{"id":2511,"date":"2026-09-27T16:14:02","date_gmt":"2026-09-27T09:14:02","guid":{"rendered":"https:\/\/cpc1.vn\/phenylmercuric-acetat\/"},"modified":"2026-09-29T12:10:30","modified_gmt":"2026-09-29T05:10:30","slug":"phenylmercuric-acetat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/phenylmercuric-acetat\/","title":{"rendered":"Phenylmercuric acetat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1"},"content":{"rendered":"

Phenylmercuric acetat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1<\/h1>\n

Phenylmercuric acetat<\/strong> (PMA) l\u00e0 h\u1ee3p ch\u1ea5t th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/strong> ph\u1ed5 r\u1ed9ng trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m, thay cho phenylmercuric borat ho\u1eb7c nitrat \u2013 \u0111\u01b0\u1ee3c \u01b0a h\u01a1n phenylmercuric nitrat v\u00ec tan t\u1ed1t h\u01a1n<\/strong>. Do ch\u1ee9a th\u1ee7y ng\u00e2n, vi\u1ec7c s\u1eed d\u1ee5ng ng\u00e0y c\u00e0ng b\u1ecb h\u1ea1n ch\u1ebf.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n(Acetato-O)phenylmercury, acetoxyphenylmercury, phenylmercury acetate, PMA, PMAC, PMAS; Gallotox, Liquiphene<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n62-38-4<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC8<\/sub>H8<\/sub>HgO2<\/sub> \u2013 336,74<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n, ch\u1ea5t s\u00e1t khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n trong thu\u1ed1c ti\u00eam v\u00e0 thu\u1ed1c nh\u1ecf m\u1eaft 0,001\u20130,002%.<\/li>\n
  • M\u1ef9 ph\u1ea9m: kh\u00f4ng qu\u00e1 0,0065% th\u1ee7y ng\u00e2n (t\u00ednh theo kim lo\u1ea1i) theo s\u00e1ch.<\/li>\n
  • C\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t trong m\u1ed9t s\u1ed1 ch\u1ebf ph\u1ea9m \u00e2m \u0111\u1ea1o \u2013 n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh tr\u1eafng \u0111\u1ebfn tr\u1eafng kem, kh\u00f4ng m\u00f9i ho\u1eb7c g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i, ho\u1eb7c l\u0103ng tr\u1ee5, v\u1ea3y nh\u1ecf tr\u1eafng.<\/li>\n
    • Kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng, t\u00e1c d\u1ee5ng s\u00e1t khu\u1ea9n v\u00e0 kh\u00e1ng n\u1ea5m ch\u1eadm, t\u01b0\u01a1ng t\u1ef1 phenylmercuric nitrat.<\/li>\n
    • N\u00f3ng ch\u1ea3y kho\u1ea3ng 150 \u00b0C (d\u01b0\u1ee3c \u0111i\u1ec3n 149\u2013153 \u00b0C); pKa 3,3; pH dung d\u1ecbch b\u00e3o h\u00f2a kho\u1ea3ng 4; h\u1ec7 s\u1ed1 ph\u00e2n b\u1ed1 d\u1ea7u kho\u00e1ng\/n\u01b0\u1edbc 0,1.<\/li>\n
    • \u0110\u1ed9 tan (20 \u00b0C): cloroform 1\/6,8; aceton 1\/19; n\u01b0\u1edbc 1\/180; ether 1\/200; ethanol 95% 1\/225 (s\u1ed1 li\u1ec7u c\u00e1c ngu\u1ed3n ch\u00eanh l\u1ec7ch nhi\u1ec1u).<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      Nh\u01b0 c\u00e1c mu\u1ed1i phenylmercuric kh\u00e1c (xem phenylmercuric nitrat). B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n
        \n
      • T\u01b0\u01a1ng k\u1ef5 v\u1edbi halogenid; ch\u1ea5t nh\u0169 h\u00f3a v\u00e0 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch anion; g\u00f4m adragant; tinh b\u1ed9t; talc; natri metabisulfit; natri thiosulfat; dinatri edetat; silicat; nh\u00f4m v\u00e0 kim lo\u1ea1i kh\u00e1c; acid amin; amoniac v\u00e0 mu\u1ed1i amoni; h\u1ee3p ch\u1ea5t l\u01b0u hu\u1ef3nh; cao su v\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i nh\u1ef1a.<\/li>\n
