{"id":2420,"date":"2026-09-27T15:45:43","date_gmt":"2026-09-27T08:45:43","guid":{"rendered":"https:\/\/cpc1.vn\/lecithin\/"},"modified":"2026-09-27T15:45:43","modified_gmt":"2026-09-27T08:45:43","slug":"lecithin","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/lecithin\/","title":{"rendered":"Lecithin \u2013 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n, l\u00e0m m\u1ec1m; th\u00e0nh ph\u1ea7n liposome"},"content":{"rendered":"

Lecithin \u2013 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n, l\u00e0m m\u1ec1m; th\u00e0nh ph\u1ea7n liposome<\/h1>\n

Lecithin<\/strong> (E322) l\u00e0 h\u1ed7n h\u1ee3p ph\u1ee9c t\u1ea1p c\u00e1c phosphatid kh\u00f4ng tan trong aceton \u2013 ch\u1ee7 y\u1ebfu phosphatidylcholin, phosphatidylethanolamin, phosphatidylserin v\u00e0 phosphatidylinositol \u2013 k\u00e8m triglycerid, acid b\u00e9o, carbohydrat. Lecithin l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n v\u00e0 \u1ed5n \u0111\u1ecbnh<\/strong> d\u00f9ng trong thu\u1ed1c ti\u00eam, dinh d\u01b0\u1ee1ng t\u0129nh m\u1ea1ch, kem, thu\u1ed1c \u0111\u1eb7t v\u00e0 liposome.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\nE322, lecithin \u0111\u1eadu n\u00e0nh, lecithin tr\u1ee9ng (ovolecithin), phospholipid \u0111\u1eadu n\u00e0nh, lecithin th\u1ef1c v\u1eadt; Phosal 53 MCT, Phospholipon 100 H, Sternpur, LSC 5050, LSC 6040<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n8002-43-5 (lecithin\/phosphatidylcholin); lecithin \u0111\u1eadu n\u00e0nh 8030-76-0; lecithin l\u00f2ng \u0111\u1ecf tr\u1ee9ng 93685-90-6<\/td>\n<\/tr>\n
Th\u00e0nh ph\u1ea7n<\/td>\nThay \u0111\u1ed5i r\u1ea5t nhi\u1ec1u theo ngu\u1ed3n v\u00e0 \u0111\u1ed9 tinh khi\u1ebft: lecithin tr\u1ee9ng ~69% phosphatidylcholin, 24% phosphatidylethanolamin; lecithin \u0111\u1eadu n\u00e0nh ~21% phosphatidylcholin, 22% phosphatidylethanolamin, 19% phosphatidylinositol<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t l\u00e0m m\u1ec1m, ch\u1ea5t nh\u0169 h\u00f3a, ch\u1ea5t h\u00f2a tan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Ch\u1ea5t ph\u00e2n t\u00e1n, nh\u0169 h\u00f3a, \u1ed5n \u0111\u1ecbnh trong thu\u1ed1c ti\u00eam b\u1eafp, ti\u00eam t\u0129nh m\u1ea1ch, nh\u0169 t\u01b0\u01a1ng dinh d\u01b0\u1ee1ng \u0111\u01b0\u1eddng ti\u00eam v\u00e0 \u0111\u01b0\u1eddng ru\u1ed9t; kem, thu\u1ed1c m\u1ee1.<\/li>\n
  • Thu\u1ed1c \u0111\u1eb7t: gi\u1ea3m \u0111\u1ed9 gi\u00f2n c\u1ee7a vi\u00ean \u0111\u1eb7t.<\/li>\n
  • Liposome: lecithin l\u00e0 th\u00e0nh ph\u1ea7n l\u1edbp k\u00e9p lipid bao g\u00f3i d\u01b0\u1ee3c ch\u1ea5t \u2013 th\u01b0\u1eddng c\u1ea7n lecithin tinh ch\u1ebf ph\u1ed1i h\u1ee3p theo t\u1ef7 l\u1ec7 x\u00e1c \u0111\u1ecbnh.<\/li>\n
