{"id":2428,"date":"2026-09-27T15:47:34","date_gmt":"2026-09-27T08:47:34","guid":{"rendered":"https:\/\/cpc1.vn\/magnesi-nhom-silicat\/"},"modified":"2026-09-28T21:57:01","modified_gmt":"2026-09-28T14:57:01","slug":"magnesi-nhom-silicat","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/magnesi-nhom-silicat\/","title":{"rendered":"Magnesi nh\u00f4m silicat (Veegum) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, \u1ed5n \u0111\u1ecbnh, d\u00ednh, r\u00e3"},"content":{"rendered":"

Magnesi nh\u00f4m silicat (Veegum) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, \u1ed5n \u0111\u1ecbnh, d\u00ednh, r\u00e3<\/h1>\n

Magnesi nh\u00f4m silicat<\/strong> (Veegum) l\u00e0 h\u1ed7n h\u1ee3p kho\u00e1ng s\u00e9t keo montmorillonit v\u00e0 saponit \u0111\u00e3 lo\u1ea1i s\u1ea1n v\u00e0 qu\u1eb7ng kh\u00f4ng tr\u01b0\u01a1ng n\u1edf. \u0110\u01b0\u1ee3c d\u00f9ng l\u00e2u n\u0103m trong vi\u00ean n\u00e9n, thu\u1ed1c m\u1ee1, kem \u2013 ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, \u1ed5n \u0111\u1ecbnh v\u00e0 t\u0103ng \u0111\u1ed9 nh\u1edbt<\/strong>, ngo\u00e0i ra l\u00e0m t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAluminum magnesium silicate, magnesium aluminosilicate, magnesium aluminum silicate colloidal; Veegum, Carrisorb, Gelsorb, Magnabite, Pharmsorb<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n12511-31-8 (aluminium magnesium silicate); 1327-43-1 (magnesium aluminum silicate)<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n (t\u00ednh theo oxid, trung b\u00ecnh)<\/td>\nSiO2<\/sub> 61,1%; MgO 13,7%; Al2<\/sub>O3<\/sub> 9,3%; Na2<\/sub>O 2,9%; CaO 2,7%; Fe2<\/sub>O3<\/sub> 0,9%; n\u01b0\u1edbc k\u1ebft h\u1ee3p 7,2%<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t h\u1ea5p ph\u1ee5, ch\u1ea5t \u1ed5n \u0111\u1ecbnh, ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, t\u00e1 d\u01b0\u1ee3c r\u00e3 vi\u00ean n\u00e9n v\u00e0 nang, t\u00e1 d\u01b0\u1ee3c d\u00ednh, ch\u1ea5t t\u0103ng \u0111\u1ed9 nh\u1edbt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

C\u1ea5u tr\u00fac g\u1ed3m l\u1edbp b\u00e1t di\u1ec7n alumina k\u1eb9p gi\u1eefa hai l\u1edbp t\u1ee9 di\u1ec7n silica; nh\u00f4m \u0111\u01b0\u1ee3c thay th\u1ebf m\u1ed9t ph\u1ea7n b\u1eb1ng magnesi (c\u00e2n b\u1eb1ng \u0111i\u1ec7n t\u00edch b\u1eb1ng natri, kali).<\/p>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch v\u00e0 \u1ed5n \u0111\u1ecbnh trong thu\u1ed1c u\u1ed1ng v\u00e0 d\u00f9ng ngo\u00e0i, d\u00f9ng ri\u00eang ho\u1eb7c ph\u1ed1i h\u1ee3p ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch kh\u00e1c \u2013 ph\u1ed1i h\u1ee3p g\u00f4m xanthan cho hi\u1ec7p \u0111\u1ed3ng t\u0103ng \u0111\u1ed9 nh\u1edbt r\u00f5 r\u1ec7t.<\/li>\n
  • Vi\u00ean n\u00e9n: t\u00e1 d\u01b0\u1ee3c d\u00ednh v\u00e0 r\u00e3, trong vi\u00ean quy \u01b0\u1edbc ho\u1eb7c gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n\n\n\n
    C\u00f4ng d\u1ee5ng<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
    Ch\u1ea5t h\u1ea5p ph\u1ee5<\/td>\n10\u201350<\/td>\n<\/tr>\n
    T\u00e1 d\u01b0\u1ee3c d\u00ednh<\/td>\n2\u201310<\/td>\n<\/tr>\n
    T\u00e1 d\u01b0\u1ee3c r\u00e3<\/td>\n2\u201310<\/td>\n<\/tr>\n
    \u1ed4n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng (u\u1ed1ng)<\/td>\n1\u20135<\/td>\n<\/tr>\n
