{"id":2542,"date":"2026-09-27T16:27:15","date_gmt":"2026-09-27T09:27:15","guid":{"rendered":"https:\/\/cpc1.vn\/polyoxyethylen-stearat\/"},"modified":"2026-09-28T21:23:33","modified_gmt":"2026-09-28T14:23:33","slug":"polyoxyethylen-stearat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/polyoxyethylen-stearat\/","title":{"rendered":"Polyoxyethylen stearat (Myrj, macrogol stearat) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kem, lotion d\u1ea7u\/n\u01b0\u1edbc"},"content":{"rendered":"

Polyoxyethylen stearat (Myrj, macrogol stearat) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kem, lotion d\u1ea7u\/n\u01b0\u1edbc<\/h1>\n

Polyoxyethylen stearat<\/strong> (macrogol stearat, PEG stearat) l\u00e0 c\u00e1c ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion t\u1ea1o b\u1edfi ethoxy h\u00f3a acid stearic. D\u00f9ng ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a cho kem v\u00e0 lotion d\u1ea7u\/n\u01b0\u1edbc<\/strong>; s\u1ed1 \u0111\u01a1n v\u1ecb ethylen oxid c\u00e0ng l\u1edbn th\u00ec c\u00e0ng th\u00e2n n\u01b0\u1edbc.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nMacrogol stearates, PEG stearates, polyethylene glycol stearates, ethoxylated fatty acid esters; Myrj, Marlosol, Crodet, Cerasynt, Hodag, Kessco, Lipo-PEG, Protamate, Ritox; polyoxyl 40 stearate = E431<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n9004-99-3 (PEG stearat); 9005-08-7 (PEG distearat)<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t h\u00f2a tan, ch\u1ea5t th\u1ea5m \u01b0\u1edbt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Hai c\u00e1ch g\u1ecdi t\u00ean:<\/strong> “polyoxyl 8 stearate” (s\u1ed1 8 l\u00e0 s\u1ed1 \u0111\u01a1n v\u1ecb oxyethylen) c\u0169ng l\u00e0 “macrogol stearate 400” \/ “PEG 400 monostearate” (400 l\u00e0 KLPT trung b\u00ecnh m\u1ea1ch polymer). V\u00ed d\u1ee5: polyoxyl 8 stearat = Myrj 45; polyoxyl 40 stearat = Myrj 52 = macrogol stearat 2000; polyoxyl 100 stearat = Myrj 59.<\/p>\n

T\u00ednh ch\u1ea5t m\u1ed9t s\u1ed1 lo\u1ea1i<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
This ingredient<\/th>\nC\u00f4ng th\u1ee9c \u2013 KLPT<\/th>\nD\u1ea1ng<\/th>\nHLB<\/th>\nTan trong n\u01b0\u1edbc<\/th>\n<\/tr>\n<\/thead>\n
Polyoxyl 6 stearat<\/td>\nC30<\/sub>H60<\/sub>O8<\/sub> \u2013 548,80<\/td>\nR\u1eafn m\u1ec1m<\/td>\n9,7<\/td>\nPh\u00e2n t\u00e1n (khi \u0111un)<\/td>\n<\/tr>\n
Polyoxyl 8 stearat<\/td>\nC34<\/sub>H68<\/sub>O10<\/sub> \u2013 636,91<\/td>\nKem s\u00e1p<\/td>\n11,1<\/td>\nPh\u00e2n t\u00e1n<\/td>\n<\/tr>\n
Polyoxyl 12 stearat<\/td>\nC42<\/sub>H84<\/sub>O14<\/sub> \u2013 813,12<\/td>\nR\u1eafn nh\u00e3o<\/td>\n13,6<\/td>\nTan<\/td>\n<\/tr>\n
Polyoxyl 20 stearat<\/td>\nC58<\/sub>H116<\/sub>O22<\/sub> \u2013 1165,55<\/td>\nR\u1eafn s\u00e1p<\/td>\n14<\/td>\nTan<\/td>\n<\/tr>\n
Polyoxyl 40 stearat<\/td>\nC98<\/sub>H196<\/sub>O42<\/sub> \u2013 2046,61<\/td>\nR\u1eafn s\u00e1p, m\u00f9i nh\u1eb9 gi\u1ed1ng m\u1ee1<\/td>\n16,9<\/td>\nTan<\/td>\n<\/tr>\n
Polyoxyl 50 stearat<\/td>\nC118<\/sub>H236<\/sub>O52<\/sub> \u2013 2487,15<\/td>\nR\u1eafn<\/td>\n17,9<\/td>\nTan<\/td>\n<\/tr>\n
Polyoxyl 100 stearat<\/td>\nC218<\/sub>H436<\/sub>O102<\/sub> \u2013 4689,80<\/td>\nR\u1eafn<\/td>\n18,8<\/td>\nTan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

