{"id":2422,"date":"2026-09-27T15:45:51","date_gmt":"2026-09-27T08:45:51","guid":{"rendered":"https:\/\/cpc1.vn\/leucin\/"},"modified":"2026-09-27T15:45:51","modified_gmt":"2026-09-27T08:45:51","slug":"leucin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/leucin\/","title":{"rendered":"Leucin (L-leucin) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, ch\u1ed1ng d\u00ednh, t\u1ea1o h\u01b0\u01a1ng"},"content":{"rendered":"<h1 class=\"kt-tieu-de\">Leucin (L-leucin) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, ch\u1ed1ng d\u00ednh, t\u1ea1o h\u01b0\u01a1ng<\/h1>\n<p><strong>Leucin<\/strong> (L-leucin) l\u00e0 acid amin thi\u1ebft y\u1ebfu, c\u00f3 trong kh\u1ea9u ph\u1ea7n \u0103n b\u00ecnh th\u01b0\u1eddng. Trong b\u00e0o ch\u1ebf, leucin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m <strong>ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng<\/strong>, v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m <strong>t\u00e1 d\u01b0\u1ee3c tr\u01a1n<\/strong> vi\u00ean n\u00e9n v\u00e0 <strong>ch\u1ea5t ch\u1ed1ng d\u00ednh<\/strong> cho b\u1ed9t h\u00edt.<\/p>\n<h2>Th\u00f4ng tin nhanh<\/h2>\n<table>\n<tbody>\n<tr>\n<td>T\u00ean kh\u00e1c<\/td>\n<td>Acid L-\u03b1-aminoisocaproic, acid 2-amino-4-methylpentanoic, Leu, 4-methylnorvalin<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1 CAS<\/td>\n<td>61-90-5 (L-leucin)<\/td>\n<\/tr>\n<tr>\n<td>C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\n<td>C<sub>6<\/sub>H<sub>13<\/sub>NO<sub>2<\/sub> \u2013 131,20<\/td>\n<\/tr>\n<tr>\n<td>Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\n<td>Ch\u1ea5t ch\u1ed1ng d\u00ednh, ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, t\u00e1 d\u01b0\u1ee3c tr\u01a1n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Applications<\/h2>\n<ul>\n<li>Ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng trong ch\u1ebf ph\u1ea9m d\u01b0\u1ee3c.<\/li>\n<li>Ch\u1ea5t ch\u1ed1ng d\u00ednh (th\u1ef1c nghi\u1ec7m): c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng t\u00e1ch r\u1eddi vi ti\u1ec3u ph\u00e2n natri cromoglicat trong b\u1ed9t h\u00edt.<\/li>\n<li>T\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n \u2013 l\u00e0 l\u1ef1a ch\u1ecdn tan trong n\u01b0\u1edbc so v\u1edbi magnesi stearat.<\/li>\n<li>Copolymer leucin \u0111\u01b0\u1ee3c d\u00f9ng t\u1ea1o nano tinh th\u1ec3 d\u01b0\u1ee3c ch\u1ea5t b\u1ec1n trong n\u01b0\u1edbc.<\/li>\n<\/ul>\n<h2>M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n<ul>\n<li>B\u1ed9t k\u1ebft tinh tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, ho\u1eb7c v\u1ea3y \u00f3ng \u00e1nh.<\/li>\n<li>T\u1ef7 tr\u1ecdng 1,293 g\/cm\u00b3; pKa 2,35; \u0111i\u1ec3m \u0111\u1eb3ng \u0111i\u1ec7n 6,04; n\u00f3ng ch\u1ea3y kho\u1ea3ng 293 \u00b0C (k\u00e8m ph\u00e2n h\u1ee7y).<\/li>\n<li>Tan trong n\u01b0\u1edbc, acid acetic, ethanol; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong ether.<\/li>\n<li>D\u01b0\u1ee3c \u0111i\u1ec3n: JP, Ph.Eur., USP quy \u0111\u1ecbnh h\u00e0m l\u01b0\u1ee3ng 98,5\u2013101,5%, g\u00f3c quay c\u1ef1c ri\u00eang d\u01b0\u01a1ng (kho\u1ea3ng +14,5\u00b0 \u0111\u1ebfn +17,3\u00b0), gi\u1edbi h\u1ea1n clorid, sulfat, amoni, s\u1eaft, kim lo\u1ea1i n\u1eb7ng, ch\u1ea5t d\u01b0\u01a1ng t\u00ednh ninhydrin.<\/li>\n<\/ul>\n<h2>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n<p>Nh\u1ea1y v\u1edbi \u00e1nh s\u00e1ng v\u00e0 \u0111\u1ed9 \u1ea9m \u2013 b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn kh\u00ed, n\u01a1i m\u00e1t, t\u1ed1i, kh\u00f4.<\/p>\n<h2>T\u01b0\u01a1ng k\u1ef5<\/h2>\n<p>T\u01b0\u01a1ng k\u1ef5 v\u1edbi ch\u1ea5t oxy h\u00f3a m\u1ea1nh.