{"id":2544,"date":"2026-09-27T16:28:00","date_gmt":"2026-09-27T09:28:00","guid":{"rendered":"https:\/\/cpc1.vn\/polyvinyl-acetat-phthalat\/"},"modified":"2026-09-27T16:28:00","modified_gmt":"2026-09-27T09:28:00","slug":"polyvinyl-acetat-phthalat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/polyvinyl-acetat-phthalat\/","title":{"rendered":"Polyvinyl acetat phthalat (PVAP, Sureteric) \u2013 polymer bao tan \u1edf ru\u1ed9t, bao c\u00e1ch ly"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Polyvinyl acetat phthalat (PVAP, Sureteric) \u2013 polymer bao tan \u1edf ru\u1ed9t, bao c\u00e1ch ly<\/h1>\n<p><strong>Polyvinyl acetat phthalat<\/strong> (PVAP) l\u00e0 s\u1ea3n ph\u1ea9m ph\u1ea3n \u1ee9ng c\u1ee7a anhydrid phthalic v\u1edbi polyvinyl acetat th\u1ee7y ph\u00e2n m\u1ed9t ph\u1ea7n, ch\u1ee9a 55,0\u201362,0% nh\u00f3m phthalyl. PVAP l\u00e0 <strong>polymer bao tan \u1edf ru\u1ed9t<\/strong> v\u00e0 <strong>bao c\u00e1ch ly nh\u00e2n vi\u00ean<\/strong> tr\u01b0\u1edbc khi bao \u0111\u01b0\u1eddng; kh\u00f4ng d\u00ednh khi bao, t\u1ea1o m\u00e0ng b\u1ec1n ch\u1eafc.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>PVAP; Phthalavin, Opaseal, Sureteric (Colorcon), Coateric<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>34481-48-6<\/td>\n<\/tr>\n<tr>\n<td>Th\u00e0nh ph\u1ea7n (USP-NF)<\/td>\n<td>Nh\u00f3m phthalyl (o-carboxybenzoyl) 55,0\u201362,0% t\u00ednh tr\u00ean ch\u1ebf ph\u1ea9m khan kh\u00f4ng c\u00f3 acid t\u1ef1 do; h\u00e0m l\u01b0\u1ee3ng acid phthalic t\u1ef1 do ph\u1ee5 thu\u1ed9c ngu\u1ed3n nguy\u00ean li\u1ec7u<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t bao<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li><strong>Bao tan \u1edf ru\u1ed9t:<\/strong> h\u00f2a tan PVAP trong h\u1ec7 dung m\u00f4i c\u00f9ng ph\u1ee5 gia (diethyl phthalat, acid stearic). M\u00e0ng kh\u00f4ng m\u00e0u d\u00f9ng methanol; m\u00e0ng c\u00f3 m\u00e0u d\u00f9ng methanol ho\u1eb7c ethanol\/n\u01b0\u1edbc t\u00f9y l\u01b0\u1ee3ng pigment. \u0110\u1ed9 t\u0103ng kh\u1ed1i l\u01b0\u1ee3ng c\u1ea7n \u0111\u1ebfn 8% (kh\u00f4ng pigment) ho\u1eb7c kho\u1ea3ng 6% (c\u00f3 pigment). Sureteric l\u00e0 c\u00f4ng th\u1ee9c bao d\u1ea1ng n\u01b0\u1edbc pha s\u1eb5n cho vi\u00ean n\u00e9n, nang c\u1ee9ng, nang m\u1ec1m v\u00e0 c\u1ed1m.<\/li>\n<li><strong>Bao c\u00e1ch ly trong bao \u0111\u01b0\u1eddng:<\/strong> thay shellac t\u1ea1o c\u00e1c l\u1edbp bao \u0111\u1ea7u ti\u00ean (sealing coat) \u2013 c\u00e0ng m\u1ecfng c\u00e0ng t\u1ed1t nh\u01b0ng \u0111\u1ee7 ch\u1eafn \u1ea9m. Th\u01b0\u1eddng 2 l\u1edbp l\u00e0 \u0111\u1ee7, \u0111\u1ebfn 5 l\u1edbp v\u1edbi vi\u00ean ch\u1ee9a th\u00e0nh ph\u1ea7n ki\u1ec1m; n\u1ebfu c\u1ea7n th\u00eam bao tan \u1edf ru\u1ed9t c\u00f3 th\u1ec3 c\u1ea7n 6\u201312 l\u1edbp.<\/li>\n<li>N\u1ed3ng \u0111\u1ed9 polymer trong d\u1ecbch bao tham kh\u1ea3o: bao tan \u1edf ru\u1ed9t kho\u1ea3ng 9\u201310%; bao c\u00e1ch ly kho\u1ea3ng 28\u201329%.