{"id":2479,"date":"2026-09-27T16:04:48","date_gmt":"2026-09-27T09:04:48","guid":{"rendered":"https:\/\/cpc1.vn\/neohesperidin-dihydrochalcon\/"},"modified":"2026-09-28T21:21:01","modified_gmt":"2026-09-28T14:21:01","slug":"neohesperidin-dihydrochalcon","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/neohesperidin-dihydrochalcon\/","title":{"rendered":"Neohesperidin dihydrochalcon (NHDC, E959) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt m\u1ea1nh, che v\u1ecb \u0111\u1eafng"},"content":{"rendered":"

Neohesperidin dihydrochalcon (NHDC, E959) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt m\u1ea1nh, che v\u1ecb \u0111\u1eafng<\/h1>\n

Neohesperidin dihydrochalcon<\/strong> (NHDC, E959) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao<\/strong> t\u1ed5ng h\u1ee3p, ng\u1ecdt kho\u1ea3ng 1500\u20131800 l\u1ea7n saccarose<\/strong> v\u00e0 20 l\u1ea7n saccharin. V\u1ec1 c\u1ea5u tr\u00fac l\u00e0 ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 neohesperidin \u2013 flavanon c\u00f3 trong cam \u0111\u1eafng (Citrus aurantium<\/em>). NHDC d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt v\u00e0 t\u0103ng h\u01b0\u01a1ng v\u1ecb<\/strong>, \u0111\u1eb7c bi\u1ec7t h\u1eefu \u00edch \u0111\u1ec3 che v\u1ecb \u0111\u1eafng<\/strong>.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nNeohesperidin DC, NHDC, E959; Citrosa, Sukor<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n20702-77-6<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC28<\/sub>H36<\/sub>O15<\/sub> \u2013 612,58<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u0103ng h\u01b0\u01a1ng v\u1ecb, ch\u1ea5t t\u1ea1o ng\u1ecdt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Che v\u1ecb \u0111\u1eafng kh\u00f3 ch\u1ecbu c\u1ee7a nhi\u1ec1u d\u01b0\u1ee3c ch\u1ea5t nh\u01b0 thu\u1ed1c kh\u00e1ng acid, kh\u00e1ng sinh, vitamin; trong ch\u1ebf ph\u1ea9m kh\u00e1ng acid, 10\u201330 ppm c\u1ea3i thi\u1ec7n r\u00f5 v\u1ecb.<\/li>\n
  • Th\u1ef1c ph\u1ea9m: th\u01b0\u1eddng 1\u20135 ppm, cao h\u01a1n nhi\u1ec1u trong k\u1eb9o cao su.<\/li>\n
  • Hi\u1ec7p \u0111\u1ed3ng v\u1edbi c\u00e1c ch\u1ea5t ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao v\u00e0 ch\u1ea5t ng\u1ecdt kh\u1ed1i kh\u00e1c: acesulfam K, aspartam, polyol, saccharin.<\/li>\n
  • V\u1ecb ng\u1ecdt c\u00f3 h\u1eadu v\u1ecb k\u00e9o d\u00e0i gi\u1ed1ng menthol.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t tr\u1eafng ho\u1eb7c tr\u1eafng ng\u00e0 v\u00e0ng, v\u1ecb r\u1ea5t ng\u1ecdt.<\/li>\n
    • N\u00f3ng ch\u1ea3y 156\u2013158 \u00b0C; h\u01a1i h\u00fat \u1ea9m (h\u1ea5p thu \u0111\u1ebfn 15% n\u01b0\u1edbc).<\/li>\n
    • \u0110\u1ed9 tan: n\u01b0\u1edbc 1\/2000 \u1edf 22 \u00b0C nh\u01b0ng 1\/1,54 \u1edf 80 \u00b0C; d\u1ec5 tan trong dimethyl sulfoxid; tan trong methanol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong diclomethan. \u0110\u1ee7 tan cho h\u1ea7u h\u1ebft \u1ee9ng d\u1ee5ng; c\u00f3 th\u1ec3 t\u0103ng \u0111\u1ed9 tan b\u1eb1ng ethanol, glycerin, propylen glycol ho\u1eb7c h\u1ed7n h\u1ee3p v\u1edbi n\u01b0\u1edbc, ho\u1eb7c tr\u1ed9n v\u1edbi ch\u1ea5t ng\u1ecdt kh\u00e1c.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • Nguy\u00ean li\u1ec7u b\u1ec1n tr\u00ean 3 n\u0103m \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng.<\/li>\n
      • Nghi\u00ean c\u1ee9u l\u00e3o h\u00f3a c\u1ea5p t\u1ed1c (30\u201360 \u00b0C, pH 1\u20137, 140 ng\u00e0y) cho th\u1ea5y dung d\u1ecbch n\u01b0\u1edbc c\u00f3 th\u1ec3 b\u1ec1n 12 th\u00e1ng \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng, pH 2\u20136. Thay m\u1ed9t ph\u1ea7n n\u01b0\u1edbc b\u1eb1ng dung m\u00f4i c\u00f3 h\u1eb1ng s\u1ed1 \u0111i\u1ec7n m\u00f4i th\u1ea5p h\u01a1n gi\u00fap k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd.<\/li>\n
      • B\u1ea3o qu\u1ea3n n\u01a1i kh\u00f4 m\u00e1t, tr\u00e1nh \u00e1nh s\u00e1ng.<\/li>\n<\/ul>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Hydro h\u00f3a c\u00f3 x\u00fac t\u00e1c trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m c\u00e1c flavanon \u0111\u1eafng neohesperidin ho\u1eb7c naringin (quy tr\u00ecnh m\u00f4 t\u1ea3 t\u1eeb th\u1eadp ni\u00ean 1960).<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ch\u1ea5t t\u1ea1o ng\u1ecdt ho\u1eb7c \u0111i\u1ec1u v\u1ecb trong th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u, M\u1ef9, \u00dac, New Zealand v\u00e0 nhi\u1ec1u n\u01b0\u1edbc ch\u00e2u Phi, ch\u00e2u \u00c1; c\u00f3 trong m\u1ed9t s\u1ed1 thu\u1ed1c u\u1ed1ng. Nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng g\u00e2y qu\u00e1i thai, kh\u00f4ng g\u00e2y ung th\u01b0 \u1edf m\u1ee9c d\u00f9ng trong th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m. Ch\u00e2u \u00c2u \u0111\u1eb7t ADI 0\u20135 mg\/kg th\u1ec3 tr\u1ecdng. Thao t\u00e1c theo bi\u1ec7n ph\u00e1p th\u00f4ng th\u01b0\u1eddng.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E959).<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong BP v\u00e0 Ph.Eur.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan:<\/strong> hesperidin<\/strong> (C28<\/sub>H34<\/sub>O15<\/sub>, 610,56; CAS 520-26-3) \u2013 flavonoid ch\u1ee7 y\u1ebfu trong chanh v\u00e0 cam ng\u1ecdt; n\u00f3ng ch\u1ea3y 258\u2013262 \u00b0C.<\/p>\n

          Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

          N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Neohesperidin Dihydrochalcone<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

          \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

          L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

          Neohesperidin dihydrochalcon (NHDC, E959) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt m\u1ea1nh, che v\u1ecb \u0111\u1eafng Neohesperidin dihydrochalcon (NHDC, E959) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao t\u1ed5ng h\u1ee3p, ng\u1ecdt kho\u1ea3ng 1500\u20131800 l\u1ea7n saccarose v\u00e0 20 l\u1ea7n saccharin. V\u1ec1 c\u1ea5u tr\u00fac l\u00e0 ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 neohesperidin \u2013 flavanon c\u00f3 trong cam \u0111\u1eafng (Citrus aurantium). NHDC d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o […]<\/p>","protected":false},"author":1,"featured_media":2478,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2479","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/neohesperidin-dihydrochalcon-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Neohesperidin dihydrochalcon (NHDC, E959) \u2013 ch\u1ea5t t\u1ea1o ng\u1ecdt m\u1ea1nh, che v\u1ecb \u0111\u1eafng Neohesperidin dihydrochalcon (NHDC, E959) l\u00e0 ch\u1ea5t t\u1ea1o ng\u1ecdt c\u01b0\u1eddng \u0111\u1ed9 cao t\u1ed5ng h\u1ee3p, ng\u1ecdt kho\u1ea3ng 1500\u20131800 l\u1ea7n saccarose v\u00e0 20 l\u1ea7n saccharin. V\u1ec1 c\u1ea5u tr\u00fac l\u00e0 ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 neohesperidin \u2013 flavanon c\u00f3 trong cam \u0111\u1eafng (Citrus aurantium). NHDC d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2479"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2479\/revisions"}],"predecessor-version":[{"id":3326,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2479\/revisions\/3326"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2478"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}