<\/p>\n<h2>S\u1ea3n xu\u1ea5t<\/h2>\n<p>S\u1ea3n xu\u1ea5t b\u1eb1ng vi sinh v\u1eadt: nu\u00f4i ch\u1ee7ng sinh acid amin (v\u00ed d\u1ee5 <em>Pseudomonas<\/em>, <em>Escherichia<\/em>, <em>Bacillus<\/em>) c\u00f3 m\u1eb7t ch\u1ea5t \u1ee9c ch\u1ebf t\u01b0\u01a1ng t\u1ef1 leucin \u0111\u1ec3 ch\u1ecdn l\u1ecdc ch\u1ee7ng \u0111\u1ed9t bi\u1ebfn kh\u00e1ng, sau \u0111\u00f3 nu\u00f4i ch\u1ee7ng \u0111\u1ed9t bi\u1ebfn n\u00e0y c\u00f3 oxy, v\u1edbi hydrocarbon l\u00e0m ngu\u1ed3n carbon duy nh\u1ea5t.<\/p>\n<h2>An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n<p>L\u00e0 acid amin thi\u1ebft y\u1ebfu, n\u00f3i chung \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng; \u0111\u1ed9c t\u00ednh trung b\u00ecnh khi ti\u00eam d\u01b0\u1edbi da. LD<sub>50<\/sub> (chu\u1ed9t c\u1ed1ng, ti\u00eam ph\u00fac m\u1ea1c): 5,379 g\/kg. Thao t\u00e1c theo bi\u1ec7n ph\u00e1p th\u00f4ng th\u01b0\u1eddng.<\/p>\n<h2>T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n<ul>\n<li>C\u00f3 trong FDA Inactive Ingredients Guide (truy\u1ec1n t\u0129nh m\u1ea1ch; vi\u00ean n\u00e9n u\u1ed1ng); c\u00f3 trong thu\u1ed1c kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh.<\/li>\n<li>C\u00f3 chuy\u00ean lu\u1eadn trong JP, Ph.Eur., USP v\u00e0 Food Chemicals Codex.<\/li>\n<\/ul>\n<p><strong>Ch\u1ea5t li\u00ean quan:<\/strong> DL-leucin, isoleucin.<\/p>\n<h2>Nguy\u00ean li\u1ec7u t\u1ea1i CPC1<\/h2>\n<p>CPC1 \u0111ang cung c\u1ea5p c\u00e1c nguy\u00ean li\u1ec7u li\u00ean quan d\u01b0\u1edbi \u0111\u00e2y. Li\u00ean h\u1ec7 \u0111\u1ec3 nh\u1eadn COA v\u00e0 b\u00e1o gi\u00e1 theo l\u00f4 h\u00e0ng hi\u1ec7n c\u00f3.<\/p>\n<ul>\n<li><a href=\"https:\/\/cpc1.vn\/en\/san-pham\/nguyen-lieu-l-leucine\/\">L-Leucine<\/a><\/li>\n<li><a href=\"https:\/\/cpc1.vn\/en\/san-pham\/nguyen-lieu-n-acetyl-dl-leucin-acetyl-leucin\/\">N-Acetyl DL-Leucin (Acetyl Leucin)<\/a><\/li>\n<\/ul>\n<h2>Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n<p>N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn <em>Leucine<\/em> trong:<br \/>\nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). <em>Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.<br \/>\nPharmaceutical Press (London) &amp; American Pharmacists Association (Washington DC), 2006.<br \/>\nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n<p><em>\u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n<p><em>L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.<br \/>\nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh<br \/>\nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Leucin (L-leucin) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, ch\u1ed1ng d\u00ednh, t\u1ea1o h\u01b0\u01a1ng Leucin (L-leucin) l\u00e0 acid amin thi\u1ebft y\u1ebfu, c\u00f3 trong kh\u1ea9u ph\u1ea7n \u0103n b\u00ecnh th\u01b0\u1eddng. Trong b\u00e0o ch\u1ebf, leucin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 ch\u1ea5t ch\u1ed1ng d\u00ednh cho b\u1ed9t h\u00edt. Th\u00f4ng tin nhanh T\u00ean [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2421,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2422","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/leucin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Leucin (L-leucin) \u2013 t\u00e1 d\u01b0\u1ee3c tr\u01a1n, ch\u1ed1ng d\u00ednh, t\u1ea1o h\u01b0\u01a1ng Leucin (L-leucin) l\u00e0 acid amin thi\u1ebft y\u1ebfu, c\u00f3 trong kh\u1ea9u ph\u1ea7n \u0103n b\u00ecnh th\u01b0\u1eddng. Trong b\u00e0o ch\u1ebf, leucin \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m ch\u1ea5t t\u1ea1o h\u01b0\u01a1ng, v\u00e0 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m t\u00e1 d\u01b0\u1ee3c tr\u01a1n vi\u00ean n\u00e9n v\u00e0 ch\u1ea5t ch\u1ed1ng d\u00ednh cho b\u1ed9t h\u00edt. Th\u00f4ng tin nhanh T\u00ean&hellip;","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2422"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2422\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2421"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}