{"id":2462,"date":"2026-09-27T15:59:28","date_gmt":"2026-09-27T08:59:28","guid":{"rendered":"https:\/\/cpc1.vn\/methylparaben\/"},"modified":"2026-09-28T21:18:43","modified_gmt":"2026-09-28T14:18:43","slug":"methylparaben","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/methylparaben\/","title":{"rendered":"Methylparaben (E218, Nipagin M) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n"},"content":{"rendered":"

Methylparaben (E218, Nipagin M) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/h1>\n

Methylparaben<\/strong> (methyl 4-hydroxybenzoat, E218, Nipagin M) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/strong> d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u2013 ri\u00eang l\u1ebb ho\u1eb7c ph\u1ed1i h\u1ee3p c\u00e1c paraben v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c. Trong m\u1ef9 ph\u1ea9m, methylparaben l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c d\u00f9ng nhi\u1ec1u nh\u1ea5t.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nMethyl p-hydroxybenzoate, 4-hydroxybenzoic acid methyl ester, E218; Nipagin M, Uniphen P-23<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n99-76-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC8<\/sub>H8<\/sub>O3<\/sub> \u2013 152,15<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t b\u1ea3o qu\u1ea3n trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m, thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i v\u00e0 nhi\u1ec1u d\u1ea1ng kh\u00e1c.<\/li>\n
  • Paraben hi\u1ec7u qu\u1ea3 trong kho\u1ea3ng pH r\u1ed9ng, ph\u1ed5 kh\u00e1ng khu\u1ea9n r\u1ed9ng, m\u1ea1nh nh\u1ea5t v\u1edbi n\u1ea5m men v\u00e0 n\u1ea5m m\u1ed1c. Ho\u1ea1t t\u00ednh t\u0103ng theo chi\u1ec1u d\u00e0i m\u1ea1ch alkyl nh\u01b0ng \u0111\u1ed9 tan trong n\u01b0\u1edbc gi\u1ea3m \u2013 n\u00ean th\u01b0\u1eddng ph\u1ed1i h\u1ee3p methyl-, ethyl-, propyl-, butylparaben \u0111\u1ec3 c\u00f3 hi\u1ec7p \u0111\u1ed3ng. Methylparaben l\u00e0 paraben y\u1ebfu nh\u1ea5t.<\/li>\n
  • T\u0103ng hi\u1ec7u qu\u1ea3 b\u1eb1ng propylen glycol (2\u20135%), phenylethyl alcol, acid edetic, ho\u1eb7c ph\u1ed1i h\u1ee3p ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c nh\u01b0 imidurea.<\/li>\n
  • Do paraben kh\u00f3 tan, mu\u1ed1i natri th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng nhi\u1ec1u h\u01a1n trong c\u00f4ng th\u1ee9c \u2013 nh\u01b0ng l\u00e0m t\u0103ng pH c\u1ee7a ch\u1ebf ph\u1ea9m (xem ch\u1ea5t li\u00ean quan).<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    D\u1ea1ng b\u00e0o ch\u1ebf<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
    Ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, d\u01b0\u1edbi da (*)<\/td>\n0,065\u20130,25<\/td>\n<\/tr>\n
    Dung d\u1ecbch h\u00edt<\/td>\n0,025\u20130,07<\/td>\n<\/tr>\n
    Ti\u00eam trong da<\/td>\n0,10<\/td>\n<\/tr>\n
    Dung d\u1ecbch nh\u1ecf m\u0169i<\/td>\n0,033<\/td>\n<\/tr>\n
    Ch\u1ebf ph\u1ea9m nh\u00e3n khoa (*)<\/td>\n0,015\u20130,2<\/td>\n<\/tr>\n
    Dung d\u1ecbch, h\u1ed7n d\u1ecbch u\u1ed1ng<\/td>\n0,015\u20130,2<\/td>\n<\/tr>\n
    Ch\u1ebf ph\u1ea9m tr\u1ef1c tr\u00e0ng<\/td>\n0,1\u20130,18<\/td>\n<\/tr>\n
    Ch\u1ebf ph\u1ea9m d\u00f9ng ngo\u00e0i<\/td>\n0,02\u20130,3<\/td>\n<\/tr>\n
    Ch\u1ebf ph\u1ea9m \u00e2m \u0111\u1ea1o<\/td>\n0,1\u20130,18<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    (*) Paraben hi\u1ec7n n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng ph\u00f9 h\u1ee3p cho thu\u1ed1c ti\u00eam v\u00e0 thu\u1ed1c nh\u1ecf m\u1eaft do kh\u1ea3 n\u0103ng k\u00edch \u1ee9ng \u2013 xem ph\u1ea7n An to\u00e0n.<\/p>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Tinh th\u1ec3 kh\u00f4ng m\u00e0u ho\u1eb7c b\u1ed9t k\u1ebft tinh tr\u1eafng, kh\u00f4ng m\u00f9i ho\u1eb7c g\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i, v\u1ecb h\u01a1i n\u00f3ng r\u00e1t.<\/li>\n
    • Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n \u1edf pH 4\u20138; hi\u1ec7u qu\u1ea3 gi\u1ea3m khi pH t\u0103ng do t\u1ea1o anion phenolat. M\u1ea1nh v\u1edbi n\u1ea5m men, n\u1ea5m m\u1ed1c h\u01a1n vi khu\u1ea9n; m\u1ea1nh v\u1edbi Gram d\u01b0\u01a1ng h\u01a1n Gram \u00e2m. N\u1ed3ng \u0111\u1ed9 \u1ee9c ch\u1ebf t\u1ed1i thi\u1ec3u trong n\u01b0\u1edbc v\u1edbi ph\u1ea7n l\u1edbn ch\u1ee7ng th\u1eed nghi\u1ec7m kho\u1ea3ng 1000\u20132000 \u00b5g\/mL. S\u1ea3n ph\u1ea9m th\u1ee7y ph\u00e2n acid p-hydroxybenzoic h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh.<\/li>\n
    • N\u00f3ng ch\u1ea3y 125\u2013128 \u00b0C; pKa 8,4 (22 \u00b0C); t\u1ef7 tr\u1ecdng th\u1ef1c 1,352 g\/cm\u00b3.<\/li>\n
    • H\u1ec7 s\u1ed1 ph\u00e2n b\u1ed1 d\u1ea7u\/n\u01b0\u1edbc thay \u0111\u1ed5i nhi\u1ec1u theo lo\u1ea1i v\u00e0 \u0111\u1ed9 tinh khi\u1ebft d\u1ea7u (v\u00ed d\u1ee5 d\u1ea7u l\u1ea1c 4,2; d\u1ea7u ng\u00f4 4,1; d\u1ea7u th\u1ea7u d\u1ea7u 6,0; isopropyl myristat 18,0; d\u1ea7u kho\u00e1ng 0,1) \u2013 quan tr\u1ecdng khi b\u1ea3o qu\u1ea3n nh\u0169 t\u01b0\u01a1ng.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
      Dung m\u00f4i (25 \u00b0C)<\/th>\n\u0110\u1ed9 tan<\/th>\n<\/tr>\n<\/thead>\n
      Ethanol<\/td>\n1\/2<\/td>\n<\/tr>\n
      Ethanol 95%<\/td>\n1\/3<\/td>\n<\/tr>\n
      Propylen glycol<\/td>\n1\/5<\/td>\n<\/tr>\n
      Ethanol 50%<\/td>\n1\/6<\/td>\n<\/tr>\n
      Ether<\/td>\n1\/10<\/td>\n<\/tr>\n
      Glycerin<\/td>\n1\/60<\/td>\n<\/tr>\n
      D\u1ea7u l\u1ea1c<\/td>\n1\/200<\/td>\n<\/tr>\n
      N\u01b0\u1edbc<\/td>\n1\/400; 1\/50 \u1edf 50 \u00b0C; 1\/30 \u1edf 80 \u00b0C<\/td>\n<\/tr>\n
      D\u1ea7u kho\u00e1ng<\/td>\nH\u1ea7u nh\u01b0 kh\u00f4ng tan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • Dung d\u1ecbch n\u01b0\u1edbc pH 3\u20136 h\u1ea5p \u0111\u01b0\u1ee3c \u1edf 120 \u00b0C trong 20 ph\u00fat kh\u00f4ng ph\u00e2n h\u1ee7y; b\u1ec1n (ph\u00e2n h\u1ee7y d\u01b0\u1edbi 10%) kho\u1ea3ng 4 n\u0103m \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng.<\/li>\n
      • Dung d\u1ecbch pH t\u1eeb 8 tr\u1edf l\u00ean th\u1ee7y ph\u00e2n nhanh (t\u1eeb 10% sau kho\u1ea3ng 60 ng\u00e0y \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng).<\/li>\n
      • B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n
          \n
        • Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n gi\u1ea3m m\u1ea1nh khi c\u00f3 ch\u1ea5t di\u1ec7n ho\u1ea1t kh\u00f4ng ion nh\u01b0 polysorbat 80 (do b\u1ecb gi\u1eef trong micelle); propylen glycol 10% gi\u00fap ph\u1ee5c h\u1ed3i ho\u1ea1t t\u00ednh v\u00e0 ng\u0103n t\u01b0\u01a1ng t\u00e1c n\u00e0y.<\/li>\n
        • T\u01b0\u01a1ng k\u1ef5 \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o v\u1edbi bentonit, magnesi trisilicat, talc, g\u00f4m adragant, natri alginat, tinh d\u1ea7u, sorbitol, atropin; ph\u1ea3n \u1ee9ng v\u1edbi nhi\u1ec1u lo\u1ea1i \u0111\u01b0\u1eddng v\u00e0 polyol.<\/li>\n
        • C\u00f3 th\u1ec3 b\u1ecb nh\u1ef1a h\u1ea5p thu t\u00f9y lo\u1ea1i nh\u1ef1a v\u00e0 ch\u1ea5t d\u1eabn; polyethylen t\u1ef7 tr\u1ecdng th\u1ea5p v\u00e0 cao \u0111\u01b0\u1ee3c cho l\u00e0 kh\u00f4ng h\u1ea5p thu methylparaben.<\/li>\n
        • \u0110\u1ed5i m\u00e0u khi c\u00f3 s\u1eaft; b\u1ecb th\u1ee7y ph\u00e2n b\u1edfi ki\u1ec1m y\u1ebfu v\u00e0 acid m\u1ea1nh.<\/li>\n<\/ul>\n