T\u1ea5t c\u1ea3 tan trong ethanol 95%; h\u1ea7u h\u1ebft kh\u00f4ng tan trong d\u1ea7u kho\u00e1ng (tr\u1eeb lo\u1ea1i HLB th\u1ea5p).<\/p>\n

Applications<\/h2>\n\n\n\n\n\n\n\n\n\n
C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Nh\u0169 h\u00f3a ph\u1ee5 tr\u1ee3 cho nh\u0169 t\u01b0\u01a1ng m\u1ee1 D\/N ti\u00eam t\u0129nh m\u1ea1ch<\/td>\n0,5\u20135<\/td>\n<\/tr>\n
Nh\u0169 h\u00f3a kem, lotion D\/N<\/td>\n0,5\u201310<\/td>\n<\/tr>\n
Thu\u1ed1c m\u1ee1 tra m\u1eaft<\/td>\n7<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n thu\u1ed1c \u0111\u1eb7t<\/td>\n1\u201310<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n<\/td>\n1\u20132<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • \u0110\u1eb7c bi\u1ec7t h\u1eefu \u00edch l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a khi c\u00f3 mu\u1ed1i l\u00e0m se ho\u1eb7c ch\u1ea5t \u0111i\u1ec7n ly m\u1ea1nh.<\/li>\n
  • Ph\u1ed1i v\u1edbi ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00e1c \u0111\u1ec3 \u0111\u1ea1t HLB mong mu\u1ed1n cho lotion, thu\u1ed1c m\u1ee1.<\/li>\n
  • Polyoxyl 40 stearat \u0111\u00e3 \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a trong d\u1ecbch truy\u1ec1n t\u0129nh m\u1ea1ch v\u00e0 thu\u1ed1c u\u1ed1ng.<\/li>\n<\/ul>\n

    \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

    N\u00f3i chung b\u1ec1n khi c\u00f3 ch\u1ea5t \u0111i\u1ec7n ly, acid v\u00e0 base y\u1ebfu; acid, base m\u1ea1nh g\u00e2y th\u1ee7y ph\u00e2n v\u00e0 x\u00e0 ph\u00f2ng h\u00f3a d\u1ea7n. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4, nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng.<\/p>\n