<\/li>\n<li><strong>Ch\u1ea5t h\u00f3a d\u1ebbo<\/strong> \u0111\u1ec3 c\u00f3 m\u00e0ng li\u00ean t\u1ee5c, \u0111\u1ed3ng nh\u1ea5t, kh\u00f4ng n\u1ee9t: triacetin, triethyl citrat, acetyl triethyl citrat, diethyl phthalat, PEG 400.<\/li>\n<li>\u0110\u00e3 \u0111\u01b0\u1ee3c so s\u00e1nh v\u1edbi cellulose acetat phthalat v\u00e0 Eudragit L 30D; c\u00f3 ph\u01b0\u01a1ng ph\u00e1p bao tan \u1edf ru\u1ed9t nang HPMC kh\u00f4ng c\u1ea7n b\u01b0\u1edbc bao c\u00e1ch ly.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t tr\u01a1n ch\u1ea3y tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0, c\u00f3 th\u1ec3 c\u00f3 m\u00f9i acid acetic nh\u1eb9; v\u1ec1 c\u01a1 b\u1ea3n v\u00f4 \u0111\u1ecbnh h\u00ecnh.<\/li>\n<li>Hai ngu\u1ed3n nguy\u00ean li\u1ec7u \u0111\u01b0\u1ee3c so s\u00e1nh: KLPT 60 700 v\u00e0 47 000; \u0111\u1ed9 \u1ea9m 3,74% v\u00e0 2,20%; t\u1ef7 tr\u1ecdng 1,31 v\u00e0 1,37 g\/cm\u00b3 \u2013 t\u00ednh ch\u1ea5t thay \u0111\u1ed5i theo nh\u00e0 s\u1ea3n xu\u1ea5t.<\/li>\n<li>Nhi\u1ec7t \u0111\u1ed9 chuy\u1ec3n th\u1ee7y tinh kho\u1ea3ng 42,5 \u00b0C, gi\u1ea3m khi th\u00eam diethyl phthalat.<\/li>\n<li><strong>T\u00ednh tan theo pH:<\/strong> kh\u00f4ng tan d\u01b0\u1edbi pH 5, tan tr\u00ean pH 5; \u0111\u00e1p \u1ee9ng pH r\u1ea5t r\u00f5 \u1edf pH 4,5\u20135,0 \u2013 th\u1ea5p h\u01a1n h\u1ea7u h\u1ebft polymer bao tan \u1edf ru\u1ed9t kh\u00e1c; tan d\u1ecdc to\u00e0n b\u1ed9 t\u00e1 tr\u00e0ng. \u0110\u1ed9 tan c\u0169ng ch\u1ecbu \u1ea3nh h\u01b0\u1edfng c\u1ee7a l\u1ef1c ion.<\/li>\n<li>\u0110\u1ed9 tan (25 \u00b0C): methanol 1\/2; aceton\/ethanol (1:1) 1\/3; methanol\/diclomethan (1:1) 1\/3; aceton\/methanol (1:1) 1\/4; ethanol 95% 1\/4; h\u01a1i tan trong aceton, 2-propanol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong cloroform, diclomethan, n\u01b0\u1edbc.<\/li>\n<li>\u0110\u1ed9 nh\u1edbt dung d\u1ecbch PVAP : methanol (1:1) kho\u1ea3ng 5000 mPa\u00b7s; trong h\u1ec7 methanol\/diclomethan \u0111\u1ed9 nh\u1edbt t\u0103ng khi t\u0103ng t\u1ef7 l\u1ec7 methanol.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed. T\u01b0\u01a1ng \u0111\u1ed1i b\u1ec1n v\u1edbi nhi\u1ec7t \u0111\u1ed9 v\u00e0 \u0111\u1ed9 \u1ea9m, kh\u00f4ng b\u1ecb l\u00e3o h\u00f3a \u2013 cho profile gi\u1ea3i ph\u00f3ng \u1ed5n \u0111\u1ecbnh sau b\u1ea3o qu\u1ea3n l\u00e2u. Tuy nhi\u00ean v\u1edbi d\u1ecbch ph\u00e2n t\u00e1n n\u01b0\u1edbc, s\u1ef1 t\u1ea1o acid t\u1ef1 do do th\u1ee7y ph\u00e2n l\u00e0m gi\u1ea3m \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh v\u1eadt l\u00fd. Nang bao b\u1eb1ng c\u00f4ng th\u1ee9c PVAP th\u01b0\u01a1ng m\u1ea1i gi\u1eef kh\u1ea3 n\u0103ng kh\u00e1ng d\u1ecbch v\u1ecb sau 9 th\u00e1ng \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng nh\u01b0ng h\u00f2a tan ch\u1eadm h\u01a1n; b\u1ea3o qu\u1ea3n 37 \u00b0C (ho\u1eb7c 37 \u00b0C\/80% \u0111\u1ed9 \u1ea9m) trong 3 th\u00e1ng l\u00e0m h\u00ecnh th\u1ee9c nang kh\u00f4ng \u0111\u1ea1t.