          S\u1ea3n xu\u1ea5t<\/h2>\n

          Ester h\u00f3a acid p-hydroxybenzoic v\u1edbi methanol.<\/p>\n

          An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n
            \n
          • D\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i. D\u00f9 t\u1eebng \u0111\u01b0\u1ee3c d\u00f9ng trong thu\u1ed1c ti\u00eam v\u00e0 nh\u1ecf m\u1eaft, paraben hi\u1ec7n n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng ph\u00f9 h\u1ee3p cho c\u00e1c d\u1ea1ng n\u00e0y do kh\u1ea3 n\u0103ng k\u00edch \u1ee9ng.<\/li>\n
          • Kh\u00f4ng g\u00e2y \u0111\u1ed9t bi\u1ebfn, kh\u00f4ng g\u00e2y qu\u00e1i thai, kh\u00f4ng g\u00e2y ung th\u01b0; m\u1eabn c\u1ea3m hi\u1ebfm, kh\u00f4ng c\u00f3 m\u1ee9c nh\u1ea1y c\u1ea3m ti\u1ebfp x\u00fac do \u00e1nh s\u00e1ng hay \u0111\u1ed9c t\u00ednh quang h\u1ecdc \u0111\u00e1ng k\u1ec3.<\/li>\n
          • \u0110\u00e3 ghi nh\u1eadn qu\u00e1 m\u1eabn, th\u01b0\u1eddng ki\u1ec3u ch\u1eadm (vi\u00eam da ti\u1ebfp x\u00fac) khi d\u00f9ng ngo\u00e0i, \u0111\u00f4i khi sau khi u\u1ed1ng; ph\u1ea3n \u1ee9ng t\u1ee9c th\u00ec sau ti\u00eam ch\u1ebf ph\u1ea9m ch\u1ee9a paraben. V\u1edbi m\u1ee9c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i, c\u00e1c ph\u1ea3n \u1ee9ng n\u00e0y t\u01b0\u01a1ng \u0111\u1ed1i \u00edt g\u1eb7p. “Ngh\u1ecbch l\u00fd paraben”: ng\u01b0\u1eddi t\u1eebng vi\u00eam da ti\u1ebfp x\u00fac v\u1eabn c\u00f3 th\u1ec3 d\u00f9ng ch\u1ebf ph\u1ea9m ch\u1ee9a paraben \u1edf v\u00f9ng da l\u00e0nh kh\u00e1c.<\/li>\n
          • C\u00f3 lo ng\u1ea1i khi d\u00f9ng trong thu\u1ed1c ti\u00eam cho tr\u1ebb s\u01a1 sinh v\u00ec c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng g\u1eafn k\u1ebft bilirubin.<\/li>\n
          • WHO \u0111\u1eb7t ADI t\u1ed5ng cho methyl-, ethyl- v\u00e0 propylparaben \u0111\u1ebfn 10 mg\/kg th\u1ec3 tr\u1ecdng.<\/li>\n
          • C\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 thao t\u00e1c n\u01a1i th\u00f4ng gi\u00f3, d\u00f9ng k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay, kh\u1ea9u trang ch\u1ed1ng b\u1ee5i.<\/li>\n<\/ul>\n