  • \u0110\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m ch\u1ea5t t\u0103ng h\u1ea5p thu (insulin qua m\u0169i); organogel poloxamer\u2013lecithin cho thu\u1ed1c NSAID d\u00f9ng ngo\u00e0i.<\/li>\n
  • M\u1ef9 ph\u1ea9m v\u00e0 th\u1ef1c ph\u1ea9m. C\u00e1c \u1ee9ng d\u1ee5ng l\u00e0m thu\u1ed1c c\u1ee7a lecithin v\u00e0 d\u1eabn ch\u1ea5t n\u1eb1m ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n
    D\u1ea1ng b\u00e0o ch\u1ebf<\/th>\nN\u1ed3ng \u0111\u1ed9 (%)<\/th>\n<\/tr>\n<\/thead>\n
    Kh\u00ed dung h\u00edt<\/td>\n0,1<\/td>\n<\/tr>\n
    Thu\u1ed1c ti\u00eam b\u1eafp<\/td>\n0,3\u20132,3<\/td>\n<\/tr>\n
    H\u1ed7n d\u1ecbch u\u1ed1ng<\/td>\n0,25\u201310,0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • D\u1ea1ng thay \u0111\u1ed5i t\u1eeb b\u00e1n l\u1ecfng s\u1ec7t \u0111\u1ebfn b\u1ed9t t\u00f9y h\u00e0m l\u01b0\u1ee3ng acid b\u00e9o t\u1ef1 do; m\u00e0u n\u00e2u \u0111\u1ebfn v\u00e0ng nh\u1ea1t t\u00f9y t\u1ea9y m\u00e0u v\u00e0 \u0111\u1ed9 tinh khi\u1ebft. G\u1ea7n nh\u01b0 kh\u00f4ng m\u00f9i; lo\u1ea1i th\u1ef1c v\u1eadt c\u00f3 v\u1ecb nh\u1ea1t ho\u1eb7c v\u1ecb h\u1ea1t nh\u01b0 d\u1ea7u \u0111\u1eadu n\u00e0nh.<\/li>\n
    • T\u1ef7 tr\u1ecdng 0,97 g\/cm\u00b3 (l\u1ecfng), 0,5 g\/cm\u00b3 (b\u1ed9t); ch\u1ec9 s\u1ed1 iod 95\u2013100 (l\u1ecfng), 82\u201388 (b\u1ed9t); \u0111i\u1ec3m \u0111\u1eb3ng \u0111i\u1ec7n 3,5; ch\u1ec9 s\u1ed1 x\u00e0 ph\u00f2ng h\u00f3a 196.<\/li>\n
    • Tan trong hydrocarbon b\u00e9o v\u00e0 th\u01a1m, hydrocarbon halogen h\u00f3a, d\u1ea7u kho\u00e1ng, acid b\u00e9o; h\u1ea7u nh\u01b0 kh\u00f4ng tan trong d\u1ea7u th\u1ef1c v\u1eadt\/\u0111\u1ed9ng v\u1eadt l\u1ea1nh, dung m\u00f4i ph\u00e2n c\u1ef1c v\u00e0 n\u01b0\u1edbc \u2013 nh\u01b0ng khi tr\u1ed9n v\u1edbi n\u01b0\u1edbc th\u00ec hydrat h\u00f3a t\u1ea1o nh\u0169 t\u01b0\u01a1ng.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n
        \n
      • Ph\u00e2n h\u1ee7y \u1edf pH qu\u00e1 cao ho\u1eb7c qu\u00e1 th\u1ea5p; h\u00fat \u1ea9m v\u00e0 d\u1ec5 b\u1ecb vi sinh v\u1eadt ph\u00e2n h\u1ee7y.<\/li>\n
      • Ti\u1ebfp x\u00fac kh\u00f4ng kh\u00ed b\u1ecb oxy h\u00f3a nhanh, s\u1eabm sang v\u00e0ng \u0111\u1eadm ho\u1eb7c n\u00e2u; \u0111un n\u00f3ng l\u00e0m oxy h\u00f3a, s\u1eabm m\u00e0u v\u00e0 ph\u00e2n h\u1ee7y \u2013 \u1edf 160\u2013180 \u00b0C ph\u00e2n h\u1ee7y trong v\u00f2ng 24 gi\u1edd.<\/li>\n
      • Lo\u1ea1i l\u1ecfng ho\u1eb7c d\u1ea1ng s\u00e1p b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng tr\u1edf l\u00ean \u2013 d\u01b0\u1edbi 10 \u00b0C c\u00f3 th\u1ec3 t\u00e1ch l\u1edbp.<\/li>\n
      • M\u1ecdi c\u1ea5p: bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng v\u00e0 oxy h\u00f3a; lecithin r\u1eafn tinh ch\u1ebf b\u1ea3o qu\u1ea3n k\u00edn \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 0 \u00b0C.<\/li>\n<\/ul>\n

