{"id":2524,"date":"2026-09-27T16:18:18","date_gmt":"2026-09-27T09:18:18","guid":{"rendered":"https:\/\/cpc1.vn\/polycarbophil\/"},"modified":"2026-09-29T12:11:17","modified_gmt":"2026-09-29T05:11:17","slug":"polycarbophil","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/polycarbophil\/","title":{"rendered":"Polycarbophil (Noveon AA-1) \u2013 polymer b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, l\u00e0m \u0111\u1eb7c"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Polycarbophil (Noveon AA-1) \u2013 polymer b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, l\u00e0m \u0111\u1eb7c<\/h1>\n<p><strong>Polycarbophil<\/strong> (Noveon AA-1) l\u00e0 polymer acid acrylic li\u00ean k\u1ebft ngang b\u1eb1ng divinyl glycol, ph\u00e2n t\u1eed l\u01b0\u1ee3ng r\u1ea5t l\u1edbn. Theo truy\u1ec1n th\u1ed1ng l\u00e0 <strong>ch\u1ea5t l\u00e0m \u0111\u1eb7c<\/strong> \u1edf n\u1ed3ng \u0111\u1ed9 r\u1ea5t th\u1ea5p (d\u01b0\u1edbi 1%) v\u00e0 ch\u1ea5t nh\u0169 h\u00f3a; n\u1ed5i b\u1eadt nh\u1ea5t l\u00e0 t\u00ednh <strong>b\u00e1m d\u00ednh sinh h\u1ecdc (mucoadhesive)<\/strong> xu\u1ea5t s\u1eafc tr\u00ean ni\u00eam m\u1ea1c m\u00e1, m\u1eaft, ru\u1ed9t, m\u0169i, \u00e2m \u0111\u1ea1o, tr\u1ef1c tr\u00e0ng.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Noveon AA-1<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>9003-01-4<\/td>\n<\/tr>\n<tr>\n<td>C\u1ea5u t\u1ea1o<\/td>\n<td>Acid polyacrylic li\u00ean k\u1ebft ngang v\u1edbi divinyl glycol; KLPT \u01b0\u1edbc t\u00ednh l\u00fd thuy\u1ebft t\u1eeb 700 000 \u0111\u1ebfn 3\u20134 t\u1ef7 (ch\u01b0a c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111o polymer ba chi\u1ec1u)<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t h\u1ea5p ph\u1ee5, ch\u1ea5t b\u00e1m d\u00ednh sinh h\u1ecdc, t\u00e1 d\u01b0\u1ee3c d\u00ednh vi\u00ean gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t, ch\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t l\u00e0m \u0111\u1eb7c, ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li><strong>L\u00e0m \u0111\u1eb7c<\/strong> \u1edf n\u1ed3ng \u0111\u1ed9 d\u01b0\u1edbi 1% cho lotion, kem, gel d\u00f9ng ngo\u00e0i, h\u1ed7n d\u1ecbch u\u1ed1ng, t\u00fai gel qua da \u2013 t\u1ea1o d\u1ea3i \u0111\u1ed9 nh\u1edbt v\u00e0 t\u00ednh ch\u1ea3y r\u1ed9ng; nh\u0169 h\u00f3a h\u1ec7 d\u1ea7u\/n\u01b0\u1edbc d\u00f9ng ngo\u00e0i.