      • \u0110\u01b0\u1ee3c b\u00e1o c\u00e1o t\u01b0\u01a1ng k\u1ef5 v\u1edbi cefuroxim v\u00e0 ceftazidim.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        \u0110un benzen v\u1edbi th\u1ee7y ng\u00e2n(II) acetat.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        Ch\u1ee7 y\u1ebfu d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n trong thu\u1ed1c d\u00f9ng ngo\u00e0i; \u0111\u00e3 c\u00f3 nhi\u1ec1u b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i v\u1edbi ch\u1ea5t b\u1ea3o qu\u1ea3n ch\u1ee9a th\u1ee7y ng\u00e2n (xem phenylmercuric nitrat). \u0110\u1ed9c t\u00ednh c\u1ea5p cao: LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 41 mg\/kg; (chu\u1ed9t nh\u1eaft, u\u1ed1ng): 13 mg\/kg. C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c; ph\u01a1i nhi\u1ec5m m\u1ea1n qua b\u1ea5t k\u1ef3 \u0111\u01b0\u1eddng n\u00e0o c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh trung \u01b0\u01a1ng. \u0110eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay, m\u1eb7t n\u1ea1. Gi\u1edbi h\u1ea1n ph\u01a1i nhi\u1ec5m t\u1ea1i Anh (h\u1ee3p ch\u1ea5t ch\u1ee9a th\u1ee7y ng\u00e2n, t\u00ednh theo Hg): 0,01 mg\/m\u00b3 (TWA 8 gi\u1edd), 0,03 mg\/m\u00b3 (ng\u1eafn h\u1ea1n).<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • Kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c ph\u00e9p d\u00f9ng l\u00e0m thu\u1ed1c tr\u1eeb s\u00e2u t\u1ea1i M\u1ef9; c\u00f3 trong FDA Inactive Ingredients Guide (nh\u00e3n khoa); c\u00f3 trong thu\u1ed1c kh\u00f4ng d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh. Ph\u00e1p cho ph\u00e9p t\u1ed1i \u0111a 0,01% trong d\u01b0\u1ee3c ph\u1ea9m. Anh h\u1ea1n ch\u1ebf d\u00f9ng trong m\u1ef9 ph\u1ea9m. Canada ch\u1ea5p nh\u1eadn ch\u1ec9 khi kh\u00f4ng c\u00f3 ch\u1ea5t b\u1ea3o qu\u1ea3n ph\u00f9 h\u1ee3p kh\u00e1c.<\/li>\n
        • Ngo\u00e0i s\u00e1ch:<\/em> C\u00f4ng \u01b0\u1edbc Minamata v\u1ec1 th\u1ee7y ng\u00e2n (hi\u1ec7u l\u1ef1c 2017) v\u00e0 quy \u0111\u1ecbnh m\u1ef9 ph\u1ea9m hi\u1ec7n h\u00e0nh ti\u1ebfp t\u1ee5c si\u1ebft h\u1ee3p ch\u1ea5t th\u1ee7y ng\u00e2n \u2013 c\u1ea7n ki\u1ec3m tra quy \u0111\u1ecbnh c\u1ee7a th\u1ecb tr\u01b0\u1eddng \u0111\u00edch tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> phenylmercuric borat, phenylmercuric nitrat, thiomersal.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Phenylmercuric Acetate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Phenylmercuric acetat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 Phenylmercuric acetat (PMA) l\u00e0 h\u1ee3p ch\u1ea5t th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m, thay cho phenylmercuric borat ho\u1eb7c nitrat \u2013 \u0111\u01b0\u1ee3c \u01b0a h\u01a1n phenylmercuric nitrat v\u00ec tan t\u1ed1t h\u01a1n. Do ch\u1ee9a th\u1ee7y ng\u00e2n, […]<\/p>\n","protected":false},"author":1,"featured_media":2510,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2511","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/phenylmercuric-acetat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Phenylmercuric acetat \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 Phenylmercuric acetat (PMA) l\u00e0 h\u1ee3p ch\u1ea5t th\u1ee7y ng\u00e2n h\u1eefu c\u01a1 d\u00f9ng l\u00e0m ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n ph\u1ed5 r\u1ed9ng trong d\u01b0\u1ee3c ph\u1ea9m v\u00e0 m\u1ef9 ph\u1ea9m, thay cho phenylmercuric borat ho\u1eb7c nitrat \u2013 \u0111\u01b0\u1ee3c \u01b0a h\u01a1n phenylmercuric nitrat v\u00ec tan t\u1ed1t h\u01a1n. Do ch\u1ee9a th\u1ee7y ng\u00e2n,…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2511"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2511\/revisions"}],"predecessor-version":[{"id":3916,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2511\/revisions\/3916"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2510"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}