{"id":2404,"date":"2026-09-27T11:46:12","date_gmt":"2026-09-27T04:46:12","guid":{"rendered":"https:\/\/cpc1.vn\/lactitol\/"},"modified":"2026-09-28T21:16:33","modified_gmt":"2026-09-28T14:16:33","slug":"lactitol","status":"publish","type":"post","link":"https:\/\/cpc1.vn\/en\/lactitol\/","title":{"rendered":"Lactitol (E966) \u2013 polyol thay \u0111\u01b0\u1eddng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n d\u1eadp th\u1eb3ng"},"content":{"rendered":"

Lactitol (E966) \u2013 polyol thay \u0111\u01b0\u1eddng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n d\u1eadp th\u1eb3ng<\/h1>\n

Lactitol<\/strong> (E966) l\u00e0 \u0111\u01b0\u1eddng alcol (polyol) thu \u0111\u01b0\u1ee3c khi hydro h\u00f3a lactose. Lactitol \u0111\u01b0\u1ee3c d\u00f9ng thay saccarose trong s\u1ea3n ph\u1ea9m kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng<\/strong>, v\u00e0 l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho d\u1ea1ng thu\u1ed1c r\u1eafn \u2013 c\u00f3 lo\u1ea1i d\u1eadp th\u1eb3ng chuy\u00ean d\u1ee5ng.<\/p>\n

Th\u00f4ng tin nhanh<\/h2>\n\n\n\n\n\n\n\n
T\u00ean kh\u00e1c<\/td>\n\u03b2-Galactosido-sorbitol, lactit, lactosit, lactobiosit, E966; Finlac DC, Lacty<\/td>\n<\/tr>\n
T\u00ean h\u00f3a h\u1ecdc<\/td>\n4-O-(\u03b2-D-Galactopyranosyl)-D-glucitol<\/td>\n<\/tr>\n
S\u1ed1 CAS<\/td>\n585-86-4 (khan); 81025-04-9 (monohydrat); 81025-03-8 (dihydrat)<\/td>\n<\/tr>\n
C\u00f4ng th\u1ee9c \u2013 KLPT<\/td>\nC12<\/sub>H24<\/sub>O11<\/sub> \u2013 344,32 (khan); monohydrat 362,34; dihydrat 380,35<\/td>\n<\/tr>\n
Nh\u00f3m ch\u1ee9c n\u0103ng<\/td>\nCh\u1ea5t t\u1ea1o ng\u1ecdt, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n vi\u00ean n\u00e9n v\u00e0 vi\u00ean nang<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications<\/h2>\n
    \n
  • Thay saccarose trong s\u1ea3n ph\u1ea9m kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng; ng\u1ecdt b\u1eb1ng kho\u1ea3ng 1\/3 saccarose; n\u0103ng l\u01b0\u1ee3ng kho\u1ea3ng 9,9 kJ\/g (2,4 kcal\/g).<\/li>\n
  • T\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho d\u1ea1ng r\u1eafn; c\u00f3 lo\u1ea1i d\u1eadp th\u1eb3ng (Finlac DC \u2013 h\u1ea1t vi tinh th\u1ec3 t\u1ea1o h\u1ea1t b\u1eb1ng n\u01b0\u1edbc) v\u00e0 h\u1ed7n h\u1ee3p d\u1eadp th\u1eb3ng lactose\u2013lactitol.<\/li>\n
  • Lactitol c\u00f2n l\u00e0 ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u1edf li\u1ec1u cao \u2013 ngo\u00e0i ph\u1ea1m vi b\u00e0i vi\u1ebft.<\/li>\n<\/ul>\n