<\/li>\n<li><strong>B\u00e1m d\u00ednh sinh h\u1ecdc:<\/strong> vi\u00ean \u0111\u1eb7t trong m\u00e1 c\u00f3 l\u1ef1c b\u00e1m cao, th\u1eddi gian l\u01b0u d\u00e0i, kh\u00f4ng k\u00edch \u1ee9ng ni\u00eam m\u1ea1c m\u00e1 ng\u01b0\u1eddi; ph\u00f9 h\u1ee3p gi\u1ea3i ph\u00f3ng c\u00f3 ki\u1ec3m so\u00e1t v\u00e0 d\u01b0\u1ee3c ch\u1ea5t ch\u1ecbu chuy\u1ec3n h\u00f3a b\u01b0\u1edbc m\u1ed9t. Vi\u00ean \u0111\u1eb7t d\u01b0\u1edbi l\u01b0\u1ee1i buprenorphin d\u00f9ng polycarbophil b\u00e1m d\u00ednh m\u1ea1nh h\u01a1n d\u00f9ng carbomer.<\/li>\n<li>Gel d\u00f9ng t\u1ea1i ch\u1ed7 v\u00f9ng l\u1ee3i, h\u1ecdng, nha chu; nh\u00e3n khoa; gel m\u0169i k\u00e9o d\u00e0i l\u01b0u gi\u1eef DNA plasmid; thu\u1ed1c \u0111\u1eb7t tr\u1ef1c tr\u00e0ng d\u1ea1ng l\u1ecfng ch\u1ee9a insulin; gel \u00e2m \u0111\u1ea1o econazol; h\u1ec7 vaccin \u00e2m \u0111\u1ea1o b\u00e1m d\u00ednh.<\/li>\n<li>Vi c\u1ea7u cho khoang mi\u1ec7ng v\u00e0 m\u0169i; vi c\u1ea7u n\u1ed5i\u2013b\u00e1m d\u00ednh l\u01b0u gi\u1eef trong d\u1ea1 d\u00e0y.<\/li>\n<li>Li\u00ean h\u1ee3p v\u1edbi L-cystein (thiomer) l\u00e0m t\u0103ng m\u1ea1nh t\u00ednh b\u00e1m d\u00ednh \u2013 n\u1ec1n t\u1ea3ng ph\u00e2n ph\u1ed1i polypeptid \u0111\u01b0\u1eddng u\u1ed1ng (heparin, insulin, kh\u00e1ng nguy\u00ean vaccin), nh\u00e3n khoa, qua da.<\/li>\n<li>\u0110\u01b0\u1ee3c b\u00e1o c\u00e1o t\u0103ng th\u1ea5m b\u1eb1ng c\u00e1ch m\u1edf thu\u1eadn ngh\u1ecbch li\u00ean k\u1ebft ch\u1eb7t gi\u1eefa c\u00e1c t\u1ebf b\u00e0o v\u00e0 b\u1ea5t ho\u1ea1t t\u1ea1i ch\u1ed7 enzym ti\u00eau h\u00f3a.<\/li>\n<li>C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t x\u1ed1p tr\u1eafng \u0111\u1ebfn tr\u1eafng ng\u00e0, h\u01a1i acid, m\u00f9i acetic nh\u1eb9.<\/li>\n<li>pH ph\u00e2n t\u00e1n 1%: 2,5\u20133,0; 0,5%: 2,7\u20133,5; pKa 6,0 \u00b1 0,5.<\/li>\n<li>T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,19\u20130,24 g\/cm\u00b3; t\u1ef7 tr\u1ecdng ri\u00eang 1,41; nhi\u1ec7t \u0111\u1ed9 chuy\u1ec3n th\u1ee7y tinh 100\u2013105 \u00b0C; \u0111\u1ed9 \u1ea9m \u2264 2,0%, \u0111\u1ed9 \u1ea9m c\u00e2n b\u1eb1ng 8\u201310% (\u0111\u1ed9 \u1ea9m t\u01b0\u01a1ng \u0111\u1ed1i 50%).<\/li>\n<li><strong>Tr\u01b0\u01a1ng n\u1edf:<\/strong> \u1edf pH tr\u00ean 4\u20136, nh\u00f3m carboxyl ion h\u00f3a \u0111\u1ea9y nhau l\u00e0m polymer du\u1ed7i ra \u2013 tr\u01b0\u01a1ng \u0111\u1ebfn kho\u1ea3ng 1000 l\u1ea7n th\u1ec3 t\u00edch (10 l\u1ea7n \u0111\u01b0\u1eddng k\u00ednh) t\u1ea1o gel.<\/li>\n<li>Ti\u1ec3u ph\u00e2n s\u01a1 c\u1ea5p trung b\u00ecnh kho\u1ea3ng 0,2 \u00b5m, k\u1ebft b\u00f4ng th\u00e0nh b\u1ed9t trung b\u00ecnh 2\u20137 \u00b5m; kh\u1ed1i k\u1ebft b\u00f4ng kh\u00f4ng t\u00e1ch l\u1ea1i th\u00e0nh ti\u1ec3u ph\u00e2n s\u01a1 c\u1ea5p.