd acid d\u1ea1 d\u00e0y. \u0110\u1ec7m cho d\u01b0\u1ee3c ch\u1ea5t acid y\u1ebfu trong vi\u00ean n\u00e9n, t\u0103ng t\u1ed1c \u0111\u1ed9 h\u00f2a tan, gi\u1ea3m k\u00edch \u1ee9ng d\u1ea1 d\u00e0y.<\/li>\n
  • \u0110\u1ec7m trong dung d\u1ecbch erythromycin, lidocain, thu\u1ed1c t\u00ea, d\u1ecbch nu\u00f4i d\u01b0\u1ee1ng t\u0129nh m\u1ea1ch; t\u1ea1o mu\u1ed1i natri tan t\u1ed1t c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t (v\u00ed d\u1ee5 niacin); ch\u1ea5t \u1ed5n \u0111\u1ecbnh \u0111\u00f4ng kh\u00f4; kem \u0111\u00e1nh r\u0103ng.<\/li>\n
  • Ch\u1ea5t sinh kh\u00ed trong h\u1ec7 b\u00e8 alginat v\u00e0 d\u1ea1ng n\u1ed5i gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t (furosemid, cisaprid); t\u0103ng h\u1ea5p thu paracetamol; c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh levothyroxin.<\/li>\n
  • Th\u1ef1c ph\u1ea9m: ch\u1ea5t ki\u1ec1m, ch\u1ea5t l\u00e0m n\u1edf. C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng m\u00f9i, v\u1ecb m\u1eb7n h\u01a1i ki\u1ec1m; tinh th\u1ec3 l\u0103ng tr\u1ee5 \u0111\u01a1n t\u00e0. C\u00f3 nhi\u1ec1u c\u1ea5p c\u1ee1 h\u1ea1t t\u1eeb b\u1ed9t m\u1ecbn \u0111\u1ebfn h\u1ea1t \u0111\u1ed3ng \u0111\u1ec1u tr\u01a1n ch\u1ea3y.<\/li>\n
    • pH dung d\u1ecbch 0,1 M m\u1edbi pha 8,3 (25 \u00b0C), t\u0103ng d\u1ea7n khi \u0111\u1ec3 l\u00e2u, l\u1eafc ho\u1eb7c \u0111un.<\/li>\n
    • T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,869, g\u00f5 1,369, th\u1ef1c 2,173 g\/cm\u00b3; n\u00f3ng ch\u1ea3y 270 \u00b0C (ph\u00e2n h\u1ee7y).<\/li>\n
    • \u0110\u1ed9 \u1ea9m d\u01b0\u1edbi 1% khi \u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i d\u01b0\u1edbi 80%; tr\u00ean 85% h\u00fat \u1ea9m m\u1ea1nh v\u00e0 c\u00f3 th\u1ec3 b\u1eaft \u0111\u1ea7u ph\u00e2n h\u1ee7y m\u1ea5t CO2<\/sub>.<\/li>\n
    • Dung d\u1ecbch 1,39% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh.<\/li>\n
    • Tan 1\/11 trong n\u01b0\u1edbc; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol 95%, ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • \u0110un \u0111\u1ebfn kho\u1ea3ng 50 \u00b0C b\u1eaft \u0111\u1ea7u ph\u00e2n ly th\u00e0nh CO2<\/sub>, natri carbonat v\u00e0 n\u01b0\u1edbc; \u1edf 250\u2013300 \u00b0C chuy\u1ec3n ho\u00e0n to\u00e0n th\u00e0nh natri carbonat khan trong th\u1eddi gian ng\u1eafn (93 \u00b0C: 90% sau 75 ph\u00fat) \u2013 l\u01b0u \u00fd khi s\u1ea5y c\u1ed1m.<\/li>\n
      • B\u1ed9t b\u1ec1n d\u01b0\u1edbi 76% \u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i \u1edf 25 \u00b0C v\u00e0 d\u01b0\u1edbi 48% \u1edf 40 \u00b0C.<\/li>\n
      • Dung d\u1ecbch n\u01b0\u1edbc ph\u00e2n h\u1ee7y ch\u1eadm \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng th\u00e0nh carbonat, nhanh h\u01a1n khi l\u1eafc ho\u1eb7c \u0111un. Ti\u1ec7t khu\u1ea9n b\u1eb1ng l\u1ecdc ho\u1eb7c h\u1ea5p \u2013 khi h\u1ea5p, s\u1ee5c CO2<\/sub> v\u00e0o dung d\u1ecbch trong bao b\u00ec cu\u1ed1i, h\u00e0n k\u00edn r\u1ed3i h\u1ea5p, v\u00e0 kh\u00f4ng m\u1edf \u00edt nh\u1ea5t 2 gi\u1edd sau khi ngu\u1ed9i \u0111\u1ec3 bicarbonat t\u00e1i t\u1ea1o.<\/li>\n
      • Dung d\u1ecbch trong th\u1ee7y tinh c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n m\u1ea3nh th\u1ee7y tinh nh\u1ecf; c\u1eb7n calci carbonat sau h\u1ea5p c\u00f3 th\u1ec3 h\u1ea1n ch\u1ebf b\u1eb1ng 0,01\u20130,02% dinatri edetat.<\/li>\n
      • B\u1ec1n trong kh\u00f4ng kh\u00ed kh\u00f4, ph\u00e2n h\u1ee7y ch\u1eadm trong kh\u00f4ng kh\u00ed \u1ea9m \u2013 b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n
          \n
        • Ph\u1ea3n \u1ee9ng v\u1edbi acid, mu\u1ed1i acid v\u00e0 nhi\u1ec1u mu\u1ed1i alcaloid, gi\u1ea3i ph\u00f3ng CO2<\/sub>; l\u00e0m t\u0103ng s\u1eabm m\u00e0u salicylat.<\/li>\n
        • Trong h\u1ed7n h\u1ee3p b\u1ed9t, \u1ea9m kh\u00f4ng kh\u00ed ho\u1eb7c n\u01b0\u1edbc k\u1ebft tinh c\u1ee7a th\u00e0nh ph\u1ea7n kh\u00e1c \u0111\u1ee7 \u0111\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi acid boric, ph\u00e8n.<\/li>\n
        • Trong dung d\u1ecbch t\u01b0\u01a1ng k\u1ef5 v\u1edbi nhi\u1ec1u d\u01b0\u1ee3c ch\u1ea5t nh\u01b0 ciprofloxacin, amiodaron, nicardipin, levofloxacin.<\/li>\n<\/ul>\n

