{"id":2577,"date":"2026-09-27T16:38:05","date_gmt":"2026-09-27T09:38:05","guid":{"rendered":"https:\/\/cpc1.vn\/propylparaben\/"},"modified":"2026-09-28T21:24:21","modified_gmt":"2026-09-28T14:24:21","slug":"propylparaben","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/propylparaben\/","title":{"rendered":"Propylparaben (Nipasol M, E216) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n paraben"},"content":{"rendered":"

Propylparaben (Nipasol M, E216) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n paraben<\/h1>\n

Propylparaben<\/strong> (propyl 4-hydroxybenzoat, Nipasol M) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/strong> nh\u00f3m paraben, d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u2013 ri\u00eang l\u1ebb, ph\u1ed1i h\u1ee3p paraben kh\u00e1c (kinh \u0111i\u1ec3n: propylparaben 0,02% + methylparaben 0,18%<\/strong>) ho\u1eb7c ch\u1ea5t kh\u00e1ng khu\u1ea9n kh\u00e1c.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nPropyl p-hydroxybenzoate, 4-hydroxybenzoic acid propyl ester, propagin, E216; Nipasol M, Propyl parasept, Solbrol P<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n94-13-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC10<\/sub>H12<\/sub>O3<\/sub> \u2013 180,20<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
D\u1ea1ng b\u00e0o ch\u1ebf<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, d\u01b0\u1edbi da (*)<\/td>\n0,005\u20130,2<\/td>\n<\/tr>\n
Dung d\u1ecbch h\u00edt<\/td>\n0,015<\/td>\n<\/tr>\n
Ti\u00eam trong da<\/td>\n0,02\u20130,26<\/td>\n<\/tr>\n
Dung d\u1ecbch nh\u1ecf m\u0169i<\/td>\n0,017<\/td>\n<\/tr>\n
Ch\u1ebf ph\u1ea9m nh\u00e3n khoa (*)<\/td>\n0,005\u20130,01<\/td>\n<\/tr>\n
Dung d\u1ecbch, h\u1ed7n d\u1ecbch u\u1ed1ng<\/td>\n0,01\u20130,02<\/td>\n<\/tr>\n
Ch\u1ebf ph\u1ea9m tr\u1ef1c tr\u00e0ng<\/td>\n0,01\u20130,02<\/td>\n<\/tr>\n
Ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i<\/td>\n0,01\u20130,6<\/td>\n<\/tr>\n
Ch\u1ebf ph\u1ea9m \u00e2m \u0111\u1ea1o<\/td>\n0,02\u20130,1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

(*) Paraben hi\u1ec7n n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng ph\u00f9 h\u1ee3p cho thu\u1ed1c ti\u00eam v\u00e0 nh\u1ecf m\u1eaft do kh\u1ea3 n\u0103ng k\u00edch \u1ee9ng.<\/p>\n

