{"id":2599,"date":"2026-09-27T16:45:13","date_gmt":"2026-09-27T09:45:13","guid":{"rendered":"https:\/\/cpc1.vn\/natri-ascorbat\/"},"modified":"2026-09-28T14:32:30","modified_gmt":"2026-09-28T07:32:30","slug":"natri-ascorbat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-ascorbat\/","title":{"rendered":"Natri ascorbat (E301) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Natri ascorbat (E301) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/h1>\n<p><strong>Natri ascorbat<\/strong> (E301, mu\u1ed1i mononatri c\u1ee7a acid L-ascorbic) d\u00f9ng l\u00e0m <strong>ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong> trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m (v\u00ed d\u1ee5 t\u0103ng hi\u1ec7u qu\u1ea3 natri nitrit ch\u1ed1ng <em>Listeria monocytogenes<\/em> trong th\u1ecbt ch\u00edn). \u0110\u1ed3ng th\u1eddi l\u00e0 ngu\u1ed3n vitamin C trong vi\u00ean n\u00e9n v\u00e0 thu\u1ed1c ti\u00eam.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>L-Ascorbic acid monosodium salt, vitamin C sodium, E301; SA-99<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>134-03-2<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>6<\/sub>H<sub>7<\/sub>NaO<sub>6<\/sub> \u2013 198,11<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a (\u0111\u1ed3ng th\u1eddi l\u00e0 d\u01b0\u1ee3c ch\u1ea5t)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong d\u01b0\u1ee3c ph\u1ea9m.<\/li>\n<li>Th\u1ef1c ph\u1ea9m: t\u0103ng hi\u1ec7u qu\u1ea3 natri nitrit trong th\u1ecbt ch\u00edn; c\u1ea3i thi\u1ec7n \u0111\u1ed9 k\u1ebft d\u00ednh gel v\u00e0 \u0111\u1ed9 ch\u1eafc c\u1ee7a s\u1ea3n ph\u1ea9m d\u1ea1ng s\u1ee3i.<\/li>\n<li>Ngu\u1ed3n vitamin C trong vi\u00ean n\u00e9n v\u00e0 thu\u1ed1c ti\u00eam (\u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft).<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c h\u01a1i v\u00e0ng, g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i, v\u1ecb m\u1eb7n d\u1ec5 ch\u1ecbu.<\/li>\n<li>pH dung d\u1ecbch 10%: 7\u20138; n\u00f3ng ch\u1ea3y 218 \u00b0C (ph\u00e2n h\u1ee7y); t\u1ef7 tr\u1ecdng th\u1ef1c 1,826 g\/cm\u00b3; t\u1ef7 tr\u1ecdng g\u00f5 0,6\u20131,1 g\/cm\u00b3 (b\u1ed9t m\u1ecbn), 0,8\u20131,1 g\/cm\u00b3 (h\u1ea1t m\u1ecbn); g\u00f3c quay c\u1ef1c ri\u00eang +104,4\u00b0 (dung d\u1ecbch 10%).<\/li>\n<li><strong>Kh\u00f4ng h\u00fat \u1ea9m:<\/strong> g\u1ea7n nh\u01b0 kh\u00f4ng h\u1ea5p thu n\u01b0\u1edbc \u0111\u1ebfn \u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i 80% (20 \u00b0C), d\u01b0\u1edbi 1% \u1edf 90%.<\/li>\n<li>C\u1ee1 h\u1ea1t t\u00f9y c\u1ea5p: v\u00ed d\u1ee5 b\u1ed9t m\u1ecbn kho\u1ea3ng 98% qua r\u00e2y 149 \u00b5m; c\u1ea5p ti\u00eau chu\u1ea9n kho\u1ea3ng 95% qua r\u00e2y 840 \u00b5m.<\/li>\n<li>\u0110\u1ed9 tan: n\u01b0\u1edbc 1\/1,6 (1\/1,3 \u1edf 75 \u00b0C); r\u1ea5t kh\u00f3 tan trong ethanol 95%; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong cloroform, ether.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>T\u01b0\u01a1ng \u0111\u1ed1i b\u1ec1n trong kh\u00f4ng kh\u00ed nh\u01b0ng s\u1eabm d\u1ea7n khi g\u1eb7p \u00e1nh s\u00e1ng. Dung d\u1ecbch n\u01b0\u1edbc kh\u00f4ng b\u1ec1n, b\u1ecb oxy h\u00f3a nhanh trong kh\u00f4ng kh\u00ed \u1edf pH tr\u00ean 6,0. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a, ion kim lo\u1ea1i n\u1eb7ng (nh\u1ea5t l\u00e0 \u0111\u1ed3ng, s\u1eaft), methenamin, natri nitrit, natri salicylat, theobromin salicylat. Dung d\u1ecbch n\u01b0\u1edbc \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o t\u01b0\u01a1ng k\u1ef5 v\u1edbi m\u00e0ng l\u1ecdc th\u00e9p kh\u00f4ng g\u1ec9.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Th\u00eam l\u01b0\u1ee3ng \u0111\u01b0\u01a1ng l\u01b0\u1ee3ng natri bicarbonat v\u00e0o dung d\u1ecbch acid ascorbic; khi h\u1ebft s\u1ee7i b\u1ecdt, th\u00eam 2-propanol \u0111\u1ec3 k\u1ebft t\u1ee7a natri ascorbat.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>Acid ascorbic v\u00e0 natri ascorbat th\u01b0\u1eddng dung n\u1ea1p t\u1ed1t; ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i ch\u1ec9 ghi nh\u1eadn khi d\u00f9ng t\u1eeb 1 g tr\u1edf l\u00ean v\u1edbi li\u1ec1u l\u00e0m thu\u1ed1c; ch\u01b0a c\u00f3 b\u00e1o c\u00e1o t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p d\u00f9ng ch\u1ed1ng oxy h\u00f3a. WHO \u0111\u1eb7t ADI cho acid ascorbic, kali v\u00e0 natri ascorbat l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a th\u1ef1c ph\u1ea9m \u0111\u1ebfn 15 mg\/kg th\u1ec3 tr\u1ecdng (ngo\u00e0i l\u01b0\u1ee3ng c\u00f3 s\u1eb5n trong th\u1ef1c ph\u1ea9m). C\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft \u2013 \u0111eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay cao su ho\u1eb7c nh\u1ef1a.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E301).<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (t\u0129nh m\u1ea1ch; vi\u00ean n\u00e9n u\u1ed1ng); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> acid ascorbic, ascorbyl palmitat, calci ascorbat.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Sodium Ascorbate<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Natri ascorbat (E301) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a Natri ascorbat (E301, mu\u1ed1i mononatri c\u1ee7a acid L-ascorbic) d\u00f9ng l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m (v\u00ed d\u1ee5 t\u0103ng hi\u1ec7u qu\u1ea3 natri nitrit ch\u1ed1ng Listeria monocytogenes trong th\u1ecbt ch\u00edn). \u0110\u1ed3ng th\u1eddi l\u00e0 ngu\u1ed3n vitamin C trong vi\u00ean n\u00e9n v\u00e0 thu\u1ed1c ti\u00eam. Th\u00f4ng tin [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2598,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2599","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-ascorbat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri ascorbat (E301) \u2013 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a Natri ascorbat (E301, mu\u1ed1i mononatri c\u1ee7a acid L-ascorbic) d\u00f9ng l\u00e0m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m (v\u00ed d\u1ee5 t\u0103ng hi\u1ec7u qu\u1ea3 natri nitrit ch\u1ed1ng Listeria monocytogenes trong th\u1ecbt ch\u00edn). \u0110\u1ed3ng th\u1eddi l\u00e0 ngu\u1ed3n vitamin C trong vi\u00ean n\u00e9n v\u00e0 thu\u1ed1c ti\u00eam. Th\u00f4ng tin&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2599","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2599"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2599\/revisions"}],"predecessor-version":[{"id":2761,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2599\/revisions\/2761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2598"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2599"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}