{"id":2424,"date":"2026-09-27T15:47:17","date_gmt":"2026-09-27T08:47:17","guid":{"rendered":"https:\/\/cpc1.vn\/acid-linoleic\/"},"modified":"2026-09-28T21:02:24","modified_gmt":"2026-09-28T14:02:24","slug":"acid-linoleic","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/acid-linoleic\/","title":{"rendered":"Acid linoleic \u2013 acid b\u00e9o omega-6 t\u0103ng th\u1ea5m qua da, nh\u0169 h\u00f3a"},"content":{"rendered":"

Acid linoleic \u2013 acid b\u00e9o omega-6 t\u0103ng th\u1ea5m qua da, nh\u0169 h\u00f3a<\/h1>\n

Acid linoleic<\/strong> l\u00e0 acid b\u00e9o kh\u00f4ng no C18 c\u00f3 hai n\u1ed1i \u0111\u00f4i cis (v\u1ecb tr\u00ed 9 v\u00e0 12) \u2013 acid b\u00e9o omega-6 thi\u1ebft y\u1ebfu. Trong b\u00e0o ch\u1ebf, acid linoleic \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m<\/strong> qua da, ch\u1ea5t t\u0103ng h\u1ea5p thu \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 ch\u1ea5t nh\u0169 h\u00f3a<\/strong> trong m\u1ef9 ph\u1ea9m.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nAcid cis,cis-9,12-octadecadienoic, linolic acid, telfairic acid; Emersol 310, Emersol 315, Pamolyn, Polylin No. 515<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n60-33-3<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC18<\/sub>H32<\/sub>O2<\/sub> \u2013 280,45<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nB\u1ed5 sung dinh d\u01b0\u1ee1ng, ch\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t t\u0103ng th\u1ea5m qua da<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t t\u0103ng th\u1ea5m trong nhi\u1ec1u c\u00f4ng th\u1ee9c d\u00f9ng ngo\u00e0i v\u00e0 qua da.<\/li>\n
  • Ch\u1ea5t t\u0103ng h\u1ea5p thu trong thu\u1ed1c u\u1ed1ng: acid linoleic li\u00ean h\u1ee3p l\u00e0m t\u0103ng t\u00ednh th\u1ea5m c\u1eadn b\u00e0o qua \u0111\u01a1n l\u1edbp t\u1ebf b\u00e0o Caco-2.<\/li>\n
  • Ch\u1ea5t nh\u0169 h\u00f3a trong m\u1ef9 ph\u1ea9m d\u00f9ng ngo\u00e0i.<\/li>\n
  • Th\u00e0nh ph\u1ea7n b\u1ed5 sung dinh d\u01b0\u1ee1ng trong nh\u0169 t\u01b0\u01a1ng ti\u00eam truy\u1ec1n.<\/li>\n
  • H\u1ec7 nh\u0169 t\u01b0\u01a1ng acid linoleic \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m m\u00f4 h\u00ecnh nghi\u00ean c\u1ee9u kh\u1ea3 n\u0103ng ch\u1ed1ng peroxy h\u00f3a lipid c\u1ee7a c\u00e1c h\u1ee3p ch\u1ea5t phenol.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • D\u1ea7u kh\u00f4ng m\u00e0u \u0111\u1ebfn v\u00e0ng nh\u1ea1t.<\/li>\n
    • N\u00f3ng ch\u1ea3y kho\u1ea3ng \u22125 \u00b0C; s\u00f4i 230 \u00b0C \u1edf 16 mmHg; t\u1ef7 tr\u1ecdng 0,9007 g\/cm\u00b3; chi\u1ebft su\u1ea5t nD<\/sub>20<\/sup> 1,4699; ch\u1ec9 s\u1ed1 iod 181,1.<\/li>\n
    • D\u1ec5 tan trong ether; tan trong ethanol 95%; tr\u1ed9n l\u1eabn v\u1edbi dimethylformamid, dung m\u00f4i ch\u1ea5t b\u00e9o v\u00e0 d\u1ea7u.<\/li>\n
    • Kh\u00f4ng c\u00f3 chuy\u00ean lu\u1eadn d\u01b0\u1ee3c \u0111i\u1ec3n; ti\u00eau chu\u1ea9n theo Food Chemicals Codex (FCC): ch\u1ec9 s\u1ed1 acid 196\u2013202, ch\u1ec9 s\u1ed1 iod 145\u2013160, ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a 194\u2013202, h\u00e0m l\u01b0\u1ee3ng \u2265 60%, n\u01b0\u1edbc \u2264 0,5%, ch\u1ea5t kh\u00f4ng x\u00e0 ph\u00f2ng h\u00f3a \u2264 2%.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      L\u00e0 acid b\u00e9o c\u00f3 hai n\u1ed1i \u0111\u00f4i n\u00ean d\u1ec5 b\u1ecb oxy h\u00f3a khi ti\u1ebfp x\u00fac kh\u00f4ng kh\u00ed, \u00e1nh s\u00e1ng, nhi\u1ec7t \u2013 n\u00ean b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, \u0111\u1ea7y, tr\u00e1nh \u00e1nh s\u00e1ng, n\u01a1i m\u00e1t.<\/p>\n

