{"id":2597,"date":"2026-09-27T16:44:16","date_gmt":"2026-09-27T09:44:16","guid":{"rendered":"https:\/\/cpc1.vn\/natri-alginat\/"},"modified":"2026-09-28T14:32:32","modified_gmt":"2026-09-28T07:32:32","slug":"natri-alginat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-alginat\/","title":{"rendered":"Natri alginat (E401) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, t\u0103ng \u0111\u1ed9 nh\u1edbt, t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3"},"content":{"rendered":"

Natri alginat (E401) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, t\u0103ng \u0111\u1ed9 nh\u1edbt, t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3<\/h1>\n

Natri alginat<\/strong> (E401) l\u00e0 mu\u1ed1i natri c\u1ee7a acid alginic \u2013 h\u1ed7n h\u1ee3p acid polyuronic g\u1ed3m acid D-mannuronic v\u00e0 L-guluronic t\u1eeb t\u1ea3o n\u00e2u. D\u00f9ng trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i: t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3<\/strong> vi\u00ean n\u00e9n, t\u00e1c nh\u00e2n gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>, l\u00e0m \u0111\u1eb7c, t\u1ea1o h\u1ed7n d\u1ecbch<\/strong> v\u00e0 \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAlgin, alginic acid sodium salt, sodium polymannuronate, E401; Kelcosol, Keltone, Protanal<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9005-38-3<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t \u1ed5n \u0111\u1ecbnh, ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, t\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean n\u00e9n v\u00e0 nang, t\u00e1 d\u01b0\u1ee3c d\u00ednh, ch\u1ea5t t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n\n\n\n\n\n\n\n\n\n
C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
B\u1ed9t nh\u00e3o v\u00e0 kem<\/td>\n5\u201310<\/td>\n<\/tr>\n
\u1ed4n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng<\/td>\n1\u20133<\/td>\n<\/tr>\n
Ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch<\/td>\n1\u20135<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean n\u00e9n<\/td>\n1\u20133<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean n\u00e9n<\/td>\n2,5\u201310<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • Vi\u00ean n\u00e9n: v\u1eeba l\u00e0 t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u1eeba l\u00e0 t\u00e1 d\u01b0\u1ee3c r\u00e3; t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n trong nang.<\/li>\n
  • Gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i: l\u00e0m ch\u1eadm h\u00f2a tan d\u01b0\u1ee3c ch\u1ea5t t\u1eeb vi\u00ean n\u00e9n, nang v\u00e0 h\u1ed7n d\u1ecbch n\u01b0\u1edbc.<\/li>\n
  • D\u00f9ng ngo\u00e0i: l\u00e0m \u0111\u1eb7c, t\u1ea1o h\u1ed7n d\u1ecbch cho b\u1ed9t nh\u00e3o, kem, gel; \u1ed5n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng D\/N.<\/li>\n
  • Vi bao d\u01b0\u1ee3c ch\u1ea5t trong m\u00f4i tr\u01b0\u1eddng n\u01b0\u1edbc (thay h\u1ec7 dung m\u00f4i h\u1eefu c\u01a1); t\u1ea1o nano h\u1ea1t; hydrogel b\u00e1m d\u00ednh, vi\u00ean b\u00e1m ni\u00eam m\u1ea1c mi\u1ec7ng, gel ng\u1eadm m\u00e1; dung d\u1ecbch nh\u1ecf m\u1eaft t\u1ea1o gel t\u1ea1i ch\u1ed7; gel t\u1ea1o t\u1ea1i ch\u1ed7 \u0111\u01b0\u1eddng u\u1ed1ng (paracetamol); h\u1ec7 ph\u00e2n ph\u1ed1i protein, peptid.<\/li>\n
  • B\u0103ng g\u1ea1c alginat cho v\u1ebft th\u01b0\u01a1ng ti\u1ebft d\u1ecbch; x\u1ed1p alginat\u2013chitosan. M\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m. \u1ee8ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng \u0111\u1ebfn n\u00e2u v\u00e0ng nh\u1ea1t, kh\u00f4ng m\u00f9i, kh\u00f4ng v\u1ecb.<\/li>\n
    • pH dung d\u1ecbch 1%: 7,2.<\/li>\n
    • Tan ch\u1eadm trong n\u01b0\u1edbc t\u1ea1o dung d\u1ecbch keo nh\u1edbt; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ethanol 95%, ether, cloroform, h\u1ed7n h\u1ee3p n\u01b0\u1edbc\u2013c\u1ed3n tr\u00ean 30% c\u1ed3n, dung m\u00f4i h\u1eefu c\u01a1 kh\u00e1c v\u00e0 dung d\u1ecbch acid pH d\u01b0\u1edbi 3.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt dung d\u1ecbch 1% (20 \u00b0C) th\u01b0\u1eddng 20\u2013400 mPa\u00b7s t\u00f9y c\u1ea5p; ph\u1ee5 thu\u1ed9c n\u1ed3ng \u0111\u1ed9, pH, nhi\u1ec7t \u0111\u1ed9, ion kim lo\u1ea1i; gi\u1ea3m tr\u00ean pH 10.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • H\u00fat \u1ea9m nh\u01b0ng b\u1ec1n \u1edf \u0111\u1ed9 \u1ea9m th\u1ea5p, nhi\u1ec7t \u0111\u1ed9 m\u00e1t. Dung d\u1ecbch b\u1ec1n nh\u1ea5t \u1edf pH 4\u201310; d\u01b0\u1edbi pH 3 t\u1ee7a acid alginic. Dung d\u1ecbch 1% sau 2 n\u0103m c\u00f2n 60\u201380% \u0111\u1ed9 nh\u1edbt ban \u0111\u1ea7u. Kh\u00f4ng ch\u1ee9a dung d\u1ecbch trong bao b\u00ec kim lo\u1ea1i.<\/li>\n