          S\u1ea3n xu\u1ea5t<\/h2>\n

          S\u1ee5c CO2<\/sub> v\u00e0o dung d\u1ecbch natri carbonat b\u00e3o h\u00f2a l\u1ea1nh, ho\u1eb7c theo quy tr\u00ecnh amoniac\u2013soda (Solvay): s\u1ee5c amoniac r\u1ed3i CO2<\/sub> v\u00e0o dung d\u1ecbch natri clorid \u0111\u1ec3 t\u1ee7a NaHCO3<\/sub>.<\/p>\n

          An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

          \u0110\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh ion natri (th\u1ea3i qua th\u1eadn) v\u00e0 bicarbonat (v\u00e0o kho d\u1ef1 tr\u1eef bicarbonat); CO2<\/sub> th\u1ea3i qua ph\u1ed5i. D\u00f9ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 g\u00e2y nhi\u1ec5m ki\u1ec1m chuy\u1ec3n h\u00f3a ho\u1eb7c qu\u00e1 t\u1ea3i natri \u2013 l\u01b0\u1ee3ng natri trong thu\u1ed1c kh\u00e1ng acid, ch\u1ebf ph\u1ea9m s\u1ee7i \u0111\u1ee7 l\u00e0m n\u1eb7ng suy tim m\u1ea1n, nh\u1ea5t l\u00e0 \u1edf ng\u01b0\u1eddi cao tu\u1ed5i. U\u1ed1ng trung h\u00f2a acid d\u1ea1 d\u00e0y, sinh CO2<\/sub> c\u00f3 th\u1ec3 g\u00e2y co th\u1eaft d\u1ea1 d\u00e0y, \u0111\u1ea7y h\u01a1i. L\u00e0m t\u00e1 d\u01b0\u1ee3c n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 v\u1ec1 c\u01a1 b\u1ea3n kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 4,22 g\/kg. \u0110eo k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 g\u0103ng tay.<\/p>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E500).<\/li>\n
          • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c ti\u00eam; nh\u00e3n khoa; nang, dung d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng); c\u00f3 trong thu\u1ed1c ti\u00eam (truy\u1ec1n, ti\u00eam t\u0129nh m\u1ea1ch) v\u00e0 kh\u00f4ng ti\u00eam (nh\u1ecf tai, r\u1eeda m\u1eaft, nang, vi\u00ean nhai, b\u1ed9t s\u1ee7i, vi\u00ean s\u1ee7i, c\u1ed1m, vi\u00ean n\u00e9n, thu\u1ed1c \u0111\u1eb7t, h\u1ed7n d\u1ecbch) \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh.<\/li>\n
          • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n

            Ch\u1ea5t li\u00ean quan:<\/strong> kali bicarbonat, natri carbonat, acid citric, acid tartric.<\/p>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Bicarbonate<\/em> trong:
            \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
            \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
            \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
            \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
            \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Natri bicarbonat \u2013 ngu\u1ed3n CO2 cho vi\u00ean s\u1ee7i, ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m Natri bicarbonat (NaHCO3, E500, baking soda) \u0111\u01b0\u1ee3c d\u00f9ng trong b\u00e0o ch\u1ebf ch\u1ee7 y\u1ebfu l\u00e0m ngu\u1ed3n CO2 cho vi\u00ean s\u1ee7i, c\u1ed1m s\u1ee7i v\u00e0 \u0111\u1ec3 t\u1ea1o ho\u1eb7c duy tr\u00ec pH ki\u1ec1m; ngo\u00e0i ra l\u00e0 ch\u1ea5t \u0111\u1ec7m trong vi\u00ean n\u00e9n v\u00e0 dung d\u1ecbch ti\u00eam. Th\u00f4ng tin […]<\/p>","protected":false},"author":1,"featured_media":2602,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-bicarbonat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri bicarbonat \u2013 ngu\u1ed3n CO2 cho vi\u00ean s\u1ee7i, ch\u1ea5t ki\u1ec1m h\u00f3a, \u0111\u1ec7m Natri bicarbonat (NaHCO3, E500, baking soda) \u0111\u01b0\u1ee3c d\u00f9ng trong b\u00e0o ch\u1ebf ch\u1ee7 y\u1ebfu l\u00e0m ngu\u1ed3n CO2 cho vi\u00ean s\u1ee7i, c\u1ed1m s\u1ee7i v\u00e0 \u0111\u1ec3 t\u1ea1o ho\u1eb7c duy tr\u00ec pH ki\u1ec1m; ngo\u00e0i ra l\u00e0 ch\u1ea5t \u0111\u1ec7m trong vi\u00ean n\u00e9n v\u00e0 dung d\u1ecbch ti\u00eam. Th\u00f4ng tin…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2603"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2603\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2602"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}