      T\u01b0\u01a1ng k\u1ef5<\/h2>\n

      T\u01b0\u01a1ng k\u1ef5 v\u1edbi base, ch\u1ea5t oxy h\u00f3a m\u1ea1nh v\u00e0 ch\u1ea5t kh\u1eed.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Chi\u1ebft xu\u1ea5t t\u1eeb c\u00e1c d\u1ea7u th\u1ef1c v\u1eadt gi\u00e0u acid linoleic, v\u00ed d\u1ee5 d\u1ea7u rum (safflower).<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      D\u00f9ng r\u1ed9ng r\u00e3i trong m\u1ef9 ph\u1ea9m v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i, n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c. Ti\u1ebfp x\u00fac v\u1edbi m\u1eaft, da, ni\u00eam m\u1ea1c c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng nh\u1eb9. N\u00ean \u0111eo g\u0103ng tay v\u00e0 k\u00ednh b\u1ea3o h\u1ed9.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n

      GRAS; \u0111\u01b0\u1ee3c ph\u00e9p d\u00f9ng trong th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u v\u00e0 Hoa K\u1ef3.<\/p>\n

      Ch\u1ea5t li\u00ean quan<\/h2>\n
        \n
      • Ethyl linoleat<\/strong> (C20<\/sub>H36<\/sub>O2<\/sub>, CAS 544-35-4, c\u00f2n g\u1ecdi “vitamin F”): ch\u1ea5t l\u00e0m m\u1ec1m, gi\u1eef \u1ea9m trong b\u00e0o ch\u1ebf; dung m\u00f4i cho ch\u1ea5t b\u00e9o.<\/li>\n
      • Methyl linoleat<\/strong> (C19<\/sub>H34<\/sub>O2<\/sub>, CAS 112-63-0): ch\u1ea5t l\u00e0m m\u1ec1m trong m\u1ef9 ph\u1ea9m.<\/li>\n<\/ul>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Linoleic Acid<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Acid linoleic \u2013 acid b\u00e9o omega-6 t\u0103ng th\u1ea5m qua da, nh\u0169 h\u00f3a Acid linoleic l\u00e0 acid b\u00e9o kh\u00f4ng no C18 c\u00f3 hai n\u1ed1i \u0111\u00f4i cis (v\u1ecb tr\u00ed 9 v\u00e0 12) \u2013 acid b\u00e9o omega-6 thi\u1ebft y\u1ebfu. Trong b\u00e0o ch\u1ebf, acid linoleic \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m qua da, ch\u1ea5t t\u0103ng h\u1ea5p thu \u0111\u01b0\u1eddng u\u1ed1ng […]<\/p>","protected":false},"author":1,"featured_media":2423,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2424","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/acid-linoleic-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Acid linoleic \u2013 acid b\u00e9o omega-6 t\u0103ng th\u1ea5m qua da, nh\u0169 h\u00f3a Acid linoleic l\u00e0 acid b\u00e9o kh\u00f4ng no C18 c\u00f3 hai n\u1ed1i \u0111\u00f4i cis (v\u1ecb tr\u00ed 9 v\u00e0 12) \u2013 acid b\u00e9o omega-6 thi\u1ebft y\u1ebfu. Trong b\u00e0o ch\u1ebf, acid linoleic \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u0103ng th\u1ea5m qua da, ch\u1ea5t t\u0103ng h\u1ea5p thu \u0111\u01b0\u1eddng u\u1ed1ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2424"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2424\/revisions"}],"predecessor-version":[{"id":3121,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2424\/revisions\/3121"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2423"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}