      • Dung d\u1ecbch d\u1ec5 nhi\u1ec5m vi sinh (\u1ea3nh h\u01b0\u1edfng \u0111\u1ed9 nh\u1edbt). Ti\u1ec7t khu\u1ea9n l\u00fd t\u01b0\u1edfng b\u1eb1ng ethylen oxid; l\u1ecdc 0,45 \u00b5m \u1ea3nh h\u01b0\u1edfng nh\u1eb9; \u0111un tr\u00ean 70 \u00b0C g\u00e2y kh\u1eed tr\u00f9ng h\u1ee3p, h\u1ea5p l\u00e0m gi\u1ea3m \u0111\u1ed9 nh\u1edbt; kh\u00f4ng d\u00f9ng chi\u1ebfu x\u1ea1 gamma<\/strong> (gi\u1ea3m m\u1ea1nh \u0111\u1ed9 nh\u1edbt).<\/li>\n
      • Ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i b\u1ea3o qu\u1ea3n b\u1eb1ng 0,1% clorocresol, 0,1% cloroxylenol ho\u1eb7c paraben; m\u00f4i tr\u01b0\u1eddng acid c\u00f3 th\u1ec3 d\u00f9ng acid benzoic.<\/li>\n
      • B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi d\u1eabn ch\u1ea5t acridin, t\u00edm tinh th\u1ec3, phenylmercuric acetat v\u00e0 nitrat, mu\u1ed1i calci, kim lo\u1ea1i n\u1eb7ng, ethanol n\u1ed3ng \u0111\u1ed9 tr\u00ean 5%. Ch\u1ea5t \u0111i\u1ec7n ly n\u1ed3ng \u0111\u1ed9 th\u1ea5p l\u00e0m t\u0103ng \u0111\u1ed9 nh\u1edbt; n\u1ed3ng \u0111\u1ed9 cao g\u00e2y salting-out (khi natri clorid tr\u00ean 4%).<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Chi\u1ebft acid alginic t\u1eeb t\u1ea3o n\u00e2u, trung h\u00f2a b\u1eb1ng natri bicarbonat.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        D\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m, d\u01b0\u1ee3c ph\u1ea9m (k\u1ec3 c\u1ea3 b\u0103ng g\u1ea1c); n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng, d\u00f9 u\u1ed1ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i. T\u00ecnh nguy\u1ec7n vi\u00ean d\u00f9ng 175\u2013200 mg\/kg\/ng\u00e0y trong 23 ng\u00e0y kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i \u0111\u00e1ng k\u1ec3. WHO kh\u00f4ng \u0111\u1eb7t ADI cho acid alginic v\u00e0 mu\u1ed1i alginat. H\u00edt b\u1ee5i c\u00f3 th\u1ec3 k\u00edch \u1ee9ng; hen ngh\u1ec1 nghi\u1ec7p li\u00ean quan b\u1ee5i t\u1ea3o h\u01a1n b\u1ee5i alginat tinh khi\u1ebft. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): > 5 g\/kg. \u0110eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i; l\u00e0m vi\u1ec7c n\u01a1i th\u00f4ng gi\u00f3.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E401).<\/li>\n
        • C\u00f3 trong FDA Inactive Ingredients Guide (h\u1ed7n d\u1ecbch v\u00e0 vi\u00ean n\u00e9n u\u1ed1ng); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> acid alginic, calci alginat, kali alginat, propylen glycol alginat.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Alginate<\/em> trong:
          \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
          \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
          \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
          \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
          \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Natri alginat (E401) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, t\u0103ng \u0111\u1ed9 nh\u1edbt, t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3 Natri alginat (E401) l\u00e0 mu\u1ed1i natri c\u1ee7a acid alginic \u2013 h\u1ed7n h\u1ee3p acid polyuronic g\u1ed3m acid D-mannuronic v\u00e0 L-guluronic t\u1eeb t\u1ea3o n\u00e2u. D\u00f9ng trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i: t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3 vi\u00ean n\u00e9n, t\u00e1c nh\u00e2n gi\u1ea3i […]<\/p>","protected":false},"author":1,"featured_media":2596,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-alginat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri alginat (E401) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, t\u0103ng \u0111\u1ed9 nh\u1edbt, t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3 Natri alginat (E401) l\u00e0 mu\u1ed1i natri c\u1ee7a acid alginic \u2013 h\u1ed7n h\u1ee3p acid polyuronic g\u1ed3m acid D-mannuronic v\u00e0 L-guluronic t\u1eeb t\u1ea3o n\u00e2u. D\u00f9ng trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i: t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3 vi\u00ean n\u00e9n, t\u00e1c nh\u00e2n gi\u1ea3i…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2597"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2597\/revisions"}],"predecessor-version":[{"id":2762,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2597\/revisions\/2762"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2596"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}