{"id":2601,"date":"2026-09-27T16:45:21","date_gmt":"2026-09-27T09:45:21","guid":{"rendered":"https:\/\/cpc1.vn\/natri-benzoat\/"},"modified":"2026-09-27T16:45:21","modified_gmt":"2026-09-27T09:45:21","slug":"natri-benzoat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-benzoat\/","title":{"rendered":"Natri benzoat (E211) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c u\u1ed1ng pH acid"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Natri benzoat (E211) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c u\u1ed1ng pH acid<\/h1>\n<p><strong>Natri benzoat<\/strong> (E211) l\u00e0 <strong>ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/strong> d\u00f9ng ch\u1ee7 y\u1ebfu trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m: 0,02\u20130,5% trong thu\u1ed1c u\u1ed1ng, 0,5% trong thu\u1ed1c ti\u00eam, 0,1\u20130,5% trong m\u1ef9 ph\u1ea9m. Hi\u1ec7u qu\u1ea3 ch\u1ec9 \u1edf <strong>kho\u1ea3ng pH acid<\/strong> (2\u20135). Ngo\u00e0i ra d\u00f9ng l\u00e0m <strong>t\u00e1 d\u01b0\u1ee3c tr\u01a1n<\/strong> vi\u00ean n\u00e9n 2\u20135%.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Benzoic acid sodium salt, benzoate of soda, sodii benzoas, sobenate, E211<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>532-32-1<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>7<\/sub>H<sub>5<\/sub>NaO<sub>2<\/sub> \u2013 144,11<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ea5t b\u1ea3o qu\u1ea3n: thu\u1ed1c u\u1ed1ng 0,02\u20130,5%; thu\u1ed1c ti\u00eam 0,5%; m\u1ef9 ph\u1ea9m 0,1\u20130,5%.<\/li>\n<li>\u0110\u01b0\u1ee3c \u01b0a h\u01a1n acid benzoic nh\u1edd tan t\u1ed1t h\u01a1n, d\u00f9 \u0111\u00f4i khi g\u00e2y v\u1ecb kh\u00f3 ch\u1ecbu.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n 2\u20135%.<\/li>\n<li>Ch\u1ea5t kh\u00e1ng khu\u1ea9n trong m\u00e0ng polymer bao g\u00f3i th\u1ef1c ph\u1ea9m.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t d\u1ea1ng h\u1ea1t ho\u1eb7c k\u1ebft tinh tr\u1eafng, h\u01a1i h\u00fat \u1ea9m; kh\u00f4ng m\u00f9i ho\u1eb7c m\u00f9i benzoin nh\u1eb9; v\u1ecb ng\u1ecdt m\u1eb7n kh\u00f3 ch\u1ecbu.<\/li>\n<li><strong>Ho\u1ea1t t\u00ednh:<\/strong> k\u00ecm khu\u1ea9n v\u00e0 kh\u00e1ng n\u1ea5m nh\u1edd acid benzoic kh\u00f4ng ph\u00e2n ly \u2013 hi\u1ec7u qu\u1ea3 t\u1ed1t nh\u1ea5t \u1edf pH 2\u20135; g\u1ea7n nh\u01b0 kh\u00f4ng t\u00e1c d\u1ee5ng trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m, t\u01b0\u01a1ng \u0111\u1ed1i k\u00e9m tr\u00ean pH kho\u1ea3ng 5.<\/li>\n<li>pH dung d\u1ecbch b\u00e3o h\u00f2a 8,0; t\u1ef7 tr\u1ecdng 1,497\u20131,527 g\/cm\u00b3; dung d\u1ecbch 2,25% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh; h\u1ec7 s\u1ed1 ph\u00e2n b\u1ed1 d\u1ea7u th\u1ef1c v\u1eadt\/n\u01b0\u1edbc 3\u20136.<\/li>\n<li>\u0110\u1ed9 tan: n\u01b0\u1edbc 1\/1,8 (1\/1,4 \u1edf 100 \u00b0C); ethanol 90% 1\/50; ethanol 95% 1\/75.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>Dung d\u1ecbch n\u01b0\u1edbc ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c b\u1eb1ng h\u1ea5p ho\u1eb7c l\u1ecdc. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<ul>\n<li>T\u01b0\u01a1ng k\u1ef5 v\u1edbi h\u1ee3p ch\u1ea5t amoni b\u1eadc b\u1ed1n, gelatin, mu\u1ed1i s\u1eaft(III), mu\u1ed1i calci, mu\u1ed1i kim lo\u1ea1i n\u1eb7ng (b\u1ea1c, ch\u00ec, th\u1ee7y ng\u00e2n).<\/li>\n<li>Ho\u1ea1t t\u00ednh b\u1ea3o qu\u1ea3n gi\u1ea3m khi t\u01b0\u01a1ng t\u00e1c v\u1edbi kaolin ho\u1eb7c ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion.<\/li>\n<li><em>Ngo\u00e0i s\u00e1ch:<\/em> trong \u0111\u1ed3 u\u1ed1ng ch\u1ee9a \u0111\u1ed3ng th\u1eddi benzoat v\u00e0 acid ascorbic, d\u01b0\u1edbi t\u00e1c \u0111\u1ed9ng nhi\u1ec7t\/\u00e1nh s\u00e1ng v\u00e0 ion kim lo\u1ea1i c\u00f3 th\u1ec3 h\u00ecnh th\u00e0nh l\u01b0\u1ee3ng v\u1ebft benzen \u2013 c\u1ea7n l\u01b0u \u00fd khi ph\u1ed1i h\u1ee3p trong ch\u1ebf ph\u1ea9m l\u1ecfng.