{"id":2518,"date":"2026-09-27T16:16:31","date_gmt":"2026-09-27T09:16:31","guid":{"rendered":"https:\/\/cpc1.vn\/acid-phosphoric\/"},"modified":"2026-09-29T11:51:48","modified_gmt":"2026-09-29T04:51:48","slug":"acid-phosphoric","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-phosphoric\/","title":{"rendered":"Acid phosphoric \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m pH"},"content":{"rendered":"

Acid phosphoric \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m pH<\/h1>\n

Acid phosphoric<\/strong> (acid orthophosphoric, H3<\/sub>PO4<\/sub>, E338) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t acid h\u00f3a v\u00e0 ch\u1ea5t \u0111\u1ec7m<\/strong> trong nhi\u1ec1u d\u1ea1ng b\u00e0o ch\u1ebf; trong th\u1ef1c ph\u1ea9m l\u00e0 ch\u1ea5t t\u1ea1o chua, t\u1ea1o h\u01b0\u01a1ng, ch\u1ea5t hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a (0,001\u20130,005%) v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nOrthophosphoric acid, E338, hydrogen phosphate, syrupy phosphoric acid, acide phosphorique<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n7664-38-2<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nH3<\/sub>PO4<\/sub> \u2013 98,00<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t acid h\u00f3a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t acid h\u00f3a, ch\u1ea5t \u0111\u1ec7m trong thu\u1ed1c ti\u00eam truy\u1ec1n, thu\u1ed1c ti\u00eam, dung d\u1ecbch u\u1ed1ng, kem, lotion, thu\u1ed1c m\u1ee1, dung d\u1ecbch d\u00f9ng ngo\u00e0i, ch\u1ebf ph\u1ea9m \u00e2m \u0111\u1ea1o.<\/li>\n
  • Th\u1ef1c ph\u1ea9m: ch\u1ea5t t\u1ea1o chua, t\u1ea1o h\u01b0\u01a1ng, hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a, t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i.<\/li>\n
  • Gel acid phosphoric 35% d\u00f9ng trong nha khoa \u0111\u1ec3 xoi m\u00f2n men r\u0103ng. C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Acid phosphoric \u0111\u1eb7c: ch\u1ea5t l\u1ecfng s\u00e1nh nh\u01b0 siro, kh\u00f4ng m\u00e0u, kh\u00f4ng m\u00f9i.<\/li>\n
    • pH dung d\u1ecbch 1%: 1,6; pKa1<\/sub> 2,15; pKa2<\/sub> 7,09; pKa3<\/sub> 12,32 \u2013 ba n\u1ea5c ph\u00e2n ly cho ph\u00e9p t\u1ea1o h\u1ec7 \u0111\u1ec7m phosphat \u1edf nhi\u1ec1u v\u00f9ng pH.<\/li>\n
    • N\u00f3ng ch\u1ea3y 42,35 \u00b0C (acid khan); s\u00f4i 117,87 \u00b0C (dung d\u1ecbch \u0111\u1eb7c).<\/li>\n
    • T\u1ef7 tr\u1ecdng (25 \u00b0C): 1,874 (100%); 1,6850 (85%); 1,3334 (50%); 1,0523 (10%).<\/li>\n
    • Tr\u1ed9n l\u1eabn v\u1edbi n\u01b0\u1edbc v\u00e0 ethanol 95%, t\u1ecfa nhi\u1ec7t.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      \u1ede nhi\u1ec7t \u0111\u1ed9 th\u1ea5p c\u00f3 th\u1ec3 \u0111\u00f4ng \u0111\u1eb7c th\u00e0nh kh\u1ed1i tinh th\u1ec3 kh\u00f4ng m\u00e0u (hemihydrat, n\u00f3ng ch\u1ea3y \u1edf 28 \u00b0C). B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i kh\u00f4 m\u00e1t; c\u00f3 th\u1ec3 d\u00f9ng b\u1ed3n th\u00e9p kh\u00f4ng g\u1ec9.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      L\u00e0 acid m\u1ea1nh, ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t ki\u1ec1m. H\u1ed7n h\u1ee3p v\u1edbi nitromethan c\u00f3 th\u1ec3 n\u1ed5.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Ph\u1ea7n l\u1edbn \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng x\u1eed l\u00fd qu\u1eb7ng phosphat (ch\u1ee7 y\u1ebfu tricalci phosphat) v\u1edbi acid sulfuric, t\u00e1ch acid phosphoric b\u1eb1ng l\u1ecdc b\u00f9n; tinh ch\u1ebf b\u1eb1ng k\u1ebft t\u1ee7a h\u00f3a h\u1ecdc, chi\u1ebft dung m\u00f4i, k\u1ebft tinh ho\u1eb7c trao \u0111\u1ed5i ion.