{"id":2513,"date":"2026-09-27T16:15:14","date_gmt":"2026-09-27T09:15:14","guid":{"rendered":"https:\/\/cpc1.vn\/phenylmercuric-borat\/"},"modified":"2026-09-29T12:10:35","modified_gmt":"2026-09-29T05:10:35","slug":"phenylmercuric-borat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/phenylmercuric-borat\/","title":{"rendered":"Phenylmercuric borat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 \u00edt k\u00edch \u1ee9ng h\u01a1n"},"content":{"rendered":"

Phenylmercuric borat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 \u00edt k\u00edch \u1ee9ng h\u01a1n<\/h1>\n

Phenylmercuric borat<\/strong> (PMB) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1, d\u00f9ng thay phenylmercuric acetat ho\u1eb7c nitrat. PMB tan t\u1ed1t h\u01a1n phenylmercuric nitrat<\/strong> v\u00e0 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u00edt k\u00edch \u1ee9ng h\u01a1n<\/strong> c\u1ea3 acetat l\u1eabn nitrat.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n(Dihydrogen borato)phenylmercury, phenylmercuriborate, phenylmercury borate, PMB<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n102-98-7 (C6<\/sub>H7<\/sub>BHgO3<\/sub>); 8017-88-7 (C12<\/sub>H13<\/sub>BHg2<\/sub>O4<\/sub>); 6273-99-0 (C12<\/sub>H11<\/sub>BHg2<\/sub>O3<\/sub>)<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n (Ph.Eur.)<\/td>\nH\u1ee3p ch\u1ea5t \u0111\u1ed3ng ph\u00e2n t\u1eed phenylmercuric hydroxid v\u1edbi phenylmercuric orthoborat (C12<\/sub>H13<\/sub>BHg2<\/sub>O4<\/sub>, 633,2) ho\u1eb7c d\u1ea1ng m\u1ea5t n\u01b0\u1edbc metaborat (C12<\/sub>H11<\/sub>BHg2<\/sub>O3<\/sub>, 615,2), ho\u1eb7c h\u1ed7n h\u1ee3p hai ch\u1ea5t<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n\n\n\n\n\n\n
C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
Ch\u1ea5t kh\u00e1ng khu\u1ea9n trong ch\u1ebf ph\u1ea9m nh\u00e3n khoa<\/td>\n0,002\u20130,004<\/td>\n<\/tr>\n
Ch\u1ea5t kh\u00e1ng khu\u1ea9n trong thu\u1ed1c ti\u00eam<\/td>\n0,002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
    \n
  • V\u1ea3y \u00f3ng \u00e1nh kh\u00f4ng m\u00e0u ho\u1eb7c b\u1ed9t k\u1ebft tinh tr\u1eafng hay h\u01a1i v\u00e0ng, kh\u00f4ng m\u00f9i.<\/li>\n
  • Kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng, t\u00e1c d\u1ee5ng s\u00e1t khu\u1ea9n v\u00e0 kh\u00e1ng n\u1ea5m ch\u1eadm, t\u01b0\u01a1ng t\u1ef1 phenylmercuric nitrat.<\/li>\n
  • pH dung d\u1ecbch 0,6%: 5,0\u20137,0; pKa 3,3; n\u00f3ng ch\u1ea3y 112\u2013113 \u00b0C.<\/li>\n
  • \u0110\u1ed9 tan (20 \u00b0C): n\u01b0\u1edbc 1\/125 (1\/100 \u1edf 100 \u00b0C); ethanol 95% 1\/150; tan trong glycerin, propylen glycol.<\/li>\n<\/ul>\n

    \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

    Nh\u01b0 c\u00e1c mu\u1ed1i phenylmercuric kh\u00e1c (t\u1ea1o c\u1eb7n th\u1ee7y ng\u00e2n kim lo\u1ea1i m\u00e0u \u0111en khi g\u1eb7p \u00e1nh s\u00e1ng ho\u1eb7c b\u1ea3o qu\u1ea3n l\u00e2u). Dung d\u1ecbch ti\u1ec7t khu\u1ea9n \u0111\u01b0\u1ee3c b\u1eb1ng h\u1ea5p. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

    T\u01b0\u01a1ng k\u1ef5<\/h2>\n

    T\u01b0\u01a1ng k\u1ef5 v\u1edbi halogenid; ch\u1ea5t nh\u0169 h\u00f3a v\u00e0 t\u1ea1o h\u1ed7n d\u1ecbch anion; g\u00f4m adragant; tinh b\u1ed9t; talc; natri metabisulfit; natri thiosulfat; dinatri edetat; silicat; nh\u00f4m v\u00e0 kim lo\u1ea1i kh\u00e1c; acid amin; amoniac v\u00e0 mu\u1ed1i amoni; h\u1ee3p ch\u1ea5t l\u01b0u hu\u1ef3nh; cao su v\u00e0 m\u1ed9t s\u1ed1 nh\u1ef1a (xem phenylmercuric nitrat).<\/p>\n