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u1ea1o ph\u1ee9c kh\u00f4ng tan k\u1ebft t\u1ee7a v\u1edbi povidon; t\u01b0\u01a1ng k\u1ef5 v\u1edbi benzocain. Erythromycin ph\u00e2n t\u00e1n \u1ed5n \u0111\u1ecbnh v\u1eadt l\u00fd trong PVAP; omeprazol t\u1ed3n t\u1ea1i d\u1ea1ng v\u00f4 \u0111\u1ecbnh h\u00ecnh trong m\u00e0ng PVAP, kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Ph\u1ea3n \u1ee9ng gi\u1eefa anhydrid phthalic, natri acetat v\u00e0 polyvinyl alcol KLPT th\u1ea5p th\u1ee7y ph\u00e2n 87\u201389% mol \u2013 t\u1ee9c l\u00e0 ester h\u00f3a m\u1ed9t ph\u1ea7n polyvinyl acetat \u0111\u00e3 th\u1ee7y ph\u00e2n m\u1ed9t ph\u1ea7n.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>D\u00f9ng trong thu\u1ed1c u\u1ed1ng; n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 v\u1ec1 c\u01a1 b\u1ea3n kh\u00f4ng k\u00edch \u1ee9ng, kh\u00f4ng \u0111\u1ed9c khi d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c. N\u00ean \u0111eo g\u0103ng tay v\u00e0 k\u00ednh b\u1ea3o h\u1ed9.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (vi\u00ean n\u00e9n u\u1ed1ng t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i ch\u00e2u \u00c2u; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> cellulose acetat phthalat, HPMC phthalat, polymethacrylat (Eudragit), shellac.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Polyvinyl Acetate Phthalate<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Polyvinyl acetat phthalat (PVAP, Sureteric) \u2013 polymer bao tan \u1edf ru\u1ed9t, bao c\u00e1ch ly Polyvinyl acetat phthalat (PVAP) l\u00e0 s\u1ea3n ph\u1ea9m ph\u1ea3n \u1ee9ng c\u1ee7a anhydrid phthalic v\u1edbi polyvinyl acetat th\u1ee7y ph\u00e2n m\u1ed9t ph\u1ea7n, ch\u1ee9a 55,0\u201362,0% nh\u00f3m phthalyl. PVAP l\u00e0 polymer bao tan \u1edf ru\u1ed9t v\u00e0 bao c\u00e1ch ly nh\u00e2n vi\u00ean tr\u01b0\u1edbc khi bao \u0111\u01b0\u1eddng; kh\u00f4ng [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2543,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2544","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyvinyl-acetat-phthalat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Polyvinyl acetat phthalat (PVAP, Sureteric) \u2013 polymer bao tan \u1edf ru\u1ed9t, bao c\u00e1ch ly Polyvinyl acetat phthalat (PVAP) l\u00e0 s\u1ea3n ph\u1ea9m ph\u1ea3n \u1ee9ng c\u1ee7a anhydrid phthalic v\u1edbi polyvinyl acetat th\u1ee7y ph\u00e2n m\u1ed9t ph\u1ea7n, ch\u1ee9a 55,0\u201362,0% nh\u00f3m phthalyl. PVAP l\u00e0 polymer bao tan \u1edf ru\u1ed9t v\u00e0 bao c\u00e1ch ly nh\u00e2n vi\u00ean tr\u01b0\u1edbc khi bao \u0111\u01b0\u1eddng; kh\u00f4ng&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2544"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2544\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2543"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}