        T\u01b0\u01a1ng k\u1ef5<\/h2>\n

        T\u01b0\u01a1ng k\u1ef5 v\u1edbi esterase (b\u1ecb th\u1ee7y ph\u00e2n). Lecithin ch\u01b0a tinh ch\u1ebf ch\u1ee9a nhi\u1ec1u th\u00e0nh ph\u1ea7n kh\u00f4ng x\u00e1c \u0111\u1ecbnh, c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi ho\u1ea1t ch\u1ea5t ho\u1eb7c t\u00e1 d\u01b0\u1ee3c kh\u00e1c v\u00e0 d\u1ec5 g\u00e2y k\u00edch \u1ee9ng h\u01a1n \u2013 c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng trong thu\u1ed1c ti\u00eam ho\u1eb7c d\u00f9ng ngo\u00e0i.<\/p>\n

        S\u1ea3n xu\u1ea5t<\/h2>\n
          \n
        • Lecithin th\u1ef1c v\u1eadt<\/strong> (\u0111\u1eadu n\u00e0nh quan tr\u1ecdng nh\u1ea5t; ngo\u00e0i ra l\u1ea1c, h\u1ea1t b\u00f4ng, h\u01b0\u1edbng d\u01b0\u01a1ng, h\u1ea1t c\u1ea3i, ng\u00f4): s\u1ea3n ph\u1ea9m ph\u1ee5 c\u1ee7a qu\u00e1 tr\u00ecnh tinh luy\u1ec7n d\u1ea7u \u2013 chi\u1ebft lipid ph\u00e2n c\u1ef1c b\u1eb1ng hexan, lo\u1ea1i dung m\u00f4i \u0111\u01b0\u1ee3c d\u1ea7u th\u00f4, r\u1ed3i t\u00e1ch lecithin b\u1eb1ng n\u01b0\u1edbc, s\u1ea5y kh\u00f4 v\u00e0 c\u00f3 th\u1ec3 tinh ch\u1ebf th\u00eam.<\/li>\n
        • Lecithin tr\u1ee9ng<\/strong> (lecithin \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n \u0111\u1ea7u ti\u00ean): g\u1eafn ch\u1eb7t v\u1edbi protein h\u01a1n n\u00ean chi\u1ebft b\u1eb1ng aceton t\u1eeb l\u00f2ng \u0111\u1ecf tr\u1ee9ng l\u1ecfng, ho\u1eb7c b\u1eb1ng ethanol 95% t\u1eeb l\u00f2ng \u0111\u1ecf \u0111\u00f4ng kh\u00f4.<\/li>\n
        • C\u00f3 th\u1ec3 t\u1ed5ng h\u1ee3p lecithin.<\/li>\n<\/ul>\n