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<ul>\n<li>B\u1ec1n, kh\u00f4ng th\u1ee7y ph\u00e2n hay oxy h\u00f3a \u1edf \u0111i\u1ec1u ki\u1ec7n th\u01b0\u1eddng. L\u00e3o h\u00f3a nhi\u1ec7t d\u01b0\u1edbi 104 \u00b0C \u0111\u1ebfn 2 gi\u1edd kh\u00f4ng \u1ea3nh h\u01b0\u1edfng; nhi\u1ec7t qu\u00e1 m\u1ee9c k\u00e9o d\u00e0i g\u00e2y \u0111\u1ed5i m\u00e0u, gi\u1ea3m \u1ed5n \u0111\u1ecbnh, c\u00f3 khi h\u00f3a d\u1ebbo; ph\u00e2n h\u1ee7y ho\u00e0n to\u00e0n khi \u0111un 260 \u00b0C trong 30 ph\u00fat.<\/li>\n<li>B\u1ed9t kh\u00f4 kh\u00f4ng cho vi sinh ph\u00e1t tri\u1ec3n; d\u1ecbch nh\u1ea7y c\u00f3 th\u1ec3 nhi\u1ec5m vi sinh \u2013 c\u1ea7n ch\u1ea5t b\u1ea3o qu\u1ea3n. Nhi\u1ec7t \u0111\u1ed9 cao l\u00e0m gi\u1ea3m \u0111\u1ed9 nh\u1edbt d\u1ecbch nh\u1ea7y.<\/li>\n<li>R\u1ea5t h\u00fat \u1ea9m: \u0111\u00f3ng g\u00f3i k\u00edn kh\u00ed trong bao b\u00ec ch\u1ed1ng \u0103n m\u00f2n, n\u01a1i kh\u00f4 m\u00e1t, \u0111\u1eady k\u00edn khi kh\u00f4ng d\u00f9ng. H\u00fat \u1ea9m kh\u00f4ng l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 nh\u01b0ng kh\u00f3 ph\u00e2n t\u00e1n v\u00e0 c\u00e2n ch\u00ednh x\u00e1c.<\/li>\n<li>Bao b\u00ec s\u1ea3n ph\u1ea9m: th\u1ee7y tinh, nh\u1ef1a ho\u1eb7c l\u00f3t nh\u1ef1a; tu\u00fdp nh\u00f4m th\u01b0\u1eddng y\u00eau c\u1ea7u pH d\u01b0\u1edbi 6,5, tu\u00fdp\/bao b\u00ec kim lo\u1ea1i kh\u00e1c y\u00eau c\u1ea7u pH tr\u00ean 7,7.<\/li>\n<\/ul>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u1ecfa nhi\u1ec7t khi ti\u1ebfp x\u00fac base m\u1ea1nh (amoniac, NaOH, KOH, amin base m\u1ea1nh). Kh\u00f4ng t\u01b0\u01a1ng h\u1ee3p v\u1edbi polymer cation, acid m\u1ea1nh v\u00e0 n\u1ed3ng \u0111\u1ed9 ch\u1ea5t \u0111i\u1ec7n ly cao (l\u00e0m gi\u1ea3m \u0111\u1ed9 nh\u1edbt gel).<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>Tr\u00f9ng h\u1ee3p k\u1ebft t\u1ee7a acid acrylic v\u1edbi ch\u1ea5t li\u00ean k\u1ebft ngang divinyl glycol trong ethyl acetat, r\u1ed3i s\u1ea5y kh\u00f4.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>C\u00f3 l\u1ecbch s\u1eed d\u00f9ng an to\u00e0n l\u00e2u d\u00e0i trong gel, kem, lotion, thu\u1ed1c m\u1ee1 d\u00f9ng ngo\u00e0i; k\u00edch \u1ee9ng r\u1ea5t th\u1ea5p, kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m khi d\u00f9ng l\u1eb7p l\u1ea1i. LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): &gt; 2,5 g\/kg; (th\u1ecf, qua da): &gt; 3,0 g\/kg; (chu\u1ed9t nh\u1eaft, t\u0129nh m\u1ea1ch): 0,070 g\/kg. H\u1ea1n ch\u1ebf t\u1ea1o b\u1ee5i (n\u1ed3ng \u0111\u1ed9 n\u1ed5 th\u1ea5p nh\u1ea5t 130 g\/m\u00b3); b\u1ee5i k\u00edch \u1ee9ng c\u01a1 h\u1ecdc m\u1eaft, ni\u00eam m\u1ea1c, \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p \u2013 r\u1eeda m\u1eaft b\u1eb1ng n\u01b0\u1edbc mu\u1ed1i sinh l\u00fd. Vi\u00eam da ti\u1ebfp x\u00fac c\u00f3 th\u1ec3 x\u1ea3y ra khi ti\u1ebfp x\u00fac k\u00e9o d\u00e0i, l\u1eb7p l\u1ea1i \u1edf \u0111i\u1ec1u ki\u1ec7n kh\u1eafc nghi\u1ec7t. D\u00f9ng g\u0103ng tay, k\u00ednh b\u1ea3o h\u1ed9, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i; l\u00e0m vi\u1ec7c n\u01a1i th\u00f4ng gi\u00f3.