    An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

    Ch\u1ee7 y\u1ebfu d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n trong thu\u1ed1c d\u00f9ng ngo\u00e0i; \u0111\u00e3 c\u00f3 nhi\u1ec1u b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i v\u1edbi ch\u1ea5t b\u1ea3o qu\u1ea3n ch\u1ee9a th\u1ee7y ng\u00e2n. PMB l\u00e0 ch\u1ea5t k\u00edch \u1ee9ng d\u00f9 \u00edt h\u01a1n acetat v\u00e0 nitrat; c\u00f3 kh\u1ea3 n\u0103ng m\u1eabn c\u1ea3m ch\u00e9o v\u1edbi c\u00e1c ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n kh\u00e1c. \u0110\u00e3 ghi nh\u1eadn h\u1ea5p thu to\u00e0n th\u00e2n khi d\u00f9ng th\u01b0\u1eddng xuy\u00ean x\u00e0 ph\u00f2ng r\u1eeda tay s\u00e1t khu\u1ea9n ch\u1ee9a 0,04% PMB, l\u00e0m t\u1ed5ng l\u01b0\u1ee3ng th\u1ee7y ng\u00e2n \u01b0\u1edbc t\u00ednh \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3 t\u0103ng t\u1eeb kho\u1ea3ng 30 l\u00ean 100 \u00b5g m\u1ed7i 24 gi\u1edd. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 \u0111eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay, m\u1eb7t n\u1ea1. Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh (t\u00ednh theo Hg): 0,01 mg\/m\u00b3 (TWA 8 gi\u1edd), 0,03 mg\/m\u00b3 (ng\u1eafn h\u1ea1n).<\/p>\n

    T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
      \n
    • C\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i ch\u00e2u \u00c2u; Ph\u00e1p cho ph\u00e9p t\u1ed1i \u0111a 0,01% trong d\u01b0\u1ee3c ph\u1ea9m; h\u1ea1n ch\u1ebf trong m\u1ef9 ph\u1ea9m t\u1ea1i Anh; Canada ch\u1ea5p nh\u1eadn trong ch\u1ebf ph\u1ea9m nh\u1ecf m\u1eaft, m\u0169i, tai khi kh\u00f4ng c\u00f3 ch\u1ea5t b\u1ea3o qu\u1ea3n thay th\u1ebf ph\u00f9 h\u1ee3p.<\/li>\n
    • Ngo\u00e0i s\u00e1ch:<\/em> C\u00f4ng \u01b0\u1edbc Minamata v\u1ec1 th\u1ee7y ng\u00e2n v\u00e0 quy \u0111\u1ecbnh m\u1ef9 ph\u1ea9m hi\u1ec7n h\u00e0nh ti\u1ebfp t\u1ee5c si\u1ebft h\u1ee3p ch\u1ea5t th\u1ee7y ng\u00e2n \u2013 ki\u1ec3m tra quy \u0111\u1ecbnh th\u1ecb tr\u01b0\u1eddng \u0111\u00edch.<\/li>\n
    • C\u00f3 chuy\u00ean lu\u1eadn trong BP v\u00e0 Ph.Eur.<\/li>\n<\/ul>\n

      Ch\u1ea5t li\u00ean quan:<\/strong> phenylmercuric acetat, phenylmercuric nitrat, thiomersal.<\/p>\n

      Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

      N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Phenylmercuric Borate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

      \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

      L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

      Phenylmercuric borat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 \u00edt k\u00edch \u1ee9ng h\u01a1n Phenylmercuric borat (PMB) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1, d\u00f9ng thay phenylmercuric acetat ho\u1eb7c nitrat. PMB tan t\u1ed1t h\u01a1n phenylmercuric nitrat v\u00e0 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u00edt k\u00edch \u1ee9ng h\u01a1n c\u1ea3 acetat l\u1eabn nitrat. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c (Dihydrogen […]<\/p>\n","protected":false},"author":1,"featured_media":2512,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2513","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-borat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Phenylmercuric borat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 \u00edt k\u00edch \u1ee9ng h\u01a1n Phenylmercuric borat (PMB) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1, d\u00f9ng thay phenylmercuric acetat ho\u1eb7c nitrat. PMB tan t\u1ed1t h\u01a1n phenylmercuric nitrat v\u00e0 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u00edt k\u00edch \u1ee9ng h\u01a1n c\u1ea3 acetat l\u1eabn nitrat. Th\u00f4ng tin nhanh T\u00ean kh\u00e1c (Dihydrogen…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2513"}],"version-history":[{"count":3,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2513\/revisions"}],"predecessor-version":[{"id":3917,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2513\/revisions\/3917"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2512"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}