{"id":2438,"date":"2026-09-27T15:51:28","date_gmt":"2026-09-27T08:51:28","guid":{"rendered":"https:\/\/cpc1.vn\/acid-malic\/"},"modified":"2026-09-28T21:02:29","modified_gmt":"2026-09-28T14:02:29","slug":"acid-malic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-malic\/","title":{"rendered":"Acid malic \u2013 ch\u1ea5t acid h\u00f3a, t\u1ea1o h\u01b0\u01a1ng, thay acid citric trong vi\u00ean s\u1ee7i"},"content":{"rendered":"

Acid malic \u2013 ch\u1ea5t acid h\u00f3a, t\u1ea1o h\u01b0\u01a1ng, thay acid citric trong vi\u00ean s\u1ee7i<\/h1>\n

Acid malic<\/strong> (acid t\u00e1o, acid hydroxysuccinic, E296) l\u00e0 acid dicarboxylic c\u00f3 trong t\u00e1o v\u00e0 nhi\u1ec1u lo\u1ea1i tr\u00e1i c\u00e2y. Trong b\u00e0o ch\u1ebf, acid malic l\u00e0 ch\u1ea5t acid h\u00f3a<\/strong> \u0111a d\u1ee5ng, ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng<\/strong> che v\u1ecb \u0111\u1eafng, v\u00e0 l\u00e0 l\u1ef1a ch\u1ecdn thay acid citric<\/strong> trong b\u1ed9t s\u1ee7i.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nApple acid, E296, acid 2-hydroxybutanedioic, acid hydroxysuccinic, DL-malic acid<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n6915-15-7 (acid malic); 617-48-1 (DL); 97-67-6 (L); 636-61-3 (D)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC4<\/sub>H6<\/sub>O5<\/sub> \u2013 134,09<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t acid h\u00f3a, ch\u1ed1ng oxy h\u00f3a, t\u1ea1o chelat v\u00e0 \u0111\u1ec7m, t\u1ea1o h\u01b0\u01a1ng<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Acid malic t\u1ed5ng h\u1ee3p s\u1ea3n xu\u1ea5t t\u1ea1i ch\u00e2u \u00c2u v\u00e0 M\u1ef9 l\u00e0 h\u1ed7n h\u1ee3p racemic (DL); d\u1ea1ng c\u00f3 trong t\u00e1o v\u00e0 th\u1ef1c v\u1eadt l\u00e0 \u0111\u1ed3ng ph\u00e2n t\u1ea3 tuy\u1ec1n (L).<\/p>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t acid h\u00f3a \u0111a d\u1ee5ng.<\/li>\n
  • V\u1ecb t\u00e1o nh\u1eb9 \u2013 d\u00f9ng t\u1ea1o h\u01b0\u01a1ng, che v\u1ecb \u0111\u1eafng, t\u1ea1o v\u1ecb chua.<\/li>\n
  • Thay acid citric trong b\u1ed9t s\u1ee7i, n\u01b0\u1edbc s\u00fac mi\u1ec7ng, vi\u00ean l\u00e0m s\u1ea1ch r\u0103ng.<\/li>\n
  • C\u00f3 t\u00ednh t\u1ea1o chelat v\u00e0 ch\u1ed1ng oxy h\u00f3a; hi\u1ec7p \u0111\u1ed3ng v\u1edbi BHT l\u00e0m ch\u1eadm oxy h\u00f3a d\u1ea7u th\u1ef1c v\u1eadt.<\/li>\n
  • C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • B\u1ed9t k\u1ebft tinh ho\u1eb7c h\u1ea1t tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, m\u00f9i nh\u1eb9, v\u1ecb r\u1ea5t chua; h\u00fat \u1ea9m.<\/li>\n
    • (D\u1ea1ng DL) n\u00f3ng ch\u1ea3y 131\u2013132 \u00b0C; s\u00f4i 150 \u00b0C (ph\u00e2n h\u1ee7y); pH dung d\u1ecbch 1% l\u00e0 2,35; pKa1<\/sub> 3,40, pKa2<\/sub> 5,05 (25 \u00b0C).<\/li>\n
    • T\u1ef7 tr\u1ecdng bi\u1ec3u ki\u1ebfn 0,81 g\/cm\u00b3; t\u1ef7 tr\u1ecdng g\u00f5 0,92 g\/cm\u00b3; t\u1ef7 tr\u1ecdng ri\u00eang 1,601 (20 \u00b0C). \u0110\u1ed9 nh\u1edbt dung d\u1ecbch 50%: 6,5 mPa\u00b7s (25 \u00b0C).<\/li>\n
    • D\u1ec5 tan trong n\u01b0\u1edbc v\u00e0 ethanol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong benzen. Dung d\u1ecbch n\u01b0\u1edbc b\u00e3o h\u00f2a ch\u1ee9a kho\u1ea3ng 56% acid malic \u1edf 20 \u00b0C.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n\n
      Dung m\u00f4i (20 \u00b0C)<\/th>\n\u0110\u1ed9 tan DL-acid malic<\/th>\n\u0110\u1ed9 tan L-acid malic<\/th>\n<\/tr>\n<\/thead>\n
      N\u01b0\u1edbc<\/td>\n1\/1,5\u20132,0<\/td>\n1\/2,8<\/td>\n<\/tr>\n
      Methanol<\/td>\n1\/1,2<\/td>\n1\/0,51<\/td>\n<\/tr>\n
      Ethanol 95%<\/td>\n1\/2,6<\/td>\n1\/1,2<\/td>\n<\/tr>\n
      Propylen glycol<\/td>\n1\/1,9<\/td>\n\u2013<\/td>\n<\/tr>\n
      Aceton<\/td>\n1\/5,6<\/td>\n1\/1,6<\/td>\n<\/tr>\n
      Ether<\/td>\n1\/119<\/td>\n1\/37<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • B\u1ec1n \u0111\u1ebfn 150 \u00b0C; tr\u00ean 150 \u00b0C m\u1ea5t n\u01b0\u1edbc r\u1ea5t ch\u1eadm t\u1ea1o acid fumaric; ph\u00e2n h\u1ee7y ho\u00e0n to\u00e0n kho\u1ea3ng 180 \u00b0C th\u00e0nh acid fumaric v\u00e0 anhydrid maleic.<\/li>\n
      • D\u1ec5 b\u1ecb nhi\u1ec1u vi sinh v\u1eadt hi\u1ebfu kh\u00ed v\u00e0 k\u1ef5 kh\u00ed ph\u00e2n h\u1ee7y.<\/li>\n
      • Tr\u00e1nh \u1ea9m cao v\u00e0 nhi\u1ec7t \u0111\u1ed9 cao \u0111\u1ec3 kh\u00f4ng b\u1ecb v\u00f3n c\u1ee5c. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        C\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng v\u1edbi ch\u1ea5t oxy h\u00f3a. Dung d\u1ecbch n\u01b0\u1edbc \u0103n m\u00f2n nh\u1eb9 th\u00e9p carbon.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n