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>GRAS.<\/li>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (gel \u00e2m \u0111\u1ea1o; vi\u00ean u\u1ed1ng, vi\u00ean ng\u1eadm); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong USP.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> <strong>calci polycarbophil<\/strong> (CAS 9003-97-8; Noveon CA-1, CA-2) \u2013 mu\u1ed1i calci, b\u1ed9t tr\u1eafng, pH ph\u00e2n t\u00e1n 1% l\u00e0 6,0\u20138,0; carbomer.<\/p>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Polycarbophil<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Polycarbophil (Noveon AA-1) \u2013 polymer b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, l\u00e0m \u0111\u1eb7c Polycarbophil (Noveon AA-1) l\u00e0 polymer acid acrylic li\u00ean k\u1ebft ngang b\u1eb1ng divinyl glycol, ph\u00e2n t\u1eed l\u01b0\u1ee3ng r\u1ea5t l\u1edbn. Theo truy\u1ec1n th\u1ed1ng l\u00e0 ch\u1ea5t l\u00e0m \u0111\u1eb7c \u1edf n\u1ed3ng \u0111\u1ed9 r\u1ea5t th\u1ea5p (d\u01b0\u1edbi 1%) v\u00e0 ch\u1ea5t nh\u0169 h\u00f3a; n\u1ed5i b\u1eadt nh\u1ea5t l\u00e0 t\u00ednh b\u00e1m d\u00ednh sinh [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2523,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2524","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/polycarbophil-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Polycarbophil (Noveon AA-1) \u2013 polymer b\u00e1m d\u00ednh ni\u00eam m\u1ea1c, l\u00e0m \u0111\u1eb7c Polycarbophil (Noveon AA-1) l\u00e0 polymer acid acrylic li\u00ean k\u1ebft ngang b\u1eb1ng divinyl glycol, ph\u00e2n t\u1eed l\u01b0\u1ee3ng r\u1ea5t l\u1edbn. Theo truy\u1ec1n th\u1ed1ng l\u00e0 ch\u1ea5t l\u00e0m \u0111\u1eb7c \u1edf n\u1ed3ng \u0111\u1ed9 r\u1ea5t th\u1ea5p (d\u01b0\u1edbi 1%) v\u00e0 ch\u1ea5t nh\u0169 h\u00f3a; n\u1ed5i b\u1eadt nh\u1ea5t l\u00e0 t\u00ednh b\u00e1m d\u00ednh sinh&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2524"}],"version-history":[{"count":3,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2524\/revisions"}],"predecessor-version":[{"id":3924,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2524\/revisions\/3924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2523"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}