    \n
  • Hi\u1ec7u qu\u1ea3 trong kho\u1ea3ng pH r\u1ed9ng, ph\u1ed5 r\u1ed9ng, m\u1ea1nh nh\u1ea5t v\u1edbi n\u1ea5m men, n\u1ea5m m\u1ed1c. Do paraben kh\u00f3 tan, mu\u1ed1i natri th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng \u2013 nh\u01b0ng c\u00f3 th\u1ec3 l\u00e0m c\u00f4ng th\u1ee9c \u0111\u1ec7m k\u00e9m b\u1ecb ki\u1ec1m h\u00f3a.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng m\u00f9i, kh\u00f4ng v\u1ecb.<\/li>\n
    • Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n \u1edf pH 4\u20138, gi\u1ea3m khi pH t\u0103ng (t\u1ea1o anion phenolat); m\u1ea1nh v\u1edbi n\u1ea5m h\u01a1n vi khu\u1ea9n, Gram d\u01b0\u01a1ng h\u01a1n Gram \u00e2m. Ho\u1ea1t t\u00ednh t\u0103ng theo chi\u1ec1u d\u00e0i m\u1ea1ch alkyl nh\u01b0ng \u0111\u1ed9 tan gi\u1ea3m; ph\u1ed1i h\u1ee3p paraben cho hi\u1ec7u qu\u1ea3 c\u1ed9ng.<\/li>\n
    • N\u00f3ng ch\u1ea3y 95\u201399 \u00b0C (d\u01b0\u1ee3c \u0111i\u1ec3n); s\u00f4i 295 \u00b0C; pKa 8,4 (22 \u00b0C); t\u1ef7 tr\u1ecdng th\u1ef1c 1,288 g\/cm\u00b3; t\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,426, g\u00f5 0,706 g\/cm\u00b3.<\/li>\n
    • H\u1ec7 s\u1ed1 ph\u00e2n b\u1ed1 d\u1ea7u\/n\u01b0\u1edbc: d\u1ea7u \u0111\u1eadu n\u00e0nh 65,9; d\u1ea7u ng\u00f4 58,0; d\u1ea7u l\u1ea1c 51,8; d\u1ea7u kho\u00e1ng 0,5 \u2013 propylparaben ph\u00e2n b\u1ed1 m\u1ea1nh v\u00e0o pha d\u1ea7u, c\u1ea7n t\u00ednh khi b\u1ea3o qu\u1ea3n nh\u0169 t\u01b0\u01a1ng.<\/li>\n
    • \u0110\u1ed9 tan (20 \u00b0C): ethanol 95% 1\/1,1; propylen glycol 1\/3,9; ethanol 50% 1\/5,6; d\u1ea7u l\u1ea1c 1\/70; propylen glycol 50% 1\/110; glycerin 1\/250; n\u01b0\u1edbc 1\/2500 (1\/4350 \u1edf 15 \u00b0C; 1\/225 \u1edf 80 \u00b0C); d\u1ea7u kho\u00e1ng 1\/3330; d\u1ec5 tan trong aceton, ether.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Dung d\u1ecbch n\u01b0\u1edbc pH 3\u20136 h\u1ea5p ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c kh\u00f4ng ph\u00e2n h\u1ee7y, b\u1ec1n (ph\u00e2n h\u1ee7y d\u01b0\u1edbi 10%) kho\u1ea3ng 4 n\u0103m \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng; pH t\u1eeb 8 tr\u1edf l\u00ean th\u1ee7y ph\u00e2n nhanh (t\u1eeb 10% sau kho\u1ea3ng 60 ng\u00e0y). B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Ho\u1ea1t t\u00ednh gi\u1ea3m m\u1ea1nh khi c\u00f3 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion (micelle h\u00f3a). B\u1ecb m\u1ed9t s\u1ed1 nh\u1ef1a h\u1ea5p thu t\u00f9y lo\u1ea1i nh\u1ef1a v\u00e0 ch\u1ea5t d\u1eabn; magnesi nh\u00f4m silicat, magnesi trisilicat, oxyd s\u1eaft v\u00e0ng, xanh ultramarin h\u1ea5p ph\u1ee5 propylparaben l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3. \u0110\u1ed5i m\u00e0u khi c\u00f3 s\u1eaft; b\u1ecb th\u1ee7y ph\u00e2n b\u1edfi ki\u1ec1m y\u1ebfu, acid m\u1ea1nh.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ester h\u00f3a acid p-hydroxybenzoic v\u1edbi n-propanol.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m, thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i. Ch\u01b0a ghi nh\u1eadn ph\u1ea3n \u1ee9ng to\u00e0n th\u00e2n nh\u01b0ng c\u00f3 li\u00ean quan ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn. WHO (theo s\u00e1ch) \u0111\u1eb7t ADI t\u1ed5ng cho methyl-, ethyl-, propylparaben \u0111\u1ebfn 10 mg\/kg th\u1ec3 tr\u1ecdng. LD50<\/sub> (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 6,33 g\/kg. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 l\u00e0m vi\u1ec7c n\u01a1i th\u00f4ng gi\u00f3, \u0111eo k\u00ednh, g\u0103ng tay, kh\u1ea9u trang.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • Theo s\u00e1ch (2006): GRAS d\u00f9ng tr\u1ef1c ti\u1ebfp trong th\u1ef1c ph\u1ea9m M\u1ef9 \u0111\u1ebfn 0,1%; Nh\u1eadt cho ph\u00e9p m\u1ecdi ester tr\u1eeb benzyl trong thu\u1ed1c ti\u00eam; m\u1ef9 ph\u1ea9m EU v\u00e0 Brazil m\u1ed7i paraben 0,4%, t\u1ed5ng 0,8%; Nh\u1eadt t\u1ed1i \u0111a 1,0%.<\/li>\n
      • C\u1eadp nh\u1eadt sau 2006 (ngo\u00e0i s\u00e1ch):<\/em> EU \u0111\u00e3 r\u00fat propylparaben (E216) kh\u1ecfi danh m\u1ee5c ph\u1ee5 gia th\u1ef1c ph\u1ea9m; JECFA \u0111\u00e3 r\u00fat propylparaben kh\u1ecfi ADI nh\u00f3m paraben; trong m\u1ef9 ph\u1ea9m EU, propyl- v\u00e0 butylparaben b\u1ecb gi\u1edbi h\u1ea1n t\u1ed5ng 0,14% (t\u00ednh theo acid) v\u00e0 kh\u00f4ng d\u00f9ng cho s\u1ea3n ph\u1ea9m l\u01b0u l\u1ea1i v\u00f9ng qu\u1ea5n t\u00e3 tr\u1ebb d\u01b0\u1edbi 3 tu\u1ed5i. C\u1ea7n ki\u1ec3m tra quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh c\u1ee7a th\u1ecb tr\u01b0\u1eddng \u0111\u00edch.<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, d\u01b0\u1edbi da; h\u00edt; nh\u00e3n khoa; nang, dung d\u1ecbch, h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; nh\u1ecf tai, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP, JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> methylparaben, ethylparaben, butylparaben; kali propylparaben (C10<\/sub>H11<\/sub>KO3<\/sub>, CAS 84930-16-5); natri propylparaben.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Propylparaben<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Propylparaben (Nipasol M, E216) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n paraben Propylparaben (propyl 4-hydroxybenzoat, Nipasol M) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n nh\u00f3m paraben, d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u2013 ri\u00eang l\u1ebb, ph\u1ed1i h\u1ee3p paraben kh\u00e1c (kinh \u0111i\u1ec3n: propylparaben 0,02% + methylparaben 0,18%) ho\u1eb7c ch\u1ea5t kh\u00e1ng khu\u1ea9n kh\u00e1c. Th\u00f4ng tin nhanh […]<\/p>","protected":false},"author":1,"featured_media":2576,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2577","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/propylparaben-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Propylparaben (Nipasol M, E216) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n paraben Propylparaben (propyl 4-hydroxybenzoat, Nipasol M) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n nh\u00f3m paraben, d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u2013 ri\u00eang l\u1ebb, ph\u1ed1i h\u1ee3p paraben kh\u00e1c (kinh \u0111i\u1ec3n: propylparaben 0,02% + methylparaben 0,18%) ho\u1eb7c ch\u1ea5t kh\u00e1ng khu\u1ea9n kh\u00e1c. Th\u00f4ng tin nhanh…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2577"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2577\/revisions"}],"predecessor-version":[{"id":3362,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2577\/revisions\/3362"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2576"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}