    T\u01b0\u01a1ng k\u1ef5<\/h2>\n
      \n
    • Kh\u00f4ng b\u1ec1n trong dung d\u1ecbch ki\u1ec1m n\u00f3ng (th\u1ee7y ph\u00e2n); b\u1ecb x\u00e0 ph\u00f2ng h\u00f3a b\u1edfi acid, base m\u1ea1nh.<\/li>\n
    • \u0110\u1ed5i m\u00e0u ho\u1eb7c k\u1ebft t\u1ee7a v\u1edbi salicylat, ch\u1ea5t phenol, mu\u1ed1i iod, mu\u1ed1i bismuth, b\u1ea1c v\u00e0 tannin; c\u00f3 th\u1ec3 t\u1ea1o ph\u1ee9c v\u1edbi ch\u1ea5t b\u1ea3o qu\u1ea3n.<\/li>\n
    • \u1ede n\u1ed3ng \u0111\u1ed9 tr\u00ean 5% c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n c\u1ee7a bacitracin, cloramphenicol, phenoxymethylpenicilin, natri penicilin, tetracyclin.<\/li>\n<\/ul>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Cho acid b\u00e9o (ch\u1ee7 y\u1ebfu acid stearic) ph\u1ea3n \u1ee9ng tr\u1ef1c ti\u1ebfp v\u1edbi ethylen oxid.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      \u0110\u00e3 \u0111\u01b0\u1ee3c th\u1eed \u0111\u1ed9c t\u00ednh r\u1ed9ng r\u00e3i tr\u00ean \u0111\u1ed9ng v\u1eadt, d\u00f9ng nhi\u1ec1u trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m; n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 v\u1ec1 c\u01a1 b\u1ea3n kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. LD50<\/sub> polyoxyl 8 stearat (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 64 g\/kg; polyoxyl 20 stearat (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 0,87 g\/kg. L\u01b0u \u00fd an to\u00e0n kho:<\/strong> s\u1ea3n ph\u1ea9m ch\u1ee9a tr\u00ean 100 ppm ethylen oxid t\u1ef1 do c\u00f3 th\u1ec3 g\u00e2y nguy c\u01a1 n\u1ed5 khi b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn do ethylen oxid t\u00edch t\u1ee5 \u1edf kho\u1ea3ng tr\u1ed1ng v\u01b0\u1ee3t gi\u1edbi h\u1ea1n n\u1ed5.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (dung d\u1ecbch nha khoa; ti\u00eam t\u0129nh m\u1ea1ch; nh\u00e3n khoa; nang v\u00e0 vi\u00ean n\u00e9n u\u1ed1ng; h\u1ed7n d\u1ecbch nh\u1ecf tai; kem, nh\u0169 t\u01b0\u01a1ng, lotion, thu\u1ed1c m\u1ee1, dung d\u1ecbch d\u00f9ng ngo\u00e0i; \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. (macrogol stearat) v\u00e0 USP-NF (polyoxyl 40 stearat\u2026).<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> polyethylen glycol, acid stearic, polysorbat, ether alkyl polyoxyethylen.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Polyoxyethylene Stearates<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Polyoxyethylen stearat (Myrj, macrogol stearat) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kem, lotion d\u1ea7u\/n\u01b0\u1edbc Polyoxyethylen stearat (macrogol stearat, PEG stearat) l\u00e0 c\u00e1c ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion t\u1ea1o b\u1edfi ethoxy h\u00f3a acid stearic. D\u00f9ng ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a cho kem v\u00e0 lotion d\u1ea7u\/n\u01b0\u1edbc; s\u1ed1 \u0111\u01a1n v\u1ecb ethylen oxid c\u00e0ng l\u1edbn th\u00ec c\u00e0ng th\u00e2n n\u01b0\u1edbc. Th\u00f4ng […]<\/p>","protected":false},"author":1,"featured_media":2541,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2542","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polyoxyethylen-stearat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Polyoxyethylen stearat (Myrj, macrogol stearat) \u2013 ch\u1ea5t nh\u0169 h\u00f3a kem, lotion d\u1ea7u\/n\u01b0\u1edbc Polyoxyethylen stearat (macrogol stearat, PEG stearat) l\u00e0 c\u00e1c ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion t\u1ea1o b\u1edfi ethoxy h\u00f3a acid stearic. D\u00f9ng ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t nh\u0169 h\u00f3a cho kem v\u00e0 lotion d\u1ea7u\/n\u01b0\u1edbc; s\u1ed1 \u0111\u01a1n v\u1ecb ethylen oxid c\u00e0ng l\u1edbn th\u00ec c\u00e0ng th\u00e2n n\u01b0\u1edbc. Th\u00f4ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2542"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2542\/revisions"}],"predecessor-version":[{"id":3353,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2542\/revisions\/3353"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2541"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}