    M\u00f4 t\u1ea3 v\u00e0 t\u00ednh ch\u1ea5t<\/h2>\n
      \n
    • Tinh th\u1ec3 tr\u1ef1c thoi tr\u1eafng, kh\u00f4ng m\u00f9i, v\u1ecb ng\u1ecdt k\u00e8m c\u1ea3m gi\u00e1c m\u00e1t; d\u1ea1ng b\u1ed9t v\u00e0 nhi\u1ec1u c\u1ee1 tinh th\u1ec3.<\/li>\n
    • pH dung d\u1ecbch 10%: 4,5\u20137,0; t\u1ef7 tr\u1ecdng 1,54 g\/cm\u00b3; m\u1ea5t n\u01b0\u1edbc k\u1ebft tinh \u1edf 145\u2013185 \u00b0C.<\/li>\n
    • \u0110\u1ed9 \u1ea9m: 4,5\u20135,5% (monohydrat); \u2264 0,5% (khan). Dung d\u1ecbch 7% \u0111\u1eb3ng th\u1ea9m th\u1ea5u v\u1edbi huy\u1ebft thanh.<\/li>\n
    • Tan 1\/1,75 trong n\u01b0\u1edbc \u1edf 20 \u00b0C (t\u0103ng theo nhi\u1ec7t \u0111\u1ed9); \u00edt tan trong ethanol 95% v\u00e0 ether.<\/li>\n
    • \u0110\u1ed9 nh\u1edbt dung d\u1ecbch (20 \u00b0C): 10% \u2013 1,3 mPa\u00b7s; 40% \u2013 6,9 mPa\u00b7s; 60% \u2013 80 mPa\u00b7s.<\/li>\n<\/ul>\n

      \u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n<\/h2>\n

      D\u1ea1ng monohydrat kh\u00f4ng h\u00fat \u1ea9m, b\u1ec1n trong \u0111i\u1ec1u ki\u1ec7n \u1ea9m; b\u1ec1n nhi\u1ec7t, kh\u00f4ng tham gia ph\u1ea3n \u1ee9ng Maillard<\/strong>. Trong dung d\u1ecbch acid th\u1ee7y ph\u00e2n ch\u1eadm th\u00e0nh sorbitol v\u00e0 galactose. R\u1ea5t b\u1ec1n v\u1edbi vi sinh v\u1eadt. Bao b\u00ec ch\u01b0a m\u1edf \u1edf 25 \u00b0C\/60% RH c\u00f3 h\u1ea1n d\u00f9ng tr\u00ean 3 n\u0103m.<\/p>\n

      S\u1ea3n xu\u1ea5t<\/h2>\n

      Hydro h\u00f3a x\u00fac t\u00e1c lactose.<\/p>\n

      An to\u00e0n v\u00e0 thao t\u00e1c<\/h2>\n

      Lactitol \u0111\u01b0\u1ee3c xem l\u00e0 kh\u00f4ng \u0111\u1ed9c, kh\u00f4ng k\u00edch \u1ee9ng. Kh\u00f4ng b\u1ecb l\u00ean men \u0111\u00e1ng k\u1ec3 trong mi\u1ec7ng n\u00ean kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng; kh\u00f4ng h\u1ea5p thu \u1edf ru\u1ed9t non m\u00e0 \u0111\u01b0\u1ee3c vi khu\u1ea9n \u0111\u1ea1i tr\u00e0ng ph\u00e2n gi\u1ea3i, chuy\u1ec3n h\u00f3a kh\u00f4ng ph\u1ee5 thu\u1ed9c insulin. Li\u1ec1u l\u1edbn c\u00f3 t\u00e1c d\u1ee5ng nhu\u1eadn tr\u00e0ng. N\u00ean \u0111eo k\u00ednh khi thao t\u00e1c.<\/p>\n

      T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd<\/h2>\n
        \n
      • \u0110\u01b0\u1ee3c ch\u1ea5p nh\u1eadn l\u00e0 ph\u1ee5 gia th\u1ef1c ph\u1ea9m t\u1ea1i ch\u00e2u \u00c2u (E966).<\/li>\n
      • C\u00f3 chuy\u00ean lu\u1eadn lactitol monohydrat trong Ph.Eur. v\u00e0 USP-NF.<\/li>\n<\/ul>\n

        Ch\u1ea5t li\u00ean quan:<\/strong> lactose, isomalt, maltitol, sorbitol, xylitol.<\/p>\n

        Ngu\u1ed3n tham kh\u1ea3o<\/h2>\n

        N\u1ed9i dung \u0111\u01b0\u1ee3c CPC1 bi\u00ean so\u1ea1n, t\u00f3m l\u01b0\u1ee3c c\u00f3 ch\u1ecdn l\u1ecdc t\u1eeb chuy\u00ean lu\u1eadn Lactitol<\/em> trong: Rowe R.C., Sheskey P.J., Owen S.C. (ch\u1ee7 bi\u00ean). Handbook of Pharmaceutical Excipients<\/em>, \u1ea5n b\u1ea3n 5. Pharmaceutical Press (London) & American Pharmacists Association (Washington DC), 2006. B\u00e0i vi\u1ebft kh\u00f4ng sao ch\u00e9p nguy\u00ean v\u0103n t\u00e0i li\u1ec7u g\u1ed1c; c\u00e1c s\u1ed1 li\u1ec7u k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c d\u1eabn l\u1ea1i t\u1eeb t\u00e0i li\u1ec7u n\u00e0y.<\/p>\n