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u1ea1ng \u0111\u1eb7c l\u00e0 acid \u0103n m\u00f2n c\u1ef1c m\u1ea1nh v\u00e0 c\u00f3 h\u1ea1i; nh\u01b0ng trong d\u01b0\u1ee3c ph\u1ea9m th\u01b0\u1eddng \u0111\u01b0\u1ee3c pha r\u1ea5t lo\u00e3ng v\u00e0 n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 v\u1ec1 c\u01a1 b\u1ea3n kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 1,53 g\/kg; (th\u1ecf, qua da): 2,74 g\/kg. G\u00e2y b\u1ecfng khi ti\u1ebfp x\u00fac da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 r\u1eeda ngay b\u1eb1ng nhi\u1ec1u n\u01b0\u1edbc; m\u1eb7c qu\u1ea7n \u00e1o b\u1ea3o h\u1ed9, g\u0103ng tay, k\u00ednh b\u1ea3o h\u1ed9. K\u00edch \u1ee9ng khi h\u00edt; c\u00f3 gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m ngh\u1ec1 nghi\u1ec7p. \u0110un n\u00f3ng t\u1ecfa kh\u00f3i \u0111\u1ed9c.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E338).<\/li>\n
      • C\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c ti\u00eam truy\u1ec1n, thu\u1ed1c ti\u00eam, dung d\u1ecbch u\u1ed1ng, kem, lotion, thu\u1ed1c m\u1ee1, dung d\u1ecbch d\u00f9ng ngo\u00e0i, ch\u1ebf ph\u1ea9m \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur., USP-NF v\u00e0 Food Chemicals Codex.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> acid phosphoric lo\u00e3ng<\/strong> \u2013 Ph.Eur.: 9,5\u201310,5% (kl\/kl) H3<\/sub>PO4<\/sub>, pha 115 g acid phosphoric v\u1edbi 885 g n\u01b0\u1edbc; USP-NF: 9,5\u201310,5% (kl\/tt), pha 69 mL acid phosphoric v\u1edbi n\u01b0\u1edbc v\u1eeba \u0111\u1ee7 1000 mL. C\u00e1c mu\u1ed1i natri, kali phosphat.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Phosphoric Acid<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Acid phosphoric \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m pH Acid phosphoric (acid orthophosphoric, H3PO4, E338) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t acid h\u00f3a v\u00e0 ch\u1ea5t \u0111\u1ec7m trong nhi\u1ec1u d\u1ea1ng b\u00e0o ch\u1ebf; trong th\u1ef1c ph\u1ea9m l\u00e0 ch\u1ea5t t\u1ea1o chua, t\u1ea1o h\u01b0\u01a1ng, ch\u1ea5t hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a (0,001\u20130,005%) v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i. Th\u00f4ng […]<\/p>\n","protected":false},"author":1,"featured_media":2517,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2518","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-phosphoric-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid phosphoric \u2013 ch\u1ea5t acid h\u00f3a, \u0111\u1ec7m pH Acid phosphoric (acid orthophosphoric, H3PO4, E338) \u0111\u01b0\u1ee3c d\u00f9ng r\u1ed9ng r\u00e3i l\u00e0m ch\u1ea5t acid h\u00f3a v\u00e0 ch\u1ea5t \u0111\u1ec7m trong nhi\u1ec1u d\u1ea1ng b\u00e0o ch\u1ebf; trong th\u1ef1c ph\u1ea9m l\u00e0 ch\u1ea5t t\u1ea1o chua, t\u1ea1o h\u01b0\u01a1ng, ch\u1ea5t hi\u1ec7p \u0111\u1ed3ng ch\u1ed1ng oxy h\u00f3a (0,001\u20130,005%) v\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c v\u1edbi ion kim lo\u1ea1i. Th\u00f4ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2518"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2518\/revisions"}],"predecessor-version":[{"id":3720,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2518\/revisions\/3720"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2517"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}