{"id":2595,"date":"2026-09-27T16:44:08","date_gmt":"2026-09-27T09:44:08","guid":{"rendered":"https:\/\/cpc1.vn\/natri-acetat\/"},"modified":"2026-09-27T16:44:08","modified_gmt":"2026-09-27T09:44:08","slug":"natri-acetat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/natri-acetat\/","title":{"rendered":"Natri acetat (E262) \u2013 ch\u1ea5t \u0111\u1ec7m, b\u1ea3o qu\u1ea3n, \u0111i\u1ec1u v\u1ecb"},"content":{"rendered":"

Natri acetat (E262) \u2013 ch\u1ea5t \u0111\u1ec7m, b\u1ea3o qu\u1ea3n, \u0111i\u1ec1u v\u1ecb<\/h1>\n

Natri acetat<\/strong> (E262) l\u00e0 mu\u1ed1i natri c\u1ee7a acid acetic, d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m<\/strong> trong thu\u1ed1c ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, d\u01b0\u1edbi da, d\u00f9ng ngo\u00e0i, nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i, nh\u1ecf tai v\u00e0 u\u1ed1ng; ngo\u00e0i ra gi\u00fap gi\u1ea3m v\u1ecb \u0111\u1eafng, t\u0103ng t\u00ednh kh\u00e1ng khu\u1ea9n v\u00e0 l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ef1c ph\u1ea9m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAcetic acid sodium salt, sodium ethanoate, E262<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n127-09-3 (khan); 6131-90-4 (trihydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC2<\/sub>H3<\/sub>NaO2<\/sub> \u2013 82,0 (khan); C2<\/sub>H3<\/sub>NaO2<\/sub>\u00b73H2<\/sub>O \u2013 136,1 (trihydrat \u2013 d\u1ea1ng \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 trong JP, Ph.Eur., USP)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t \u0111\u1ec7m, ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, ch\u1ea5t \u1ed5n \u0111\u1ecbnh<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t \u0111\u1ec7m trong nhi\u1ec1u d\u1ea1ng thu\u1ed1c ti\u00eam, nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i, nh\u1ecf tai, u\u1ed1ng, d\u00f9ng ngo\u00e0i.<\/li>\n
  • Gi\u1ea3m v\u1ecb \u0111\u1eafng c\u1ee7a thu\u1ed1c u\u1ed1ng.<\/li>\n
  • T\u0103ng t\u00ednh kh\u00e1ng khu\u1ea9n c\u1ee7a c\u00f4ng th\u1ee9c \u2013 \u1ee9c ch\u1ebf S. aureus<\/em>, E. coli<\/em> (kh\u00f4ng \u1ee9c ch\u1ebf C. albicans<\/em>) trong dung d\u1ecbch th\u1ee7y ph\u00e2n protein.<\/li>\n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n ph\u1ed5 bi\u1ebfn trong th\u1ef1c ph\u1ea9m. \u1ee8ng d\u1ee5ng l\u00e0m thu\u1ed1c (d\u1ecbch l\u1ecdc m\u00e1u, \u0111i\u1ec1u ch\u1ec9nh toan chuy\u1ec3n h\u00f3a) n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Tinh th\u1ec3 trong su\u1ed1t kh\u00f4ng m\u00e0u ho\u1eb7c b\u1ed9t k\u1ebft tinh d\u1ea1ng h\u1ea1t, m\u00f9i acid acetic nh\u1eb9.<\/li>\n
    • pH dung d\u1ecbch 5%: 7,5\u20139,0; n\u00f3ng ch\u1ea3y 58 \u00b0C (trihydrat), 324 \u00b0C (khan); t\u1ef7 tr\u1ecdng 1,53.<\/li>\n
    • C\u1ea3 d\u1ea1ng khan v\u00e0 trihydrat \u0111\u1ec1u h\u00fat \u1ea9m.<\/li>\n
    • Tan 1\/0,8 trong n\u01b0\u1edbc; 1\/20 trong ethanol 95%.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Ph\u1ea3n \u1ee9ng v\u1edbi th\u00e0nh ph\u1ea7n acid v\u00e0 base; ph\u1ea3n \u1ee9ng m\u00e3nh li\u1ec7t v\u1edbi flo, kali nitrat, diketen.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Trung h\u00f2a acid acetic b\u1eb1ng natri carbonat.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m, d\u01b0\u1ee3c ph\u1ea9m; n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. G\u00e0 \u0103n kh\u1ea9u ph\u1ea7n b\u1ed5 sung 5,44% natri acetat gi\u1ea3m t\u0103ng tr\u01b0\u1edfng (do natri). \u0110\u1ed9c khi ti\u00eam t\u0129nh m\u1ea1ch, \u0111\u1ed9c trung b\u00ecnh khi nu\u1ed1t, k\u00edch \u1ee9ng nh\u1eb9 da v\u00e0 m\u1eaft. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 3,53 g\/kg; (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 0,38 g\/kg. \u0110eo g\u0103ng tay, k\u00ednh b\u1ea3o h\u1ed9; h\u00edt b\u1ee5i c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E262).<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c ti\u00eam, nh\u1ecf m\u0169i, nh\u1ecf tai, nh\u00e3n khoa, u\u1ed1ng).<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> acid acetic, kali acetat, natri diacetat.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Sodium Acetate<\/em> trong:
        \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
        \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
        \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
        \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
        \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Natri acetat (E262) \u2013 ch\u1ea5t \u0111\u1ec7m, b\u1ea3o qu\u1ea3n, \u0111i\u1ec1u v\u1ecb Natri acetat (E262) l\u00e0 mu\u1ed1i natri c\u1ee7a acid acetic, d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m trong thu\u1ed1c ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, d\u01b0\u1edbi da, d\u00f9ng ngo\u00e0i, nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i, nh\u1ecf tai v\u00e0 u\u1ed1ng; ngo\u00e0i ra gi\u00fap gi\u1ea3m v\u1ecb \u0111\u1eafng, t\u0103ng t\u00ednh kh\u00e1ng khu\u1ea9n v\u00e0 l\u00e0m ch\u1ea5t b\u1ea3o […]<\/p>","protected":false},"author":1,"featured_media":2594,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2595","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/natri-acetat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Natri acetat (E262) \u2013 ch\u1ea5t \u0111\u1ec7m, b\u1ea3o qu\u1ea3n, \u0111i\u1ec1u v\u1ecb Natri acetat (E262) l\u00e0 mu\u1ed1i natri c\u1ee7a acid acetic, d\u00f9ng l\u00e0m ch\u1ea5t \u0111\u1ec7m trong thu\u1ed1c ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, d\u01b0\u1edbi da, d\u00f9ng ngo\u00e0i, nh\u1ecf m\u1eaft, nh\u1ecf m\u0169i, nh\u1ecf tai v\u00e0 u\u1ed1ng; ngo\u00e0i ra gi\u00fap gi\u1ea3m v\u1ecb \u0111\u1eafng, t\u0103ng t\u00ednh kh\u00e1ng khu\u1ea9n v\u00e0 l\u00e0m ch\u1ea5t b\u1ea3o…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2595"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2595\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2594"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}