    \u1ed4n \u0111\u1ecbnh nh\u0169 t\u01b0\u01a1ng (d\u00f9ng ngo\u00e0i)<\/td>\n2\u20135<\/td>\n<\/tr>\n
    T\u1ea1o h\u1ed7n d\u1ecbch (u\u1ed1ng)<\/td>\n0,5\u20132,5<\/td>\n<\/tr>\n
    T\u1ea1o h\u1ed7n d\u1ecbch (d\u00f9ng ngo\u00e0i)<\/td>\n1\u201310<\/td>\n<\/tr>\n
    Ch\u1ea5t \u1ed5n \u0111\u1ecbnh, \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ed9 nh\u1edbt<\/td>\n0,5\u20132,5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • V\u1ea3y nh\u1ecf m\u1ec1m, tr\u01a1n ho\u1eb7c b\u1ed9t m\u1ecbn vi h\u00f3a, m\u00e0u tr\u1eafng ng\u00e0 \u0111\u1ebfn tr\u1eafng kem, kh\u00f4ng m\u00f9i, kh\u00f4ng v\u1ecb. V\u1ea3y c\u1ee1 kho\u1ea3ng 0,3\u00d70,4 mm \u0111\u1ebfn 1,0\u00d72,0 mm, d\u00e0y kho\u1ea3ng 25\u2013240 \u00b5m; b\u1ed9t 45\u2013297 \u00b5m.<\/li>\n
    • USP-NF ph\u00e2n 4 lo\u1ea1i theo \u0111\u1ed9 nh\u1edbt v\u00e0 t\u1ef7 l\u1ec7 Al\/Mg:
      \n\n\n\n\n\n\n\n\n
      This ingredient<\/th>\n\u0110\u1ed9 nh\u1edbt (mPa\u00b7s)<\/th>\nT\u1ef7 l\u1ec7 Al\/Mg<\/th>\n<\/tr>\n<\/thead>\n
      IA<\/td>\n225\u2013600<\/td>\n0,5\u20131,2<\/td>\n<\/tr>\n
      IB<\/td>\n150\u2013450<\/td>\n0,5\u20131,2<\/td>\n<\/tr>\n
      IC<\/td>\n800\u20132200<\/td>\n0,5\u20131,2<\/td>\n<\/tr>\n
      IIA<\/td>\n100\u2013300<\/td>\n1,4\u20132,8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/li>\n
    • T\u1ef7 tr\u1ecdng 2,418 g\/cm\u00b3; \u0111\u1ed9 \u1ea9m 6,0\u20139,98%; c\u1ea7n 6\u20138 mL HCl 0,1 N \u0111\u1ec3 \u0111\u01b0a pH c\u1ee7a 1 g xu\u1ed1ng pH 4.<\/li>\n
    • H\u1ea7u nh\u01b0 kh\u00f4ng tan trong n\u01b0\u1edbc, alcol v\u00e0 dung m\u00f4i h\u1eefu c\u01a1. Tr\u01b0\u01a1ng n\u1edf thu\u1eadn ngh\u1ecbch nhi\u1ec1u l\u1ea7n th\u1ec3 t\u00edch ban \u0111\u1ea7u t\u1ea1o ph\u00e2n t\u00e1n keo; c\u00f3 th\u1ec3 s\u1ea5y kh\u00f4 v\u00e0 hydrat h\u00f3a l\u1ea1i nhi\u1ec1u l\u1ea7n.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt ph\u00e2n t\u00e1n n\u01b0\u1edbc: 1\u20132% l\u00e0 h\u1ed7n d\u1ecbch keo lo\u00e3ng; t\u1eeb 3% \u0111\u1ee5c v\u00e0 thixotrop; 4\u20135% sol keo tr\u1eafng \u0111\u1eb7c; 10% gel ch\u1eafc. \u0110\u1ed9 nh\u1edbt t\u0103ng khi \u0111un n\u00f3ng, th\u00eam ch\u1ea5t \u0111i\u1ec7n ly v\u00e0 (\u1edf n\u1ed3ng \u0111\u1ed9 cao) theo th\u1eddi gian.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      B\u1ec1n v\u00f4 th\u1eddi h\u1ea1n khi b\u1ea3o qu\u1ea3n kh\u00f4; b\u1ec1n trong kho\u1ea3ng pH r\u1ed9ng, c\u00f3 kh\u1ea3 n\u0103ng trao \u0111\u1ed5i cation, h\u1ea5p ph\u1ee5 m\u1ed9t s\u1ed1 ch\u1ea5t h\u1eefu c\u01a1, t\u01b0\u01a1ng h\u1ee3p dung m\u00f4i h\u1eefu c\u01a1. B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4 m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      Do tr\u01a1 n\u00ean \u00edt t\u01b0\u01a1ng k\u1ef5, nh\u01b0ng kh\u00f4ng ph\u00f9 h\u1ee3p v\u1edbi dung d\u1ecbch acid pH d\u01b0\u1edbi 3,5. Nh\u01b0 c\u00e1c lo\u1ea1i s\u00e9t kh\u00e1c, c\u00f3 th\u1ec3 h\u1ea5p ph\u1ee5 m\u1ed9t s\u1ed1 d\u01b0\u1ee3c ch\u1ea5t \u2013 g\u00e2y gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng n\u1ebfu d\u01b0\u1ee3c ch\u1ea5t g\u1eafn ch\u1eb7t ho\u1eb7c nh\u1ea3 ch\u1eadm, v\u00ed d\u1ee5 amfetamin sulfat, tolbutamid, natri warfarin, diazepam.