          An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

          Lecithin l\u00e0 th\u00e0nh ph\u1ea7n m\u00e0ng t\u1ebf b\u00e0o, c\u00f3 s\u1eb5n trong kh\u1ea9u ph\u1ea7n \u0103n h\u1eb1ng ng\u00e0y; t\u01b0\u01a1ng h\u1ee3p sinh h\u1ecdc cao, d\u00f9 d\u00f9ng qu\u00e1 nhi\u1ec1u c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i (li\u1ec1u u\u1ed1ng \u0111\u1ebfn 80 g\/ng\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn). D\u00f9ng ngo\u00e0i n\u00f3i chung kh\u00f4ng k\u00edch \u1ee9ng, kh\u00f4ng g\u00e2y m\u1eabn c\u1ea3m. H\u1ed9i \u0111\u1ed3ng CIR \u0111\u00e3 n\u00e2ng n\u1ed3ng \u0111\u1ed9 an to\u00e0n trong m\u1ef9 ph\u1ea9m t\u1eeb 1,95% l\u00ean 15% (s\u1ea3n ph\u1ea9m r\u1eeda tr\u00f4i v\u00e0 l\u01b0u l\u1ea1i), nh\u01b0ng ch\u01b0a \u0111\u1ee7 d\u1eef li\u1ec7u cho s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 b\u1ecb h\u00edt. Lecithin c\u00f3 th\u1ec3 k\u00edch \u1ee9ng m\u1eaft \u2013 n\u00ean \u0111eo k\u00ednh b\u1ea3o h\u1ed9 v\u00e0 g\u0103ng tay.<\/p>\n

          T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
            \n
          • GRAS; ph\u1ee5 gia th\u1ef1c ph\u1ea9m \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn t\u1ea1i ch\u00e2u \u00c2u (E322).<\/li>\n
          • C\u00f3 trong FDA Inactive Ingredients Guide (h\u00edt; ti\u00eam b\u1eafp, t\u0129nh m\u1ea1ch; nh\u1ecf tai; nang, h\u1ed7n d\u1ecbch, vi\u00ean n\u00e9n u\u1ed1ng; tr\u1ef1c tr\u00e0ng, d\u00f9ng ngo\u00e0i, \u00e2m \u0111\u1ea1o); c\u00f3 trong thu\u1ed1c ti\u00eam v\u00e0 kh\u00f4ng ti\u00eam \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p t\u1ea1i Anh; c\u00f3 trong danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn c\u1ee7a Canada.<\/li>\n
          • C\u00f3 chuy\u00ean lu\u1eadn trong USP-NF v\u00e0 Food Chemicals Codex.<\/li>\n<\/ul>\n

            Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

            N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Lecithin<\/em> trong:
            \nRowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5.
            \nPharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006.
            \nB\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

            \u1ea2nh minh h\u1ecda: thi\u1ebft k\u1ebf c\u1ee7a CPC1.<\/em><\/p>\n

            L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006.
            \nTi\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh
            \nhi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

            Lecithin \u2013 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n, l\u00e0m m\u1ec1m; th\u00e0nh ph\u1ea7n liposome Lecithin (E322) l\u00e0 h\u1ed7n h\u1ee3p ph\u1ee9c t\u1ea1p c\u00e1c phosphatid kh\u00f4ng tan trong aceton \u2013 ch\u1ee7 y\u1ebfu phosphatidylcholin, phosphatidylethanolamin, phosphatidylserin v\u00e0 phosphatidylinositol \u2013 k\u00e8m triglycerid, acid b\u00e9o, carbohydrat. Lecithin l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n v\u00e0 \u1ed5n \u0111\u1ecbnh d\u00f9ng trong thu\u1ed1c ti\u00eam, dinh d\u01b0\u1ee1ng […]<\/p>","protected":false},"author":1,"featured_media":2419,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lecithin-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Lecithin \u2013 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n, l\u00e0m m\u1ec1m; th\u00e0nh ph\u1ea7n liposome Lecithin (E322) l\u00e0 h\u1ed7n h\u1ee3p ph\u1ee9c t\u1ea1p c\u00e1c phosphatid kh\u00f4ng tan trong aceton \u2013 ch\u1ee7 y\u1ebfu phosphatidylcholin, phosphatidylethanolamin, phosphatidylserin v\u00e0 phosphatidylinositol \u2013 k\u00e8m triglycerid, acid b\u00e9o, carbohydrat. Lecithin l\u00e0 ch\u1ea5t nh\u0169 h\u00f3a, ph\u00e2n t\u00e1n v\u00e0 \u1ed5n \u0111\u1ecbnh d\u00f9ng trong thu\u1ed1c ti\u00eam, dinh d\u01b0\u1ee1ng…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2420"}],"version-history":[{"count":0,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2420\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2419"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}