            T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
              \n
            • M\u1ef9: methylparaben v\u00e0 propylparaben l\u00e0 ch\u1ea5t GRAS d\u00f9ng tr\u1ef1c ti\u1ebfp trong th\u1ef1c ph\u1ea9m \u0111\u1ebfn 0,1%. Nh\u1eadt B\u1ea3n: m\u1ecdi ester tr\u1eeb benzyl \u0111\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong thu\u1ed1c ti\u00eam.<\/li>\n
            • M\u1ef9 ph\u1ea9m (theo s\u00e1ch, 2006): EU v\u00e0 Brazil cho ph\u00e9p m\u1ed7i paraben \u0111\u1ebfn 0,4%, t\u1ed5ng c\u00e1c paraben kh\u00f4ng qu\u00e1 0,8%; Nh\u1eadt B\u1ea3n gi\u1edbi h\u1ea1n tr\u00ean 1,0%.<\/li>\n
            • C\u1eadp nh\u1eadt sau 2006 (ngo\u00e0i s\u00e1ch):<\/em> EU \u0111\u00e3 si\u1ebft quy \u0111\u1ecbnh paraben trong m\u1ef9 ph\u1ea9m t\u1eeb 2014 \u2013 methyl- v\u00e0 ethylparaben v\u1eabn gi\u1eef gi\u1edbi h\u1ea1n 0,4% (ri\u00eang l\u1ebb) v\u00e0 0,8% (h\u1ed7n h\u1ee3p), trong khi propyl- v\u00e0 butylparaben b\u1ecb h\u1ea1 xu\u1ed1ng t\u1ed5ng 0,14% v\u00e0 m\u1ed9t s\u1ed1 paraben kh\u00e1c b\u1ecb c\u1ea5m. C\u1ea7n ki\u1ec3m tra quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh c\u1ee7a th\u1ecb tr\u01b0\u1eddng \u0111\u00edch.<\/li>\n
            • Ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u. C\u00f3 trong FDA Inactive Ingredients Guide (ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch, d\u01b0\u1edbi da; h\u00edt; nh\u00e3n khoa; nang, vi\u00ean n\u00e9n, dung d\u1ecbch, h\u1ed7n d\u1ecbch u\u1ed1ng; nh\u1ecf tai, tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
            • C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

              Ch\u1ea5t li\u00ean quan<\/h2>\n
                \n
              • Natri methylparaben<\/strong> (C8<\/sub>H7<\/sub>NaO3<\/sub>, 174,14; CAS 5026-62-0; E219): b\u1ed9t k\u1ebft tinh tr\u1eafng, h\u00fat \u1ea9m; pH dung d\u1ecbch 0,1% l\u00e0 9,5\u201310,5.<\/li>\n
              • Kali methylparaben<\/strong> (C8<\/sub>H7<\/sub>KO3<\/sub>, 190,25; CAS 26112-07-2): d\u00f9ng thay methylparaben nh\u1edd tan trong n\u01b0\u1edbc t\u1ed1t h\u01a1n.<\/li>\n
              • Ethylparaben, propylparaben, butylparaben.<\/li>\n<\/ul>\n

                Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

                N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Methylparaben<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

                \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

                L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                Methylparaben (E218, Nipagin M) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n Methylparaben (methyl 4-hydroxybenzoat, E218, Nipagin M) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u2013 ri\u00eang l\u1ebb ho\u1eb7c ph\u1ed1i h\u1ee3p c\u00e1c paraben v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c. Trong m\u1ef9 ph\u1ea9m, methylparaben l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c […]<\/p>\n","protected":false},"author":1,"featured_media":2461,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/methylparaben-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Methylparaben (E218, Nipagin M) \u2013 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n Methylparaben (methyl 4-hydroxybenzoat, E218, Nipagin M) l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1ng khu\u1ea9n d\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m \u2013 ri\u00eang l\u1ebb ho\u1eb7c ph\u1ed1i h\u1ee3p c\u00e1c paraben v\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n kh\u00e1c. Trong m\u1ef9 ph\u1ea9m, methylparaben l\u00e0 ch\u1ea5t b\u1ea3o qu\u1ea3n \u0111\u01b0\u1ee3c…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2462"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2462\/revisions"}],"predecessor-version":[{"id":3301,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2462\/revisions\/3301"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2461"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}