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      T\u1eeb qu\u1eb7ng silicat nh\u00f3m montmorillonit gi\u00e0u magnesi: tr\u1ed9n v\u1edbi n\u01b0\u1edbc th\u00e0nh b\u00f9n \u0111\u1ec3 lo\u1ea1i t\u1ea1p v\u00e0 t\u00e1ch ph\u00e2n \u0111o\u1ea1n keo, s\u1ea5y tr\u1ed1ng th\u00e0nh v\u1ea3y nh\u1ecf r\u1ed3i vi h\u00f3a t\u1ea1o c\u00e1c c\u1ea5p b\u1ed9t.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      N\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng \u1edf m\u1ee9c d\u00f9ng l\u00e0m t\u00e1 d\u01b0\u1ee3c. Chu\u1ed9t c\u1ed1ng v\u00e0 ch\u00f3 \u0103n 10% kh\u1ea9u ph\u1ea7n trong 90 ng\u00e0y kh\u00f4ng c\u00f3 b\u1ea5t th\u01b0\u1eddng, k\u1ec3 c\u1ea3 khi gi\u1ea3i ph\u1eabu v\u00e0 m\u00f4 b\u1ec7nh h\u1ecdc. LD50<\/sub> (chu\u1ed9t c\u1ed1ng, u\u1ed1ng): > 16 g\/kg. N\u00ean \u0111eo k\u00ednh b\u1ea3o h\u1ed9, g\u0103ng tay; th\u00f4ng gi\u00f3 v\u00e0 h\u1ea1n ch\u1ebf t\u1ea1o b\u1ee5i.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • C\u00f3 trong FDA Inactive Ingredients Guide (c\u1ed1m, dung d\u1ecbch, h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; tr\u1ef1c tr\u00e0ng; d\u00f9ng ngo\u00e0i; \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn trong Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> bentonit, kaolin, magnesi trisilicat, talc, g\u00f4m xanthan. L\u01b0u \u00fd: magnesi aluminometasilicat (Neusilin) l\u00e0 ch\u1ea5t kh\u00e1c, d\u00f9ng l\u00e0m ch\u1ea5t h\u1ea5p ph\u1ee5 v\u00e0 t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Magnesium Aluminum Silicate<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Magnesi nh\u00f4m silicat (Veegum) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, \u1ed5n \u0111\u1ecbnh, d\u00ednh, r\u00e3 Magnesi nh\u00f4m silicat (Veegum) l\u00e0 h\u1ed7n h\u1ee3p kho\u00e1ng s\u00e9t keo montmorillonit v\u00e0 saponit \u0111\u00e3 lo\u1ea1i s\u1ea1n v\u00e0 qu\u1eb7ng kh\u00f4ng tr\u01b0\u01a1ng n\u1edf. \u0110\u01b0\u1ee3c d\u00f9ng l\u00e2u n\u0103m trong vi\u00ean n\u00e9n, thu\u1ed1c m\u1ee1, kem \u2013 ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, \u1ed5n \u0111\u1ecbnh v\u00e0 […]<\/p>","protected":false},"author":1,"featured_media":2427,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2428","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/magnesi-nhom-silicat-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Magnesi nh\u00f4m silicat (Veegum) \u2013 ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, \u1ed5n \u0111\u1ecbnh, d\u00ednh, r\u00e3 Magnesi nh\u00f4m silicat (Veegum) l\u00e0 h\u1ed7n h\u1ee3p kho\u00e1ng s\u00e9t keo montmorillonit v\u00e0 saponit \u0111\u00e3 lo\u1ea1i s\u1ea1n v\u00e0 qu\u1eb7ng kh\u00f4ng tr\u01b0\u01a1ng n\u1edf. \u0110\u01b0\u1ee3c d\u00f9ng l\u00e2u n\u0103m trong vi\u00ean n\u00e9n, thu\u1ed1c m\u1ee1, kem \u2013 ch\u1ee7 y\u1ebfu l\u00e0m ch\u1ea5t t\u1ea1o h\u1ed7n d\u1ecbch, \u1ed5n \u0111\u1ecbnh v\u00e0…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2428"}],"version-history":[{"count":2,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2428\/revisions"}],"predecessor-version":[{"id":3403,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2428\/revisions\/3403"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2427"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}