        \u1ea2nh minh h\u1ecda: c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o do CPC1 v\u1ebd l\u1ea1i t\u1eeb d\u1eef li\u1ec7u c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u00f4ng khai.<\/em><\/p>\n

        L\u01b0u \u00fd: th\u00f4ng tin mang t\u00ednh tham kh\u1ea3o cho ng\u01b0\u1eddi l\u00e0m chuy\u00ean m\u00f4n b\u00e0o ch\u1ebf, d\u1ef1a tr\u00ean \u1ea5n b\u1ea3n n\u0103m 2006. Ti\u00eau chu\u1ea9n ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 t\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd c\u00f3 th\u1ec3 \u0111\u00e3 thay \u0111\u1ed5i \u2014 lu\u00f4n \u0111\u1ed1i chi\u1ebfu d\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 quy \u0111\u1ecbnh hi\u1ec7n h\u00e0nh tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

        Lactitol (E966) \u2013 polyol thay \u0111\u01b0\u1eddng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n d\u1eadp th\u1eb3ng Lactitol (E966) l\u00e0 \u0111\u01b0\u1eddng alcol (polyol) thu \u0111\u01b0\u1ee3c khi hydro h\u00f3a lactose. Lactitol \u0111\u01b0\u1ee3c d\u00f9ng thay saccarose trong s\u1ea3n ph\u1ea9m kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng, v\u00e0 l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho d\u1ea1ng thu\u1ed1c r\u1eafn \u2013 c\u00f3 lo\u1ea1i d\u1eadp th\u1eb3ng chuy\u00ean d\u1ee5ng. Th\u00f4ng tin nhanh T\u00ean […]<\/p>","protected":false},"author":1,"featured_media":2403,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[122],"tags":[],"class_list":["post-2404","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ta-duoc"],"blocksy_meta":[],"acf":[],"uagb_featured_image_src":{"full":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol.png",1200,675,false],"thumbnail":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol-150x150.png",150,150,true],"medium":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol-300x169.png",300,169,true],"medium_large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol-768x432.png",768,432,true],"large":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol-1024x576.png",1024,576,true],"1536x1536":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol.png",1200,675,false],"2048x2048":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol.png",1200,675,false],"trp-custom-language-flag":["https:\/\/cpc1.vn\/wp-content\/uploads\/2026\/09\/lactitol-18x10.png",18,10,true]},"uagb_author_info":{"display_name":"cpc1vn","author_link":"https:\/\/cpc1.vn\/en\/author\/cpc1vn\/"},"uagb_comment_info":0,"uagb_excerpt":"Lactitol (E966) \u2013 polyol thay \u0111\u01b0\u1eddng, t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n d\u1eadp th\u1eb3ng Lactitol (E966) l\u00e0 \u0111\u01b0\u1eddng alcol (polyol) thu \u0111\u01b0\u1ee3c khi hydro h\u00f3a lactose. Lactitol \u0111\u01b0\u1ee3c d\u00f9ng thay saccarose trong s\u1ea3n ph\u1ea9m kh\u00f4ng g\u00e2y s\u00e2u r\u0103ng, v\u00e0 l\u00e0m t\u00e1 d\u01b0\u1ee3c \u0111\u1ed9n cho d\u1ea1ng thu\u1ed1c r\u1eafn \u2013 c\u00f3 lo\u1ea1i d\u1eadp th\u1eb3ng chuy\u00ean d\u1ee5ng. Th\u00f4ng tin nhanh T\u00ean…","_links":{"self":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/comments?post=2404"}],"version-history":[{"count":1,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2404\/revisions"}],"predecessor-version":[{"id":3278,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/posts\/2404\/revisions\/3278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media\/2403"}],"wp:attachment":[{"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/media?parent=2404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/categories?post=2404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cpc1.vn\/en\/wp-json\/wp\/v2\/tags?post=2404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}