<\/li>\n<\/ul>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Cho acid benzoic ph\u1ea3n \u1ee9ng v\u1edbi natri carbonat ho\u1eb7c natri bicarbonat.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<ul>\n<li>U\u1ed1ng v\u00e0o \u0111\u01b0\u1ee3c li\u00ean h\u1ee3p v\u1edbi glycin \u1edf gan th\u00e0nh acid hippuric th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u; tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c benzoat gi\u1ed1ng salicylat. D\u1ea1ng acid t\u1ef1 do c\u00f3 th\u1ec3 k\u00edch \u1ee9ng d\u1ea1 d\u00e0y m\u1ea1nh, nh\u01b0ng mu\u1ed1i benzoat dung n\u1ea1p t\u1ed1t v\u1edbi l\u01b0\u1ee3ng l\u1edbn.<\/li>\n<li>C\u00f3 th\u1ec3 g\u00e2y m\u00e0y \u0111ay ti\u1ebfp x\u00fac v\u00e0 ph\u1ea3n \u1ee9ng ti\u1ebfp x\u00fac t\u1ee9c th\u00ec kh\u00f4ng qua mi\u1ec5n d\u1ecbch \u2013 ch\u1ec9 khu tr\u00fa \u1edf da, d\u00f9ng \u0111\u01b0\u1ee3c \u0111\u1ebfn 5%, nh\u01b0ng c\u1ea7n c\u00e2n nh\u1eafc v\u1edbi c\u00f4ng th\u1ee9c cho tr\u1ebb nh\u0169 nhi v\u00e0 tr\u1ebb nh\u1ecf. \u0110\u00e3 ghi nh\u1eadn ph\u1ea3n v\u1ec7, m\u00e0y \u0111ay (nghi\u00ean c\u1ee9u c\u00f3 \u0111\u1ed1i ch\u1ee9ng cho th\u1ea5y t\u1ef7 l\u1ec7 m\u00e0y \u0111ay kh\u00f4ng cao h\u01a1n gi\u1ea3 d\u01b0\u1ee3c lactose).<\/li>\n<li>Khuy\u1ebfn c\u00e1o kh\u00f4ng d\u00f9ng thu\u1ed1c ti\u00eam cafein\u2013natri benzoat cho tr\u1ebb s\u01a1 sinh; c\u00f3 \u00fd ki\u1ebfn v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ch\u1ea5t b\u1ea3o qu\u1ea3n benzoat l\u00ean h\u00e0nh vi tr\u1ebb 3 tu\u1ed5i.<\/li>\n<li>WHO \u0111\u1eb7t ADI t\u1ed5ng benzoat (t\u00ednh theo acid benzoic) \u0111\u1ebfn 5 mg\/kg. LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 4,1 g\/kg.<\/li>\n<li>C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft, da \u2013 \u0111eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay.<\/li>\n<\/ul>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E211).<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (nha khoa; ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch; nang, dung d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; tr\u1ef1c tr\u00e0ng; d\u00f9ng ngo\u00e0i); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur., USP-NF v\u00e0 Food Chemicals Codex.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> acid benzoic, kali benzoat, kali sorbat.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Sodium Benzoate<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Natri benzoat (E211) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c u\u1ed1ng pH acid Natri benzoat (E211) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n d\u00f9ng ch\u1ee7 y\u1ebfu trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m: 0,02\u20130,5% trong thu\u1ed1c u\u1ed1ng, 0,5% trong thu\u1ed1c ti\u00eam, 0,1\u20130,5% trong m\u1ef9 ph\u1ea9m. Hi\u1ec7u qu\u1ea3 ch\u1ec9 \u1edf kho\u1ea3ng pH acid (2\u20135). Ngo\u00e0i ra d\u00f9ng [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2600,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2601","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-benzoat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri benzoat (E211) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n cho thu\u1ed1c u\u1ed1ng pH acid Natri benzoat (E211) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n d\u00f9ng ch\u1ee7 y\u1ebfu trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m: 0,02\u20130,5% trong thu\u1ed1c u\u1ed1ng, 0,5% trong thu\u1ed1c ti\u00eam, 0,1\u20130,5% trong m\u1ef9 ph\u1ea9m. Hi\u1ec7u qu\u1ea3 ch\u1ec9 \u1edf kho\u1ea3ng pH acid (2\u20135). Ngo\u00e0i ra d\u00f9ng&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2601"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2601\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2600"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}