        Hydrat h\u00f3a acid maleic v\u00e0 acid fumaric v\u1edbi x\u00fac t\u00e1c th\u00edch h\u1ee3p, r\u1ed3i t\u00e1ch acid malic kh\u1ecfi h\u1ed7n h\u1ee3p c\u00e2n b\u1eb1ng.<\/p>\n

        An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

        D\u00f9ng trong thu\u1ed1c u\u1ed1ng, d\u00f9ng ngo\u00e0i, thu\u1ed1c ti\u00eam v\u00e0 th\u1ef1c ph\u1ea9m; n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng, nh\u01b0ng dung d\u1ecbch \u0111\u1eb7c c\u00f3 th\u1ec3 k\u00edch \u1ee9ng da, m\u1eaft, ni\u00eam m\u1ea1c \u2013 n\u00ean \u0111eo g\u0103ng tay, k\u00ednh b\u1ea3o h\u1ed9. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): 1,6 g\/kg; (ti\u00eam ph\u00fac m\u1ea1c): 0,1 g\/kg.<\/p>\n

        T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
          \n
        • GRAS; c\u1ea3 d\u1ea1ng racemic v\u00e0 d\u1ea1ng L \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0m ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u.<\/li>\n
        • D\u1ea1ng DL v\u00e0 L c\u00f3 trong FDA Inactive Ingredients Guide (thu\u1ed1c u\u1ed1ng); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
        • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur., USP-NF v\u00e0 Food Chemicals Codex.<\/li>\n<\/ul>\n

          Ch\u1ea5t li\u00ean quan<\/h2>\n
            \n
          • L-acid malic<\/strong>: n\u00f3ng ch\u1ea3y 99\u2013100 \u00b0C; g\u00f3c quay c\u1ef1c ri\u00eang kho\u1ea3ng \u22125,7\u00b0 (aceton).<\/li>\n
          • D-acid malic<\/strong>: n\u00f3ng ch\u1ea3y 99\u2013101 \u00b0C; g\u00f3c quay c\u1ef1c ri\u00eang kho\u1ea3ng +5,2\u00b0 (aceton).<\/li>\n
          • Acid citric, acid fumaric, acid tartric.<\/li>\n<\/ul>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Malic Acid<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Acid malic \u2013 ch\u1ea5t acid h\u00f3a, t\u1ea1o h\u01b0\u01a1ng, thay acid citric trong vi\u00ean s\u1ee7i Acid malic (acid t\u00e1o, acid hydroxysuccinic, E296) l\u00e0 acid dicarboxylic c\u00f3 trong t\u00e1o v\u00e0 nhi\u1ec1u lo\u1ea1i tr\u00e1i c\u00e2y. Trong b\u00e0o ch\u1ebf, acid malic l\u00e0 ch\u1ea5t acid h\u00f3a \u0111a d\u1ee5ng, ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng che v\u1ecb \u0111\u1eafng, v\u00e0 l\u00e0 l\u1ef1a ch\u1ecdn thay acid […]<\/p>\n","protected":false},"author":1,"featured_media":2437,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2438","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-malic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid malic \u2013 ch\u1ea5t acid h\u00f3a, t\u1ea1o h\u01b0\u01a1ng, thay acid citric trong vi\u00ean s\u1ee7i Acid malic (acid t\u00e1o, acid hydroxysuccinic, E296) l\u00e0 acid dicarboxylic c\u00f3 trong t\u00e1o v\u00e0 nhi\u1ec1u lo\u1ea1i tr\u00e1i c\u00e2y. Trong b\u00e0o ch\u1ebf, acid malic l\u00e0 ch\u1ea5t acid h\u00f3a \u0111a d\u1ee5ng, ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng che v\u1ecb \u0111\u1eafng, v\u00e0 l\u00e0 l\u1ef1a ch\u1ecdn thay acid…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2438"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2438\/revisions"}],"predecessor-version":[{"id":3122,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2438\/revisions\/3122"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2437"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2438"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2438"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}