{"id":2562,"date":"2026-09-27T16:33:04","date_gmt":"2026-09-27T09:33:04","guid":{"rendered":"https:\/\/cpc1.vn\/kali-sorbat\/"},"modified":"2026-09-27T16:33:04","modified_gmt":"2026-09-27T09:33:04","slug":"kali-sorbat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/kali-sorbat\/","title":{"rendered":"Kali sorbat (E202) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Kali sorbat (E202) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i<\/h1>\n<p><strong>Kali sorbat<\/strong> (E202) l\u00e0 mu\u1ed1i kali c\u1ee7a acid sorbic \u2013 <strong>ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m<\/strong> v\u00e0 kh\u00e1ng khu\u1ea9n d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, ch\u1ebf ph\u1ea9m dinh d\u01b0\u1ee1ng qua \u1ed1ng v\u00e0 m\u1ef9 ph\u1ea9m. N\u1ed3ng \u0111\u1ed9 th\u01b0\u1eddng d\u00f9ng <strong>0,1\u20130,2%<\/strong> trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i, nh\u1ea5t l\u00e0 c\u00f4ng th\u1ee9c ch\u1ee9a ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Potassium (E,E)-hexa-2,4-dienoate, sorbic acid potassium salt, E202<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>24634-61-5<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>6<\/sub>H<sub>7<\/sub>O<sub>2<\/sub>K \u2013 150,22<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ea5t b\u1ea3o qu\u1ea3n 0,1\u20130,2% trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i.<\/li>\n<li>\u0110\u01b0\u1ee3c d\u00f9ng trong s\u1ed1 c\u00f4ng th\u1ee9c d\u01b0\u1ee3c ph\u1ea9m nhi\u1ec1u g\u1ea5p kho\u1ea3ng \u0111\u00f4i acid sorbic nh\u1edd tan v\u00e0 b\u1ec1n trong n\u01b0\u1edbc t\u1ed1t h\u01a1n.<\/li>\n<li>\u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u t\u0103ng sinh kh\u1ea3 d\u1ee5ng timolol nh\u1ecf m\u1eaft.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t k\u1ebft tinh tr\u1eafng, m\u00f9i nh\u1eb9 \u0111\u1eb7c tr\u01b0ng.<\/li>\n<li><strong>Ho\u1ea1t t\u00ednh:<\/strong> ch\u1ee7 y\u1ebfu kh\u00e1ng n\u1ea5m, c\u00f3 t\u00ednh kh\u00e1ng khu\u1ea9n; ph\u1ee5 thu\u1ed9c m\u1ee9c \u0111\u1ed9 ph\u00e2n ly \u2013 h\u1ea7u nh\u01b0 kh\u00f4ng kh\u00e1ng khu\u1ea9n tr\u00ean pH 6. Hi\u1ec7u qu\u1ea3 t\u0103ng theo nhi\u1ec7t \u0111\u1ed9, n\u1ed3ng \u0111\u1ed9 v\u00e0 khi ph\u1ed1i h\u1ee3p ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c ho\u1eb7c glycol (hi\u1ec7p \u0111\u1ed3ng).<\/li>\n<li>MIC (\u00b5g\/mL) \u1edf pH 5,5 \/ 6,0 \/ 7,0: <em>E. coli<\/em> 1400 \/ 1500 \/ 3800; <em>P. aeruginosa<\/em> 1600\u20132300 \/ 1900\u20132500 \/ 5600\u20139000; <em>S. aureus<\/em> 1200 \/ 1000 \/ 3800.<\/li>\n<li>T\u1ef7 tr\u1ecdng 1,363 g\/cm\u00b3; n\u00f3ng ch\u1ea3y kho\u1ea3ng 270 \u00b0C (ph\u00e2n h\u1ee7y).<\/li>\n<li>\u0110\u1ed9 tan (20 \u00b0C): n\u01b0\u1edbc 1\/1,72; ethanol 5% 1\/1,7; propylen glycol 1\/1,8; ethanol 95% 1\/35; ethanol 1\/50; aceton 1\/1000; r\u1ea5t kh\u00f3 tan trong cloroform, d\u1ea7u ng\u00f4, ether; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong benzen.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>B\u1ec1n trong dung d\u1ecbch n\u01b0\u1edbc h\u01a1n acid sorbic; dung d\u1ecbch ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c b\u1eb1ng h\u1ea5p. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, kh\u00f4ng qu\u00e1 40 \u00b0C.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>M\u1ea5t m\u1ed9t ph\u1ea7n ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n khi c\u00f3 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion v\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i nh\u1ef1a (xem th\u00eam acid sorbic).<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>T\u1eeb acid sorbic v\u00e0 kali hydroxid.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>N\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c khi d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i; \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng k\u00edch \u1ee9ng da, c\u00f3 th\u1ec3 ki\u1ec3u d\u1ecb \u1ee9ng qu\u00e1 m\u1eabn; ch\u01b0a c\u00f3 b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng to\u00e0n th\u00e2n khi u\u1ed1ng. WHO \u0111\u1eb7t ADI t\u1ed5ng cho acid sorbic v\u00e0 c\u00e1c mu\u1ed1i calci, kali, natri sorbat (t\u00ednh theo acid sorbic) \u0111\u1ebfn 25 mg\/kg th\u1ec3 tr\u1ecdng. LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 4,92 g\/kg. K\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 \u0111eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay; d\u00f9ng m\u1eb7t n\u1ea1 n\u01a1i th\u00f4ng gi\u00f3 k\u00e9m.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E202).<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (x\u1ecbt m\u0169i; nang, dung d\u1ecbch, h\u1ed7n d\u1ecbch, siro, vi\u00ean n\u00e9n u\u1ed1ng; kem, lotion d\u00f9ng ngo\u00e0i); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> acid sorbic, natri benzoat, kali benzoat.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Potassium Sorbate<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Kali sorbat (E202) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i Kali sorbat (E202) l\u00e0 mu\u1ed1i kali c\u1ee7a acid sorbic \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m v\u00e0 kh\u00e1ng khu\u1ea9n d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, ch\u1ebf ph\u1ea9m dinh d\u01b0\u1ee1ng qua \u1ed1ng v\u00e0 m\u1ef9 ph\u1ea9m. N\u1ed3ng \u0111\u1ed9 th\u01b0\u1eddng d\u00f9ng 0,1\u20130,2% trong thu\u1ed1c u\u1ed1ng [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2561,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/kali-sorbat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Kali sorbat (E202) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m cho thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i Kali sorbat (E202) l\u00e0 mu\u1ed1i kali c\u1ee7a acid sorbic \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng n\u1ea5m v\u00e0 kh\u00e1ng khu\u1ea9n d\u00f9ng trong d\u01b0\u1ee3c ph\u1ea9m, th\u1ef1c ph\u1ea9m, ch\u1ebf ph\u1ea9m dinh d\u01b0\u1ee1ng qua \u1ed1ng v\u00e0 m\u1ef9 ph\u1ea9m. N\u1ed3ng \u0111\u1ed9 th\u01b0\u1eddng d\u00f9ng 0,1\u20130,2% trong thu\u1ed1c u\u1ed1ng&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2562"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2562\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2561"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}